LOCUS       NM_194281                943 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens INO80 complex subunit C (INO80C), transcript variant
            2, mRNA.
ACCESSION   NM_194281 XM_058924
VERSION     NM_194281.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 943)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 943)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 943)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 943)
  AUTHORS   Yau,E.H., Kummetha,I.R., Lichinchi,G., Tang,R., Zhang,Y. and
            Rana,T.M.
  TITLE     Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in
            Mutant KRAS Colorectal Cancers
  JOURNAL   Cancer Res 77 (22), 6330-6339 (2017)
   PUBMED   28954733
  REMARK    GeneRIF: Data indicate metabolic enzymes NAD kinase and
            ketohexokinase as candidate metabolic gene targets, and the
            chromatin remodeling protein INO80C as a tumor suppressor in
            KRAS(MUT) colorectal tumor xenograft.
REFERENCE   5  (bases 1 to 943)
  AUTHORS   Zhang,S., Zhou,B., Wang,L., Li,P., Bennett,B.D., Snyder,R.,
            Garantziotis,S., Fargo,D.C., Cox,A.D., Chen,L. and Hu,G.
  TITLE     INO80 is required for oncogenic transcription and tumor growth in
            non-small cell lung cancer
  JOURNAL   Oncogene 36 (10), 1430-1439 (2017)
   PUBMED   27641337
REFERENCE   6  (bases 1 to 943)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   7  (bases 1 to 943)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   8  (bases 1 to 943)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
  REMARK    GeneRIF: C18orf37, similar in sequence to yeast Ies6p.  A subunit
            of the Ino80 chromatin remodeling complex, which has roles in
            transcription and DNA repair.
REFERENCE   9  (bases 1 to 943)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 943)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ887287.1 and BF475320.1.
            
            On Jun 2, 2019 this sequence version replaced NM_194281.3.
            
            Transcript Variant: This variant (2) lacks two alternate in-frame
            exons in the 5' coding region, compared to variant 1. The resulting
            protein (isoform 2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039404.1, BQ951150.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334598.12/ ENSP00000334473.6
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               BQ887287.1         32-621
            591-602             BF475320.1         347-358             c
            603-617             BQ887287.1         634-648
            618-943             BF475320.1         6-331               c
FEATURES             Location/Qualifiers
     source          1..943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..943
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /note="INO80 complex subunit C"
                     /db_xref="GeneID:125476"
                     /db_xref="HGNC:HGNC:26994"
     exon            1..242
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..665
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /note="isoform 2 is encoded by transcript variant 2; IES6
                     homolog"
                     /codon_start=1
                     /product="INO80 complex subunit C isoform 2"
                     /protein_id="NP_919257.2"
                     /db_xref="CCDS:CCDS11914.1"
                     /db_xref="GeneID:125476"
                     /db_xref="HGNC:HGNC:26994"
                     /translation="MAAQIPIVATTSTPGIVRNSKKRPASPSHNGSSGGGYGASKKKK
                     ASASSFAQGISMEAMSENKMVPSEFSTGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKN
                     RTWKNLKQILASERALPWQLNDPNYFSIDAPPSFKPAKKYSDVSGLLANYTDPQSKLR
                     FSTIEEFSYIRRLPSDVVTGYLALRKATSIVP"
     exon            243..353
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /inference="alignment:Splign:2.1.0"
     exon            354..465
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /inference="alignment:Splign:2.1.0"
     exon            466..533
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /inference="alignment:Splign:2.1.0"
     exon            534..943
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      921..926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /note="hexamer: AATAAA"
     polyA_site      943
                     /gene="INO80C"
                     /gene_synonym="C18orf37; hIes6; IES6"
                     /note="major polyA site"
ORIGIN      
        1 atcaagacgg aagtaacagc ggaaaggaag ttccaaggcc cgcgctggga aaaaggtggg
       61 gggaccaggg gaagactcgg agtgcgatgg cggcgcaaat tccaattgtg gccaccactt
      121 ccactcccgg aatagtccgg aacagcaaga agaggccggc cagcccttcc cacaatggca
      181 gcagcggcgg gggctatggc gccagtaaga agaaaaaagc gtccgcttcc agctttgcgc
      241 agggtatcag catggaagcc atgagtgaga ataaaatggt gccctctgag tttagcacag
      301 gacctgtgga aaaagctgcc aaacctttgc catttaagga tcccaacttt gtgcactctg
      361 gccacggtgg cgcagtagct ggcaagaaga acagaacctg gaagaacctg aaacaaatcc
      421 tcgcttctga aagggcattg ccgtggcaac tgaacgatcc taactacttc agtattgatg
      481 ctcctccatc ctttaagcca gctaagaagt attctgatgt ttcaggtctg cttgccaact
      541 acacagaccc ccagagcaaa ctgcggttca gcaccattga agagttttcc tacattcgga
      601 ggctgccctc tgacgtcgtc accggctacc tggccctgag gaaggccacg agcatcgttc
      661 cctgagcccc agaaagggag atgaagtgga aagctgtttc aaaaacagac tctggactca
      721 tgattttgtt tcacggaaac aaactcgttc tgctgtcaat ctgaaaatgc cagtgctgtg
      781 ccttggaaag aatgtttggc tttaatttaa gggttttttt tttttttagt gtgtgttttc
      841 cctccaagtg tgatatttcc tgctgaatta aattatactt cagttgttgc ctcaagtaaa
      901 ggtgtttgac aagaagatac aataaaacca tacttttcat tta
//
