LOCUS       NM_019071               3749 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens inhibitor of growth family member 3 (ING3), transcript
            variant 1, mRNA.
ACCESSION   NM_019071
VERSION     NM_019071.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3749)
  AUTHORS   Cheng,S., Li,M., Zheng,W., Li,C., Hao,Z., Dai,Y., Wang,J., Zhuo,J.
            and Zhang,L.
  TITLE     ING3 inhibits the malignant progression of lung adenocarcinoma by
            negatively regulating ITGB4 expression to inactivate Src/FAK
            signaling
  JOURNAL   Cell Signal 117, 111066 (2024)
   PUBMED   38281617
  REMARK    GeneRIF: ING3 inhibits the malignant progression of lung
            adenocarcinoma by negatively regulating ITGB4 expression to
            inactivate Src/FAK signaling.
REFERENCE   2  (bases 1 to 3749)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 3749)
  AUTHORS   Song,Y., Hou,G., Diep,J., Ooi,Y.S., Akopyants,N.S., Beverley,S.M.,
            Carette,J.E., Greenberg,H.B. and Ding,S.
  TITLE     Inhibitor of growth protein 3 epigenetically silences endogenous
            retroviral elements and prevents innate immune activation
  JOURNAL   Nucleic Acids Res 49 (22), 12706-12715 (2021)
   PUBMED   34791430
  REMARK    GeneRIF: Inhibitor of growth protein 3 epigenetically silences
            endogenous retroviral elements and prevents innate immune
            activation.
REFERENCE   4  (bases 1 to 3749)
  AUTHORS   Melekhova,A. and Baniahmad,A.
  TITLE     ING Tumour Suppressors and ING Splice Variants as Coregulators of
            the Androgen Receptor Signalling in Prostate Cancer
  JOURNAL   Cells 10 (10), 2599 (2021)
   PUBMED   34685579
  REMARK    GeneRIF: ING Tumour Suppressors and ING Splice Variants as
            Coregulators of the Androgen Receptor Signalling in Prostate
            Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3749)
  AUTHORS   Martinez-Vargas,Y.D.C., Silva-Filho,T.J.D., Oliveira,D.H.I.P.,
            Goncalo,R.I.C. and Queiroz,L.M.G.
  TITLE     ING3 and ING4 immunoexpression and their relation to the
            development of benign odontogenic lesions
  JOURNAL   Braz Dent J 32 (4), 74-82 (2021)
   PUBMED   34787253
  REMARK    GeneRIF: ING3 and ING4 immunoexpression and their relation to the
            development of benign odontogenic lesions.
REFERENCE   6  (bases 1 to 3749)
  AUTHORS   Doyon,Y. and Cote,J.
  TITLE     The highly conserved and multifunctional NuA4 HAT complex
  JOURNAL   Curr Opin Genet Dev 14 (2), 147-154 (2004)
   PUBMED   15196461
  REMARK    Review article
REFERENCE   7  (bases 1 to 3749)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   8  (bases 1 to 3749)
  AUTHORS   Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I.,
            Parmely,T.J., Conaway,R.C. and Conaway,J.W.
  TITLE     Identification of new subunits of the multiprotein mammalian
            TRRAP/TIP60-containing histone acetyltransferase complex
  JOURNAL   J Biol Chem 278 (44), 42733-42736 (2003)
   PUBMED   12963728
REFERENCE   9  (bases 1 to 3749)
  AUTHORS   Nagashima,M., Shiseki,M., Pedeux,R.M., Okamura,S.,
            Kitahama-Shiseki,M., Miura,K., Yokota,J. and Harris,C.C.
  TITLE     A novel PHD-finger motif protein, p47ING3, modulates p53-mediated
            transcription, cell cycle control, and apoptosis
  JOURNAL   Oncogene 22 (3), 343-350 (2003)
   PUBMED   12545155
  REMARK    GeneRIF: we have isolated a novel ING family gene, p47ING3, which
            modulates p53-mediated transcription, cell cycle control, and
            apoptosis. The p47ING3 gene is located at chromosome 7q31.3 and
            consists of 12 exons that encode 418 amino acids
REFERENCE   10 (bases 1 to 3749)
  AUTHORS   Gunduz,M., Ouchida,M., Fukushima,K., Ito,S., Jitsumori,Y.,
            Nakashima,T., Nagai,N., Nishizaki,K. and Shimizu,K.
  TITLE     Allelic loss and reduced expression of the ING3, a candidate tumor
            suppressor gene at 7q31, in human head and neck cancers
  JOURNAL   Oncogene 21 (28), 4462-4470 (2002)
   PUBMED   12080476
  REMARK    GeneRIF: Allelic loss and reduced expression of the ING3, a
            candidate tumor suppressor gene at 7q31, in human head and neck
            cancers.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000096.1, AF074968.1,
            BU684039.1, BU677936.1 and AC004537.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_019071.2.
            
            Summary: The protein encoded by this gene is similar to ING1, a
            tumor suppressor protein that can interact with TP53, inhibit cell
            growth, and induce apoptosis. This protein contains a PHD-finger,
            which is a common motif in proteins involved in chromatin
            remodeling. This gene can activate p53 trans-activated promoters,
            including promoters of p21/waf1 and bax. Overexpression of this
            gene has been shown to inhibit cell growth and induce apoptosis.
            Allelic loss and reduced expression of this gene were detected in
            head and neck cancers. Two alternatively spliced transcript
            variants encoding different isoforms have been observed. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.133292.1,
                                           SRR1660805.170840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315870.10/ ENSP00000320566.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK000096.1         16-24
            10-1816             AF074968.1         1-1807
            1817-1823           AK000096.1         1832-1838
            1824-2110           BU684039.1         99-385              c
            2111-2116           BU677936.1         91-96               c
            2117-2190           BU684039.1         18-91               c
            2191-3749           AC004537.1         58578-60136
FEATURES             Location/Qualifiers
     source          1..3749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.31"
     gene            1..3749
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /note="inhibitor of growth family member 3"
                     /db_xref="GeneID:54556"
                     /db_xref="HGNC:HGNC:14587"
                     /db_xref="MIM:607493"
     exon            1..148
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1377
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inhibitor of growth protein 3"
                     /codon_start=1
                     /product="inhibitor of growth protein 3 isoform 1"
                     /protein_id="NP_061944.2"
                     /db_xref="CCDS:CCDS5778.1"
                     /db_xref="GeneID:54556"
                     /db_xref="HGNC:HGNC:14587"
                     /db_xref="MIM:607493"
                     /translation="MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVS
                     EFFMNAKKNKPEWREEQMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELA
                     KFKMELEADNAGITEILERRSLELDTPSQPVNNHHAHSHTPVEKRKYNPTSHHTTTDH
                     IPEKKFKSEALLSTLTSDASKENTLGCRNNNSTASSNNAYNVNSSQPLGSYNIGSLSS
                     GTGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQLGKEFSMARETVGYS
                     SSSALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSSSSSSLSSCSSSSTVVQE
                     ISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVG
                     LTEAPKGKWYCPQCTAAMKRRGSRHK"
     exon            149..220
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            221..321
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..387
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..484
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..556
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..676
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            677..834
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1028
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1221
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1260
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..3749
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2170..2175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /note="hexamer: AATAAA"
     polyA_site      2190
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /note="major polyA site"
     regulatory      3723..3728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
                     /note="hexamer: AATAAA"
     polyA_site      3749
                     /gene="ING3"
                     /gene_synonym="Eaf4; ING2; MEAF4; p47ING3"
ORIGIN      
        1 ccggagtcga gcgggtgctg ctagcggagg cgccatattg gaggggacaa aactccggcg
       61 acagcgagtg acacaaataa acccctggac ccccttgttc cctcagctct aagggccgcg
      121 atgttgtacc tagaagacta tctggaaatg attgagcagc ttcctatgga tctgcgggac
      181 cgcttcacgg aaatgcgcga gatggacctg caggtgcaga atgcaatgga tcaactagaa
      241 caaagagtca gtgaattctt tatgaatgca aagaaaaata aacctgagtg gagggaagag
      301 caaatggcat ccatcaaaaa agactactat aaagctttgg aagatgcaga tgagaaggtt
      361 cagttggcaa accagatata tgacttggta gatcgacact tgagaaagct ggatcaggaa
      421 ctggctaagt ttaaaatgga gctggaagct gataatgctg gaattacaga aatattagag
      481 aggcgatctt tggaattaga cactccttca cagccagtga acaatcacca tgctcattca
      541 catactccag tggaaaaaag gaaatataat ccaacttctc accatacgac aacagatcat
      601 attcctgaaa agaaatttaa atctgaagct cttctatcca cccttacgtc agatgcctct
      661 aaggaaaata cactaggttg tcgaaataat aattccacag cctcttctaa caatgcctac
      721 aatgtgaatt cctcccaacc tctgggatcc tataacattg gctcgttatc ttcaggaact
      781 ggtgcagggg caattaccat ggcagctgct caagcagttc aggctacagc tcagatgaag
      841 gagggacgaa gaacatcaag tttaaaagcc agttatgaag catttaagaa taatgacttt
      901 cagttgggaa aagaattttc aatggccagg gaaacagttg gctattcatc atcttcggca
      961 cttatgacaa cattaacaca gaatgccagt tcatcagcag ccgactcacg gagtggtcga
     1021 aagagcaaaa acaacaacaa gtcttcaagc cagcagtcat catcttcctc ctcctcttct
     1081 tccttatcat cgtgttcttc atcatcaact gttgtacaag aaatctctca acaaacaact
     1141 gtagtgccag aatctgattc aaatagtcag gttgattgga cttacgaccc aaatgaacct
     1201 cgatactgca tttgtaatca ggtatcttat ggtgagatgg tgggatgtga taaccaagat
     1261 tgccctatag aatggttcca ttatggctgc gttggattga cagaggcacc aaaaggcaaa
     1321 tggtactgtc cacagtgcac tgctgcaatg aagagaagag gcagcagaca caaataaagg
     1381 tggtcctttt gtttgatgaa gaaataaact tcagctgaag attttatata ggactttaaa
     1441 aagaagagaa gagaaagaag aaacaatgca tttccaggca accacttaaa ggatttacat
     1501 agacaatcct ataagatctt gaacttgaat tttatgggtt gtattttaat aatgtaagta
     1561 aattatttat gcactcctgg tgtgctatga atattattcc agttagcctt ggattatttc
     1621 agtggccaac atatgcagac atttgtactc ctcaaccatt ttctcaaagt aatgggcatt
     1681 ctatgattta gacttcaagg aattccaatg atgaagattt taaggaaagt attttatatt
     1741 caacaggtat attctgctgc atgtactgta ctccagagct gttatgtaac actgtatata
     1801 aatggttgca aaaaaaaaaa aaagtcagtg cttctaaaaa gaatttaaga taatggtttt
     1861 taaaatgcct ttataataag ctttgtttct ttgtgaaact aattcagcag gctgaaggaa
     1921 atggttcatg tgataatgtg ggctggtatc ctctagagta cctgggtaca taaacagaaa
     1981 ctcctgtagg taaaaagtaa tttgtgccat tagtctttct atgtttctgc atccagatag
     2041 agtgcagttc atgagggagg gggcggggga ctgaagggga aagggcgtta aagtgataca
     2101 tttttatacc aaatgtgttt atttttttgt gcaagtaatc cttaaaattg caattgtatt
     2161 aggtgttaaa ataaagtttt taaaaaatta cttgtattta tactttacat acttaataat
     2221 gaaaatttct gaattccaat taactttcaa ctttcataat ctaaaaagaa tcagagaccc
     2281 aggacacaga atactgtgta atctgtgatg tctttaatga tgtttagagt ttgtgatata
     2341 agaatacagg aaagacattt ttaatgtaaa tttgaaatgc caatgtattt ttttaagaac
     2401 atcatctggc ttttccttca gtctaaaaga catgaaagaa gtgtaagtat agcagttaaa
     2461 acgaaaataa tggttatggg tgttttgact ggaggcaatg tagccaaata gagtaaagag
     2521 acccccctgg tcgggagctc caaattgagc tatttttgat tctaccactt actgatatga
     2581 cagttaattc aaattttgta tcactctggg ccttactaca ccagggtgat gctgactgca
     2641 gaatagatct tattctaagg tgctatttaa attataaatt tgcatagtgg aggttttatt
     2701 taaagtataa tattgagtct ggtcgataga aaaatcctta acttttaaga tacttaatat
     2761 atcatatata ttttatattg aaacttactg ggtccatcag atttctgctt taattaaacc
     2821 acttatgagc ttcttagaac ttattcagat aacagtgtaa aatctatgca gtgctaccca
     2881 aagggtgtga ggtagatagg ggatttcaaa gatctcttcc acctttgaga tcccatgatt
     2941 ctgagctgcc acagtctgat tatacaactc taccagctcc ctaaacaagt taggttcatt
     3001 tgtgagtact catcatttca taatatcatg attatcacga tttcatgata ctcaatattt
     3061 tgagatttta taacccttta agaagtgata aataatgtag tattcaattc gtttatcaaa
     3121 gtatattgcc tggaaatgct cacatgtatc atttacatcc tctatatatt atgactattc
     3181 caaactcatt cattttatag aaatggtcaa aggaaaaagc cttatgtaca gccttatttg
     3241 aagagaaagt tctttgtctg agtcaggaac atcctgttat ccagctgcta catccccttt
     3301 cagtgtgaat tccactcctt accaaatcac ttagaaaaca ctttgacaag ttttaaactc
     3361 aaacactgaa tattttatga agcatgtgta aagaaagaaa ccaaaatttg gtgcaggtat
     3421 ttagtaatgg gtagaacctg ttaatatctg agtcatatat aatggggcca aacatggaac
     3481 tacctcatca accccccaaa aatgtggcca actattaata ttctttgtga catttacacc
     3541 aaggggcata gtaagtattt ttggtattat aaaatacaca ttcaaaatct ctgttgtaca
     3601 aaactcatgt aacagttggg acaaaatatc caaatgtggg ttcacagttc acaggtggtg
     3661 aaaattgagg ccttactgct atggagtgta tatcaaaatg ttcatggtga cacatttgaa
     3721 gcaataaatg gcttaattaa atgccaaaa
//
