LOCUS       NM_032329               5197 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens inhibitor of growth family member 5 (ING5), transcript
            variant 1, mRNA.
ACCESSION   NM_032329 XM_376200
VERSION     NM_032329.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5197)
  AUTHORS   Yang,J., Liu,X., Sun,Y., Zhang,X., Zhao,Y., Zhang,H., Mei,Q.,
            Meng,J., Zhang,F. and Zhang,T.
  TITLE     ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT
            and invasion of lung cancer cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (5), 809-817 (2023)
   PUBMED   37249332
  REMARK    GeneRIF: ING5 overexpression upregulates miR-34c-5p/Snail1 to
            inhibit EMT and invasion of lung cancer cells.
REFERENCE   2  (bases 1 to 5197)
  AUTHORS   Ouyang,X., Shi,G., Wang,S., Chen,L., Xu,J. and Xie,D.
  TITLE     Hsa_circ_0010729 is Involved in Oxygen-Glucose
            Deprivation/Reoxygenation-Induced Human Microvascular Endothelial
            Cell Deprivation by Targeting miR-665/ING5
  JOURNAL   Biochem Genet 60 (6), 2455-2470 (2022)
   PUBMED   35482130
  REMARK    GeneRIF: Hsa_circ_0010729 is Involved in Oxygen-Glucose
            Deprivation/Reoxygenation-Induced Human Microvascular Endothelial
            Cell Deprivation by Targeting miR-665/ING5.
REFERENCE   3  (bases 1 to 5197)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5197)
  AUTHORS   Wang,Y., Tan,J., Li,J., Chen,H. and Wang,W.
  TITLE     ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by
            Downregulating the IL-6/CXCL12 Signaling Pathway
  JOURNAL   Technol Cancer Res Treat 20, 15330338211039940 (2021)
   PUBMED   34520285
  REMARK    GeneRIF: ING5 Inhibits Migration and Invasion of Esophageal Cancer
            Cells by Downregulating the IL-6/CXCL12 Signaling Pathway.
REFERENCE   5  (bases 1 to 5197)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5197)
  AUTHORS   Ullah,M., Pelletier,N., Xiao,L., Zhao,S.P., Wang,K., Degerny,C.,
            Tahmasebi,S., Cayrou,C., Doyon,Y., Goh,S.L., Champagne,N., Cote,J.
            and Yang,X.J.
  TITLE     Molecular architecture of quartet MOZ/MORF histone
            acetyltransferase complexes
  JOURNAL   Mol Cell Biol 28 (22), 6828-6843 (2008)
   PUBMED   18794358
  REMARK    Erratum:[Mol Cell Biol. 2009 Feb;29(3):942]
REFERENCE   7  (bases 1 to 5197)
  AUTHORS   Champagne,K.S., Saksouk,N., Pena,P.V., Johnson,K., Ullah,M.,
            Yang,X.J., Cote,J. and Kutateladze,T.G.
  TITLE     The crystal structure of the ING5 PHD finger in complex with an
            H3K4me3 histone peptide
  JOURNAL   Proteins 72 (4), 1371-1376 (2008)
   PUBMED   18623064
  REMARK    GeneRIF: the PHD domain of ING5 has the characteristic tertiary
            fold of a zinc finger.
REFERENCE   8  (bases 1 to 5197)
  AUTHORS   Shi,X., Hong,T., Walter,K.L., Ewalt,M., Michishita,E., Hung,T.,
            Carney,D., Pena,P., Lan,F., Kaadige,M.R., Lacoste,N., Cayrou,C.,
            Davrazou,F., Saha,A., Cairns,B.R., Ayer,D.E., Kutateladze,T.G.,
            Shi,Y., Cote,J., Chua,K.F. and Gozani,O.
  TITLE     ING2 PHD domain links histone H3 lysine 4 methylation to active
            gene repression
  JOURNAL   Nature 442 (7098), 96-99 (2006)
   PUBMED   16728974
REFERENCE   9  (bases 1 to 5197)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   10 (bases 1 to 5197)
  AUTHORS   Shiseki,M., Nagashima,M., Pedeux,R.M., Kitahama-Shiseki,M.,
            Miura,K., Okamura,S., Onogi,H., Higashimoto,Y., Appella,E.,
            Yokota,J. and Harris,C.C.
  TITLE     p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
  JOURNAL   Cancer Res 63 (10), 2373-2378 (2003)
   PUBMED   12750254
  REMARK    GeneRIF: p29ING4 and p28ING5 may be significant modulators of p53
            function.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC133528.4, AF189286.1,
            AK074422.1, AI701412.1, BQ187350.1, AK128322.1, BC039028.1 and
            BI962551.1.
            
            On Jun 2, 2019 this sequence version replaced NM_032329.5.
            
            Summary: This gene encodes a tumor suppressor protein that inhibits
            cell growth and induces apoptosis. This protein contains a PHD-type
            zinc finger. It interacts with tumor suppressor p53 and p300, a
            component of the histone acetyl transferase complex, suggesting a
            role in transcriptional regulation. Alternative splicing and the
            use of multiple promoters and 3' terminal exons results in multiple
            transcript variants. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.33000.1, AK074422.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313552.11/ ENSP00000322142.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC133528.4         9881-9905           c
            26-1093             AF189286.1         1-1068
            1094-1282           AK074422.1         1092-1280
            1283-1625           AI701412.1         180-522
            1626-2101           BQ187350.1         90-565
            2102-4204           AK128322.1         41-2143
            4205-4353           BC039028.1         270-418
            4354-5194           AK128322.1         2293-3133
            5195-5197           BI962551.1         267-269
FEATURES             Location/Qualifiers
     source          1..5197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..5197
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /note="inhibitor of growth family member 5"
                     /db_xref="GeneID:84289"
                     /db_xref="HGNC:HGNC:19421"
                     /db_xref="MIM:608525"
     exon            1..64
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..750
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inhibitor of growth protein 5"
                     /codon_start=1
                     /product="inhibitor of growth protein 5 isoform 1"
                     /protein_id="NP_115705.2"
                     /db_xref="CCDS:CCDS33425.1"
                     /db_xref="GeneID:84289"
                     /db_xref="HGNC:HGNC:19421"
                     /db_xref="MIM:608525"
                     /translation="MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDI
                     LAAEYISTVKTLSPDQRVERLQKIQNAYSKCKEYSDDKVQLAMQTYEMVDKHIRRLDA
                     DLARFEADLKDKMEGSDFESSGGRGLKKGRGQKEKRGSRGRGRRTSEEDTPKKKKHKG
                     GSEFTDTILSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVD
                     LTTKPKGKWFCPRCVQEKRKKK"
     exon            65..136
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /inference="alignment:Splign:2.1.0"
     exon            137..303
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /inference="alignment:Splign:2.1.0"
     exon            304..415
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /inference="alignment:Splign:2.1.0"
     exon            416..509
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /inference="alignment:Splign:2.1.0"
     exon            510..645
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /inference="alignment:Splign:2.1.0"
     exon            646..707
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /inference="alignment:Splign:2.1.0"
     exon            708..5197
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1700..1705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /note="hexamer: AATGAA"
     polyA_site      1719
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /note="major polyA site"
     regulatory      2106..2111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /note="hexamer: AATAAA"
     polyA_site      2129
                     /gene="ING5"
                     /gene_synonym="p28ING5"
     regulatory      5175..5180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /note="hexamer: AATAAA"
     polyA_site      5197
                     /gene="ING5"
                     /gene_synonym="p28ING5"
                     /note="major polyA site"
ORIGIN      
        1 agaccccgag cgcggccgcg gacgaagatg gcgaccgcca tgtacttgga gcactatctg
       61 gacagtatcg agaaccttcc ctgcgaactt cagaggaact tccagctgat gcgagagctg
      121 gaccagagga cggaagataa gaaagcagag attgacatcc tggctgcaga gtacatctcc
      181 acggtgaaga cgctgtctcc agaccagcgc gtggagcgcc tgcagaagat ccagaacgcc
      241 tacagcaagt gcaaggaata cagtgacgac aaagtgcagc tggccatgca gacctacgag
      301 atggtggata aacacattcg aaggcttgat gcagacctgg cgcgctttga agcagatctg
      361 aaggacaaga tggagggcag tgattttgaa agctccggag ggcgagggtt aaaaaaaggc
      421 cggggtcaga aagaaaaaag agggtcccgg ggccgaggca ggaggacatc agaggaagac
      481 acaccaaaga aaaagaagca caaaggaggg tctgagttca ctgacaccat cctgtccgtg
      541 cacccctctg atgtgctgga catgcccgtg gacccaaacg aacccacgta ctgcctgtgc
      601 caccaggtct cctatgggga gatgattggc tgtgacaatc cagactgtcc aattgagtgg
      661 tttcactttg cctgcgtgga ccttaccacg aaacccaaag gaaaatggtt ctgtccacgg
      721 tgtgtccagg aaaagaggaa gaagaagtag gaggagctgt gtgcccggat ccgaggagca
      781 agttaatctg tcccttcatt cgtgtcgcaa tatttccctt ccttttaaaa ctaccttgtt
      841 cggttgatac ttagtaactc cgtggccagt tgaagcgctg gatgtttcct agaacaagaa
      901 ccaccaaagc ctgttcgcac agaagggcga ccttgcaggg actcgccgcc gcgacctcag
      961 tgtggctttt acaggactcc ccccgagcat cagcagggac cccggcggac gtgggcgggc
     1021 gcgcgtgagc tcgggctgcc cggccgggcg tgcgggcggg gacatggtaa cctggtccac
     1081 ggagggcggc cgccaccctc gcgtagcttt cctgtggttt tccaggactg tccggtacag
     1141 cccgggctcc gcgtgccccg cccgctggag cacctgccac cgaggcgcgc gtggggccac
     1201 tgccgtggcg gcggctgccc tcctcacact cggctccgcg ccgcctccgg ccaccgtgcg
     1261 ctcccgcgtg gggcgcctcg gatgggcccg ggagggctgg gggctcttcc ctggaggaag
     1321 cggcctccgc ttcgctggcg ccgccttttt agcttggact tcagtcctcc ctcggggact
     1381 cacctccgga gtaaacggct cttcattagc ttggagtggc cgcaggtccc gtgaccagca
     1441 cccgcgagac cctgtgcgac agctgggctg atgctccgtt tctctgggaa ttggtgattt
     1501 tttactgtga agatgaaatt accctaatag catgaagatc gtgggtctgt gtgtccgtga
     1561 agtgagtccc gtctgccagg agctgacgaa ccacgaatgc ttctgcctgt gctgtgcatt
     1621 cccaggcccg cagctcccgg tcgaggggac tccgatgtga atttgttgtg aatttgttgt
     1681 gccacaatag cagttctgga atgaagctag gaaactcgag tgtgcttttt gtttaatgag
     1741 cgttcaccaa gctgagccgg agccatcctt tcggtggtag ttggggaagg ctatgcagat
     1801 ttgctctgtt gtgacgcgtt ggtgacggtg cccagcctgc ggttccccac agcatcgcag
     1861 gcgctcggaa atcctctccc gtgcctttag aggaaggaga ggattgctga ggaatgcagg
     1921 gacgcctgtt tctgtcctca caccacagaa agaaacctga gggaaaactg agacgtgagg
     1981 ttcctgattt aagaagcctg ggtttcttca tggtgggggg ccatttggaa tgacagcctc
     2041 acttccttct gatggctaca tctgtatctt ttcctcctgt gtttaatgtt tcactaggga
     2101 gaggaaataa agcagaagga acgtgtgaag ctctgtgtct cagacggggc cctcccgtcg
     2161 agaagctggt agtcagtgag tgagaacaag agaacaagaa caccctgaac agtcctggtt
     2221 gggatggtgt ccacattcat gttctgcggt tcttgaacac acggatgcct ctgggccacc
     2281 tgtccttttc cgagggtgtg ggtgggagtg gatcctccgg gcgcaggtgc caggcaggtg
     2341 caggcgggcg gtcggccact gctgctgctc gtccctgcca gtgtctgggc ctgaaggggc
     2401 tccctccaag cggtgccttc ctgcggctta gaagggaaag cgccagagag ggcaggctac
     2461 agtgcttcac acccttcgcc acggctgtga aactggagat gggtgggttt tgtatgttaa
     2521 tttttttttt tgagacggag tcttgctctg tcacccaggc tggagagcag tggcgtgatc
     2581 tcggctcact gcaagctccg cctcccgggt tcacgccatt ctcctgcctc agcccccccg
     2641 agtagctggg actacaggcg cccgccacca cgcctggcta attttttata tttttagtag
     2701 agacagggtt tcaccatgtt aaccaggatg gtctcgatct cctgacctca cgatttgccc
     2761 gcctcggctt cccagagtgc tgggattaca ggcgtgagcc accgcgcctg gccacccagc
     2821 taagtttgta tttttgttgg agacggggtt tcaccatatt ggccagactg gtctcaaact
     2881 cctggggtca aatgatccgc ctgcgtcggc ttcccagagt gctgggatta caggtgtcag
     2941 ccactgcgct cagctgggag atgaattttc atttaatgac ttaacttttt gttagcacag
     3001 gttttgtgtg tgtgtgtgtg tgtgtgtttt gttttttgtt ttgtgttttt gaaacggagt
     3061 tttgctctgt cacccaggct ggaatgcaat ggcaccatct tggctcactg caacctctgc
     3121 ttcctgggtt caagtgattc tcttgcctta gcctcccgag cagctgggat tataggcgtc
     3181 caccaccacg cccagctaat ttttgtattt ttagtagaaa tggggtttca ccatgtgtgg
     3241 ccaggctggt ctcgaactcc tgacctgaag tgatccaccc gcctcgacct cccaaagtgc
     3301 tgggatgaca ggcatgagcc accgcacccg gccaacacag atgtttattg atcgtggagg
     3361 atacattgtg gaaaatgttt ttctctcttt taccattttt gggaagaggg ataggtaagt
     3421 gcagggagtt tgtgctgaaa cagcgcctgg caatttttca gaaatgaatt tgatattgcg
     3481 ctccaccttt gagctgttca cacctgtggc tacccctgga aagcgctggg gttgttgatg
     3541 cttttggctg cccggcttcc tgaggtctcg ctgctttttg gggaaagatg actggcttcc
     3601 ctgtgggacg cttttgtctg acacgtgatg atgtggtcct gcctgccact gtgcaccatc
     3661 ccaggtattg aattttgacc ttttcttttc aagtttctgt gcttagtgtt tttaatgttt
     3721 acttttgcca cttacaataa tatcaccaaa ataatatgca tagagttttg gaagaaacat
     3781 agaaaacatg agcagaatga gacaattcct tgggctgtag tttggaccca actgaatcct
     3841 gagtgctctg tggctgacgc tgtctacccg tgggagagac acactcagga gtggccgttt
     3901 ggccagaaaa gaaggtcatg gcccctggcc tggcccccgc cctgcaggga cacagaagcc
     3961 acaccatttg caccatccac gccttgctcc agaaggcctg gccgccttct ccctgggggt
     4021 gattcaagga tttggtctcg gaccagaccc ccctccacag ctgcccggcc ccagacccat
     4081 ctcttggatt gagggtgtgt gggctggaac cagtgggtca ctgtggcagc ttcatctgag
     4141 ccgaaggtgt gggtcctctg tggctgtgcg attgacctcg atgggaagga gcgttctacc
     4201 cattttcctt gttttcagtg ctgcggtatc agtcagtgat ctgaggaaat cctgtagggg
     4261 aaggcaggct gcagtgaaaa caggagctgg tgaaaccgag ccctctgcat ctgcgaatgt
     4321 gccctaggtg ctgctgctgg ggacatggat gccaagcgga ggcctgcgtg gcctcctgag
     4381 cagcagctga ccgcccgtct catgctggac gggacccctg ggcgggtgga catgagacca
     4441 ctgttggcca gggacgccgt gcggaggcct acgtggctgc ctgagcagca gctgaccgcc
     4501 cgtctcactg ttggccaggg ctttgtggcg tgggtgtttt ccagtctgcc tggagcagcg
     4561 agaagcagct gtgcagactg gtggcggtgg gagggtttgc tgggactgat ggggacaccg
     4621 gccagcttgt ctggtgtcca gcagccctgc cggacttggc ctcctgtcct gtcgttggga
     4681 gccctggctg gggctgcttt gagcaatgac gctggcccag agcagcttcc cacatgaccc
     4741 cagagccgag ggtctgccct gtcctaggtt aggtcttcat ggtttagagt aaaaccgtga
     4801 gggatgttaa ttatgggcat tgaagactta aggttttctt aaatttttag tgagcagtga
     4861 ttggccttca atacttgtgc tgagaggaat tttaagccag gggaagtgta agaaaatgtt
     4921 cccattcagg agagattgtg ttggagtttc tttcttcctc tgtatgtatt ttgtggtgtc
     4981 cacctttaac cacgtttcat ccaaaacgat gatgcagctt taacatgaat gttacatttt
     5041 tattttcaag gaattattat ctatgttccc tttgtaaagg aaagataatg ttgtaaatct
     5101 ttttattaga taatgtaaag atgtatatca gtatttttgg atcatgttat agattatgga
     5161 tatattgttt aataaataaa gtattttttg gaacaaa
//
