LOCUS       NM_005538               3202 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens inhibin subunit beta C (INHBC), mRNA.
ACCESSION   NM_005538
VERSION     NM_005538.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3202)
  AUTHORS   Ottley,E.C., Reader,K.L., Lee,K., Marino,F.E., Nicholson,H.D.,
            Risbridger,G.P. and Gold,E.
  TITLE     Over-Expression of Activin-betaC Is Associated with Murine and
            Human Prostate Disease
  JOURNAL   Horm Cancer 8 (2), 100-107 (2017)
   PUBMED   28116672
  REMARK    GeneRIF: Study shows an up-regulation of activin-C in aggressive
            prostate cancer only, suggesting that activin-C may play a role in
            the advanced stages of the disease.
REFERENCE   2  (bases 1 to 3202)
  AUTHORS   Chang,H.M., Cheng,J.C., Klausen,C., Taylor,E.L. and Leung,P.C.
  TITLE     Effects of recombinant activins on steroidogenesis in human
            granulosa-lutein cells
  JOURNAL   J Clin Endocrinol Metab 99 (10), E1922-E1932 (2014)
   PUBMED   25062451
  REMARK    GeneRIF: Activin A, B, and AB have similar effects on
            steroidogenesis in human granulosa cells; in contrast, activin AC
            is not biologically active and does not act as a competitive
            antagonist.
REFERENCE   3  (bases 1 to 3202)
  AUTHORS   Walentowicz,P., Krintus,M., Sadlecki,P., Grabiec,M.,
            Mankowska-Cyl,A., Sokup,A. and Walentowicz-Sadlecka,M.
  TITLE     Serum inhibin A and inhibin B levels in epithelial ovarian cancer
            patients
  JOURNAL   PLoS One 9 (3), e90575 (2014)
   PUBMED   24599287
  REMARK    GeneRIF: Serum inhibin levels correlate with clinical
            characteristics and mortality in epithelial ovarian cancer
            patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3202)
  AUTHORS   Juckstock,J., Kimmich,T., Mylonas,I., Friese,K. and Dian,D.
  TITLE     The inhibin-betaC subunit is down-regulated, while inhibin-betaE is
            up-regulated by interferon-beta1a in Ishikawa carcinoma cell line
  JOURNAL   Arch Gynecol Obstet 288 (4), 883-888 (2013)
   PUBMED   23580013
  REMARK    GeneRIF: The inhibin-betaC subunit is down-regulated, while
            inhibin-betaE is up-regulated by interferon-beta1a in Ishikawa
            carcinoma cell line.
REFERENCE   5  (bases 1 to 3202)
  AUTHORS   Li,Q., Wu,H., Chen,B., Hu,G., Huang,L., Qin,K., Chen,Y., Yuan,X.
            and Liao,Z.
  TITLE     SNPs in the TGF-beta signaling pathway are associated with
            increased risk of brain metastasis in patients with non-small-cell
            lung cancer
  JOURNAL   PLoS One 7 (12), e51713 (2012)
   PUBMED   23284751
  REMARK    GeneRIF: Single Nucleotide Polymorphisms in INHBC gene is
            associated with brain metastasis in non-small-cell lung cancer
REFERENCE   6  (bases 1 to 3202)
  AUTHORS   Mellor,S.L., Cranfield,M., Ries,R., Pedersen,J., Cancilla,B., de
            Kretser,D., Groome,N.P., Mason,A.J. and Risbridger,G.P.
  TITLE     Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in
            humanprostate and evidence for formation of new activin
            heterodimers of beta(C)-subunit
  JOURNAL   J Clin Endocrinol Metab 85 (12), 4851-4858 (2000)
   PUBMED   11134153
REFERENCE   7  (bases 1 to 3202)
  AUTHORS   Thomas,T.Z., Chapman,S.M., Hong,W., Gurusingfhe,C., Mellor,S.L.,
            Fletcher,R., Pedersen,J. and Risbridger,G.P.
  TITLE     Inhibins, activins, and follistatins: expression of mRNAs and
            cellular localization in tissues from men with benign prostatic
            hyperplasia
  JOURNAL   Prostate 34 (1), 34-43 (1998)
   PUBMED   9428386
REFERENCE   8  (bases 1 to 3202)
  AUTHORS   Schmitt,J., Hotten,G., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Pohl,J. and Schrewe,H.
  TITLE     Structure, chromosomal localization, and expression analysis of the
            mouse inhibin/activin beta C (Inhbc) gene
  JOURNAL   Genomics 32 (3), 358-366 (1996)
   PUBMED   8838799
REFERENCE   9  (bases 1 to 3202)
  AUTHORS   H tten,G., Neidhardt,H., Schneider,C. and Pohl,J.
  TITLE     Cloning of a new member of the TGF-beta family: a putative new
            activin beta C chain
  JOURNAL   Biochem Biophys Res Commun 206 (2), 608-613 (1995)
   PUBMED   7826378
REFERENCE   10 (bases 1 to 3202)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP237373.1, BC130324.1,
            AC022506.38 and BX105206.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005538.3.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate a subunit of
            homodimeric and heterodimeric activin complexes. The heterodimeric
            complex may function in the inhibition of activin A signaling.
            Transgenic mice overexpressing this gene exhibit defects in testis,
            liver and prostate. [provided by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.261333.1, BC130324.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309668.3/ ENSP00000308716.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BP237373.1         100-119
            21-1841             BC130324.1         1-1821
            1842-3063           AC022506.38        156163-157384       c
            3064-3202           BX105206.1         258-396
FEATURES             Location/Qualifiers
     source          1..3202
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..3202
                     /gene="INHBC"
                     /gene_synonym="IHBC"
                     /note="inhibin subunit beta C"
                     /db_xref="GeneID:3626"
                     /db_xref="HGNC:HGNC:6068"
                     /db_xref="MIM:601233"
     exon            1..416
                     /gene="INHBC"
                     /gene_synonym="IHBC"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1162
                     /gene="INHBC"
                     /gene_synonym="IHBC"
                     /note="inhibin beta C chain; activin beta-C chain; inhibin
                     beta C subunit"
                     /codon_start=1
                     /product="inhibin beta C chain preproprotein"
                     /protein_id="NP_005529.1"
                     /db_xref="CCDS:CCDS8938.1"
                     /db_xref="GeneID:3626"
                     /db_xref="HGNC:HGNC:6068"
                     /db_xref="MIM:601233"
                     /translation="MTSSLLLAFLLLAPTTVATPRAGGQCPACGGPTLELESQRELLL
                     DLAKRSILDKLHLTQRPTLNRPVSRAALRTALQHLHGVPQGALLEDNREQECEIISFA
                     ETGLSTINQTRLDFHFSSDRTAGDREVQQASLMFFVQLPSNTTWTLKVRVLVLGPHNT
                     NLTLATQYLLEVDASGWHQLPLGPEAQAACSQGHLTLELVLEGQVAQSSVILGGAAHR
                     PFVAARVRVGGKHQIHRRGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFC
                     IGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDS
                     NIVKTDIPDMVVEACGCS"
     exon            417..3202
                     /gene="INHBC"
                     /gene_synonym="IHBC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1317..1322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INHBC"
                     /gene_synonym="IHBC"
                     /note="hexamer: AAGAAA"
     polyA_site      1338
                     /gene="INHBC"
                     /gene_synonym="IHBC"
                     /note="major polyA site"
     regulatory      3181..3186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INHBC"
                     /gene_synonym="IHBC"
                     /note="hexamer: AATAAA"
     polyA_site      3202
                     /gene="INHBC"
                     /gene_synonym="IHBC"
                     /note="major polyA site"
ORIGIN      
        1 acacttcttc cagggcctct ggcagccagg acagagttga gaccacagct gttgagaccc
       61 tgagccctga gtctgtattg ctcaagaagg gccttcccca gcaatgacct cctcattgct
      121 tctggccttt ctcctcctgg ctccaaccac agtggccact cccagagctg gcggtcagtg
      181 tccagcatgt ggggggccca ccttggaact ggagagccag cgggagctgc ttcttgatct
      241 ggccaagaga agcatcttgg acaagctgca cctcacccag cgcccaacac tgaaccgccc
      301 tgtgtccaga gctgctttga ggactgcact gcagcacctc cacggggtcc cacagggggc
      361 acttctagag gacaacaggg aacaggaatg tgaaatcatc agctttgctg agacaggcct
      421 ctccaccatc aaccagactc gtcttgattt tcacttctcc tctgatagaa ctgctggtga
      481 cagggaggtc cagcaggcca gtctcatgtt ctttgtgcag ctcccttcca ataccacttg
      541 gaccttgaaa gtgagagtcc ttgtgctggg tccacataat accaacctca ccttggctac
      601 tcagtacctg ctggaggtgg atgccagtgg ctggcatcaa ctccccctag ggcctgaagc
      661 tcaagctgcc tgcagccagg ggcacctgac cctggagctg gtacttgaag gccaggtagc
      721 ccagagctca gtcatcctgg gtggagctgc ccataggcct tttgtggcag cccgggtgag
      781 agttgggggc aaacaccaga ttcaccgacg aggcatcgac tgccaaggag ggtccaggat
      841 gtgctgtcga caagagtttt ttgtggactt ccgtgagatt ggctggcacg actggatcat
      901 ccagcctgag ggctacgcca tgaacttctg catagggcag tgcccactac acatagcagg
      961 catgcctggt attgctgcct cctttcacac tgcagtgctc aatcttctca aggccaacac
     1021 agctgcaggc accactggag ggggctcatg ctgtgtaccc acggcccggc gccccctgtc
     1081 tctgctctat tatgacaggg acagcaacat tgtcaagact gacatacctg acatggtagt
     1141 agaggcctgt gggtgcagtt agtctatgtg tggtatgggc agcccaaggt tgcatgggaa
     1201 aacacgcccc tacagaagtg cacttccttg agaggaggga atgacctcat tctctgtcca
     1261 gaatgtggac tccctcttcc tgagcatctt atggaaatta ccccaccttt gacttgaaga
     1321 aaccttcatc taaagcaagt cactgtgcca tcttcctgac cactaccctc tttcctaggg
     1381 catagtccat cccgctagtc catcccgcta gccccactcc agggactcag acccatctcc
     1441 aaccatgagc aatgccatct ggttcccagg caaagacacc cttagctcac ctttaataga
     1501 ccccataacc cactatgcct tcctgtcctt tctactcaat ggtccccact ccaagatgag
     1561 ttgacacaac cccttccccc aatttttgtg gatctccaga gaggcccttc tttggattca
     1621 ccaaagttta gatcactgct gcccaaaata gaggcttacc tacccccctc tttgttgtga
     1681 gcccctgtcc ttcttagttg tccaggtgaa ctactaaagc tctctttgca taccttcatc
     1741 cattttttgt ccttctctgc ctttctctat gcccttaagg gctgacttgc ctgagctcta
     1801 tcacctgagc tcccctgccc tctggcttcc tgctgaggtc agggcatttc ttatccctgt
     1861 tccctctctg tctaggtgtc atggttctgt gtaactgtgg ctattctgtg tccctacact
     1921 acctggctac ccccttccat ggccccagct ctgcctacat tctgatataa ctgcttcaac
     1981 actagggggt cctaaaggct ttctatcttg ctagtccctg gggcctcaac atctcatact
     2041 ggttccctta actctgccta tacctctgta aataattcct tcactaagtt ctcttgatga
     2101 agcaaaaaca gacagctgaa aagtcctcta tctcctacaa gggccctaac tggcacccca
     2161 gatgacacag agcctgcctg cttatgctgt agtctgccta ctctgctgtc tcttcacatg
     2221 gtctcctcag aactgaacta ttgtatccat ctcacacttt atgcctcttc tttcttaggc
     2281 accccgtccc tccatccttc cagaaccatc tttgaggtct catggctaat aaaaacctag
     2341 gctttacctg ttccctctgt aatccctcca aaagatgaga cagatctatg cttggtcatc
     2401 cagtaaactg accagctgtg ggcacgcaag tgtgggaggc agaggcatgc tcagagctgg
     2461 ctgccaggac ctctgacttg ccttcctttc acccaccccc agtgctccac ccaggagtcc
     2521 tgcctggaag ctggaatggg caagggctgc tggagtggga cagggagaag aggaaggcct
     2581 ggatgaggag agggtggcat ttgctctgag actgggtcct ttttagacct ttgcccgtcc
     2641 tcccccacat ctcctccctt tggctggaca gtcctgaacc atgaggtcga taatgtctgc
     2701 agcccaaggc cgagtttgcg caaaacccat gtgttctttg gtaaacgtga tgtctgtgtt
     2761 tgctcagttt atgaccccct cctatgaggg taagaggtcc ctgaaatagg aaccctagag
     2821 gagaaagtct gaaaaggact gcctggggga ctgtaaatct gagcttgagg gcttcctgag
     2881 caacccatgg aagttatccc acctttgact tgaggagacc ttcatctaag gagaatctaa
     2941 ggaggccttc tggtgtctcc cccacacatc cccgaccccc agatctaacc tccttcccaa
     3001 ttacagctta gtctccaggg ctaggactgg ggtaaagcaa agtgagtcat tcacctgggg
     3061 gggctaaatt ttaagggggt ggtgaacaat ttattaatca agataggact ttaatgcaat
     3121 attattttaa agtcaaaatt aatgcaaaaa atccatgatg aacaaaatag cctactttta
     3181 aataaaaaca ggatcagcat ta
//
