LOCUS       NM_031288               1181 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens INO80 complex subunit B (INO80B), mRNA.
ACCESSION   NM_031288
VERSION     NM_031288.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1181)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1181)
  AUTHORS   Zhang,S., Zhou,B., Wang,L., Li,P., Bennett,B.D., Snyder,R.,
            Garantziotis,S., Fargo,D.C., Cox,A.D., Chen,L. and Hu,G.
  TITLE     INO80 is required for oncogenic transcription and tumor growth in
            non-small cell lung cancer
  JOURNAL   Oncogene 36 (10), 1430-1439 (2017)
   PUBMED   27641337
REFERENCE   3  (bases 1 to 1181)
  AUTHORS   Cao,L., Ding,J., Dong,L., Zhao,J., Su,J., Wang,L., Sui,Y., Zhao,T.,
            Wang,F., Jin,J. and Cai,Y.
  TITLE     Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin
            Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest
            and Abnormal Chromosome Stability
  JOURNAL   PLoS One 10 (9), e0137411 (2015)
   PUBMED   26340092
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1181)
  AUTHORS   Oudejans,C.B., Michel,O.J., Janssen,R., Habets,R., Poutsma,A.,
            Sistermans,E.A., Weiss,M.M., Incarnato,D., Oliviero,S.,
            Kleiverda,G., Van Dijk,M. and Arngrimsson,R.
  TITLE     Susceptibility allele-specific loss of miR-1324-mediated silencing
            of the INO80B chromatin-assembly complex gene in pre-eclampsia
  JOURNAL   Hum Mol Genet 24 (1), 118-127 (2015)
   PUBMED   25143393
  REMARK    GeneRIF: pathway-guided genome-wide meta-analysis and mutational
            analysis identified INO80B gene is a susceptibility gene for
            pre-eclampsia.
REFERENCE   5  (bases 1 to 1181)
  AUTHORS   Vassileva,I., Yanakieva,I., Peycheva,M., Gospodinov,A. and
            Anachkova,B.
  TITLE     The mammalian INO80 chromatin remodeling complex is required for
            replication stress recovery
  JOURNAL   Nucleic Acids Res 42 (14), 9074-9086 (2014)
   PUBMED   25016522
REFERENCE   6  (bases 1 to 1181)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   7  (bases 1 to 1181)
  AUTHORS   Miyako,K., Cobb,L.J., Francis,M., Huang,A., Peng,B., Pintar,J.E.,
            Ariga,H. and Cohen,P.
  TITLE     PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its
            growth-promoting actions
  JOURNAL   Mol Endocrinol 23 (2), 169-175 (2009)
   PUBMED   19095771
REFERENCE   8  (bases 1 to 1181)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   9  (bases 1 to 1181)
  AUTHORS   Kuroda,T.S., Maita,H., Tabata,T., Taira,T., Kitaura,H., Ariga,H.
            and Iguchi-Ariga,S.M.
  TITLE     A novel nucleolar protein, PAPA-1, induces growth arrest as a
            result of cell cycle arrest at the G1 phase
  JOURNAL   Gene 340 (1), 83-98 (2004)
   PUBMED   15556297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB451812.1 and BC064425.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031288.3.
            
            Summary: This gene encodes a subunit of an ATP-dependent chromatin
            remodeling complex, INO80, which plays a role in DNA and
            nucleosome-activated ATPase activity and ATP-dependent nucleosome
            sliding. Readthrough transcription of this gene into the
            neighboring downstream gene, which encodes WW domain-binding
            protein 1, generates a non-coding transcript. [provided by RefSeq,
            Feb 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064425.1, ERR279845.3562.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233331.12/ ENSP00000233331.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DB451812.1         65-93
            30-1181             BC064425.1         1-1152
FEATURES             Location/Qualifiers
     source          1..1181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..1181
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /note="INO80 complex subunit B"
                     /db_xref="GeneID:83444"
                     /db_xref="HGNC:HGNC:13324"
                     /db_xref="MIM:616456"
     exon            1..88
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1101
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /note="PAP (Pim-1 associated protein) associated protein
                     1; high mobility group AT-hook 1-like 4; zinc finger, HIT
                     type 4; IES2 homolog; PAP-1 binding protein;
                     PAP-1-associated protein 1; zinc finger HIT
                     domain-containing protein 4"
                     /codon_start=1
                     /product="INO80 complex subunit B"
                     /protein_id="NP_112578.2"
                     /db_xref="CCDS:CCDS1942.2"
                     /db_xref="GeneID:83444"
                     /db_xref="HGNC:HGNC:13324"
                     /db_xref="MIM:616456"
                     /translation="MSKLWRRGSTSGAMEAPEPGEALELSLAGAHGHGVHKKKHKKHK
                     KKHKKKHHQEEDAGPTQPSPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLM
                     VVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLSGGLGGQEEEEEQRWLDALEKGE
                     LDDNGDLKKEINERLLTARQRALLQKARSQPSPMLPLPVAEGCPPPALTEEMLLKREE
                     RARKRRLQAARRAEEHKNQTIERLTKTAATSGRGGRGGARGERRGGRAAAPAPMVRYC
                     SGAQGSTLSFPPGVPAPTAVSQRPSPSGPPPRCSVPGCPHPRRYACSRTGQALCSLQC
                     YRINLQMRLGGPEGPGSPLLAT"
     exon            89..281
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /inference="alignment:Splign:2.1.0"
     exon            282..400
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /inference="alignment:Splign:2.1.0"
     exon            401..570
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1181
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1163..1168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /note="hexamer: ATTAAA"
     polyA_site      1181
                     /gene="INO80B"
                     /gene_synonym="hIes2; HMGA1L4; HMGIYL4; IES2; PAP-1BP;
                     PAPA-1; PAPA1; ZNHIT4"
                     /note="major polyA site"
ORIGIN      
        1 atttctagtc ccctttcctc gcaggacctc atgagtaagc tgtggcggcg tgggagcacc
       61 tctggggcta tggaggcccc tgagccggga gaagccctgg agttgagcct ggcgggtgcc
      121 catggccatg gagtgcacaa gaaaaaacac aagaagcaca agaagaaaca caagaagaaa
      181 caccatcagg aagaagacgc cgggcccacg cagccgtccc ctgccaagcc tcagctcaaa
      241 ctcaaaatca agcttggggg acaagtcctg gggaccaaga gtgttcctac cttcactgtg
      301 atcccagagg ggcctcgctc accctctccc cttatggttg tggataatga agaggaacct
      361 atggaaggag tcccccttga gcagtaccgt gcctggctgg atgaagacag taatctctct
      421 ccctctccac ttcgggacct atcaggaggg ttagggggtc aggaggaaga ggaggaacag
      481 aggtggctgg atgccctgga gaagggggag ctggatgaca atggagacct caagaaggag
      541 atcaatgagc ggctgcttac tgctcgacag cgagctctgc tccagaaggc gcggagtcaa
      601 ccttccccta tgctgccgct gcctgtagct gagggctgcc cacctcccgc cctcacagag
      661 gagatgctgc tgaagcgcga ggagcgggcg cggaagcggc ggctccaggc ggcgcggcgg
      721 gcagaagagc acaagaacca gactatcgag cgcctcacca agactgcggc gaccagtggg
      781 cggggaggcc gggggggcgc acggggcgag cggcggggag ggcgggctgc ggctccggcc
      841 cccatggtgc gctactgcag cggagcacag ggttccaccc tttccttccc acctggcgtc
      901 cccgccccca cggcagtgtc tcagcggcca tccccctcag gcccgccgcc gcgctgctct
      961 gtccccggct gtccccatcc gcgccgctac gcttgctccc gcacaggcca ggcactctgt
     1021 agtcttcagt gctaccgcat caacctgcag atgcggctgg gggggcccga gggtcctgga
     1081 tccccccttt tggctacgta aggcccttaa cccggactct gcgccccgtc ccatgcccgc
     1141 tcttgagtat cttccccacc ctattaaatt acatccggtg c
//
