LOCUS       NM_203370               1033 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens inka box actin regulator 1 (INKA1), transcript variant
            1, mRNA.
ACCESSION   NM_203370 XM_371640
VERSION     NM_203370.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1033)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1033)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1033)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1033)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1033)
  AUTHORS   Kaufmann,K.B., Garcia-Prat,L., Liu,Q., Ng,S.W.K., Takayanagi,S.I.,
            Mitchell,A., Wienholds,E., van Galen,P., Cumbaa,C.A., Tsay,M.J.,
            Pastrello,C., Wagenblast,E., Krivdova,G., Minden,M.D.,
            Lechman,E.R., Zandi,S., Jurisica,I., Wang,J.C.Y., Xie,S.Z. and
            Dick,J.E.
  TITLE     A stemness screen reveals C3orf54/INKA1 as a promoter of human
            leukemia stem cell latency
  JOURNAL   Blood 133 (20), 2198-2211 (2019)
   PUBMED   30796022
  REMARK    GeneRIF: A competitive in vivo gain-of-function screen identifies
            C3orf54/INKA1 as a gene regulating leukemia stem cells (LSCs)
            repopulation kinetics. INKA1 overexpression stalls LSC transiently
            in G0 without abolishing regenerative potential; silencing has the
            opposite effect.
REFERENCE   6  (bases 1 to 1033)
  AUTHORS   Baskaran,Y., Ang,K.C., Anekal,P.V., Chan,W.L., Grimes,J.M.,
            Manser,E. and Robinson,R.C.
  TITLE     An in cellulo-derived structure of PAK4 in complex with its
            inhibitor Inka1
  JOURNAL   Nat Commun 6, 8681 (2015)
   PUBMED   26607847
  REMARK    GeneRIF: Inka1 is an endogenous inhibitor of PAK4 that binds to the
            catalytic domain and forms crystals with PAK4 in cells.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1033)
  AUTHORS   Reid,B.S., Sargent,T.D. and Williams,T.
  TITLE     Generation and characterization of a novel neural crest marker
            allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube
            closure
  JOURNAL   Dev Dyn 239 (4), 1188-1196 (2010)
   PUBMED   20175189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012170.1.
            
            On Sep 28, 2018 this sequence version replaced NM_203370.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012170.1, SRR1163658.292218.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000333323.6/
                                                ENSP00000329735.5
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1033              BC012170.1         8-1040
FEATURES             Location/Qualifiers
     source          1..1033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1033
                     /gene="INKA1"
                     /gene_synonym="C3orf54; FAM212A; INCA"
                     /note="inka box actin regulator 1"
                     /db_xref="GeneID:389119"
                     /db_xref="HGNC:HGNC:32480"
                     /db_xref="MIM:620426"
     exon            1..183
                     /gene="INKA1"
                     /gene_synonym="C3orf54; FAM212A; INCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..990
                     /gene="INKA1"
                     /gene_synonym="C3orf54; FAM212A; INCA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM212A; Induced in Neural Crest by AP-2alpha;
                     HInca; induced in neural crest by AP2-alpha protein
                     homolog; PAK4-inhibitor INKA1; family with sequence
                     similarity 212 member A"
                     /codon_start=1
                     /product="PAK4-inhibitor INKA1 isoform 1"
                     /protein_id="NP_976248.2"
                     /db_xref="CCDS:CCDS2804.2"
                     /db_xref="GeneID:389119"
                     /db_xref="HGNC:HGNC:32480"
                     /db_xref="MIM:620426"
                     /translation="MHSARLDSFLSQLRWELLCGRDTGSPSMPGPLQPTSQTGPDVQP
                     SHQLRASGALEEDSVCCVEEEEEEEEEAVVTEDRDAALGGPREHALDWDSGFSEVSGS
                     TWREEELPVSQRPAPSAQPLRRQCLSVSGLPMPSRAPVASVPPVHHPRPKSTPDACLE
                     HWQGLEAEDWTAALLNRGRSRQPLVLGDNCFADLVHNWMELPETGSEGGDGGGHRARA
                     RPPQFLLGLSEQLRRRLARARRTAMAGKRLSCPPRPEPELPADVSRFAALMSCRSRQP
                     IICNDVSYL"
     exon            184..1033
                     /gene="INKA1"
                     /gene_synonym="C3orf54; FAM212A; INCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1012..1017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INKA1"
                     /gene_synonym="C3orf54; FAM212A; INCA"
                     /note="hexamer: AATAAA"
     polyA_site      1033
                     /gene="INKA1"
                     /gene_synonym="C3orf54; FAM212A; INCA"
                     /note="major polyA site"
ORIGIN      
        1 acggagagcg aggagtcgcg caggcaggcg gaggctgagg gcgccgctgg ccggccctcc
       61 cagccctctc cgcgcggctc cgccggggtt ccaagaggag ctagtaggtt cggtgggggc
      121 cctggcatgg acatgcacag cgctcggctt gacagcttcc ttagccagct ccgctgggaa
      181 ctgttgtgtg gtcgggacac aggctcaccc tcaatgcctg gtcccctgca gccaacctcc
      241 caaactggcc cagatgtgca gcccagccac cagcttaggg cctcgggtgc cttggaagag
      301 gactcagtct gctgtgtgga ggaggaggaa gaggaggagg aggaagcagt ggtgacagaa
      361 gacagggatg cagccttggg aggccccagg gagcatgccc tggactggga ctctggcttc
      421 tcggaggtgt caggcagcac atggcgagag gaagaactgc ctgtatccca gcgcccagca
      481 ccctcagcac agccccttcg taggcagtgc ctctcagtca gtggcctccc catgcccagc
      541 agggcccctg tagccagtgt accacctgtc caccatccac ggcccaagtc caccccagac
      601 gcctgcctgg agcactggca gggactggaa gcagaggact ggacagcagc cctactgaac
      661 aggggtcgca gtcgccagcc cctggtacta ggggacaatt gctttgctga cttggtgcac
      721 aactggatgg agctgcctga gacagggagt gaagggggtg acggaggtgg gcaccgtgcc
      781 cgtgctcggc cccctcagtt cctgcttggc ctctctgagc agcttcggcg ccggctggcc
      841 agggctcggc ggacagctat ggcaggaaag cggctgtcat gcccacctcg cccagaacct
      901 gaactgcctg cggatgtctc acgctttgca gctctcatga gctgtcgtag ccgccagccc
      961 atcatctgca atgatgtcag ctacctctga ccctgccctc cagcctggga caataaaagc
     1021 cttttttcta gac
//
