LOCUS       NM_002193               3206 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens inhibin subunit beta B (INHBB), mRNA.
ACCESSION   NM_002193
VERSION     NM_002193.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3206)
  AUTHORS   Chaudhary,S., Walia,R., Bhansali,A., Dayal,D., Sachdeva,N.,
            Singh,T. and Bhadada,S.K.
  TITLE     Basal and FSH-stimulated Inhibin B in Precocious Puberty
  JOURNAL   Indian Pediatr 61 (8), 756-759 (2024)
   PUBMED   38803096
  REMARK    GeneRIF: Basal and FSH-stimulated Inhibin B in Precocious Puberty.
REFERENCE   2  (bases 1 to 3206)
  AUTHORS   Jiang,M., Gao,Y., Qu,T., Ji,Y., Niu,Y., Zhang,J. and Huang,L.
  TITLE     Dose inhibin B or anti-Mullerian hormone relate to precocious
            puberty in girls? result of a systematic review and meta-analysis
  JOURNAL   J Ovarian Res 16 (1), 227 (2023)
   PUBMED   37996919
  REMARK    GeneRIF: Dose inhibin B or anti-Mullerian hormone relate to
            precocious puberty in girls? result of a systematic review and
            meta-analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3206)
  AUTHORS   Jin,Y., Cai,Q., Wang,L., Ji,J., Sun,Y., Jiang,J., Wang,C., Wu,J.,
            Zhang,B., Zhao,L., Qi,F., Yu,B. and Zhang,J.
  TITLE     Paracrine activin B-NF-kappaB signaling shapes an inflammatory
            tumor microenvironment in gastric cancer via fibroblast
            reprogramming
  JOURNAL   J Exp Clin Cancer Res 42 (1), 269 (2023)
   PUBMED   37858201
  REMARK    GeneRIF: Paracrine activin B-NF-kappaB signaling shapes an
            inflammatory tumor microenvironment in gastric cancer via
            fibroblast reprogramming.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3206)
  AUTHORS   Yang,X., Jia,Q., Zou,Z., Liu,X., Li,X., Chen,H., Ma,H. and Chen,L.
  TITLE     INHBB promotes tumor aggressiveness and stemness of glioblastoma
            via activating EGFR signaling
  JOURNAL   Pathol Res Pract 245, 154460 (2023)
   PUBMED   37116368
  REMARK    GeneRIF: INHBB promotes tumor aggressiveness and stemness of
            glioblastoma via activating EGFR signaling.
REFERENCE   5  (bases 1 to 3206)
  AUTHORS   Zhang,H., Wang,Z., Zhou,Q., Cao,Z., Jiang,Y., Xu,M., Liu,J.,
            Zhou,J., Yan,G. and Sun,H.
  TITLE     Downregulated INHBB in endometrial tissue of recurrent implantation
            failure patients impeded decidualization through the ADCY1/cAMP
            signalling pathway
  JOURNAL   J Assist Reprod Genet 40 (5), 1135-1146 (2023)
   PUBMED   36913138
  REMARK    GeneRIF: Downregulated INHBB in endometrial tissue of recurrent
            implantation failure patients impeded decidualization through the
            ADCY1/cAMP signalling pathway.
REFERENCE   6  (bases 1 to 3206)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
REFERENCE   7  (bases 1 to 3206)
  AUTHORS   Schmelzer,C.H., Burton,L.E., Tamony,C.M., Schwall,R.H., Mason,A.J.
            and Liegeois,N.
  TITLE     Purification and characterization of recombinant human activin B
  JOURNAL   Biochim Biophys Acta 1039 (2), 135-141 (1990)
   PUBMED   2364091
REFERENCE   8  (bases 1 to 3206)
  AUTHORS   Mason,A.J., Berkemeier,L.M., Schmelzer,C.H. and Schwall,R.H.
  TITLE     Activin B: precursor sequences, genomic structure and in vitro
            activities
  JOURNAL   Mol Endocrinol 3 (9), 1352-1358 (1989)
   PUBMED   2575216
REFERENCE   9  (bases 1 to 3206)
  AUTHORS   Barton,D.E., Yang-Feng,T.L., Mason,A.J., Seeburg,P.H. and
            Francke,U.
  TITLE     Mapping of genes for inhibin subunits alpha, beta A, and beta B on
            human and mouse chromosomes and studies of jsd mice
  JOURNAL   Genomics 5 (1), 91-99 (1989)
   PUBMED   2767687
REFERENCE   10 (bases 1 to 3206)
  AUTHORS   Feng,Z.M., Bardin,C.W. and Chen,C.L.
  TITLE     Characterization and regulation of testicular inhibin beta-subunit
            mRNA
  JOURNAL   Mol Endocrinol 3 (6), 939-948 (1989)
   PUBMED   2739657
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012363.6, BI545428.1,
            M31682.1, BC030029.2, M13437.1, AI659282.1, CK430845.1 and
            AI671596.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002193.3.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate a subunit of
            the dimeric activin and inhibin protein complexes. These complexes
            activate and inhibit, respectively, follicle stimulating hormone
            secretion from the pituitary gland. Polymorphisms near this gene
            are associated with pre-eclampsia in female human patients.
            [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030029.2, M31682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295228.4/ ENSP00000295228.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC012363.6         190861-190866
            7-168               BI545428.1         5-166
            169-191             M31682.1           55-77
            192-1028            BC030029.2         185-1021
            1029-1356           M13437.1           816-1143
            1357-1647           BC030029.2         1350-1640
            1648-2156           AI659282.1         18-526              c
            2157-2620           CK430845.1         117-580
            2621-2783           BC030029.2         2614-2776
            2784-3206           AI671596.1         6-428               c
FEATURES             Location/Qualifiers
     source          1..3206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..3206
                     /gene="INHBB"
                     /note="inhibin subunit beta B"
                     /db_xref="GeneID:3625"
                     /db_xref="HGNC:HGNC:6067"
                     /db_xref="MIM:147390"
     exon            1..501
                     /gene="INHBB"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1277
                     /gene="INHBB"
                     /note="activin AB beta polypeptide; Inhibin, beta-2;
                     inhibin beta B chain; activin beta-B chain; inhibin beta B
                     subunit"
                     /codon_start=1
                     /product="inhibin beta B chain preproprotein"
                     /protein_id="NP_002184.2"
                     /db_xref="CCDS:CCDS2132.1"
                     /db_xref="GeneID:3625"
                     /db_xref="HGNC:HGNC:6067"
                     /db_xref="MIM:147390"
                     /translation="MDGLPGRALGAACLLLLAAGWLGPEAWGSPTPPPTPAAPPPPPP
                     PGSPGGSQDTCTSCGGFRRPEELGRVDGDFLEAVKRHILSRLQMRGRPNITHAVPKAA
                     MVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSRVRLY
                     FFISNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKVYFQEQGHGDRWNMVEKR
                     VDLKRSGWHTFPLTEAIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESHRPFV
                     VVQARLGDSRHRIRKRGLECDGRTNLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEG
                     SCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIV
                     KRDVPNMIVEECGCA"
     exon            502..3206
                     /gene="INHBB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INHBB"
                     /note="hexamer: AATAAA"
     polyA_site      3206
                     /gene="INHBB"
                     /note="major polyA site"
ORIGIN      
        1 cggctcgact cggctcgcct cgcggcgggc gccctcgtcg ccagcggcgc accatggacg
       61 ggctgcccgg tcgggcgctg ggggccgcct gccttctgct gctggcggcc ggctggctgg
      121 ggcctgaggc ctggggctca cccacgcccc cgccgacgcc tgccgcgccg ccgccacccc
      181 cgccacccgg atccccgggt ggctcgcagg acacctgtac gtcgtgcggc ggcttccggc
      241 ggccagagga gctcggccga gtggacggcg acttcctgga ggcggtgaag cggcacatct
      301 tgagccgcct gcagatgcgg ggccggccca acatcacgca cgccgtgcct aaggccgcca
      361 tggtcacggc cctgcgcaag ctgcacgcgg gcaaggtgcg cgaggacggc cgcgtggaga
      421 tcccgcacct cgacggccac gccagcccgg gcgccgacgg ccaggagcgc gtttccgaaa
      481 tcatcagctt cgccgagaca gatggcctcg cctcctcccg ggtccgccta tacttcttca
      541 tctccaacga aggcaaccag aacctgtttg tggtccaggc cagcctgtgg ctttacctga
      601 aactcctgcc ctacgtcctg gagaagggca gccggcggaa ggtgcgggtc aaagtgtact
      661 tccaggagca gggccacggt gacaggtgga acatggtgga gaagagggtg gacctcaagc
      721 gcagcggctg gcataccttc ccactcacgg aggccatcca ggccttgttt gagcggggcg
      781 agcggcgact caacctagac gtgcagtgtg acagctgcca ggagctggcc gtggtgccgg
      841 tgttcgtgga cccaggcgaa gagtcgcacc ggccctttgt ggtggtgcag gctcggctgg
      901 gcgacagcag gcaccgcatt cgcaagcgag gcctggagtg cgatggccgg accaacctct
      961 gttgcaggca acagttcttc attgacttcc gcctcatcgg ctggaacgac tggatcatag
     1021 cacccaccgg ctactacggg aactactgtg agggcagctg cccagcctac ctggcagggg
     1081 tccccggctc tgcctcctcc ttccacacgg ctgtggtgaa ccagtaccgc atgcggggtc
     1141 tgaaccccgg cacggtgaac tcctgctgca ttcccaccaa gctgagcacc atgtccatgc
     1201 tgtacttcga tgatgagtac aacatcgtca agcgggacgt gcccaacatg attgtggagg
     1261 agtgcggctg cgcctgacag tgcaaggcag gggcacggtg gtggggcacg gagggcagtc
     1321 ccgggtgggc ttcttccagc ccccgcggga acgggggtac acggtgggct gagtacagtc
     1381 attctgttgg gctgtggaga tagtgccagg gtgcggcctg agatattttt ctacagcttc
     1441 atagagcaac cagtcaaaac cagagcgaga accctcaact gacatgaaat actttaaaat
     1501 gcacacgtag ccacgcacag ccagacgcat cctgccaccc acacagcagc ctccaggata
     1561 ccagcaaatg gatgcggtga caaatggcag cttagctaca aatgcctgtc agtcggagag
     1621 aatggggtga gcagccacca ttcccaccag ctggcccggc cactctgaat tgcgccttcc
     1681 gagcacacat aaaagcacaa agacagagac gcagagagag agagagagcc acggagagga
     1741 aaagcagatg caggggtggg gagcgcagct cggcggaggc tgcgtgtgcc ccgtggcttt
     1801 taccaggcct gctctgcctg gctcgatgtc tgcttcttcc ccagcctggg atccttcgtg
     1861 cttcaaggcc tggggagcct gtccttccat gcccttgtcg agggaaagag acccagaaag
     1921 gacacaaccc gtcagagacc tgggagcagg ggcaatgacc gtttgactgt ttgtggcttg
     1981 ggcctctgac atgacttatg tgtgtgtgtg tttttggggt ggggagggag ggagagaaga
     2041 gggggctaaa tttgatgctt taactgatct ccaacagttg acaggtcatc cttgccagtt
     2101 gtataactga aaaaggactt ttctaccagg tatgaccttt taagtgaaaa tctgaattgt
     2161 tctaaatgga aagaaaaaaa gttgcaatct gtgcccttca ttggggacat tcctctagga
     2221 ctggtttggg gacgggtggg aatgacccct aggcaagggg atgagaccgc aggaggaaat
     2281 ggcggggagg aggcattctt gaactgctga ggatgggggg tgtcccctca gcggaggcca
     2341 agggagggga gcagcctagt tggtcttgga gagatgggga aggctttcag ctgatttgca
     2401 gaagttgccc atgtgggccc cagccatcag ggctggccgt ggacgtggcc cctgcccact
     2461 cacctgcccg cctgcccgcc cgcccgcata gcacttgcag acctgcctga acgcacatga
     2521 catagcactt gccgatctgc gtgtgtccag aagtggccct tggccgagcg ccgaactcgc
     2581 tcgccctcta gatgtccaag tgccacgtga actatgcaat ttaaagggtt gacccacact
     2641 agacgaaact ggactcgtac gactcttttt atatttttta tacttgaaat gaaatccttt
     2701 gcttcttttt taagcgaatg attgctttta atgtttgcac tgatttagtt gcatgattag
     2761 tcagaaactg ccatttgaaa aaaagttatt tttatagcag caaaaaaaaa aaaaaaagaa
     2821 tacagttaaa tgtattatac ataattttgg aaccaaagag gccaacagat cagttttaat
     2881 tttattagac ggtgaggcca tctgagatga ggtggacgtt ctgagcagtc ccttgagtgg
     2941 cctgccaacg tttcagggta tgaatggatt ttgtttattc ggtttgatgt gtcttttcca
     3001 tccttacaca cccagaaggt agagtaaaaa tgactatgat agaatgcagg tgtgtatcct
     3061 taaatcctca tctttatgtt tatttaataa agctcccctt agattctgtt tcataataat
     3121 ttaaaaccaa acaattttcc catagacttg ctgttaaagt attgtacgtt tgtgtacagt
     3181 ttaagaaaat aaaagattga gtgcca
//
