LOCUS       NM_031479               2460 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens inhibin subunit beta E (INHBE), mRNA.
ACCESSION   NM_031479
VERSION     NM_031479.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2460)
  AUTHORS   Cao,J., Zhong,Q., Huang,Y., Zhu,M., Wang,Z. and Xiong,Z.
  TITLE     Identification and validation of INHBE and P4HA1 as hub genes in
            non-alcoholic fatty liver disease
  JOURNAL   Biochem Biophys Res Commun 686, 149180 (2023)
   PUBMED   37922570
  REMARK    GeneRIF: Identification and validation of INHBE and P4HA1 as hub
            genes in non-alcoholic fatty liver disease.
REFERENCE   2  (bases 1 to 2460)
  AUTHORS   Akbari,P., Sosina,O.A., Bovijn,J., Landheer,K., Nielsen,J.B.,
            Kim,M., Aykul,S., De,T., Haas,M.E., Hindy,G., Lin,N.,
            Dinsmore,I.R., Luo,J.Z., Hectors,S., Geraghty,B., Germino,M.,
            Panagis,L., Parasoglou,P., Walls,J.R., Halasz,G., Atwal,G.S.,
            Jones,M., LeBlanc,M.G., Still,C.D., Carey,D.J., Giontella,A.,
            Orho-Melander,M., Berumen,J., Kuri-Morales,P., Alegre-Diaz,J.,
            Torres,J.M., Emberson,J.R., Collins,R., Rader,D.J., Zambrowicz,B.,
            Murphy,A.J., Balasubramanian,S., Overton,J.D., Reid,J.G.,
            Shuldiner,A.R., Cantor,M., Abecasis,G.R., Ferreira,M.A.R.,
            Sleeman,M.W., Gusarova,V., Altarejos,J., Harris,C.,
            Economides,A.N., Idone,V., Karalis,K., Della Gatta,G., Mirshahi,T.,
            Yancopoulos,G.D., Melander,O., Marchini,J., Tapia-Conyer,R.,
            Locke,A.E., Baras,A., Verweij,N. and Lotta,L.A.
  CONSRTM   Regeneron Genetics Center; DiscovEHR Collaboration
  TITLE     Multiancestry exome sequencing reveals INHBE mutations associated
            with favorable fat distribution and protection from diabetes
  JOURNAL   Nat Commun 13 (1), 4844 (2022)
   PUBMED   35999217
  REMARK    GeneRIF: Multiancestry exome sequencing reveals INHBE mutations
            associated with favorable fat distribution and protection from
            diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2460)
  AUTHORS   Deaton,A.M., Dubey,A., Ward,L.D., Dornbos,P., Flannick,J., Yee,E.,
            Ticau,S., Noetzli,L., Parker,M.M., Hoffing,R.A., Willis,C.,
            Plekan,M.E., Holleman,A.M., Hinkle,G., Fitzgerald,K., Vaishnaw,A.K.
            and Nioi,P.
  CONSRTM   AMP-T2D-GENES Consortium
  TITLE     Rare loss of function variants in the hepatokine gene INHBE protect
            from abdominal obesity
  JOURNAL   Nat Commun 13 (1), 4319 (2022)
   PUBMED   35896531
  REMARK    GeneRIF: Rare loss of function variants in the hepatokine gene
            INHBE protect from abdominal obesity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2460)
  AUTHORS   Xu,Z.B., Gan,M.F., Yu,H.Y., Mo,L.C., Xia,Y.H., Yu,Q.X. and
            Zheng,J.M.
  TITLE     The Significance of INHBE Expression in the Cancer Cells of
            Clear-Cell Renal Cell Carcinoma
  JOURNAL   Urol Int 106 (4), 376-386 (2022)
   PUBMED   34515260
  REMARK    GeneRIF: The Significance of INHBE Expression in the Cancer Cells
            of Clear-Cell Renal Cell Carcinoma.
REFERENCE   5  (bases 1 to 2460)
  AUTHORS   Sugiyama,M., Kikuchi,A., Misu,H., Igawa,H., Ashihara,M.,
            Kushima,Y., Honda,K., Suzuki,Y., Kawabe,Y., Kaneko,S. and
            Takamura,T.
  TITLE     Inhibin betaE (INHBE) is a possible insulin resistance-associated
            hepatokine identified by comprehensive gene expression analysis in
            human liver biopsy samples
  JOURNAL   PLoS One 13 (3), e0194798 (2018)
   PUBMED   29596463
  REMARK    GeneRIF: INHBE functions as a possible hepatokine to alter the
            whole-body metabolic status under obese insulin-resistant condition
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2460)
  AUTHORS   Kimmich,T., Bruning,A., Kaufl,S.D., Makovitzky,J., Kuhn,C.,
            Jeschke,U., Friese,K. and Mylonas,I.
  TITLE     Inhibin/activin-betaC and -betaE subunits in the Ishikawa human
            endometrial adenocarcinoma cell line
  JOURNAL   Arch Gynecol Obstet 282 (2), 185-191 (2010)
   PUBMED   20012305
  REMARK    GeneRIF: Expression of the inhibin betaC and betaE subunits was
            demonstrated at the protein level and at the transcriptional level
            in normal human endometrial tissue and in the Ishikawa human
            endometrial carcinoma cell line.
REFERENCE   7  (bases 1 to 2460)
  AUTHORS   Bergauer,F., Bruning,A., Shabani,N., Blankenstein,T., Juckstock,J.,
            Dian,D. and Mylonas,I.
  TITLE     Inhibin/activin-betaE subunit in normal and malignant human
            cervical tissue and cervical cancer cell lines
  JOURNAL   J Mol Histol 40 (5-6), 353-359 (2009)
   PUBMED   20033758
  REMARK    GeneRIF: An immunolabelling of the inhibin-betaE subunit in normal
            and malignant cervical tissue, as well as cervical cancer cells, is
            demonstrated.
REFERENCE   8  (bases 1 to 2460)
  AUTHORS   Purdue,M.P., Graubard,B.I., Chanock,S.J., Rubertone,M.V.,
            Erickson,R.L. and McGlynn,K.A.
  TITLE     Genetic variation in the inhibin pathway and risk of testicular
            germ cell tumors
  JOURNAL   Cancer Res 68 (8), 3043-3048 (2008)
   PUBMED   18413775
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2460)
  AUTHORS   Hashimoto,O., Ushiro,Y., Sekiyama,K., Yamaguchi,O., Yoshioka,K.,
            Mutoh,K. and Hasegawa,Y.
  TITLE     Impaired growth of pancreatic exocrine cells in transgenic mice
            expressing human activin betaE subunit
  JOURNAL   Biochem Biophys Res Commun 341 (2), 416-424 (2006)
   PUBMED   16426570
  REMARK    GeneRIF: activin E has a role in regulating the proliferation of
            pancreatic exocrine cells
REFERENCE   10 (bases 1 to 2460)
  AUTHORS   Hashimoto,O., Tsuchida,K., Ushiro,Y., Hosoi,Y., Hoshi,N., Sugino,H.
            and Hasegawa,Y.
  TITLE     cDNA cloning and expression of human activin betaE subunit
  JOURNAL   Mol Cell Endocrinol 194 (1-2), 117-122 (2002)
   PUBMED   12242034
  REMARK    GeneRIF: cDNA cloning from a liver cDNA library, deduction of amino
            acid sequence, binding to follistatin, and analysis of the
            transcript in human liver
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA050178.1, BC005161.2,
            BU632022.1 and AC022506.38.
            
            On Nov 22, 2018 this sequence version replaced NM_031479.4.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate an inhibin
            beta subunit. Inhibins have been implicated in regulating numerous
            cellular processes including cell proliferation, apoptosis, immune
            response and hormone secretion. This gene may be upregulated under
            conditions of endoplasmic reticulum stress, and this protein may
            inhibit cellular proliferation and growth in pancreas and liver.
            [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA046954.1, BC005161.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266646.3/ ENSP00000266646.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA050178.1         18-31
            15-2443             BC005161.2         1-2429
            2444-2448           BU632022.1         17-21               c
            2449-2460           AC022506.38        150061-150072       c
FEATURES             Location/Qualifiers
     source          1..2460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..2460
                     /gene="INHBE"
                     /note="inhibin subunit beta E"
                     /db_xref="GeneID:83729"
                     /db_xref="HGNC:HGNC:24029"
                     /db_xref="MIM:612031"
     exon            1..528
                     /gene="INHBE"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1283
                     /gene="INHBE"
                     /note="inhibin beta E chain; activin beta-E chain; inhibin
                     beta E subunit"
                     /codon_start=1
                     /product="inhibin beta E chain preproprotein"
                     /protein_id="NP_113667.1"
                     /db_xref="CCDS:CCDS8939.1"
                     /db_xref="GeneID:83729"
                     /db_xref="HGNC:HGNC:24029"
                     /db_xref="MIM:612031"
                     /translation="MRLPDVQLWLVLLWALVRAQGTGSVCPSCGGSKLAPQAERALVL
                     ELAKQQILDGLHLTSRPRITHPPPQAALTRALRRLQPGSVAPGNGEEVISFATVTDST
                     SAYSSLLTFHLSTPRSHHLYHARLWLHVLPTLPGTLCLRIFRWGPRRRRQGSRTLLAE
                     HHITNLGWHTLTLPSSGLRGEKSGVLKLQLDCRPLEGNSTVTGQPRRLLDTAGHQQPF
                     LELKIRANEPGAGRARRRTPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYC
                     SGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNV
                     VKTDVPDMVVEACGCS"
     exon            529..2460
                     /gene="INHBE"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2395
                     /gene="INHBE"
                     /note="major polyA site"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INHBE"
                     /note="hexamer: ATTACA"
     polyA_site      2460
                     /gene="INHBE"
                     /note="major polyA site"
ORIGIN      
        1 agtagccaga catgagctgt gagggtcaag cacagctatc catcagatga tctactttca
       61 gccttcctga gtcccagaca atagaagaca ggtggctgta cccttggcca agggtaggtg
      121 tggcagtggt gtctgctgtc actgtgccct cattggcccc cagcaatcag actcaacaga
      181 cggagcaact gccatccgag gctcctgaac cagggccatt caccaggagc atgcggctcc
      241 ctgatgtcca gctctggctg gtgctgctgt gggcactggt gcgagcacag gggacagggt
      301 ctgtgtgtcc ctcctgtggg ggctccaaac tggcacccca agcagaacga gctctggtgc
      361 tggagctagc caagcagcaa atcctggatg ggttgcacct gaccagtcgt cccagaataa
      421 ctcatcctcc accccaggca gcgctgacca gagccctccg gagactacag ccagggagtg
      481 tggctccagg gaatggggag gaggtcatca gctttgctac tgtcacagac tccacttcag
      541 cctacagctc cctgctcact tttcacctgt ccactcctcg gtcccaccac ctgtaccatg
      601 cccgcctgtg gctgcacgtg ctccccaccc ttcctggcac tctttgcttg aggatcttcc
      661 gatggggacc aaggaggagg cgccaagggt cccgcactct cctggctgag caccacatca
      721 ccaacctggg ctggcatacc ttaactctgc cctctagtgg cttgaggggt gagaagtctg
      781 gtgtcctgaa actgcaacta gactgcagac ccctagaagg caacagcaca gttactggac
      841 aaccgaggcg gctcttggac acagcaggac accagcagcc cttcctagag cttaagatcc
      901 gagccaatga gcctggagca ggccgggcca ggaggaggac ccccacctgt gagcctgcga
      961 cccccttatg ttgcaggcga gaccattacg tagacttcca ggaactggga tggcgggact
     1021 ggatactgca gcccgagggg taccagctga attactgcag tgggcagtgc cctccccacc
     1081 tggctggcag cccaggcatt gctgcctctt tccattctgc cgtcttcagc ctcctcaaag
     1141 ccaacaatcc ttggcctgcc agtacctcct gttgtgtccc tactgcccga aggcccctct
     1201 ctctcctcta cctggatcat aatggcaatg tggtcaagac ggatgtgcca gatatggtgg
     1261 tggaggcctg tggctgcagc tagcaagagg acctggggct ttggagtgaa gagaccaaga
     1321 tgaagtttcc caggcacagg gcatctgtga ctggaggcat cagattcctg atccacaccc
     1381 caacccaaca accacctggc aatatgactc acttgacccc tatgggaccc aaatgggcac
     1441 tttcttgtct gagactctgg cttattccag gttggctgat gtgttgggag atgggtaaag
     1501 cgtttcttct aaaggggtct acccagaaag catgatttcc tgccctaagt cctgtgagaa
     1561 gatgtcaggg actagggagg gagggaggga aggcagagaa aaattactta gcctctccca
     1621 agatgagaaa gtcctcaagt gaggggagga ggaagcagat agatggtcca gcaggcttga
     1681 agcagggtaa gcaggctggc ccagggtaag ggctgttgag gtaccttaag ggaaggtcaa
     1741 gagggagatg ggcaaggcgc tgagggagga tgcttagggg acccccagaa acaggagtca
     1801 ggaaaatgag gcactaagcc taagaagttc cctggttttt cccaggggac aggacccact
     1861 gggagacaag catttatact ttctttcttc ttttttattt ttttgagatc gagtctcgct
     1921 ctgtcaccag gctggagtgc agtgacacga tcttggctca ctgcaacctc cgtctcctgg
     1981 gttcaagtga ttcttctgcc tcagcctccc gagcagctgg gattacaggc gcccactaat
     2041 ttttgtattc ttagtagaaa cgaggtttca acatgttggc caggatggtc tcaatctctt
     2101 gacctcttga tccacccgac ttggcctccc gaagtgatga gattataggc gtgagccacc
     2161 gcgcctggct tatactttct taataaaaag gagaaagaaa atcaacaaat gtgagtcata
     2221 aagaagggtt agggtgatgg tccagagcaa cagttcttca agtgtactct gtaggcttct
     2281 gggaggtccc ttttcagggg tgtccacaaa gtcaaagcta ttttcataat aatactaaca
     2341 tgttatttgc cttttgaatt ctcattatct taaaattgta ttgtggagtt ttccagaggc
     2401 cgtgtgacat gtgattacat catctttctg acatcattgt taatggaatg tgtgcttgta
//
