LOCUS       NM_017553               6365 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens INO80 complex ATPase subunit (INO80), transcript
            variant 1, mRNA.
ACCESSION   NM_017553
VERSION     NM_017553.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6365)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6365)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6365)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6365)
  AUTHORS   Xian,S., Zhang,Y., Wang,L., Yao,F., Ding,J., Wang,Y., Yang,X.,
            Dai,F., Yin,T. and Cheng,Y.
  TITLE     INO80 participates in the pathogenesis of recurrent miscarriage by
            epigenetically regulating trophoblast migration and invasion
  JOURNAL   J Cell Mol Med 25 (8), 3885-3897 (2021)
   PUBMED   33724648
  REMARK    GeneRIF: INO80 participates in the pathogenesis of recurrent
            miscarriage by epigenetically regulating trophoblast migration and
            invasion.
REFERENCE   5  (bases 1 to 6365)
  AUTHORS   Seo,H.R., Jeong,D., Lee,S., Lee,H.S., Lee,S.A., Kang,S.W. and
            Kwon,J.
  TITLE     CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and
            Stability for DNA Replication
  JOURNAL   Mol Cells 44 (2), 101-115 (2021)
   PUBMED   33658435
  REMARK    GeneRIF: CHIP and BAP1 Act in Concert to Regulate INO80
            Ubiquitination and Stability for DNA Replication.
REFERENCE   6  (bases 1 to 6365)
  AUTHORS   Bakshi,R., Mehta,A.K., Sharma,R., Maiti,S., Pasha,S. and
            Brahmachari,V.
  TITLE     Characterization of a human SWI2/SNF2 like protein hINO80:
            demonstration of catalytic and DNA binding activity
  JOURNAL   Biochem Biophys Res Commun 339 (1), 313-320 (2006)
   PUBMED   16298340
  REMARK    GeneRIF: report the cloning, expression, and functional activity of
            the domains from hINO80 gene both in terms of the DNA dependent
            ATPase as well as DNA binding activity
REFERENCE   7  (bases 1 to 6365)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
  REMARK    GeneRIF: Identifies INOC1 gene product as a SNF2-like helicase
            associated with human INO80 chromatin remodeling complex (hINO80).
            hINO80 includes orthologs of 8 subunits of the yeast INO80 complex,
            as well as additional, metazoan-specific proteins.
REFERENCE   8  (bases 1 to 6365)
  AUTHORS   Bakshi,R., Prakash,T., Dash,D. and Brahmachari,V.
  TITLE     In silico characterization of the INO80 subfamily of SWI2/SNF2
            chromatin remodeling proteins
  JOURNAL   Biochem Biophys Res Commun 320 (1), 197-204 (2004)
   PUBMED   15207721
REFERENCE   9  (bases 1 to 6365)
  AUTHORS   Becker,P.B. and Horz,W.
  TITLE     ATP-dependent nucleosome remodeling
  JOURNAL   Annu Rev Biochem 71, 247-273 (2002)
   PUBMED   12045097
  REMARK    Review article
REFERENCE   10 (bases 1 to 6365)
  AUTHORS   Shen,X., Mizuguchi,G., Hamiche,A. and Wu,C.
  TITLE     A chromatin remodelling complex involved in transcription and DNA
            processing
  JOURNAL   Nature 406 (6795), 541-544 (2000)
   PUBMED   10952318
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB458576.1, AB033085.1,
            CB155560.1, BC046115.2, AC020661.8 and AL137280.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 1, 2018 this sequence version replaced NM_017553.2.
            
            Summary: This gene encodes a subunit of the chromatin remodeling
            complex, which is classified into subfamilies depending on sequence
            features apart from the conserved ATPase domain. This protein is
            the catalytic ATPase subunit of the INO80 chromatin remodeling
            complex, which is characterized by a DNA-binding domain. This
            protein is proposed to bind DNA and be recruited by the YY1
            transcription factor to activate certain genes. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146785.1, AB033085.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648947.1/ ENSP00000497609.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               DB458576.1         75-212
            139-5101            AB033085.1         1-4963
            5102-5397           CB155560.1         238-533
            5398-5724           BC046115.2         168-494
            5725-5725           AC020661.8         114618-114618       c
            5726-6365           AL137280.1         1471-2110
FEATURES             Location/Qualifiers
     source          1..6365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..6365
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /note="INO80 complex ATPase subunit"
                     /db_xref="GeneID:54617"
                     /db_xref="HGNC:HGNC:26956"
                     /db_xref="MIM:610169"
     exon            1..308
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..494
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..5022
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /EC_number="3.6.4.12"
                     /note="homolog of yeast INO80; INO80 complex subunit A;
                     putative DNA helicase INO80 complex homolog 1; DNA
                     helicase-related protein INO80; DNA helicase-related INO80
                     complex homolog 1"
                     /codon_start=1
                     /product="chromatin-remodeling ATPase INO80"
                     /protein_id="NP_060023.1"
                     /db_xref="CCDS:CCDS10071.1"
                     /db_xref="GeneID:54617"
                     /db_xref="HGNC:HGNC:26956"
                     /db_xref="MIM:610169"
                     /translation="MASELGARDDGGCTELAKPLYLQYLERALRLDHFLRQTSAIFNR
                     NISSDDSEDGLDDSNPLLPQSGDPLIQVKEEPPNSLLGETSGAGSSGMLNTYSLNGVL
                     QSESKCDKGNLYNFSKLKKSRKWLKSILLSDESSEADSQSEDDDEEELNLSREELHNM
                     LRLHKYKKLHQNKYSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKKKFKEEKKL
                     KAKLKKVKKKRRRDEELSSEESPRRHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNAR
                     RRKVWLSIVKKELPKANKQKASARNLFLTNSRKLAHQCMKEVRRAALQAQKNCKETLP
                     RARRLTKEMLLYWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLITQT
                     ELYAHFMSRKRDMGHDGIQEEILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQ
                     ALKNAENAYHIHQARTRSFDEDAKESRAAALRAANKSGTGFGESYSLANPSIRAGEDI
                     PQPTIFNGKLKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENI
                     WGPFLIISPASTLNNWHQEFTRFVPKFKVLPYWGNPHDRKVIRRFWSQKTLYTQDAPF
                     HVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLTGT
                     PIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSRLHMILK
                     PFMLRRIKKDVENELSDKIEILMYCQLTSRQKLLYQALKNKISIEDLLQSSMGSTQQA
                     QNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYHISKFIYRHGQIRVFNHS
                     RDRWLRVLSPFAPDYIQRSLFHRKGINEESCFSFLRFIDISPAEMANLMLQGLLARWL
                     ALFLSLKASYRLHQLRSWGAPEGESHQRYLRNKDFLLGVNFPLSFPNLCSCPLLKSLV
                     FSSHCKAVSGYSDQVVHQRRSATSSLRRCLLTELPSFLCVASPRVTAVPLDSYCNDRS
                     AEYERRVLKEGGSLAAKQCLLNGAPELAADWLNRRSQFFPEPAGGLWSIRPQNGWSFI
                     RIPGKESLITDSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMR
                     LDGSSKISERRDMVADFQNRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQ
                     QAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAKEKSEIQRMVISGGNFKPDTLKPK
                     EVVSLLLDDEELEKKLRLRQEEKRQQEETNRVKERKRKREKYAEKKKKEDELDGKRRK
                     EGVNLVIPFVPSADNSNLSADGDDSFISVDSAMPSPFSEISISSELHTGSIPLDESSS
                     DMLVIVDDPASSAPQSRATNSPASITGSVSDTVNGISIQEMPAAGRGHSARSRGRPKG
                     SGSTAKGAGKGRSRKSTAGSAAAMAGAKAGAAAASAAAYAAYGYNVSKGISASSPLQT
                     SLVRPAGLADFGPSSASSPLSSPLSKGNNVPGNPKNLHMTSSLAPDSLVRKQGKGTNP
                     SGGR"
     exon            495..664
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..732
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..888
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1009
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1224
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1278
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1482
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1678
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1746
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1956
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2037
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2133
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2193
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2336
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2421
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2539
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2625
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2793
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2927
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..2992
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3086
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3258
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3399
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3625
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3753
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3848
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..3921
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4080
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4081..4183
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4272
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4428
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4429..4588
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4589..4804
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4805..6365
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6335..6340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /note="hexamer: AATAAA"
     polyA_site      6365
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /note="major polyA site"
ORIGIN      
        1 atggcgcctc tcctcccccc cgccatggct ccccgtgtcc ctgctccgct cctctcagtg
       61 agtgaaagtg gccgccgccg ccgccggccc agcgcccgca gccgcctcag cgccgccgcc
      121 atcttggggt cccaggagcc gcggagggag cgagctagga gcgtccacgc ccaacgcagt
      181 caccgtccca cggcctcaga gagcgaaccg cggctccacc gtcggcgggg cgaccccccc
      241 ctccggaccc cgcccgcacc ccgccccccc tccgccgccg tcgcggcggc ggggccaggc
      301 ggcccgagcc gtgcagtcgg aggtccttgt gcatgaagac agatttgttc tatggcctcg
      361 gagttgggtg ccagggatga tggaggctgc actgagctgg caaagcccct ctatcttcag
      421 tacttggaga gggccctccg gttggaccat tttctgcgac aaacgtcagc tatcttcaat
      481 aggaatattt ctagtgatga cagtgaagat ggactggatg acagtaatcc attattgccc
      541 cagtctgggg atcccttaat acaagttaag gaagaacctc caaattcatt gcttggtgaa
      601 acttctggag caggcagttc tggaatgtta aacacatatt ctctgaatgg agttctacag
      661 tcagaatcaa aatgtgataa ggggaattta tataatttct ctaagctgaa gaaaagcaga
      721 aagtggctaa agagcattct gctaagtgat gaatccagcg aggctgattc tcagagtgaa
      781 gacgatgatg aagaagaact caatctcagc agagaagaac ttcacaacat gcttcgacta
      841 cacaaatata agaaacttca ccaaaataag tatagtaaag acaaggagtt gcagcaatat
      901 cagtactaca gtgcaggcct gctctccaca tatgaccctt tctatgagca acaacggcac
      961 ctacttggac ccaagaaaaa gaaatttaag gaggaaaaga aacttaaagc taagttgaaa
     1021 aaagtgaaga aaaaaagacg aagagatgaa gaactttcct ctgaagaatc ccctcgtcgc
     1081 catcaccacc agaccaaagt ctttgccaag ttttctcacg atgcacctcc ccctggcact
     1141 aagaaaaagc acttatccat tgagcagctg aatgctcgtc gcaggaaagt atggctcagc
     1201 attgtgaaaa aggaactacc aaaggcaaat aagcagaaag cttcagctcg taacctgttt
     1261 ctcaccaata gccgaaagct tgctcaccag tgcatgaagg aggtgcgtcg agctgccttg
     1321 caggcccaga agaactgtaa ggaaaccttg cctcgtgccc gccgcctcac caaggagatg
     1381 cttctgtact ggaagaaata tgagaaagta gagaaggagc accgcaagag agcagagaag
     1441 gaagctttgg agcagcggaa gttggatgag gaaatgcggg aggccaagag gcaacagcga
     1501 aaactcaact tcttaattac ccagacagag ttgtatgccc atttcatgag tcgcaaacga
     1561 gatatgggtc atgatggtat ccaggaagaa atcctaagga aactggaaga cagttctacc
     1621 cagagacaaa tcgatatagg tggaggagtg gtagttaaca tcacacagga ggattatgat
     1681 agtaaccatt ttaaagccca ggccctgaag aatgctgaaa atgcttacca tattcaccaa
     1741 gctcggacaa ggtcatttga tgaagatgca aaagaaagtc gagcagctgc cctacgggca
     1801 gcaaacaagt ctggcactgg gtttggggag agttatagcc tggctaaccc atctatccgg
     1861 gctggtgagg atattccaca gcccacaatt tttaatggca aattgaaagg ttatcaactg
     1921 aaaggcatga attggttggc caatctatat gaacagggta ttaatggcat tcttgctgat
     1981 gaaatgggcc ttggtaaaac agtacagagc attgcccttc tggcccatct ggctgagaga
     2041 gagaacattt ggggaccttt cttaataatt tcacctgcgt ctacacttaa caattggcac
     2101 caggagttta ctagatttgt tcctaaattt aaggtgctac catattgggg aaatcctcat
     2161 gatagaaaag tcatcagaag gttctggagt cagaagaccc tctacactca ggatgccccc
     2221 ttccatgtgg ttattaccag ctatcagctg gtggtgcagg atgtaaagta tttccagcgg
     2281 gtcaagtggc aatacatggt actggatgag gctcaggcgc tcaagagtag ttccagtgtt
     2341 cgttggaaga tcctcttaca gttccagtgt cggaatcggc ttttgctaac cgggacccca
     2401 attcagaaca ccatggcaga gctttgggct ctgctgcatt tcattatgcc aacattattt
     2461 gattcacatg aggaatttaa tgaatggttt tccaaggaca ttgagagcca tgccgaaaac
     2521 aaatctgcta ttgatgagaa tcaactttct cgcttacaca tgattttgaa gccatttatg
     2581 ctgaggagaa tcaagaaaga tgtggaaaat gaattatctg acaagattga gattctaatg
     2641 tattgccaac tgaccagccg acagaagctg ctatatcagg cactaaagaa caaaatttcc
     2701 attgaggatt tattgcagtc ttctatgggc tctacccaac aagcacagaa caccaccagc
     2761 agcctcatga atctggtcat gcagtttagg aaggtgtgta atcacccgga gttatttgaa
     2821 cggcaagaaa cttggtctcc atttcatatt tccctaaagc cataccacat ttcaaagttt
     2881 atctaccgtc atggacagat cagggtcttc aatcattcac gagacaggtg gttaagggtt
     2941 ctttctccat ttgcaccaga ctatatccaa cggtctctct ttcacagaaa aggtattaat
     3001 gaagaaagct gtttctcttt ccttcgcttt attgatatat ctccagcaga aatggcaaac
     3061 cttatgcttc agggactttt ggccagatgg ttagctcttt tcctgtctct gaaagcctcc
     3121 tacaggctcc atcagctacg ctcctgggga gcgccagaag gggagagcca ccagagatac
     3181 ctgaggaaca aggatttcct tcttggggtt aattttccac tctcctttcc aaacctttgc
     3241 agctgccctt tgttaaagtc tcttgttttc agcagccact gtaaagcagt gagtggctac
     3301 tcagaccagg ttgtccatca gcggagatca gctacctcct cgctgcgtcg ctgcctgctc
     3361 actgagctgc catctttttt gtgtgtggcc agtccacgag ttaccgcagt gccattggat
     3421 tcttactgca atgaccgaag tgcagaatat gaaaggcgag ttctgaagga aggagggagt
     3481 ctggcagcca agcagtgttt gttgaatggg gcccctgaac tggctgcaga ctggctaaat
     3541 agacgatcac agttcttccc agagccagct ggaggtctgt ggagcatcag acctcagaat
     3601 ggctggtctt tcatcaggat tccaggcaag gagagcctca tcactgacag tggaaagctg
     3661 tatgcccttg atgtcctgct gactcggctc aagtctcaag ggcatagggt ccttatctac
     3721 tcccagatga ccaggatgat agacctactg gaggaataca tggtttacag gaagcatacc
     3781 tacatgaggc ttgatggctc atccaagatc tcggagaggc gagacatggt tgctgatttt
     3841 cagaacagga atgacatctt tgtgttcctg ttaagcacac gagctggagg actgggtatc
     3901 aatctcactg ctgcagacac agtgattttc tatgatagcg actggaaccc cactgtggac
     3961 cagcaggcca tggacagggc ccaccgctta gggcagacaa agcaggttac tgtgtaccgg
     4021 ctcatctgta aaggcaccat tgaagaacgc attctgcaaa gagccaagga gaagagtgag
     4081 attcagcgga tggtgatttc aggtgggaac ttcaaaccag ataccttgaa acccaaagag
     4141 gtggttagtc ttcttctaga cgacgaagag ttggagaaga aactgaggct gcggcaggaa
     4201 gagaaacggc aacaggagga aaccaaccga gtgaaagagc gcaagcggaa gcgggaaaag
     4261 tatgcagaga agaagaaaaa agaagatgaa ttggatggga aaaggagaaa agagggtgtg
     4321 aacctggtga tcccatttgt tccctcggct gataactcca acctctctgc tgacggagat
     4381 gactccttca ttagcgtgga ctcagccatg ccaagccctt tcagtgagat ctccatcagc
     4441 agtgagctgc acactggctc cattcccctg gacgagagca gcagtgacat gctggtcatt
     4501 gtggatgacc cagcctcctc agcccctcag tctcgagcta ccaactctcc cgcatccata
     4561 acaggctccg tctcagatac cgtgaatgga atttccattc aggaaatgcc agctgcagga
     4621 cgtggtcact cagcccgaag ccgaggccgc cccaaaggtt caggaagcac agccaaagga
     4681 gcagggaagg gccggagccg aaagtccacg gcaggcagtg ctgctgcaat ggcaggagcc
     4741 aaagccgggg ctgcagcggc ctctgcagct gcctatgccg catacgggta caacgtgtct
     4801 aaaggaatct ccgccagcag tcctctgcag acatcccttg ttcggcctgc tggccttgct
     4861 gactttggac cttcaagcgc ctcttctcct ttgagttccc ctttgagcaa gggaaataat
     4921 gttcctggga atcccaagaa cctccacatg accagcagcc tagccccaga ctctctggtc
     4981 cggaaacagg gcaaaggcac caacccctct ggaggacggt aaccatctgg gccctccgac
     5041 ttccttcaac caaaccaggg ctagagtcct gacctgccag tggtctttgg atggcttgcc
     5101 ccgtgcagca tcttgcatcc tgagtcagaa gtggaaatgt ccagcagggg aaggacaggc
     5161 aggtggatgg tgtgagcact tttatcatct gtgtctcatc aggagcatct ggggtgcctg
     5221 taggaggaag gccacagggc atggatcagc cccactgcat ctcaagtgaa ctgtatagcc
     5281 aagtcttaaa cctctcacgg ggcaagcctg acacagaccc cctttagatg ctcaggcata
     5341 ctgtttccat cccgattcca ctcttcggct ctgacacgtc ccttgcaaag tctccgcagg
     5401 tgctgtgaag agccttccat ggtagagatt tctcttaaga gtgtgatttc tcatagggct
     5461 agtaagggag attgtatacc tgttgtccac agtcttcagg cagctcccca ggtctctgaa
     5521 ccccagagtg tcatcattgg agagagcagt gactgcgaga gatggtggag gccgctaagc
     5581 atggtagagg ctagaggaag tctatccaca ggcagttgtg ttcccagcaa ttcctcccat
     5641 cctgcatggt tcacaccaag agaaccttca gatcctacca gcaaccgtag caccttccac
     5701 ccaggggact cccagaagcc agtagagaga ccaggagcca cctcaatcag caggacagcc
     5761 tcactgcccc tcttgcagag tcccctttgc ccatcctgaa tgcacagtct ccctgctcat
     5821 gcccttcagt cccctgcttg gctgtatgca ctgtctatat tgcactgaga gaggaaggga
     5881 cagcaggagt gaggtgaaga gggcggagag agggggcagg ctcggcaccg gccctcccag
     5941 cccggccagc ctgagcttgc tgccctccag tagagacaga ggggcagtgt ttgcatggga
     6001 ggtgtttctg cctgtccctg cctgatgtcc ctggtggagc aggtacctcc gggcgggcaa
     6061 gcctctgatt tgcacacctg aaaatcgcgg aattgagttt cgatagattg atttttaaaa
     6121 cttttttgga gtagggggta taggggaatc atttaattta aatcattaag attcccctgc
     6181 tcaaacccag attcctgtgt acagatgcta tttagaggga atcagaaaaa tgccaagcct
     6241 tttctctttg aatgtgctat ttttataact gaacttgtac atatgtataa agagagacac
     6301 atcttccttt tactaactgg ataaaaaaat cttaaataaa atggagtgag ataattttat
     6361 gtaaa
//
