LOCUS       NM_002192               6046 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens inhibin subunit beta A (INHBA), mRNA.
ACCESSION   NM_002192
VERSION     NM_002192.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6046)
  AUTHORS   Abutalebi,M., Li,D., Ahmad,W., Mokhtari,K., Entezari,M.,
            Hashemi,M., Fu,J. and Maghsoudloo,M.
  TITLE     Discovery of PELATON links to the INHBA gene in the TGF-beta
            pathway in colorectal cancer using a combination of bioinformatics
            and experimental investigations
  JOURNAL   Int J Biol Macromol 270 (Pt 1), 132239 (2024)
   PUBMED   38735606
  REMARK    GeneRIF: Discovery of PELATON links to the INHBA gene in the
            TGF-beta pathway in colorectal cancer using a combination of
            bioinformatics and experimental investigations.
REFERENCE   2  (bases 1 to 6046)
  AUTHORS   Chen,X. and Fan,R.
  TITLE     Inhibin A contributes to the tumorigenesis of oral squamous cell
            carcinoma by KIAA1429-mediated m6A modification
  JOURNAL   J Oral Pathol Med 53 (4), 266-274 (2024)
   PUBMED   38531807
  REMARK    GeneRIF: Inhibin A contributes to the tumorigenesis of oral
            squamous cell carcinoma by KIAA1429-mediated m6A modification.
REFERENCE   3  (bases 1 to 6046)
  AUTHORS   Abou Kors,T., Hofmann,L., Betzler,A., Payer,K., Bens,M., Truong,J.,
            von Witzleben,A., Thomas,J., Kraus,J.M., Kalaajieh,R., Huber,D.,
            Ezic,J., Benckendorff,J., Greve,J., Schuler,P.J., Ottensmeier,C.H.,
            Kestler,H.A., Hoffmann,T.K., Theodoraki,M.N., Brunner,C. and
            Laban,S.
  TITLE     INHBA is Enriched in HPV-negative Oropharyngeal Squamous Cell
            Carcinoma and Promotes Cancer Progression
  JOURNAL   Cancer Res Commun 4 (2), 571-587 (2024)
   PUBMED   38329386
  REMARK    GeneRIF: INHBA is Enriched in HPV-negative Oropharyngeal Squamous
            Cell Carcinoma and Promotes Cancer Progression.
REFERENCE   4  (bases 1 to 6046)
  AUTHORS   Hu,C., Ye,M., Bai,J., Liu,P., Lu,F., Chen,J., Xu,Y., Yan,L., Yu,P.,
            Xiao,Z., Gu,D., Xu,L., Tian,Y. and Tang,Q.
  TITLE     FOXA2-initiated transcriptional activation of INHBA induced by
            methylmalonic acid promotes pancreatic neuroendocrine neoplasm
            progression
  JOURNAL   Cell Mol Life Sci 81 (1), 50 (2024)
   PUBMED   38252148
  REMARK    GeneRIF: FOXA2-initiated transcriptional activation of INHBA
            induced by methylmalonic acid promotes pancreatic neuroendocrine
            neoplasm progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6046)
  AUTHORS   Wu,Z., Chen,J., Yang,L., Sun,K., Jiang,Q., Dong,F., Lu,W., Chen,R.
            and Chen,Y.
  TITLE     Elevated INHBA Promotes Tumor Progression of Cervical Cancer
  JOURNAL   Technol Cancer Res Treat 23, 15330338241234798 (2024)
   PUBMED   38419562
  REMARK    GeneRIF: Elevated INHBA Promotes Tumor Progression of Cervical
            Cancer.
REFERENCE   6  (bases 1 to 6046)
  AUTHORS   Shao,L., Frigon,N.L. Jr., Young,A.L., Yu,A.L., Mathews,L.S.,
            Vaughan,J., Vale,W. and Yu,J.
  TITLE     Effect of activin A on globin gene expression in purified human
            erythroid progenitors
  JOURNAL   Blood 79 (3), 773-781 (1992)
   PUBMED   1310063
REFERENCE   7  (bases 1 to 6046)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
REFERENCE   8  (bases 1 to 6046)
  AUTHORS   Tanimoto,K., Handa,S., Ueno,N., Murakami,K. and Fukamizu,A.
  TITLE     Structure and sequence analysis of the human activin beta A subunit
            gene
  JOURNAL   DNA Seq 2 (2), 103-110 (1991)
   PUBMED   1777673
REFERENCE   9  (bases 1 to 6046)
  AUTHORS   Mason,A.J., Berkemeier,L.M., Schmelzer,C.H. and Schwall,R.H.
  TITLE     Activin B: precursor sequences, genomic structure and in vitro
            activities
  JOURNAL   Mol Endocrinol 3 (9), 1352-1358 (1989)
   PUBMED   2575216
REFERENCE   10 (bases 1 to 6046)
  AUTHORS   Barton,D.E., Yang-Feng,T.L., Mason,A.J., Seeburg,P.H. and
            Francke,U.
  TITLE     Mapping of genes for inhibin subunits alpha, beta A, and beta B on
            human and mouse chromosomes and studies of jsd mice
  JOURNAL   Genomics 5 (1), 91-99 (1989)
   PUBMED   2767687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU137531.1, BC007858.2,
            AC005027.3, AK001903.1 and AA491465.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002192.3.
            
            Summary: This gene encodes a member of the TGF-beta (transforming
            growth factor-beta) superfamily of proteins. The encoded
            preproprotein is proteolytically processed to generate a subunit of
            the dimeric activin and inhibin protein complexes. These complexes
            activate and inhibit, respectively, follicle stimulating hormone
            secretion from the pituitary gland. The encoded protein also plays
            a role in eye, tooth and testis development. Elevated expression of
            this gene may be associated with cancer cachexia in human patients.
            [provided by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.577620.1, BC007858.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242208.5/ ENSP00000242208.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               AU137531.1         19-571
            554-1626            BC007858.2         542-1614
            1627-4114           AC005027.3         53597-56084         c
            4115-5090           AK001903.1         1-976
            5091-6045           AK001903.1         978-1932
            6046-6046           AA491465.1         42-42               c
FEATURES             Location/Qualifiers
     source          1..6046
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..6046
                     /gene="INHBA"
                     /gene_synonym="EDF; FRP"
                     /note="inhibin subunit beta A"
                     /db_xref="GeneID:3624"
                     /db_xref="HGNC:HGNC:6066"
                     /db_xref="MIM:147290"
     exon            1..86
                     /gene="INHBA"
                     /gene_synonym="EDF; FRP"
                     /inference="alignment:Splign:2.1.0"
     exon            87..617
                     /gene="INHBA"
                     /gene_synonym="EDF; FRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1510
                     /gene="INHBA"
                     /gene_synonym="EDF; FRP"
                     /note="Inhibin, beta-1; inhibin, beta A (activin A,
                     activin AB alpha polypeptide); inhibin beta A chain;
                     follicle-stimulating hormone-releasing protein;
                     FSH-releasing protein; erythroid differentiation factor;
                     activin beta-A chain; erythroid differentiation protein;
                     inhibin beta A subunit"
                     /codon_start=1
                     /product="inhibin beta A chain preproprotein"
                     /protein_id="NP_002183.1"
                     /db_xref="CCDS:CCDS5464.1"
                     /db_xref="GeneID:3624"
                     /db_xref="HGNC:HGNC:6066"
                     /db_xref="MIM:147290"
                     /translation="MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALP
                     KDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVE
                     IEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLK
                     VPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTW
                     HVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGE
                     GGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIG
                     WNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCV
                     PTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS"
     exon            618..6046
                     /gene="INHBA"
                     /gene_synonym="EDF; FRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6022..6027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INHBA"
                     /gene_synonym="EDF; FRP"
                     /note="hexamer: AATAAA"
     polyA_site      6046
                     /gene="INHBA"
                     /gene_synonym="EDF; FRP"
                     /note="major polyA site"
ORIGIN      
        1 acagtgccaa taccatgaag aggagctcag acagctctta ccacatgata caagagccgg
       61 ctggtggaag agtggggacc agaaagagaa tttgctgaag aggagaagga aaaaaaaaac
      121 accaaaaaaa aaaataaaaa aatccacaca cacaaaaaaa cctgcgcgtg aggggggagg
      181 aaaagcaggg ccttttaaaa aggcaatcac aacaactttt gctgccagga tgcccttgct
      241 ttggctgaga ggatttctgt tggcaagttg ctggattata gtgaggagtt cccccacccc
      301 aggatccgag gggcacagcg cggcccccga ctgtccgtcc tgtgcgctgg ccgccctccc
      361 aaaggatgta cccaactctc agccagagat ggtggaggcc gtcaagaagc acattttaaa
      421 catgctgcac ttgaagaaga gacccgatgt cacccagccg gtacccaagg cggcgcttct
      481 gaacgcgatc agaaagcttc atgtgggcaa agtcggggag aacgggtatg tggagataga
      541 ggatgacatt ggaaggaggg cagaaatgaa tgaacttatg gagcagacct cggagatcat
      601 cacgtttgcc gagtcaggaa cagccaggaa gacgctgcac ttcgagattt ccaaggaagg
      661 cagtgacctg tcagtggtgg agcgtgcaga agtctggctc ttcctaaaag tccccaaggc
      721 caacaggacc aggaccaaag tcaccatccg cctcttccag cagcagaagc acccgcaggg
      781 cagcttggac acaggggaag aggccgagga agtgggctta aagggggaga ggagtgaact
      841 gttgctctct gaaaaagtag tagacgctcg gaagagcacc tggcatgtct tccctgtctc
      901 cagcagcatc cagcggttgc tggaccaggg caagagctcc ctggacgttc ggattgcctg
      961 tgagcagtgc caggagagtg gcgccagctt ggttctcctg ggcaagaaga agaagaaaga
     1021 agaggagggg gaagggaaaa agaagggcgg aggtgaaggt ggggcaggag cagatgagga
     1081 aaaggagcag tcgcacagac ctttcctcat gctgcaggcc cggcagtctg aagaccaccc
     1141 tcatcgccgg cgtcggcggg gcttggagtg tgatggcaag gtcaacatct gctgtaagaa
     1201 acagttcttt gtcagtttca aggacatcgg ctggaatgac tggatcattg ctccctctgg
     1261 ctatcatgcc aactactgcg agggtgagtg cccgagccat atagcaggca cgtccgggtc
     1321 ctcactgtcc ttccactcaa cagtcatcaa ccactaccgc atgcggggcc atagcccctt
     1381 tgccaacctc aaatcgtgct gtgtgcccac caagctgaga cccatgtcca tgttgtacta
     1441 tgatgatggt caaaacatca tcaaaaagga cattcagaac atgatcgtgg aggagtgtgg
     1501 gtgctcatag agttgcccag cccaggggga aagggagcaa gagttgtcca gagaagacag
     1561 tggcaaaatg aagaaatttt taaggtttct gagttaacca gaaaaataga aattaaaaac
     1621 aaaacaaaaa aaaaaacaaa aaaaaacaaa agtaaattaa aaacaaaacc tgatgaaaca
     1681 gatgaaggaa gatgtggaaa aaatccttag ccagggctca gagatgaagc agtgaaagag
     1741 acaggaattg ggagggaaag ggagaatggt gtacccttta tttcttctga aatcacactg
     1801 atgacatcag ttgtttaaac ggggtattgt cctttccccc cttgaggttc ccttgtgagc
     1861 cttgaatcaa ccaatctagt ctgcagtagt gtggactaga acaacccaaa tagcatctag
     1921 aaagccatga gtttgaaagg gcccatcaca ggcactttcc tacccaatta cccaggtcat
     1981 aaggtatgtc tgtgtgacac ttatctctgt gtatatcagc atacacacac acacacacac
     2041 acacacacac acacacaggc atttccacac attacatata tacacatact ggtaaaagaa
     2101 caatcgtgtg caggtggtca cacttccttt ttctgtacca cttttgcaac aaaacaaaac
     2161 aaacaacatt aaaaaattga gaacaagtat ggaaagaatg aaagatcaag gaaaaaagaa
     2221 taccaagtta catttcgtta aggtgcttat gatcttagaa ctatgcaacc taataggttt
     2281 gaaactgttt acctgagaga gaacaaaaag agagactttt ttgtattgga agtaatctga
     2341 ttaattttta ttttcttcaa ggagagatac ttgaaaggaa tatgtttgtc catctgttgg
     2401 atccaaacat ttctatattt tgtaaatgtt gttgttgttt tttttttaat cgtttactat
     2461 ttgcactaca atggtgtttg acctgtctaa tccttattta acaagtattt tctttggttg
     2521 ggggtggggg tggggtttaa gagctgcact taatgtgagc tataaaagaa ctgctacagc
     2581 acacaaaata gctattttta ttattataat tataattatt attattattt tgtaccttaa
     2641 aaaatagaca catacaccaa agacatttgt gtgagccttt aaacagtctg tctgtggttg
     2701 gtatcattca ccatcaatga gtcaggggtt gggattcaag gttgagtagt gtggattgtg
     2761 ttcaggctta aaagacctga gaagtttggt ttttgactcc ttttacatcc atgaaacagg
     2821 acatttcata ctggatgtac agtagttgta cactgttgga tatcaagttc aatcaaattc
     2881 atggaactac atgcttgtat gtgtatatat acattgcttg tgcatatgca tatctgtatg
     2941 tatatataca tgtattgtac catgtccata cacattttaa gcacttcagg ctgtcatttt
     3001 ttaatgttct taaagcaatg aatgtttgtg tgcaaaacac agtattttta agaaggatag
     3061 gctatagttt ttgcttttac tctgaactag gtgggcgcat ttcaaaaatt cggatgggaa
     3121 aaagcctgga aattccagtg aatattcagc aaggccctct ttcattgtac agggatcaaa
     3181 tttcctcctc ttttttgtgc cccctcccac ttctacaagt tatcccctgt ggggaaaaca
     3241 ggatgataat caaaactctg ggctgatgtt tttccaactt agtgtctatt ggaatcaatc
     3301 ttaaatcaga agctttttca gaaaaataat atttaggcca gaattagagt tgagtgtatt
     3361 ttttaaaaat gattaaggct tggttgtgag aaatattacc tgtaccagct gggaaaaata
     3421 atgtcatcac taactaaaag ataattaatt tgagagaaag tgttaagaga gggagagtaa
     3481 ggaagagaac agttaagagg aggcagaggt gagggcagta gtaaaaatct ctaaaatttt
     3541 aatttacagc caaaattctt catgtgtaaa tttgtattga ttcagatgca gaaatgaaaa
     3601 aaaaacacct ttgttttata aatatcaaag tacatgctta aagccaagtt tttatctagt
     3661 ttattctagt acttagcttg cctggaatag ctaataaatt attcatgtat gtgcttttga
     3721 aaatccagag ccctattttt acacacttgt gtgaagttgg caaacatttt gaaaaatgga
     3781 aaaaagtttc taataattgg gaacaattac attaattaat attttgtaaa atattgaagc
     3841 ttttagccct atgtcaattt gtagattaaa ataaattaat tataggaaag gaagataaca
     3901 gtgagaaacc aaacattaca aaaggtggtt tagctctcct tgaaaaatat actaagttgg
     3961 tatactataa cacttggcta tatgtaggca atgtcactac tgggcaaata cacttactgt
     4021 gttctagagg cagccctttc ttatgcagaa aatacaatac gcactgcatg agaagcttga
     4081 gagtggattc taatccaggt ctgtcgacct tggatatcat gcatgtggga aggtgggtgt
     4141 ggtgagaaaa gttttaaggc aagagtagat ggccatgttc aactttacaa aatttcttgg
     4201 aaaactggca gtattttgaa ctgcatcttc tttggtaccg gaacctgcag aaacagtgtg
     4261 agaaattaag tcctggttca ctgcgcagta gcaaagatgg tcaaggccat ggaaaaagca
     4321 gaaatttacc aagaaagctg atacccatgt atagttccca ctcatctcaa atacatctgc
     4381 tatcttttta agctaagtcc tagacatatc ggggataaca tgggggttga ttagtgacca
     4441 cagttatcag aagcagagaa atgtaattcc atattttatt tgaaacttat tccatatttt
     4501 aattggatat tgagtgattg ggttatcaaa cacccacaaa ctttaatttt gttaaattta
     4561 tatggctttg aaatagaagt ataagttgct accatttttt gataacattg aaagatagta
     4621 ttttaccatc tttaatcatc ttggaaaata caagtcctgt gaacaaccac tctttcacct
     4681 agcagcatga ggccaaaagt aaaggcttta aattataaca tatgggattc ttagtagtat
     4741 gtttttttct tgaaactcag tggctctatc taaccttact atctcctcac tctttctcta
     4801 agactaaact ctaggctctt aaaaatctgc ccacaccaat cttagaagct ctgaaaagaa
     4861 tttgtcttta aatatctttt aatagtaaca tgtattttat ggaccaaatt gacattttcg
     4921 actatttttt ccaaaaaagt caggtgaatt tcagcacact gagttgggaa tttcttatcc
     4981 cagaagacca accaatttca tatttattta agattgattc catactccgt tttcaaggag
     5041 aatccctgca gtctccttaa aggtagaaca aatactttct attttttttt caccattgtg
     5101 ggattggact ttaagaggtg actctaaaaa aacagagaac aaatatgtct cagttgtatt
     5161 aagcacggac ccatattatc atattcactt aaaaaaatga tttcctgtgc accttttggc
     5221 aacttctctt ttcaatgtag ggaaaaactt agtcaccctg aaaacccaca aaataaataa
     5281 aacttgtaga tgtgggcaga aggtttgggg gtggacattg tatgtgttta aattaaaccc
     5341 tgtatcactg agaagctgtt gtatgggtca gagaaaatga atgcttagaa gctgttcaca
     5401 tcttcaagag cagaagcaaa ccacatgtct cagctatatt attatttatt ttttatgcat
     5461 aaagtgaatc atttcttctg tattaatttc caaagggttt taccctctat ttaaatgctt
     5521 tgaaaaacag tgcattgaca atgggttgat atttttcttt aaaagaaaaa tataattatg
     5581 aaagccaaga taatctgaag cctgttttat tttaaaactt tttatgttct gtggttgatg
     5641 ttgtttgttt gtttgtttct attttgttgg ttttttactt tgttttttgt tttgttttgt
     5701 tttgttttgc atactacatg cagttcttta accaatgtct gtttggctaa tgtaattaaa
     5761 gttgttaatt tatatgagtg catttcaact atgtcaatgg tttcttaata tttattgtgt
     5821 agaagtactg gtaatttttt tatttacaat atgtttaaag agataacagt ttgatatgtt
     5881 ttcatgtgtt tatagcagaa gttatttatt tctatggcat tccagcggat attttggtgt
     5941 ttgcgaggca tgcagtcaat attttgtaca gttagtggac agtattcagc aacgcctgat
     6001 agcttctttg gccttatgtt aaataaaaag acctgtttgg gatgta
//
