LOCUS       NM_173618               1154 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens INO80 complex subunit E (INO80E), transcript variant
            1, mRNA.
ACCESSION   NM_173618
VERSION     NM_173618.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1154)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1154)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1154)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1154)
  AUTHORS   Cox,E., Hwang,W., Uzoma,I., Hu,J., Guzzo,C.M., Jeong,J.,
            Matunis,M.J., Qian,J., Zhu,H. and Blackshaw,S.
  TITLE     Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as
            a Key Regulator of the INO80 Chromatin Remodeling Complex
  JOURNAL   Mol Cell Proteomics 16 (5), 812-823 (2017)
   PUBMED   28254775
REFERENCE   5  (bases 1 to 1154)
  AUTHORS   Zhang,S., Zhou,B., Wang,L., Li,P., Bennett,B.D., Snyder,R.,
            Garantziotis,S., Fargo,D.C., Cox,A.D., Chen,L. and Hu,G.
  TITLE     INO80 is required for oncogenic transcription and tumor growth in
            non-small cell lung cancer
  JOURNAL   Oncogene 36 (10), 1430-1439 (2017)
   PUBMED   27641337
REFERENCE   6  (bases 1 to 1154)
  AUTHORS   Vassileva,I., Yanakieva,I., Peycheva,M., Gospodinov,A. and
            Anachkova,B.
  TITLE     The mammalian INO80 chromatin remodeling complex is required for
            replication stress recovery
  JOURNAL   Nucleic Acids Res 42 (14), 9074-9086 (2014)
   PUBMED   25016522
REFERENCE   7  (bases 1 to 1154)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   8  (bases 1 to 1154)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   9  (bases 1 to 1154)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
REFERENCE   10 (bases 1 to 1154)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075133.1, BC047712.2 and AC093512.2.
            
            On Nov 22, 2018 this sequence version replaced NM_173618.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075133.1, AK130409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000563197.6/ ENSP00000457016.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1096              AK075133.1         32-1127
            1097-1153           BC047712.2         1090-1146
            1154-1154           AC093512.2         73841-73841
FEATURES             Location/Qualifiers
     source          1..1154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1154
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /note="INO80 complex subunit E"
                     /db_xref="GeneID:283899"
                     /db_xref="HGNC:HGNC:26905"
     exon            1..151
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..805
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain containing 95; coiled-coil
                     domain-containing protein 95"
                     /codon_start=1
                     /product="INO80 complex subunit E isoform 1"
                     /protein_id="NP_775889.1"
                     /db_xref="CCDS:CCDS10665.1"
                     /db_xref="GeneID:283899"
                     /db_xref="HGNC:HGNC:26905"
                     /translation="MNGPADGEVDYKKKYRNLKRKLKFLIYEHECFQEELRKAQRKLL
                     KVSRDKSFLLDRLLQYENVDEDSSDSDATASSDNSETEGTPKLSDTPAPKRKRSPPLG
                     GAPSPSSLSLPPSTGFPLQASGVPSPYLSSLASSRYPPFPSDYLALQLPEPSPLRPKR
                     EKRPRLPRKLKMAVGPPDCPVGGPLTFPGRGSGAGVGTTLTPLPPPKMPPPTILSTVP
                     RQMFSDAGSGDDALDGDDDLVIDIPE"
     exon            152..222
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /inference="alignment:Splign:2.1.0"
     exon            223..275
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /inference="alignment:Splign:2.1.0"
     exon            276..354
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /inference="alignment:Splign:2.1.0"
     exon            355..466
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /inference="alignment:Splign:2.1.0"
     exon            467..583
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /inference="alignment:Splign:2.1.0"
     exon            584..1154
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1135..1140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /note="hexamer: ATTAAA"
     polyA_site      1154
                     /gene="INO80E"
                     /gene_synonym="CCDC95"
                     /note="major polyA site"
ORIGIN      
        1 gggagcggca cggcagccac tgcttggggt agcgggaggg cagactctgg gcgccactcc
       61 cgggccggtc atgaacgggc cggcggacgg cgaagtggac tacaaaaaaa aataccggaa
      121 tctgaagcgg aagctcaagt tcctcatcta cgagcacgag tgcttccagg aggagctgag
      181 gaaagcgcaa aggaaattac tgaaggtgtc ccgggacaag agtttcctcc tagaccgact
      241 tctgcagtac gagaacgtgg atgaagactc ttcggactca gatgccactg catcatcaga
      301 taacagcgag acggagggga cacccaagtt gtctgacaca ccggccccta agaggaagag
      361 aagccctccg ctggggggcg ccccctctcc ctccagcctc tccctgcctc cttcaacagg
      421 gtttcccctt caggcctccg gggtcccctc cccatacctg agctcgctgg cctcctcccg
      481 ctacccccca ttcccttctg actacctggc cctgcagctg cccgagccca gtcccctgag
      541 gcccaagcgg gagaaacggc cccgcctgcc ccggaaactc aagatggcgg tgggaccccc
      601 cgactgccct gtgggagggc cgctgacctt ccctggccgg ggttctgggg ctggggtcgg
      661 gacaaccctg acccccctcc caccccctaa gatgcccccc cccacgatcc tgagcacggt
      721 ccctcggcag atgttcagcg atgcaggtag cggggacgat gccttggatg gagacgatga
      781 cctggtgatc gacatcccgg agtgaccgtg acatcacgcc atgcccacca cggccccgcc
      841 cggcgccctc cccgtgccag cacacacgag tccagcttcc tcggaggtgt ttattgatgc
      901 ccagctgcca tgctccggcc actgacacaa ccagaaaagg cgtaaacatg cacgggtgtc
      961 ccccaggagg gtggcagggg ccctgccttc aaaccccggc cccctccagg ggacagttat
     1021 ttaaacgagt ggccgggagc atctgccacc tgctggggag gcagagaccc tgcaatggcc
     1081 acctctttaa aagggcagct gtacagggct aggttttttc aatgaagttt ctgtattaaa
     1141 ggagtggctc tggg
//
