LOCUS       NM_017759              14128 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens INO80 complex subunit D (INO80D), mRNA.
ACCESSION   NM_017759
VERSION     NM_017759.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14128)
  AUTHORS   Chang,C.C., Liu,T.Y., Lee,Y.T., Chen,Y.C., Yeh,K.T., Lee,C.C.,
            Chen,Y.L., Lin,P.C., Chang,Y.S., Chan,W.L., Liu,T.C. and Chang,J.G.
  TITLE     Genome-wide analysis of lncRNAs in 3'-untranslated regions:
            CR933609 acts as a decoy to protect the INO80D gene
  JOURNAL   Int J Oncol 53 (1), 417-433 (2018)
   PUBMED   29750421
  REMARK    GeneRIF: expression levels of CR933609 and INO80D were decreased in
            CR933609-knockdown NSCLC cells, but only expression levels of
            INO80D decreased in INO80D knockdown cells. It was shown that there
            are independent promoters in CR933609 and INO80D
REFERENCE   2  (bases 1 to 14128)
  AUTHORS   Zhang,S., Zhou,B., Wang,L., Li,P., Bennett,B.D., Snyder,R.,
            Garantziotis,S., Fargo,D.C., Cox,A.D., Chen,L. and Hu,G.
  TITLE     INO80 is required for oncogenic transcription and tumor growth in
            non-small cell lung cancer
  JOURNAL   Oncogene 36 (10), 1430-1439 (2017)
   PUBMED   27641337
REFERENCE   3  (bases 1 to 14128)
  AUTHORS   Cao,L., Ding,J., Dong,L., Zhao,J., Su,J., Wang,L., Sui,Y., Zhao,T.,
            Wang,F., Jin,J. and Cai,Y.
  TITLE     Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin
            Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest
            and Abnormal Chromosome Stability
  JOURNAL   PLoS One 10 (9), e0137411 (2015)
   PUBMED   26340092
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14128)
  AUTHORS   Shameer,K., Klee,E.W., Dalenberg,A.K. and Kullo,I.J.
  TITLE     Whole exome sequencing implicates an INO80D mutation in a syndrome
            of aortic hypoplasia, premature atherosclerosis, and arterial
            stiffness
  JOURNAL   Circ Cardiovasc Genet 7 (5), 607-614 (2014)
   PUBMED   25122053
  REMARK    GeneRIF: INO80D is a subunit of the human INO80 chromatin
            remodeling complex; its Ser818Cys mutation has a role in
            accelerated arterial aging
REFERENCE   5  (bases 1 to 14128)
  AUTHORS   Vassileva,I., Yanakieva,I., Peycheva,M., Gospodinov,A. and
            Anachkova,B.
  TITLE     The mammalian INO80 chromatin remodeling complex is required for
            replication stress recovery
  JOURNAL   Nucleic Acids Res 42 (14), 9074-9086 (2014)
   PUBMED   25016522
REFERENCE   6  (bases 1 to 14128)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   7  (bases 1 to 14128)
  AUTHORS   Cotsapas,C., Speliotes,E.K., Hatoum,I.J., Greenawalt,D.M.,
            Dobrin,R., Lum,P.Y., Suver,C., Chudin,E., Kemp,D., Reitman,M.,
            Voight,B.F., Neale,B.M., Schadt,E.E., Hirschhorn,J.N., Kaplan,L.M.
            and Daly,M.J.
  CONSRTM   GIANT Consortium
  TITLE     Common body mass index-associated variants confer risk of extreme
            obesity
  JOURNAL   Hum Mol Genet 18 (18), 3502-3507 (2009)
   PUBMED   19553259
  REMARK    Erratum:[Hum Mol Genet. 2010 Sep 15;19(18):3690-1]
REFERENCE   8  (bases 1 to 14128)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096585.1, DB233201.1, AC007679.4, BC004193.2, AK000316.1 and
            CR746991.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017759.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.216272.1,
                                           SRR1803613.231593.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403263.6/ ENSP00000384198.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AK096585.1         10-182
            174-274             DB233201.1         136-236
            275-831             AK096585.1         284-840
            832-832             AC007679.4         165745-165745       c
            833-2035            BC004193.2         558-1760
            2036-2118           AK096585.1         2045-2127
            2119-2119           AC007679.4         118633-118633       c
            2120-2574           AK000316.1         1448-1902
            2575-2965           AK096585.1         2584-2974
            2966-3309           CR746991.1         146-489
            3310-4007           AK096585.1         3069-3766
            4008-14128          AC007679.4         102739-112859       c
FEATURES             Location/Qualifiers
     source          1..14128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..14128
                     /gene="INO80D"
                     /note="INO80 complex subunit D"
                     /db_xref="GeneID:54891"
                     /db_xref="HGNC:HGNC:25997"
                     /db_xref="MIM:619207"
     exon            1..274
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            275..368
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            369..615
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..3481
                     /gene="INO80D"
                     /codon_start=1
                     /product="INO80 complex subunit D"
                     /protein_id="NP_060229.3"
                     /db_xref="CCDS:CCDS46500.1"
                     /db_xref="GeneID:54891"
                     /db_xref="HGNC:HGNC:25997"
                     /db_xref="MIM:619207"
                     /translation="MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDK
                     TAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKV
                     RHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPLHYLETELEDPFAFNEEDDDL
                     KKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPPPAPSQQQPPQQHSHLSPLSTS
                     LKPPAPPQGSVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPTVD
                     PPRTDRILMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEEPE
                     DSEQASPYQVAWSIRETLRYQRHASDDDDAESRSSRVTQLCTYFQQKYKHLCRLERAE
                     SRQKKCRHTFRKALLQAASKEPECTGQLIQELRRAACSRTSISRTKLREVEPAACSGT
                     VKGEQCANKALPFTRHCFQHILLNHSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCE
                     EHAKKMDNFLRGDNSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAV
                     PQGNLSMPASVSLPVEASHIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDV
                     LPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLAQSDGVPV
                     QELSDRGIGVFSTGTGASGIQSLSREVNTDLGELLNGRIVHDNFSSLELDENLLRSAT
                     LSNPPTPLAGQIQGQFSAPANVGLTSATLISQSALGERAFPGQFHGLHDGSHASQRPH
                     PAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNM
                     AATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLGADGHLL
                     STSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQL
                     PQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPFPSPN"
     exon            616..1361
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1470
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1695
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1805
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1939
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2157
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2315
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..14128
                     /gene="INO80D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14108..14113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INO80D"
                     /note="hexamer: AATAAA"
     polyA_site      14128
                     /gene="INO80D"
                     /note="major polyA site"
ORIGIN      
        1 gtacagcccc ggcagccctg ccttcttggc tggagagtat attcagggat ttccccttaa
       61 taatcaccga ccctgggagc actttttagt ttccaaaata aaaatatgat cctcacccct
      121 cttgcttgac agggaaaggc tctcgccgga gcccaggggg gagcagtagc agcggcagcc
      181 gagcttccta gtccattgcc agcgcctctc actctgatct gtcagcccag ccgagggaac
      241 aggggggaag gagaaaaaaa aaagcagctg aaagacaatc tgcttcatcc tgattctgcg
      301 gcattccaaa ctgtggtatc cttgggggtt ctcttaacat tgctatggtg cagaagattt
      361 aaaatcagct gatgttcaca aggaatagag tcacgtgatg tatgaaggga aacatataca
      421 cttctctgag gttgacaata agcccttgtg ctcatatagc cccaaactgt gcaagcagag
      481 gcgactcaac ggctacgcct tctgtatcag acacgttctg gaggacaaga ctgccccctt
      541 caagcaatgt gaatatgtgg ccaagtataa cagccaacgc tgcaccaacc ccatccccaa
      601 atcagaggat cgtaggtact gcaacagcca cttgcaggta cttggcttta tcccgaaaaa
      661 agagaggaag aaaaagaatg atcctataga tgaggtgaag gtcaggcacc agatggatac
      721 catggccttt agcctgacag tgcccacgtt ggccttgaag atgcccaacg gactggatgg
      781 aatgtccctc tctccacctg gggcaagggt ccctctccac tacctggaaa ccgaattgga
      841 agacccattt gctttcaatg aggaagatga tgacctaaag aaaggggcaa ctgtgagaaa
      901 gaagttgcag agcaagttgg cccagaatcg gcagcgccag agagagacag agattttaaa
      961 agttcgacaa gagcacttta gtccccctcc tgcaccttca cagcagcagc ctccgcagca
     1021 gcactcccac ctgtcacctt tatctacttc tttaaaacct ccagcgccac cgcagggttc
     1081 agtctgcaag tcacctcaac ctcagaacac cagcctacca atgcagggag tggcacccac
     1141 cacacacact atagcacaag cacggcagtt gtctcacaag aggcctctgc ccctcctgcc
     1201 atccagtagg gctcccactg tggacccacc caggactgac cggatcctca tgaaagccac
     1261 agccttctct ccacacttct catgtataag ccgactgcag agactggtga aactgtgcac
     1321 ccagaaacat cagttggaca ctgatctgtt tccccattta ggtttggact ggtctgaaga
     1381 gagcggagag gaaccagagg actcagagca ggcctcgccc taccaggttg catggtccat
     1441 ccgggaaacc ctcagatatc aaagacatgc gtcagatgat gatgatgcgg agagtaggag
     1501 ctccagggtg actcaacttt gcacttactt tcagcagaaa tataagcacc tctgccgcct
     1561 ggagcgggca gaatctcgtc aaaagaaatg ccggcatacg tttaggaaag ctttgctgca
     1621 ggcggccagt aaagaaccag aatgcactgg tcagttaata caagaactgc ggagagctgc
     1681 atgcagtcga accagcataa gccggaccaa gctgagggag gtggaaccag cagcatgcag
     1741 tggaaccgtg aagggtgaac agtgcgctaa caaagccctt ccattcacca gacattgttt
     1801 ccaacatatc ctcttgaacc actctcagca gctcttctca agttgcacag ccaagtttgc
     1861 agatggacag cagtgctctg tgccagtttt tgacattaca catcagacac ctctgtgtga
     1921 agaacatgcc aaaaaaatgg ataatttctt gagaggagat aactcccgta aagttcagca
     1981 ccagcagcag aggaaaccca ggaaaaaaac caagcctcct gcactaacca aaaaacacaa
     2041 gaagaagaga aggcgtggac ctcgtcgacc ccaaaaaccc attccacctg cagtccccca
     2101 agggaacctc agcatgcccg ccagcgtctc actgccagtg gaggcctctc acatccggag
     2161 cccatccacg ccagagctga gtgctgatga gttgccggat gacattgcca atgagatcac
     2221 tgacattcca catgacttgg aattgaacca ggaggacttt tcagatgtcc tgccacggct
     2281 acctgatgac ttacaagatt ttgatttttt tgaagggaag aatggagacc tcctcccaac
     2341 taccgaagag gctgaggagc ttgaacgggc cttgcaggct gtaacttctc tcgagtgcct
     2401 gagtaccatt ggggtccttg cccagtcaga tggtgtgcca gtccaggagt tgtcagatag
     2461 aggaataggg gtgttctcca caggtactgg agcttcagga atacaatcct tgagccgaga
     2521 ggtgaacaca gacctagggg agctattgaa tgggcgtata gtacatgata atttttctag
     2581 tctagagctg gatgagaacc tgctccgttc tgctaccttg tcaaacccac ctacacccct
     2641 ggcagggcag atccaggggc agttctctgc cccagccaac gttggcctta cttctgccac
     2701 tctgatcagc cagagtgcac ttggggagag agccttccca ggacagtttc atggacttca
     2761 tgacggcagc catgcctccc agaggccaca tcctgcccag ctgctgagca aggcagatga
     2821 cctaatcacc tcacgacagc aatacagcag tgatcactca cactcctcac cccatggaag
     2881 ccattatgat agtgagcatg tgccgtctcc ctacagtgac catatcacct ctccccacac
     2941 aacatcgtac tctggtgata atatggcagc taccttttca gcagagatgc ccatcatggc
     3001 gcagcacttg ctcccaaccc aacttgaggt gccacttgga ggcgtggtaa accccagaac
     3061 tcactggggc aatctccctg tcaaccttgg agacccctct ccatttagca accttctcgg
     3121 cgcagatgga catcttcttt ccacttccct atccacgcca cccaccactt cgaactcaga
     3181 gaccacacag cctgccttcg ccaccgtgac ccccagcagc tccagtgtgc ttccggggtt
     3241 accacagacc agcttcagtg gcatggggcc ttctgctgaa ctaatggcct ccacctctcc
     3301 caagcagcaa ctccctcagt tcagcgcagc ctttggccac cagctgagtt ctcacagtgg
     3361 cattcctaag gacctgcagc ccagccacag ctctatagcc cctcctacag gcttcacagt
     3421 aacaggtgcc acagctacaa gtaccaataa tgcatcttct ccctttccct cccctaactg
     3481 agggtgtctg tgtgtttgca ggcaggtggg gaacccagtg ttttctatct ttgtttcctc
     3541 tttagcaccc ctctcccctt ttcctaaaga agatataaca gatggggatc agaggggcac
     3601 cccccttccc agttcaatga gtggccctgc agtggacctc gctacagtgt tcacatgtgc
     3661 tccttagcac tggtgctcat tccctcctgg caggcccact ccgccccagt ggtttcctta
     3721 gtggttcagc acagtgactg gataggattg atttttagca gcaagtccta gaagtggaag
     3781 atacctcaga ataccagtgc cctttactat ttcctagtat tcagatcagt gctttccatt
     3841 ctgttgccag gtttttacat aggtggttct agatagaatg atcttattaa ttgagttcct
     3901 gtataagaga cagcaaatgg tgtgtggcag gtcaagattc tgacctagca ccaactgcta
     3961 aacaccacag tgaggccagg attccattcg taattgtgat catgtttaac taaaagaaaa
     4021 aaatgtgtct tttgactgcc tgtgagtatg cgtgtgccca cgcgtgtgtt tttgtgcagt
     4081 gcaggaagca gctgtcccat tagtttgatt tttttttgtt ctccccttcc ccctacttaa
     4141 tgagtataaa actcttactt ttctcctgtc ctacatctca cagtcctaat aaggttggtc
     4201 cttcttttcc tcaagtttcc tgaataggga gggtggtgga ctggtcgtgt gagtagcaca
     4261 acctttttct gctaaaagtt agcccaagaa gaaacagaac atagaaagct tggattcccg
     4321 tcagtgaggt agggatgtcc taaaaagctt gcctgggatg actgcaggct gccggggttc
     4381 tggggcctga tggtcacttt gtcttttcag acatttgttt gtttctaaat ccctctctca
     4441 tggaatacat ttgcaagatg taattaaaga aaatattttg atgtgaaaaa gcaggatagg
     4501 tcagatagat ttgaaaagat gggatctgtc aactccttga tccatctttt gcttttgaat
     4561 ttttcatgtt tacagtagtg attctttggt aagatttgta aaatgttaag acacttgtag
     4621 aatcagtgta ccagttgtga agtgatgtgt aatatctgaa ggatacacat tttaaagttt
     4681 ctttcaaagc agaatatgga aattagatat aaattttatt cgccctttgg tccttttaaa
     4741 ataattcaag tacttgggtt taagtaaatt tgaaaatagc tttgggaaat gtttttaaaa
     4801 tgccaggatt ttaggggtta aagatcatat ggggtagttt aggaagtttg tgactatgag
     4861 atgaatttgt gaggtttctt gcctaccttt tttccccccc agagaagggt ggaactagat
     4921 tttaaaggca tctctactct gcttttgctg agtagtttca ctgtcccttg agataccatt
     4981 ggctatttat acctgagtct agtctaattc acatatatat atattttaaa agttgagaga
     5041 acatacctat tgatgtggtt caataattca tttgtcaggg aatatttgat cttaattcct
     5101 ttctaatagg tagtgattgg atgtattttc ctacttcctg tatgtaatct ctttatgcca
     5161 tgctagttct aaccagtccc ttcttttgaa agcttttctt tctctgcttt ttaaaggaat
     5221 gatggtgatc agcaggcatt atgcagatac cacgtgcctg aggttatgga ggggaaatgt
     5281 cacatgactg tatgaaatca ttatatgccc tattttgtat ttattgatgt ttctttttgt
     5341 gggccaaaaa tatgtttgta atatatttag tttttttaaa atcatggtaa ttgattggaa
     5401 gatttatttt taatagcttt gccttttttg cagagtgcaa aatttctaaa ttataactta
     5461 tgtcataaag caaaattata tttggtatca ccataaattt ctattctgaa tggtgagaac
     5521 agataatttg aatatttctc acctgtgagt ctatattagt aagctttttt attttaatgt
     5581 actgtaatga agtggtcacg agtagttacc tcggctcaaa aatgtcattt agtttgttaa
     5641 actattttca caaccatcat aagcataact agataactgt ccattcccag cagttcagtt
     5701 tagtctccat tgtgtattta aaggttgtcg cagagcagca cattgacttc ctcatcagcc
     5761 ctttgacaag gaagggaaag tcgtgggtag tcgatttgaa ctttttctgt ctacttgtcc
     5821 cctcatgtta gctgcttgaa attcttcagt tatgatacaa agctgagttt gcagtaagtt
     5881 gcacatttta ttgtttgcaa ttttctgttt tatgtgcatt taaaagccct tctctgcttt
     5941 ctagtaagga ggcatgaaat tatcaggaat gttgctagtt acagcttcac accaaaaact
     6001 ttgagtaaat acattttcgt ttggatgccc atgatgaaag ctgaggaaag tggttgagga
     6061 attatcaaca acaaactttt cctcttattt tatctagttc aaaacagata tcaaagtttg
     6121 caatttgctt tgctcttgct gtttcttatg agtccctttt tggaagagag gagaacatct
     6181 ataagcccag agagatctgt gtttttcttt tacttaatag agccattctc gtctattagt
     6241 aggaactttg ctattaatat gtatagaaag gaatgaagtg gcttttactc cagaaatatg
     6301 aaaattagta tcttttaaaa tagcacttat gctatcacaa ggcaatactg gaatgaaaaa
     6361 caaatcttat ataaggtcct aaataggtag aaactagctt ttattctagt gttgaaccca
     6421 ggagaaatag tggcaaagaa gtttcactct gtttctgcag ttctttggga ctatttataa
     6481 aggccagtta gattgtgtta ctgtgattta atttacaaag ttgctgcagt taatggatac
     6541 attctgtgct ctgagaatct gaattccatt ctaatgtgtg atattcactg gctatgatca
     6601 gtagtatctg aagaaaagat gggctttttc tcctttactc tctctacata attattaata
     6661 ttattttaat taaagtactt aagacattgt tttttcttct gtaaaaatgg cttagcaatt
     6721 tgcacatctg ggtaggttat gtagctagta aacaactcaa tagtaagtag caattatact
     6781 taacccacca agtgacagac tatgcaatgg aaaaattttc taattatcgt cacatagctt
     6841 agacagcaaa ggattatttt ctctggtgac ctaccatgtg tgatataact gctttataaa
     6901 tgacttcctg agcaatttca tgttggcagg cagtgtggtg tgtctagtgc ccctctatga
     6961 gaagactata atttaatcag aaacaaatag taggcatggg gagcaagttg gaaagtgagg
     7021 ttattatttt ttttccttaa aattggtgtt actgtcttta gtggcttgag gctaaagaaa
     7081 gctgatactt tatctttgcc aaataattat ttataagatt tatttttaaa taagcccaat
     7141 ctctcacctg cagttaagaa tcatcatttt ctgtgactga cactaaagct cttccttatc
     7201 agagcttgtt ctcaatctgt gatcacagtc cacagtggca aagacaactc tttgattagg
     7261 aaggaaacca tgtttgggat gcacagaggt gccctgtcca tacggttttc ttcttacatg
     7321 aaagaattga cctttctgtt gacctatacc attctgtttt tataaagtgg gattagaatt
     7381 tgagcatatc tagtaaatgc cgtgtggtca gtccgctgat gcttgcccgc cgtctttgcc
     7441 gtgccttggc atcctagggg tgctggtgat ggtcagtggg catcatcggt cagcagtgca
     7501 cgtgtaaggc aatctcctct cctccaggtt agttcagaag gtcgctatgg gttggtattg
     7561 caaaaagatg agtatatgaa cactaaactt attaagaggt ttgaaattca ttaaaaatta
     7621 gttttcagtt tcttcatctt tcttttcaga cttctttaaa aatactgttc ttaatctggt
     7681 atatatagaa atctaatatt atggtcttct aaatggtcaa cagaactctc cagtttaatg
     7741 aggcaattta gaggattcct tgaaagaaaa tttcatcata ctgaacagtc ctcatttgta
     7801 tctcttttgt taccagtatt tacattgttc caaggatttt tttcctgaca aaaaatatat
     7861 ttctcgggag tggagagttt tttatatata tatatgaaag aacatagatg tttccccccg
     7921 cccaatacat taactgaatc ttcactggca ttctgtagaa aagttaaaac agtttaataa
     7981 tgtcttaaca tctttataca ttttcctata ttctggagga aaccagaatc atgtttagta
     8041 gattaaagta acattttaaa tactaccttt ccaataattt gtaataaaat accagtgaag
     8101 gacatgtttg gatatctgtt aagcattttt ccctgactaa tgaattagga aagaaaacat
     8161 aaaacataaa tgaatagtta tgtctcttct aataaacagt gtcattaatg ctgcagttgt
     8221 gggtcaaact tagggagcct tatttctaaa tagcaaaaat tctgttttca cttcagccct
     8281 tatttttttt tgttagtttt tctctgcact gtgatacaga gctaataaga ggaaatgtga
     8341 cgtttcagag agagagcaag caaattgggt atgacttttt taccctatgt tccccaatac
     8401 tggggatgtt tggctacttt gaacagcagt ttttagtgat ctaaagttta gatcaatact
     8461 cgtataagag aaaaatctaa ctctcagtga gctccatagg gcagcacagc tttccatctt
     8521 ctctttcgcc ttcttgcgtc tgcccaccac agtcccgaag aatgcacacg cacatatgat
     8581 ctgtacccat cccgcccgaa gagtcataga atcctcttct ttcacttgtt tcttttttct
     8641 tcgtttgttt gtttttgttt gtttgttttt taagctgggg accactgaag taagctctgt
     8701 atgcacccaa agttcccctt ggaaaaattt tcaacacgca gtgcagaagg ctccagtgca
     8761 gctaaatgcc acaccattgg ttctacctgg gggaatagac tgatttgccc taaaatgact
     8821 ccaacctgca tcattaaggt acagttggct ccagtggatt agtgctgaaa tgatgggaag
     8881 tctgacactt gttgacattg tcttcatctg tttggaaggg ttgaatctgt tcctctcaac
     8941 agtgatagtt cttttcactg tatagtattg agtatgtctc agggattcct tgtggaaatt
     9001 agggcagttt ttaaaataag aaaatagttt taaaagaaac taaaggtgac tcatcattga
     9061 agagagcgga agaaagagga aacatttggt tttgtagccc acagtgtctt gcataggact
     9121 ttttcctttc tcctccaggc tctcatctca gcttcagaat acagaatcct ttcccatcac
     9181 gcacagcttt aaaactttta tttaaaaatt tccttcccca atgagctttc agaatactta
     9241 ttgtagattt taagagaaaa ggtatattaa tttatgctat taacatcacc tcataaatta
     9301 taagttttat actaaagctg tatcgagtgt aatgaattat gttgcctatg tgtttaatag
     9361 ctaaatatat atgagctttt tttttttttt ttttttttga caaaacaaac tagtgaagca
     9421 cctttttaca ctggatctct gccgtgtcaa ggtgtatagc tatcctttgc taccttgcag
     9481 atatataaaa taaaaggata tcctggggcc tcaaaatgta gaacaccttt agaccattta
     9541 taactgttcc tagaactgtt gagaatcatg ttctttagta aatgatctgt ggtttacact
     9601 taagatggct agaagcttag ttacagggta catagaaata catagatcaa gtaaaactcc
     9661 aactactgta gctggaattt gtaaactaag tttgtaagac ctcttttatt tcctatggag
     9721 ttattcttta atttacagtt tattctgtaa gttgggaagt aaaatagaga aaataataaa
     9781 tctagatgtt ctcagtgtct tattcaggaa ctttttatcc ctcctcacta aggaattccc
     9841 actgtgactt taaaatagaa ctaaattact tgtgtgcatg tatatgtctg tattttttac
     9901 acacatgcaa aaatatacat tgggggcacg tgtgtgagag atatgaatgt gtgcttatat
     9961 aaaaatagat aaaggtaacc gaatgtattg tagaaacatg atttatttag ttgagggtat
    10021 tggagttact ttctcattgt ctctgttgta taaatacacc aaattaatca ttatgttatc
    10081 ttatgttaaa aggctagctc tgatatcatg tgcattttat gttaaccttt ggattaactt
    10141 atattatgct atgttcataa aatgacatga gaaacaggag gttctaagat cagcctctca
    10201 ctttcgagca taaaaataag agagggagac agacagcccc agacatgagc tgtgtttatc
    10261 tattgtggtg atgggaccac agatctattg aatctttttt atgttaatta tagatttctt
    10321 tatattcgag taagaaaata ttgttgatca tcttttcttg gtgaagttaa gaaaaagtat
    10381 aggcctttca taaacaattt ttggaagggg ctgctttgtt taaggagttg gtgggatcat
    10441 ttcaccgtgc atatttcaaa gctggggtga tttcatttat ttccaaaatt tttcaaaaaa
    10501 cttttactca gttctgctgt tatttattaa cttaagagtg ctcccatccc catatttcag
    10561 ctataggaaa attgtgctac ccctgattca tatggaatta aaaaaaaata catcccttta
    10621 ttttgagttt taagttgtta ttttgctata catttattac tggagtatct ggtggtctga
    10681 aatagtcaaa agtagagttg gtattaaatg ttccaatgac atttattttt aatacttaaa
    10741 aaatcatgta ctttgaaata tgtcaaagca acttctgata atatacctga atttgtagtt
    10801 gtctcttgag catcatttac ttcatcttag atatagtgaa gatctaggaa agctctatat
    10861 gctgttcttt tctacagttg tatttttgca gcatctcctg gtttcattca ctcttgtttt
    10921 gggatttttt tttagatctg catatttctt gtacatatgc atgcaaatga aagaagggag
    10981 tttgtactgg tgccatttct cccttcagtt gctggttaat gggatttgct agaaaaaatt
    11041 ctcccggttg aagggtgaaa acagaccctt atgtgtatat ctgtacagag atgtgtatat
    11101 gggatgtggt ggcactttgc tgaatgtgaa cttgccttgt caatggaaag attgaaaagt
    11161 attatgttta tttatacatt tgtataaatc tatatataca cgtatgtata tgtgtgtgta
    11221 tagataaagc tatatacata tatttccctt aaaaatgtgt gtgtataata ggtaaacagc
    11281 ctttgttaag caagattaat gtctatggaa agttctggat tattctgtaa gccagaggag
    11341 gtgacagtct agagtacatc atcagaacat actaaaatgg aagtcctttg gattatagtt
    11401 ttgtttatgg atattacaca atgaatgctt gtctgaacag ttcttacttg ccagttccac
    11461 tattcttcat cttcaccacc ttctactggt cagtctttca tcacttaaaa aaaaaaaaaa
    11521 aatcacacat cattgtggtt tttttccccc ttaattctgt ctcttctagc cagaagcatc
    11581 tggcttaagc atatttcatc aacttctctg ttatttcttt taaagatctt tatctctgaa
    11641 attttcccag aagatacaag ttttggtaat attatcaata ggaattttga gacttgggca
    11701 ttcatctttg tctcaaaaac aaacagaaag ccaaccttca aataaaacaa atttgaaagt
    11761 tttagctcaa taatttgggg acattttact taaattacaa aagaacataa ttatgatttt
    11821 atgatcgata ttagtgttag gtttatttcc acacttactg tcattaattt gtcatttaca
    11881 tatttttatt tgctttgtag tttaatcata acttcaccat ttacatttta atggaaagca
    11941 tacaaggtca catgttagcc tcttgaattc tgtaactaac tcatttttct catgatgaaa
    12001 ctgctttgat gaattcctgt gtgatgaatt ctgctatatt tccttttgac ttttctcagt
    12061 ttgtgacatt ctgtattaac tttgctgcag ctctctagaa aacttgcatc cctatatatt
    12121 gtgcctttaa agctcttatg cacacacaga caaaagtgta tatatacatg tcagagcatg
    12181 tgtacatatg ctttcgtatg tactcacaca gtatgtctct agtatatatt gtgggagtag
    12241 atatatagat attcaaaggc aatgaaatat tgctctccag atatatatgt atataaatag
    12301 tgttgatata actgtatata cacatgtata tgtatgagtt ttaaatggca atcttttaca
    12361 tttagcaaaa tgctgcccct actggaatat tgtcactgca gtggcagttg tatgtaatga
    12421 tttaaaatac attatcaaaa gttatttaaa gaacatttaa agtctcatct aaagacatcc
    12481 acacactatt tatttatctt ccttttcctt ttattgttgt gtttttctta actgaaaggg
    12541 agactgtcat tttaaaaatg ccatctgtcc catgagagta agaaagagct ggagattcac
    12601 ttgaggagct ttgtgcattt ttcctctctc tgaagtggag atgttccaca gaccagactg
    12661 tttatttcac ttataaagca atcctaatat ttccgttagt gtatgtcagc caccatctcc
    12721 tagatcaact taattcacca atttgcctcc tcctttcatt aataaataat gattattgag
    12781 atcattttgc ctgggggaag ttaactactc ccatgctgca gggaaatata tcacctaatt
    12841 gttattttgc cttgttcaaa attcaaattt gaaagaaggc agctctctca tgaagctgtc
    12901 ttaagcacat tttagttaag ggccctccca aactcttttt tctttctttc tttctttctt
    12961 tttttttttt ttttgcgagt tccaagttgc atgtgcttga aatagattta attcttattc
    13021 cccacagttt aggtattttt cattagtaca tcaatttgac acactgaatg caagactatt
    13081 aaggaagaac gattaaatat tattttattt tgtgaagagt tggcagcaga ttacatctca
    13141 agaacttgca gagagaggaa ggtagatgga caatcctaaa ttgtaagatg ttacaaaaaa
    13201 cagtgaagta agagtactcc tgaagactaa aatagagagg ctggggtttg agccatttta
    13261 ctgagtagct tagctggaac ctgatatcag aagtagcctt taacaaaaag cctcttggca
    13321 attgtatggt actaacaact agagtactga agtgtaagtt gaaaccaagt tgcagtggga
    13381 aatcaaaggt gaggtagctt atttgaaacc agcaaatgag acaggttgga cagttttaaa
    13441 atctcttcta acaaagaaac tgcacggtag caaggactag cggttctcaa agcccttctt
    13501 tttcagtgtt ctcattcacc ttggcaccca agtatgttta acaggccatg cattaaaaat
    13561 aaatacaaaa atataaaagc cgcttaaagg gaacttacaa actgacaatc tctcctctgt
    13621 atttgtgttc atagtggctg ggagtttaat tatatgcaca aaagttagga gccacttgtt
    13681 tctgcacaga ctgtaggagc aagatgagga gatgggcagg ttttggtaag agcccccagt
    13741 tctggtggac aggcatactt gtggcattgg gtgcggcatt gctgggagga ccacgtcttg
    13801 ggaggcgatt gacttttggt ttgtaatttc cctttaaaca agaagagatg gctcacattt
    13861 tccatatata tctcaatgaa tgtactgtat tactgtttta aaaatttgat gaaataataa
    13921 tgaattggtc tccttttgtt atctggtcct tgtttaattt gtttaagggt ttttgtatac
    13981 aaaagtttac atttttatgt atatttttct tgtgtaaaaa ctgatgtaat atgtgtatga
    14041 aacactgtat gtattatctg tatatagtgt gacaaaatca tttttctttc tttcttttgg
    14101 atgtattaat aaatcttgct gtgaagta
//
