LOCUS       NM_006774               2559 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens indolethylamine N-methyltransferase (INMT), transcript
            variant 1, mRNA.
ACCESSION   NM_006774
VERSION     NM_006774.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Fukumoto,Y., Kyono,R., Shibukawa,Y., Tanaka,Y.K., Suzuki,N. and
            Ogra,Y.
  TITLE     Differential molecular mechanisms of substrate recognition by
            selenium methyltransferases, INMT and TPMT, in selenium
            detoxification and excretion
  JOURNAL   J Biol Chem 300 (2), 105599 (2024)
   PUBMED   38159853
  REMARK    GeneRIF: Differential molecular mechanisms of substrate recognition
            by selenium methyltransferases, INMT and TPMT, in selenium
            detoxification and excretion.
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Zhong,S., Jeong,J.H., Huang,C., Chen,X., Dickinson,S.I.,
            Dhillon,J., Yang,L. and Luo,J.L.
  TITLE     Targeting INMT and interrupting its methylation pathway for the
            treatment of castration resistant prostate cancer
  JOURNAL   J Exp Clin Cancer Res 40 (1), 307 (2021)
   PUBMED   34587977
  REMARK    GeneRIF: Targeting INMT and interrupting its methylation pathway
            for the treatment of castration resistant prostate cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2559)
  AUTHORS   Torres,B., Tyler,J.S., Satyshur,K.A. and Ruoho,A.E.
  TITLE     Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed
            methylation of tryptamine, dimethylsulfide and dimethylselenide is
            enhanced under reducing conditions - A comparison between 254C and
            254F, two common hINMT variants
  JOURNAL   PLoS One 14 (7), e0219664 (2019)
   PUBMED   31310642
  REMARK    GeneRIF: analysis of 254C and 254F variants of hINMT reveals
            differences in methylation of tryptamine, dimethylsulfide and
            dimethylselenide
            Erratum:[PLoS One. 2019 Oct 1;14(10):e0223546. doi:
            10.1371/journal.pone.0223546.. PMID: 31574131]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2559)
  AUTHORS   Kuehnelt,D., Engstrom,K., Skroder,H., Kokarnig,S., Schlebusch,C.,
            Kippler,M., Alhamdow,A., Nermell,B., Francesconi,K., Broberg,K. and
            Vahter,M.
  TITLE     Selenium metabolism to the trimethylselenonium ion (TMSe) varies
            markedly because of polymorphisms in the indolethylamine
            N-methyltransferase gene
  JOURNAL   Am J Clin Nutr 102 (6), 1406-1415 (2015)
   PUBMED   26537946
  REMARK    GeneRIF: genome-wide association studies in populations in
            Argentina/Bangladeshi: Three SNPs in INMT (rs6970396, rs1061644,
            rs4270015) are associated with production of trimethylselenonium
            (TMSe); urinary Se excretion is up-regulated in TMSe-producing
            women.
REFERENCE   6  (bases 1 to 2559)
  AUTHORS   Kopantzev,E.P., Monastyrskaya,G.S., Vinogradova,T.V.,
            Zinovyeva,M.V., Kostina,M.B., Filyukova,O.B., Tonevitsky,A.G.,
            Sukhikh,G.T. and Sverdlov,E.D.
  TITLE     Differences in gene expression levels between early and later
            stages of human lung development are opposite to those between
            normal lung tissue and non-small lung cell carcinoma
  JOURNAL   Lung Cancer 62 (1), 23-34 (2008)
   PUBMED   18394749
REFERENCE   7  (bases 1 to 2559)
  AUTHORS   Karkkainen,J., Forsstrom,T., Tornaeus,J., Wahala,K., Kiuru,P.,
            Honkanen,A., Stenman,U.H., Turpeinen,U. and Hesso,A.
  TITLE     Potentially hallucinogenic 5-hydroxytryptamine receptor ligands
            bufotenine and dimethyltryptamine in blood and tissues
  JOURNAL   Scand J Clin Lab Invest 65 (3), 189-199 (2005)
   PUBMED   16095048
REFERENCE   8  (bases 1 to 2559)
  AUTHORS   Kim,Y.H. and Joo,2nd.
  TITLE     Arylamine N-methyltransferase and thiol methyltransferase
            activities in cholestatic rat liver induced by common bile duct
            ligation
  JOURNAL   Exp Mol Med 33 (1), 23-28 (2001)
   PUBMED   11322482
REFERENCE   9  (bases 1 to 2559)
  AUTHORS   Thompson,M.A., Moon,E., Kim,U.J., Xu,J., Siciliano,M.J. and
            Weinshilboum,R.M.
  TITLE     Human indolethylamine N-methyltransferase: cDNA cloning and
            expression, gene cloning, and chromosomal localization
  JOURNAL   Genomics 61 (3), 285-297 (1999)
   PUBMED   10552930
REFERENCE   10 (bases 1 to 2559)
  AUTHORS   Strahilevitz,M., Othmer,E., Narasimhachari,N., Othmer,S.C. and
            Jacobs,L.S.
  TITLE     Plasma indolethylamine-n-methyltransferase activity and growth
            hormone level during sleep: a pilot study
  JOURNAL   Biol Psychiatry 12 (2), 171-180 (1977)
   PUBMED   192352
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF128846.1, AC006022.1 and
            BC033813.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006774.4.
            
            Summary: N-methylation of endogenous and xenobiotic compounds is a
            major method by which they are degraded. This gene encodes an
            enzyme that N-methylates indoles such as tryptamine. Alternative
            splicing results in multiple transcript variants. Read-through
            transcription also exists between this gene and the downstream
            MINDY4 (aka FAM188B) gene. In rodents and other mammals such as
            cetartiodactyla this gene is in the opposite orientation compared
            to its orientation in human and other primates and this gene
            appears to have been lost in carnivora and chiroptera. [provided by
            RefSeq, Jul 2019].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF128846.1, BC103712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000013222.5/ ENSP00000013222.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-628               AF128846.1         1-628
            629-1871            AC006022.1         14198-15440
            1872-2559           BC033813.1         1863-2550
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..2559
                     /gene="INMT"
                     /gene_synonym="TEMT"
                     /note="indolethylamine N-methyltransferase"
                     /db_xref="GeneID:11185"
                     /db_xref="HGNC:HGNC:6069"
                     /db_xref="MIM:604854"
     exon            1..170
                     /gene="INMT"
                     /gene_synonym="TEMT"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..808
                     /gene="INMT"
                     /gene_synonym="TEMT"
                     /EC_number="2.1.1.49"
                     /EC_number="2.1.1.96"
                     /note="isoform 1 is encoded by transcript variant 1;
                     aromatic alkylamine N-methyltransferase; arylamine
                     N-methyltransferase; amine N-methyltransferase; nicotine
                     N-methyltransferase; indolamine N-methyltransferase;
                     thioether S-methyltransferase"
                     /codon_start=1
                     /product="indolethylamine N-methyltransferase isoform 1"
                     /protein_id="NP_006765.4"
                     /db_xref="CCDS:CCDS5430.1"
                     /db_xref="GeneID:11185"
                     /db_xref="HGNC:HGNC:6069"
                     /db_xref="MIM:604854"
                     /translation="MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLEC
                     LHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEP
                     GAYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCV
                     LTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEK
                     EEVEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCFIVARKKPGP"
     exon            171..378
                     /gene="INMT"
                     /gene_synonym="TEMT"
                     /inference="alignment:Splign:2.1.0"
     exon            379..2559
                     /gene="INMT"
                     /gene_synonym="TEMT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2538..2543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INMT"
                     /gene_synonym="TEMT"
                     /note="hexamer: AATAAA"
     polyA_site      2559
                     /gene="INMT"
                     /gene_synonym="TEMT"
                     /note="major polyA site"
ORIGIN      
        1 acatttcagg gacaccatga agggtggctt cactgggggt gatgagtacc agaagcactt
       61 cctgcccagg gactacttgg ctacttacta cagcttcgat ggcagcccct cacccgaggc
      121 cgagatgctg aagtttaact tggaatgtct ccacaagacc ttcggccctg gaggcctcca
      181 aggggacacg ctgattgaca ttggctcagg tcctaccatc taccaagttc ttgctgcctg
      241 tgattccttc caagacatca ctctctccga ctttaccgac cgcaaccggg aggagctgga
      301 aaagtggctg aagaaggagc cgggggccta tgactggacc ccagcggtga aattcgcctg
      361 tgagctggaa ggaaacagcg gccgatggga ggagaaggag gagaagctgc gggcagcggt
      421 gaagcgggtg ctcaagtgcg atgtccacct gggcaacccg ctggccccgg ctgtgttgcc
      481 tctcgccgac tgtgtgctca ccctgctggc catggagtgt gcctgctgta gccttgatgc
      541 ctaccgcgct gccctgtgca accttgcctc actgctcaag ccgggtggcc acctggtgac
      601 cactgtcacg cttcggctcc cgtcctacat ggtggggaag cgtgaatttt cctgcgtggc
      661 cctggagaaa gaggaggtgg agcaggctgt cctggatgct ggctttgaca ttgaacagct
      721 cctacacagt ccccagagct actctgtcac caatgctgcc aacaatgggg tctgcttcat
      781 tgtggctcgc aagaagcctg ggccctgagc caggagggcc agccagaggt ctggtcaggc
      841 tgtgaggcct tggccatctg tatgctagag aggggtgagg aatggatact gtctaacagt
      901 ctctgatttc aacactaaca ttccatcttc tgaaattctg agattctaac atccttgttt
      961 tagaattcta agtttccaac attcctcatt ctaggatcct aggagtggaa ttttccattt
     1021 tctaatatac taagccttac agctatctta gatgcgatct gactcctgtg tgactgtgga
     1081 gcacccaggg acgtggtttt agagtctacc taatatgtta aggacaagga aacctctgag
     1141 tctacctaat atgttaagga caaggaaacc tctggacagt ggtatattgg ggaatttttt
     1201 tttttttttt gagacggagt ctggctctgt cacccaggct agagtgcaat ggcacgatct
     1261 cggctcactg caagctctgc gtcctgggtt gacgccattc tcctgcctca gcctcccgag
     1321 tagctgggac tacaggagct cgccaccaca cccagctaat tttttttttt ttttttttat
     1381 ttgagacgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcgactcac
     1441 tgcaagctcc gcctcccggg ttcacgccat tctcctgcct cagcctcccg tgtagctggg
     1501 actacaggca cgcgccacca tgcccggcta atttttgtat ttttagtaga gatggggttt
     1561 caccgtgtta gccaggatgg tctcgatctc ctgacctggt gatccaccca ccttggcctc
     1621 ccaaagtgct gggattacag gcgtgagcca ccgcacccag ccagggggaa tgttctataa
     1681 ccagctctgt aaaggaaaag cactgatgtg tggtagtcac caatttctgt ggtgtaaata
     1741 ctcccaccat ggttgatttc aagccaccag tggtttaata accagctcat aaatctccta
     1801 aatattttac agttgactct catgagctga ttggagtcag ctggaacata ccactgcctc
     1861 tagactaagg tcagcagatt tagcaaatac agactgcccc agttcattga attttagata
     1921 aatgaaataa atctataagg ttaagtatgt ccccagaact gcatggaaca tgcttaatct
     1981 aaacaatgat ttgttgttca cctgaaattc aaatttagct gggtgtcctg tatttcatct
     2041 ggcaacccta cttcagaccc aggtgtaagg tacatggatg tgctttggtc aaggaatagg
     2101 ccaaggcaga gatccatgcc tgcatgactc agtgggtttg gtgcacaggc acacacctcc
     2161 acttgttata taacctgttt gtgtaagttc atacttggtc tgagccactg ttgtctgtaa
     2221 aaggtaattg tcctgctaat gctgtacagg ggctcttggg gttcggctca gctcaacatg
     2281 gcttgacatg gtgggcacac tggcgcccag taagagagag agagagccaa agctgtccgt
     2341 tttgcagatg gacaggaagg agccaggaca cagctcagct tgctcacgcc cagagagaga
     2401 aaaagttaag ctgctgaccc tgaaggcaag ggagagcagg ctgcacagct gtgtgtggaa
     2461 gccacgggct caagcagcca aggcagggcg gacagtgtga gagagctagt gtaagctgtt
     2521 gatgagagct gttgctgaat aaaaccatat tcacctgcc
//
