LOCUS       NM_016162               1659 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens inhibitor of growth family member 4 (ING4), transcript
            variant 1, mRNA.
ACCESSION   NM_016162
VERSION     NM_016162.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1659)
  AUTHORS   Cui,Z., Sun,S., Li,J., Li,J., Sha,T., He,J. and Zuo,L.
  TITLE     Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral
            Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA
            Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde
            Dehydrogenase 1A2 (ALDH1A2)
  JOURNAL   Curr Cancer Drug Targets 22 (9), 771-783 (2022)
   PUBMED   35388759
  REMARK    GeneRIF: Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role
            in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B
            (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of
            Aldehyde Dehydrogenase 1A2 (ALDH1A2).
REFERENCE   2  (bases 1 to 1659)
  AUTHORS   Shatnawi,A., Ayoub,N.M. and Alkhalifa,A.E.
  TITLE     ING4 Expression Landscape and Association With Clinicopathologic
            Characteristics in Breast Cancer
  JOURNAL   Clin Breast Cancer 21 (4), e319-e331 (2021)
   PUBMED   33334698
  REMARK    GeneRIF: ING4 Expression Landscape and Association With
            Clinicopathologic Characteristics in Breast Cancer.
REFERENCE   3  (bases 1 to 1659)
  AUTHORS   Martinez-Vargas,Y.D.C., Silva-Filho,T.J.D., Oliveira,D.H.I.P.,
            Goncalo,R.I.C. and Queiroz,L.M.G.
  TITLE     ING3 and ING4 immunoexpression and their relation to the
            development of benign odontogenic lesions
  JOURNAL   Braz Dent J 32 (4), 74-82 (2021)
   PUBMED   34787253
  REMARK    GeneRIF: ING3 and ING4 immunoexpression and their relation to the
            development of benign odontogenic lesions.
REFERENCE   4  (bases 1 to 1659)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1659)
  AUTHORS   Fu,Z.Y. and Tao,F.
  TITLE     [Expression levels of MMP-14, ING4 and HIF-1alpha in 60 patients
            with oral squamous cell carcinoma and their clinical significance]
  JOURNAL   Shanghai Kou Qiang Yi Xue 29 (6), 642-646 (2020)
   PUBMED   33778834
  REMARK    GeneRIF: [Expression levels of MMP-14, ING4 and HIF-1alpha in 60
            patients with oral squamous cell carcinoma and their clinical
            significance].
REFERENCE   6  (bases 1 to 1659)
  AUTHORS   Raho,G., Miranda,C., Tamborini,E., Pierotti,M.A. and Greco,A.
  TITLE     Detection of novel mRNA splice variants of human ING4 tumor
            suppressor gene
  JOURNAL   Oncogene 26 (36), 5247-5257 (2007)
   PUBMED   17325660
  REMARK    GeneRIF: data suggest that alternative splicing could modulate the
            activity of ING4 tumor suppressor protein
REFERENCE   7  (bases 1 to 1659)
  AUTHORS   Zhang,X., Xu,L.S., Wang,Z.Q., Wang,K.S., Li,N., Cheng,Z.H.,
            Huang,S.Z., Wei,D.Z. and Han,Z.G.
  TITLE     ING4 induces G2/M cell cycle arrest and enhances the
            chemosensitivity to DNA-damage agents in HepG2 cells
  JOURNAL   FEBS Lett 570 (1-3), 7-12 (2004)
   PUBMED   15251430
  REMARK    GeneRIF: ING4 induces G2/M cell cycle arrest and enhances the
            chemosensitivity to DNA-damage agents in HepG2 cells
REFERENCE   8  (bases 1 to 1659)
  AUTHORS   Garkavtsev,I., Kozin,S.V., Chernova,O., Xu,L., Winkler,F.,
            Brown,E., Barnett,G.H. and Jain,R.K.
  TITLE     The candidate tumour suppressor protein ING4 regulates brain tumour
            growth and angiogenesis
  JOURNAL   Nature 428 (6980), 328-332 (2004)
   PUBMED   15029197
  REMARK    GeneRIF: In mice, xenografts of human glioblastoma U87MG, which has
            decreased expression of ING4, grow significantly faster and have
            higher vascular volume fractions than control tumours
REFERENCE   9  (bases 1 to 1659)
  AUTHORS   Shiseki,M., Nagashima,M., Pedeux,R.M., Kitahama-Shiseki,M.,
            Miura,K., Okamura,S., Onogi,H., Higashimoto,Y., Appella,E.,
            Yokota,J. and Harris,C.C.
  TITLE     p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
  JOURNAL   Cancer Res 63 (10), 2373-2378 (2003)
   PUBMED   12750254
  REMARK    GeneRIF: p29ING4 and p28ING5 may be significant modulators of p53
            function.
REFERENCE   10 (bases 1 to 1659)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP303219.1, BC095434.1,
            AW614868.1 and AC135892.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016162.3.
            
            Summary: This gene encodes a tumor suppressor protein that contains
            a PHD-finger, which is a common motif in proteins involved in
            chromatin remodeling. This protein can bind TP53 and EP300/p300, a
            component of the histone acetyl transferase complex, suggesting its
            involvement in the TP53-dependent regulatory pathway. Multiple
            alternatively spliced transcript variants have been observed that
            encode distinct proteins. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses a different splice site
            in the coding region, compared to variant 9. The resulting protein
            (isoform 1) is shorter by 1 aa compared to isoform 9. Other names
            for this variant are ING4_v2 and '3 bp skip variant'.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.348370.1,
                                           SRR1803617.226103.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341550.9/ ENSP00000343396.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BP303219.1         24-36
            14-1369             BC095434.1         1-1356
            1370-1422           AW614868.1         14-66               c
            1423-1659           AC135892.1         50384-50620         c
FEATURES             Location/Qualifiers
     source          1..1659
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1659
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /note="inhibitor of growth family member 4"
                     /db_xref="GeneID:51147"
                     /db_xref="HGNC:HGNC:19423"
                     /db_xref="MIM:608524"
     exon            1..55
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..765
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     candidate tumor suppressor p33 ING1 homolog; brain my036
                     protein; inhibitor of growth protein 4"
                     /codon_start=1
                     /product="inhibitor of growth protein 4 isoform 1"
                     /protein_id="NP_057246.2"
                     /db_xref="CCDS:CCDS8555.1"
                     /db_xref="GeneID:51147"
                     /db_xref="HGNC:HGNC:19423"
                     /db_xref="MIM:608524"
                     /translation="MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDK
                     LATEYMSSARSLSSEEKLALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDT
                     DLARFEADLKEKQIESSDYDSSSSKGKKSRTQKEKKAARARSKGKNSDEEAPKTAQKK
                     LKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSI
                     EWFHFACVGLTTKPRGKWFCPRCSQERKKK"
     exon            56..127
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            128..294
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            295..409
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..515
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            516..663
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            664..725
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1659
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1350..1355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /note="hexamer: AATAAA"
     polyA_site      1369
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /note="major polyA site"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
                     /note="hexamer: AATAAA"
     polyA_site      1659
                     /gene="ING4"
                     /gene_synonym="my036; p29ING4"
ORIGIN      
        1 gctttgtttt gcttcgagat ggctgcgggg atgtatttgg aacattatct ggacagtatt
       61 gaaaaccttc cctttgaatt acagagaaac tttcagctca tgagggacct agaccaaaga
      121 acagaggacc tgaaggctga aattgacaag ttggccactg agtatatgag tagtgcccgc
      181 agcctgagct ccgaggaaaa attggccctt ctcaaacaga tccaggaagc ctatggcaag
      241 tgcaaggaat ttggtgacga caaggtgcag cttgccatgc agacctatga gatggtggac
      301 aaacacattc ggcggctgga cacagacctg gcccgttttg aggctgatct caaggagaaa
      361 cagattgagt caagtgacta tgacagctct tccagcaaag gcaaaaagag ccggactcaa
      421 aaggagaaga aagctgctcg tgctcgttcc aaagggaaaa actcggatga agaagccccc
      481 aagactgccc agaagaagtt aaagctcgtg cgcacaagtc ctgagtatgg gatgccctca
      541 gtgacctttg gcagtgtcca cccctctgat gtgttggata tgcctgtgga tcccaacgaa
      601 cccacctatt gcctttgtca ccaggtctcc tatggagaga tgattggctg tgacaaccct
      661 gattgttcca ttgagtggtt ccattttgcc tgtgtggggc tgacaaccaa gcctcggggg
      721 aaatggtttt gcccacgctg ctcccaagaa cggaagaaga aatagataag ggccttggat
      781 tccaacacag tttcttccac atcccctgac ttgggctagt gggcagagga atgcctgtgc
      841 tggggccagg ggttcaggga ggagtggatg gcacagtgct gtcatccctt ctcctcccct
      901 ctccccactc ccggtgctga ggctgcatca gaccctggta gggaggggtg ccgcagccac
      961 taacggtatg tgctctcctt cagccctctc ccttcggagg gacgtggtct tgcccactgt
     1021 ccttttgcct ccatgctgag gtcggtgctg tatttcagag ggagggtcct tttcattctc
     1081 cttgctttgt atttaaggac tggggcatag catgggggca gtcccccaga cctcttcatt
     1141 ccccctcctg tggtgagggc taggtgtgat caacactttt cttctccatt cccttcctgc
     1201 ttttttcatg gtgggggatc caccaggtca tctaggctct ggccctagtt gaaggggcac
     1261 cccttcctct gtgccaagag gattcatcct gggagagggg gcaaggtgga atgcagataa
     1321 ctcacatgta aaaggaactt gggtaggtaa ataaaagcta tacatgttgg cctgctgtgt
     1381 ttattgtaga gacactgttt tagtaaacat gctgagcatt cattttgcgt cctctgggtt
     1441 ggatgcaatg tgagaggatg gcatgccaga attaggacac gacatgaaac cagagtggtg
     1501 cctctgtccg agaacttgta agttctcaac ttgggaaaga cagaggtgct ggagggtagg
     1561 cctcagacca gggggtctcc aaaactttgt aaatcatgca tcttttctcc ataaaacatc
     1621 tttcacttaa tttccaataa atgatgtatt tgtgctata
//
