LOCUS       NM_019099               5951 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens inka box actin regulator 2 (INKA2), transcript variant
            1, mRNA.
ACCESSION   NM_019099
VERSION     NM_019099.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5951)
  AUTHORS   Chen,G.L., Li,R., Chen,X.X., Wang,J., Cao,S., Song,R., Zhao,M.C.,
            Li,L.M., Hannemmann,N., Schett,G., Qian,C. and Bozec,A.
  TITLE     Fra-2/AP-1 regulates melanoma cell metastasis by downregulating
            Fam212b
  JOURNAL   Cell Death Differ 28 (4), 1364-1378 (2021)
   PUBMED   33188281
  REMARK    GeneRIF: Fra-2/AP-1 regulates melanoma cell metastasis by
            downregulating Fam212b.
REFERENCE   2  (bases 1 to 5951)
  AUTHORS   Baskaran,Y., Ang,K.C., Anekal,P.V., Chan,W.L., Grimes,J.M.,
            Manser,E. and Robinson,R.C.
  TITLE     An in cellulo-derived structure of PAK4 in complex with its
            inhibitor Inka1
  JOURNAL   Nat Commun 6, 8681 (2015)
   PUBMED   26607847
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5951)
  AUTHORS   Iwasaki,Y., Yumoto,T. and Sakakibara,S.
  TITLE     Expression profiles of inka2 in the murine nervous system
  JOURNAL   Gene Expr Patterns 19 (1-2), 83-97 (2015)
   PUBMED   26292052
REFERENCE   4  (bases 1 to 5951)
  AUTHORS   Clague,J., Lippman,S.M., Yang,H., Hildebrandt,M.A., Ye,Y., Lee,J.J.
            and Wu,X.
  TITLE     Genetic variation in MicroRNA genes and risk of oral premalignant
            lesions
  JOURNAL   Mol Carcinog 49 (2), 183-189 (2010)
   PUBMED   19851984
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 5951)
  AUTHORS   Horikawa,Y., Wood,C.G., Yang,H., Zhao,H., Ye,Y., Gu,J., Lin,J.,
            Habuchi,T. and Wu,X.
  TITLE     Single nucleotide polymorphisms of microRNA machinery genes modify
            the risk of renal cell carcinoma
  JOURNAL   Clin Cancer Res 14 (23), 7956-7962 (2008)
   PUBMED   19047128
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA306915.1 and AL049557.19.
            
            On Nov 23, 2018 this sequence version replaced NM_019099.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA344685.1, SRR1803615.84726.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357260.6/ ENSP00000349805.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               DA306915.1         30-578
            550-5951            AL049557.19        73505-78906         c
FEATURES             Location/Qualifiers
     source          1..5951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..5951
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /note="inka box actin regulator 2"
                     /db_xref="GeneID:55924"
                     /db_xref="HGNC:HGNC:28045"
                     /db_xref="MIM:620403"
     exon            1..210
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1047
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM212B; HInca-r; induced in neural crest by
                     AP2-alpha protein-related homolog; PAK4-inhibitor INKA2;
                     family with sequence similarity 212 member B; inca-r"
                     /codon_start=1
                     /product="PAK4-inhibitor INKA2 isoform 1"
                     /protein_id="NP_061972.1"
                     /db_xref="CCDS:CCDS841.1"
                     /db_xref="GeneID:55924"
                     /db_xref="HGNC:HGNC:28045"
                     /db_xref="MIM:620403"
                     /translation="MTMESREMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELK
                     LLQVQTALEQLEISGGGPVPGSPEGPRTQCEHPCWEGGRGPARPTVCSPSSQPSLGSS
                     TKFPSHRSVCGRDLAPLPRTQPHQSCAQQGPERVEPDDWTSTLMSRGRNRQPLVLGDN
                     VFADLVGNWLDLPELEKGGEKGETGGAREPKGEKGQPQELGRRFALTANIFKKFLRSV
                     RPDRDRLLKEKPGWVTPMVPESRTGRSQKVKKRSLSKGSGHFPFPGTGEHRRGENPPT
                     SCPKALEHSPSGFDINTAVWV"
     exon            211..5951
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /note="hexamer: AATAAA"
     polyA_site      1509
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /note="major polyA site"
     regulatory      4108..4113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /note="hexamer: AACAAG"
     polyA_site      4120
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
     regulatory      5192..5197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /note="hexamer: AAGAAA"
     polyA_site      5212
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /note="major polyA site"
     regulatory      5929..5934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
                     /note="hexamer: AATAAA"
     polyA_site      5951
                     /gene="INKA2"
                     /gene_synonym="C1orf183; FAM212B"
ORIGIN      
        1 gactctgagt cccgggctcg gagcgcaggc tcagctccgc gctgcgagcg ctacgggcgc
       61 aggggcgggg agccggcccg gagcgcagtt tccagtgggg ccggggtttc acccgggccc
      121 tctctgtttg aaccgaaccc gacaaatggg cgcatgacga tggagagcag ggaaatggac
      181 tgctatctcc gtcgcctcaa acaggagctg atgtccatga aggaggtggg tgatggctta
      241 caggatcaga tgaactgcat gatgggtgca ctgcaagaac tgaagctcct ccaggtgcag
      301 acagcactgg aacagctgga gatctctgga gggggtcctg tgccaggcag ccctgaaggt
      361 cccaggaccc agtgcgagca cccttgttgg gagggtggca gaggtcctgc caggcccaca
      421 gtctgttccc cctccagtca accttctctt ggcagcagca ccaagtttcc atcccatagg
      481 agtgtctgtg gaagggattt agcccccttg cccaggacac agccacatca aagctgtgct
      541 cagcaggggc cagagcgagt ggaaccggat gactggacct ccacgttgat gtcccggggc
      601 cggaatcgac agcctctggt gttaggggac aacgtttttg cagacctggt gggcaattgg
      661 ctagacttgc cagaactgga gaagggtggg gagaagggtg agactggggg ggcacgtgaa
      721 cccaaaggag agaaaggcca gccccaggag ctgggccgca ggttcgccct gacagcaaac
      781 atctttaaga agttcttgcg tagtgtgcgg cctgaccgtg accggctgct gaaggagaag
      841 ccaggctggg tgacacccat ggtccctgag tcccgaaccg gccgctcaca gaaggtcaag
      901 aagcggagcc tttccaaggg ctctggacat ttccccttcc caggcaccgg ggagcacagg
      961 cgaggggaga atccccccac aagctgcccc aaggccctgg agcactcacc ctcaggattt
     1021 gatattaaca cagctgtttg ggtctgaatc ctagagacag aaagttgact gagcctgaaa
     1081 gggccaggtc ccagtgctgg gcccctgggg aggagggagg gtgggcggta tggctctcga
     1141 aagcccaact ccaagttcct ttcccccaga aagcggggag aagccagagt tcttggctca
     1201 ggactgaagg gaaggtggtt gggagaggct gtcttggggg ctagctggtg gaggaggtaa
     1261 gagtagctgg agagtgagct gtgcgtgtgt gtgtgtgtgt gtgcatgtgt gtgtctgtct
     1321 ggcatgcatg cactcacttt ggggctggag gtgacagtag gtgagggcag aggaggagat
     1381 cagaaaatcc ctctgacatc tccactgccc ccaaagacct ccgttgaaca ttctgtatgg
     1441 aaaagagccc tggagcatca ggttccccag ataggccccc aaataaagac ctgtctatgg
     1501 ctctcccaac cttctgtcag cttctttggc aagacattgc tccaggcaca gggactgaac
     1561 cccaggcctc ctgggactgg agcagcagtg aggcaaaacc cgacctgcta gccctttctg
     1621 ccttggaggt ttcagtccat acctggactc tgagaaaatg agctgaataa ggagtacagt
     1681 gtgtaaggag cagccaggga agccctagac actccccgcg tctcccccat gcacagggga
     1741 aggatgttga catagcactg ggctgtttga atgccttttc atctccatgg tctcatttga
     1801 aagtgagcga ggcaggcagg catgatccca ttttccagat aaggaaacaa gcctagatat
     1861 gctacatgtc caggaacaac tgcagccagg aggcagaaca gcctaggtct aactgcagag
     1921 tagaagctgg accctggagt taccaacact cctccccaac agttcttagc accccgcagg
     1981 ctgggcgctg tggctcacgc ctgtaatccc agcactttgg gagggcaagg caggcggatt
     2041 acctggggtc aggagttcat gaccagcctg gccaacatgg tgaaaccccg tctctactaa
     2101 aaaaatacgt aaaaattagc caggcgtggt ggcacacgcc tgtaaaccca gctacttggg
     2161 aggctgaggc aggagaattg cttgagcccg ggagagggag gttgcagtga ggcgagatca
     2221 tgccactgca ctccagcctg gctgacagag caagactccc ctgtctcaaa aaaaataaaa
     2281 aaaaacagtt cgtagggccc cataccccac aacccctgtc tcctgcactt aactcccacc
     2341 tgggtcagag aacagccaat tcaccagtga ggtagaagtg aacccagaag aaatagccac
     2401 ttgattttaa aattcccagc tccattccgt ggccttctcc ccactagaca cagcagtccc
     2461 aggcctcctg ttccctcctc acctagaggc agccgggacg gagggggaag ggccaggcag
     2521 cagctcagct ccggcttctc taaagccact ctgggcacgt ggcccaggag ggccacctag
     2581 tgatccaggc ccccccccag gactgccctg ggaagccact gtccctccca ctccagtagg
     2641 gaacactcac tggctgggaa aagacaatgt ggatcttctt ttgggctgac caagccagga
     2701 gggcacaccc tcccactgcc cctctctgcc tcccactgat tgtccctcag cctgatgggg
     2761 tgtgacagct gcaattagag gcaggattcc ttcccaccct caaagcatta atagccagtt
     2821 ggagaggcaa aatagtaaga aaaggctctt ctgcttgctt cctggatccc tggggagagt
     2881 ggagagaggg gcagagctca agatgggatt atgggggcgc agccgcggtg gttagggtca
     2941 ctctcaaatc ctacccagtc aaatggtaag atgtttcatt tttggtgggg gagctgcagg
     3001 agggaggaag gcgctcatgc tttttgggtt ttgttgagca ctcactgtct gtcaggtaat
     3061 gtgcacatct ctcaaactta gaaggaccct agaaggcatt gttctccaga cacatctatg
     3121 gaggttatta gggggcgtgt aaactgcccc gattaggctg ctagcaaagg aaaggacaga
     3181 gatttgaaca gagggttggg ttatctggct ccaaaacccc tgtccttttc ttgctatttc
     3241 tctacctgga gtttgccaac tgagcaagcc cactctggtg gagccagcca ctgcaaatcc
     3301 tttgtgtctt cccagagaat accaacattt cagttttgag tgagggaacg ttggctctga
     3361 ctgcctttgg aggtggagat ggtggaggtg gtggtggtgg tggtggtagt ggtggtgtgt
     3421 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgc ctgcgcgtgc taagaaactg catgttaaga
     3481 ttccacctac tgaatcatga gcggaggaag tcgtgggaca ctggctggtg gagaagccat
     3541 ctagcatatt attcaagatg acaccagctc caagtctgga atgagtctgt gggaaaccaa
     3601 ggtacttctt ggacattcac ctataactca cgtgtttcgt ggactggtca cagtggttcg
     3661 gataaattga acagaacttt atgaacacct cccagcacca ggtgttgtta tagaaactaa
     3721 gaacagagca atgagaagga cccaactcct gctctcaaat ggatgcagtg gaaaataagc
     3781 agactttgaa ccattggtta gtcagaagag acttgggaga ctgaaaactt gtttcaactt
     3841 gggccagaac aaaaaattag gaagcaacac ttgctgccaa catgatttac aagtgccagc
     3901 accttcacct ctgttacttc cttctcacta cacactgaaa gcagttgctc ttgttttaca
     3961 tggacaggct cagagaagtt aagcaacttg tccaaggtca cacagtagtg gaattgagat
     4021 tgaatcagtt ccaactgact tgcaatcttg tgcttttcag acgatcccac taattgtcca
     4081 tatctgttcc aaagccaaat caagaggaac aagagcaaaa tctgtcctct catattattc
     4141 atggtcctgc gtggatcata aatggcatgc tgactgtctg atggagactt acttttccct
     4201 tccccctgga cacctgccat ggcaatgaca gaggctgtat tttactgaag tggagggaag
     4261 aggtgaatgc aaatgcctag ggcctaagta tacaggaagg tgtagggaga ggtaagcagt
     4321 gtgtatgtgg aggagatagc agacgtaagc agagagaaat cagagagctt agttcttcct
     4381 ctggggcgca ctttgtggtt aattaggaca tgcaaatgag ctagaagctc atttaatatc
     4441 ctccctgaca tgtagcccca ccccaccctg ccccacttcc ctggcaggta caagggccac
     4501 ctgattggcc caggtatctg tggaaggttc cacctgcttc tttgtggccc agggaacaga
     4561 aaagagtccc tgctgggcat gctagtgggg ccggcctggt ctccctcctc cctttctctt
     4621 cccaaccttt cagacttggg acctctcttt tccctctccc tcagacactt cccttgtgcc
     4681 ccgcccctca gggtgatctc tgaacccaaa cttgccccaa agaaggttgc tctgtcctct
     4741 ccacatcccc atctcctccc tagggccttg ttggggagag gctcctccat ctttcccaag
     4801 tcacaccatc gtttcctacg tggtctggac aagagcaaga gcacaccttg tccccacctt
     4861 ctccagagca gccagaaccc acctcaggtg ccttccccat ccggtgcagt taaggcactt
     4921 ctgccagcac catggtatga gcactagact tggagttaag atttgagagc cccctctgtc
     4981 actgtggaag cttgagcatg ttgcttgatc tctctgaacc ttgtgtttct catctgtgaa
     5041 aggtgataat gtggggctgc tgtgagattt aaaggacata atgcacctac ggtccaagca
     5101 ctgcctggaa tacagcagaa gctcagcaga tactggacaa cccatcccct tagtagaggc
     5161 actaaccatg tgacccaagg caaaagtgct taagaaaaag tgctttctct gagcgttggt
     5221 ctcttcttct gtcgaaacat ttatattgat ttaatatctc acaggattgt agcaagggtc
     5281 agagaagaca ataggtgaca tgtttttgta cactgtatac tagccaccca gatgggctgt
     5341 tatttgctaa atggcaaatt tacactgttc cccaaaggat gacatgcact ggggaggcgg
     5401 ggggtgtgga ggtggagaaa ggctgagctt ggagaaaagg tgcttgagga ccccactgcc
     5461 taaggacctg ctctaggaaa cattcccact ccctacaccc tagctgcccc tcacagtcaa
     5521 cccttaagga cctcaaattc ttggcaaggg gtaaagagtt gaaagtgcca agtcctagtg
     5581 gttttgagaa gcctctggtc tgctctttct gctctgtaaa gtcttagttg ccagagtccc
     5641 ctatagcccc cacatcgctc ccttcctcct gccctccggc caccctggaa actaatggcc
     5701 taaaggtgct gtggctgtcc tcctaaaatc cattccctcc tgatggggtg gaggaatctg
     5761 tgaagcccac cttcaggaga ggtctcgggg ctcgggctgg tgctgccaga gaaagggtga
     5821 ctgaaccaga aaggcctagg ggaaagcagc tcaaactgca gccatcccct tagtacgatt
     5881 actaggatgt cccttgcctt ccttttgcct cctccaccca acccctaaaa taaacagtat
     5941 gatgaaacct c
//
