LOCUS       NM_021218               4114 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens INTS3 and NABP interacting protein (INIP), transcript
            variant 1, mRNA.
ACCESSION   NM_021218
VERSION     NM_021218.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Vidhyasagar,V., He,Y., Guo,M., Talwar,T., Singh,R.S., Yadav,M.,
            Katselis,G., Vizeacoumar,F.J., Lukong,K.E. and Wu,Y.
  TITLE     Biochemical characterization of INTS3 and C9ORF80, two subunits of
            hNABP1/2 heterotrimeric complex in nucleic acid binding
  JOURNAL   Biochem J 475 (1), 45-60 (2018)
   PUBMED   29150435
  REMARK    GeneRIF: INTS3, but not C9ORF80, affects the nucleic acid-binding
            ability of hNABP1 and hNABP2, indicating that INTS3 might regulate
            hNABP1/hNABP2 biological function, while the role of C9ORF80
            remains unknown.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4114)
  AUTHORS   Ren,W., Chen,H., Sun,Q., Tang,X., Lim,S.C., Huang,J. and Song,H.
  TITLE     Structural basis of SOSS1 complex assembly and recognition of ssDNA
  JOURNAL   Cell Rep 6 (6), 982-991 (2014)
   PUBMED   24630995
REFERENCE   5  (bases 1 to 4114)
  AUTHORS   Skaar,J.R., Richard,D.J., Saraf,A., Toschi,A., Bolderson,E.,
            Florens,L., Washburn,M.P., Khanna,K.K. and Pagano,M.
  TITLE     INTS3 controls the hSSB1-mediated DNA damage response
  JOURNAL   J Cell Biol 187 (1), 25-32 (2009)
   PUBMED   19786574
  REMARK    GeneRIF: MISE is part of the INTS3/MISE/hSSB1 (IMS1) complex, which
            controls the DNA damage response
REFERENCE   6  (bases 1 to 4114)
  AUTHORS   Li,Y., Bolderson,E., Kumar,R., Muniandy,P.A., Xue,Y., Richard,D.J.,
            Seidman,M., Pandita,T.K., Khanna,K.K. and Wang,W.
  TITLE     HSSB1 and hSSB2 form similar multiprotein complexes that
            participate in DNA damage response
  JOURNAL   J Biol Chem 284 (35), 23525-23531 (2009)
   PUBMED   19605351
  REMARK    GeneRIF: hSSBIP1 forms complexes with INTS3/hSSB1 and INTS3/hSSB2
            and participates in the DNA damage response
REFERENCE   7  (bases 1 to 4114)
  AUTHORS   Huang,J., Gong,Z., Ghosal,G. and Chen,J.
  TITLE     SOSS complexes participate in the maintenance of genomic stability
  JOURNAL   Mol Cell 35 (3), 384-393 (2009)
   PUBMED   19683501
  REMARK    GeneRIF: SOSS-C is part of an ssDNA-binding heterotrimeric complex,
            SOSS which is involved in the maintenance of genome stability.
REFERENCE   8  (bases 1 to 4114)
  AUTHORS   Richard,D.J., Bolderson,E., Cubeddu,L., Wadsworth,R.I., Savage,K.,
            Sharma,G.G., Nicolette,M.L., Tsvetanov,S., McIlwraith,M.J.,
            Pandita,R.K., Takeda,S., Hay,R.T., Gautier,J., West,S.C.,
            Paull,T.T., Pandita,T.K., White,M.F. and Khanna,K.K.
  TITLE     Single-stranded DNA-binding protein hSSB1 is critical for genomic
            stability
  JOURNAL   Nature 453 (7195), 677-681 (2008)
   PUBMED   18449195
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ219222.1, BC065210.1 and
            AL390067.19.
            
            On Nov 23, 2018 this sequence version replaced NM_021218.2.
            
            Summary: The protein encoded by this gene is a subunit of
            single-stranded DNA binding complexes that are important for
            maintaining genome stability. These complexes are involved in G2/M
            checkpoint control and homologous recombination repair. [provided
            by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.75719.1,
                                           SRR1803617.115936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374242.9/ ENSP00000363360.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BQ219222.1         33-44
            13-1290             BC065210.1         1-1278
            1291-4114           AL390067.19        46016-48839         c
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..4114
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /note="INTS3 and NABP interacting protein"
                     /db_xref="GeneID:58493"
                     /db_xref="HGNC:HGNC:24994"
                     /db_xref="MIM:613273"
     exon            1..131
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..212
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..502
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /note="isoform a is encoded by transcript variant 1; SOSS
                     complex subunit C; minute INTS3/hSSB-associated element;
                     hSSB-interacting protein 1; SSB-interacting protein 1;
                     sensor of ssDNA subunit C; sensor of single-strand DNA
                     complex subunit C; single-stranded DNA-binding
                     protein-interacting protein 1"
                     /codon_start=1
                     /product="SOSS complex subunit C isoform a"
                     /protein_id="NP_067041.1"
                     /db_xref="CCDS:CCDS6785.1"
                     /db_xref="GeneID:58493"
                     /db_xref="HGNC:HGNC:24994"
                     /db_xref="MIM:613273"
                     /translation="MAANSSGQGFQNKNRVAILAELDKEKRKLLMQNQSSTNHPGASI
                     ALSRPSLNKDFRDHAEQQHIAAQQKAALQHAHAHSSGYFITQDSAFGNLILPVLPRLD
                     PE"
     exon            213..315
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..406
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..4114
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1051..1056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1073
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
     regulatory      4079..4084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /note="hexamer: AATAAA"
     polyA_site      4114
                     /gene="INIP"
                     /gene_synonym="C9orf80; HSPC043; hSSBIP1; MISE; SOSSC;
                     SSBIP1"
                     /note="major polyA site"
ORIGIN      
        1 aggaggcgga agcgcagcgg gggcgggaag gttgtagtgc cgcgagttga gctcctcttg
       61 cctaagtggt cgcgccccct ttaagagcag cgattgtaag gagaggcggt cccggtgtcc
      121 tcgggtccca ggtgattgtg aagtgctgac caattgccac tggacatact tgaaacaaaa
      181 taggaaaatg gcagcaaact cttcaggaca aggttttcaa aacaaaaata gagttgcaat
      241 cttggcagaa ctggacaaag agaaaagaaa actacttatg cagaaccagt cttcaacaaa
      301 tcatcctgga gctagcattg cactctcgag accctctctt aataaggact tccgggatca
      361 cgctgagcag cagcatattg cagcccaaca gaaggcagct ttgcagcatg ctcatgcaca
      421 ttcatctgga tacttcatca ctcaagactc tgcatttggg aaccttattc ttcctgtttt
      481 acctcgcctt gacccagaat gaagaaaaca tttgcgatgg aaaagtgact ttgtaatatc
      541 aaatgccaaa gctactatca ttcagtgcta catgaactgt gactttaaga attttggtga
      601 actttgatat tttttgtttg tctgaaagaa aggaatgtgt aagtgaaagc tgaaagaaga
      661 ataaccagga tgatgagagc tgtggaagct gtatcgtcca aggaattgat tatgtaccgt
      721 gactgtaact tttttgtaat gctgtttaac tctcaatcag actgtgaact ggatggtcac
      781 gaagtcattc cccaactcct agcaagtttg actgaatata tcatgtccac agtagatttt
      841 caagaatcat ttatagtact taactttaaa gaaacaaggc tgcttttaaa aaatgaacta
      901 ataggcttaa atcaattgca tccatatttg ctgtttatag gattgctatc agtatacctt
      961 ttgcgtttat agtcaacatg tatcatcctg aaatattctt tctggactta taactacttc
     1021 cccctttttc actttaaaac aaacctcaag aataaattac taaccagtct taaccatctt
     1081 ttataaacat atgctcttat aaatgttgtg actagatgca attaaaaata atagggaatg
     1141 tggtaggttt ttaatttgta catcctctta tttagtgtta ccacataaat gatgagtttg
     1201 tgtggttctg ttttccattt ttgttctaac tgaaaacttt ttggctgggc acggtgcctc
     1261 atgcctgtaa tcccagcact ttgggaggcc aaggcgggca gatcacttga gatcaggagt
     1321 ttgagaccag cctggccaac atggtgaaac cctgtctcta ctaaaagtat aaaaaattag
     1381 ccatgtgtgg tggcacacgc ctgtaatccc agctactcag gaggctgagg caggagaatc
     1441 gcttgaacct gggaggcagg ggttgcagtg agctgagacg gtgtcactgc actccagcct
     1501 gggtgacagt gagtctttgt ctcaaagaaa aaaagaaaaa gaaaacttat gcaagtcgag
     1561 ctccttttta attaagtagg aagggattag gttaagaaag tctctcaaca tgacccatct
     1621 ttagcagtat ctggggtgct tatttaagta tgcagtccca ctaccctacc ctagtcctac
     1681 agaattagaa tctgattcaa aataaagtct gaaaaccatg agatagagaa ttctatgaaa
     1741 tatcttgtac agattttcgt gatatattta tacacgcatg ggtttgtaga tccctgaaac
     1801 ttagaggtca tttagctaaa atctacattt tttttaactt ttaataggat tgaaatgata
     1861 ttttacactg tatcacagat acagtatttt atataacttt ttgtaactga ccttatcttg
     1921 gccttgagtc ccatcctctc tggtggtagc gtaaaactga aaattccagt ttgggtcaat
     1981 atttagtgaa agttctactt tcttttcaga gagtttgttc ccccctttct tccttagatg
     2041 ttttcaaaca cacagcccca tcctactcaa accaagtgaa gcaagagtgg acaattctag
     2101 aattggctgt gccatgtagg ttttttttag aatttgaact gatttccttc attttgatga
     2161 ggtggcaact gtccccattg taatggtcac cattgcagcg aggatagcct tacttctgcg
     2221 gcgcagagct cctcaggggg cctctggctc ctgtccttcc tcaggtccat ccaactactc
     2281 cttgggcctc cttatggtag ccctcattgt cttgagttga tttcactagg tttctgttct
     2341 ctgtcatctg caacataact gacatggttc taaatctgtc tctaaggaga taacacatta
     2401 gtatattttc tacactattg aagcctctac ctaatgtatg acttttgtag ctcaggtaaa
     2461 gagatctttt taccagtgtt atcgtttcta gtctgtttgt tagtcttctt ttaaatagat
     2521 atggcctaaa tcctgtattc ctggctagga agcacttctc tccacccctc tgctttgagt
     2581 tacaaattca attcaatttc ctatgtattt attaatacct acagataaag tactgtgctt
     2641 tgggggacac aaaggtgact ggtacctgct cttttaggag gtcaccgtgc agaggatcct
     2701 attctggtac accaatagtt ataaagcaag ccacagccta ggcaacatag tgagacccct
     2761 gtctctacta aaaaattaaa aaaaaaaaaa aaagattggc taggtgtgct ggtgcatgca
     2821 tagagtccca gccactcggg aggctgaggt gggaggattg cttgagcctg ggaggttgag
     2881 gctgcagtgg gccatgattg cacaacttgg caacagagtg agaccctgtc tctaaatcaa
     2941 tcaatcaagc gagccagaat gcagtagtgg cctgagagag gcatcctgga acgcagtgcg
     3001 gtctggctag gcttagaagt attcatgtga tttttacctg acaagggaag gaagagctgc
     3061 tccacgtgca gagcaaggtt tcagaatgag aggagaagag caggcactgc agagggtgag
     3121 ggaaagggca gcagtggact gggaagccct caggtggagg tcagcattgc ttccctcaga
     3181 tcatgggtga atttgaggaa ctcagttaat atctttgtat gttcctccct ccataaggtg
     3241 agaacaagca catgctctgc ccatgtcaga aattgtctag actagtgttt ttcaaagtgc
     3301 aaaagcctca acccattact gagttgagaa gccaacttaa tggtttaaca ggattgacca
     3361 gcattttttc cgaaaaaatc aaaaacatct gagtgtactg catatagaaa taggtggttt
     3421 tgcctcatga atattctgtt tctgtgtgtt cctatatttt actttgtatt gtgttggttt
     3481 tttaagagac agtcctgctc tgtcatccag gctggagtgc agtggtataa tcatagctca
     3541 ctgcaagact ccttgaatcc ctgggctcaa gcaatcctca acccttagcc tcccaagtag
     3601 ctgagactac aggcacatgc caccatgccc agctaatttt tttttttttt taatttttgt
     3661 agagacagca tcttgctatg ttgcccaggc tggtcttgaa ctcttggcct caagcagtcc
     3721 tctcgatcct cccaccttgg cctcctaaag tgctgagatt acaggtgtga gccactgcat
     3781 ctggcttact tattttgtct attgtctgtt ccactagtat gtaaagtctt agagagcaag
     3841 aatttttgtt tatttctttc tcttcctcct ttcctttctt cctcttttac ttcgttcact
     3901 actgtattcc acataaaata tatttggcat atagtaggtg ttcaatatgt tgaaggaatg
     3961 aaagaattta tagacttgag ttgcaatata aaatgtattt ttttttactg tgagttatgg
     4021 caaaaaaagt tttgaaagcc gcttctaaat aatgcagatg tcagtgcttt gaccctggaa
     4081 taaaaactga aatgacttag tgatttcaaa ggca
//
