LOCUS       NM_001564               2458 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens inhibitor of growth family member 2 (ING2), transcript
            variant 1, mRNA.
ACCESSION   NM_001564
VERSION     NM_001564.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2458)
  AUTHORS   Ricordel,C., Chaillot,L., Blondel,A., Archambeau,J., Jouan,F.,
            Mouche,A., Tiercin,M., Burel,A., Lena,H., Desrues,B.,
            Guillaudeux,T. and Pedeux,R.
  TITLE     ING2 tumor suppressive protein translocates into mitochondria and
            is involved in cellular metabolism homeostasis
  JOURNAL   Oncogene 40 (24), 4111-4123 (2021)
   PUBMED   34017078
  REMARK    GeneRIF: ING2 tumor suppressive protein translocates into
            mitochondria and is involved in cellular metabolism homeostasis.
REFERENCE   2  (bases 1 to 2458)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2458)
  AUTHORS   Ma,Y., Yan,R., Wan,Q., Lv,B., Yang,Y., Lv,T. and Xin,W.
  TITLE     Inhibitor of growth 2 regulates the high glucose-induced cell cycle
            arrest and epithelial-to-mesenchymal transition in renal proximal
            tubular cells
  JOURNAL   J Physiol Biochem 76 (3), 373-382 (2020)
   PUBMED   32424454
  REMARK    GeneRIF: Inhibitor of growth 2 regulates the high glucose-induced
            cell cycle arrest and epithelial-to-mesenchymal transition in renal
            proximal tubular cells.
            Erratum:[J Physiol Biochem. 2020 Aug;76(3):483. doi:
            10.1007/s13105-020-00752-2.. PMID: 32562166]
REFERENCE   4  (bases 1 to 2458)
  AUTHORS   Cheng,S., Li,C., Xie,W., Miao,Y., Guo,J., Wang,J. and Zhang,Y.
  TITLE     Integrated analysis of DNA methylation and mRNA expression profiles
            to identify key genes involved in the regrowth of clinically
            non-functioning pituitary adenoma
  JOURNAL   Aging (Albany NY) 12 (3), 2408-2427 (2020)
   PUBMED   32015217
  REMARK    GeneRIF: Integrated analysis of DNA methylation and mRNA expression
            profiles to identify key genes involved in the regrowth of
            clinically non-functioning pituitary adenoma.
REFERENCE   5  (bases 1 to 2458)
  AUTHORS   Tao,X.C., Zhang,X.Y., Sun,S.B. and Wu,D.Q.
  TITLE     miR-92a contributes to cell proliferation, apoptosis and
            doxorubicin chemosensitivity in gastric carcinoma cells
  JOURNAL   Oncol Rep 42 (1), 313-320 (2019)
   PUBMED   31180538
  REMARK    GeneRIF: Findings provide evidence that ING2 is a direct target of
            miR92a.
REFERENCE   6  (bases 1 to 2458)
  AUTHORS   Gozani,O., Karuman,P., Jones,D.R., Ivanov,D., Cha,J.,
            Lugovskoy,A.A., Baird,C.L., Zhu,H., Field,S.J., Lessnick,S.L.,
            Villasenor,J., Mehrotra,B., Chen,J., Rao,V.R., Brugge,J.S.,
            Ferguson,C.G., Payrastre,B., Myszka,D.G., Cantley,L.C., Wagner,G.,
            Divecha,N., Prestwich,G.D. and Yuan,J.
  TITLE     The PHD finger of the chromatin-associated protein ING2 functions
            as a nuclear phosphoinositide receptor
  JOURNAL   Cell 114 (1), 99-111 (2003)
   PUBMED   12859901
REFERENCE   7  (bases 1 to 2458)
  AUTHORS   Kuzmichev,A., Zhang,Y., Erdjument-Bromage,H., Tempst,P. and
            Reinberg,D.
  TITLE     Role of the Sin3-histone deacetylase complex in growth regulation
            by the candidate tumor suppressor p33(ING1)
  JOURNAL   Mol Cell Biol 22 (3), 835-848 (2002)
   PUBMED   11784859
REFERENCE   8  (bases 1 to 2458)
  AUTHORS   Nagashima,M., Shiseki,M., Miura,K., Hagiwara,K., Linke,S.P.,
            Pedeux,R., Wang,X.W., Yokota,J., Riabowol,K. and Harris,C.C.
  TITLE     DNA damage-inducible gene p33ING2 negatively regulates cell
            proliferation through acetylation of p53
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9671-9676 (2001)
   PUBMED   11481424
  REMARK    GeneRIF: p33ING2/ING1L is a DNA damage-inducible gene that
            negatively regulates cell proliferation through activation of p53
            by enhancing its acetylation.
REFERENCE   9  (bases 1 to 2458)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   10 (bases 1 to 2458)
  AUTHORS   Shimada,Y., Saito,A., Suzuki,M., Takahashi,E. and Horie,M.
  TITLE     Cloning of a novel gene (ING1L) homologous to ING1, a candidate
            tumor suppressor
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 232-235 (1998)
   PUBMED   10072587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314000.1, AB012853.1, BC030128.2 and AC107214.5.
            
            On Nov 22, 2018 this sequence version replaced NM_001564.3.
            
            Summary: This gene is a member of the inhibitor of growth (ING)
            family. Members of the ING family associate with and modulate the
            activity of histone acetyltransferase (HAT) and histone deacetylase
            (HDAC) complexes and function in DNA repair and apoptosis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.149145.1,
                                           SRR1803612.196524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302327.4/ ENSP00000307183.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AK314000.1         9-60
            53-1013             AB012853.1         6-966
            1014-1125           BC030128.2         1002-1113
            1126-2458           AC107214.5         46025-47357
FEATURES             Location/Qualifiers
     source          1..2458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..2458
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
                     /note="inhibitor of growth family member 2"
                     /db_xref="GeneID:3622"
                     /db_xref="HGNC:HGNC:6063"
                     /db_xref="MIM:604215"
     exon            1..310
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..981
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inhibitor of growth protein 2; p32; ING1Lp; inhibitor of
                     growth 1-like protein"
                     /codon_start=1
                     /product="inhibitor of growth protein 2 isoform 1"
                     /protein_id="NP_001555.1"
                     /db_xref="CCDS:CCDS3833.1"
                     /db_xref="GeneID:3622"
                     /db_xref="HGNC:HGNC:6063"
                     /db_xref="MIM:604215"
                     /translation="MLGQQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQR
                     NVSVLRELDNKYQETLKEIDDVYEKYKKEDDLNQKKRLQQLLQRALINSQELGDEKIQ
                     IVTQMLELVENRARQMELHSQCFQDPAESERASDKAKMDSSQPERSSRRPRRQRTSES
                     RDLCHMANGIEDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCN
                     QVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKD
                     RRSR"
     exon            311..2458
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1105..1110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
                     /note="hexamer: ATTAAA"
     polyA_site      1125
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
                     /note="major polyA site"
     polyA_site      2298
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
     regulatory      2434..2439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
                     /note="hexamer: AATAAT"
     polyA_site      2458
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
ORIGIN      
        1 gagcgcggcc gtgccctctc gagcggctgc ggggtccccg cggcgccggg ctgctgagct
       61 gagggcccgc ggcggccgcg gccggtgcat gtgcggctgc tggatgcgga ggcggcggcg
      121 acggcgcgga tcggcaggat gttagggcag cagcagcagc aactgtactc gtcggccgcg
      181 ctcctgaccg gggagcggag ccggctgctc acctgctacg tgcaggacta ccttgagtgc
      241 gtggagtcgc tgccccacga catgcagagg aacgtgtctg tgctgcgaga gctggacaac
      301 aaatatcaag aaacgttaaa ggaaattgat gatgtctacg aaaaatataa gaaagaagat
      361 gatttaaacc agaagaaacg tctacagcag cttctccaga gagcactaat taatagtcaa
      421 gaattgggag atgaaaaaat acagattgtt acacaaatgc tcgaattggt ggaaaatcgg
      481 gcaagacaaa tggagttaca ctcacagtgt ttccaagatc ctgctgaaag tgaacgagcc
      541 tcagataaag caaagatgga ttccagccaa ccagaaagat cttcaagaag accccgcagg
      601 cagcggacca gtgaaagccg tgatttatgt cacatggcaa atgggattga agactgtgat
      661 gatcagccac ctaaagaaaa gaaatccaag tcagcaaaga aaaagaaacg ctccaaggcc
      721 aagcaggaaa gggaagcttc acctgttgag tttgcaatag atcctaatga acctacatac
      781 tgcttatgca accaagtgtc ttatggggag atgataggat gtgacaatga acagtgtcca
      841 attgaatggt ttcacttttc atgtgtttca cttacctata aaccaaaggg gaaatggtat
      901 tgcccaaagt gcaggggaga taatgagaaa acaatggaca aaagtactga aaagacaaaa
      961 aaggatagaa gatcgaggta gtaaaggcca tccacatttt aaagggttat ttgtctttta
     1021 tataattcgt ttgctttcag aaaatgtttt agggtaaatg cataagacta tgcaataatt
     1081 tttaatcatt agtattaatg gtgtattaaa agttgttgta ctttgtctgt gaccttaatt
     1141 ttctgcactg agttaccaaa tatttccaac caggtagtct tcagatcacc tgatgaaagg
     1201 agcagggaac aggaagaggg tggtgtaaac attataaaaa tttcacaaac catgcctatt
     1261 tcattttcac ttaaaactgc aatgttattt tttgggtaaa cacaaaagtt tcactagcat
     1321 tttagttata catgcttaaa aaaatgttag atgtagtggg atttctctta agcatcaaat
     1381 gatcttgggt actttaaaat acagacacta tgccatttga gctgcttttt ccctagtcct
     1441 atttatacgt tggcttgttc atctctagtc ttctaggagt ttaaggaact ggagataaga
     1501 gtaatttggg attccatgtg gaataatgtg ctcttatgag agtacgtgct gctgtctttt
     1561 gcttagtagc attttgatcc actgtcagta gcccatttgt caatgccttg ctgctgcttt
     1621 gtagatatac ttagtctagt gcttaataag ggagttgttt tgtgttttct tttaattggg
     1681 acaggtaaga gtagttagca taccaaaaat atacattggc ttacattggc aaactttggg
     1741 ttatatagta tcacggctca aggttgaaca atttaaaaat acatcttaat taatagtatt
     1801 ttccatgtga cctgctgcca ggatgcgtag ccacaggcct atcagtggaa aggggcatat
     1861 agtagtcttt aaatattgcc tttatgtcag agagttgttt taaatggttt tgctagtggt
     1921 tattgttcat ttctgtccca atcagtgact attttaaata atagtgtatt tactgtctta
     1981 acttctagta ttggtgctgt ttgatgtttt cacatttaat taacttattt catcatcata
     2041 atgcaattaa tgtatttgta aattgaattt tccaagattc tgatatttga agggtaagca
     2101 tcttgatgga tatatgtcca tatgtttaga gaaggttttg gttttggggg cagcagattg
     2161 actagttctt taaatctgtg tgtaacgtat gttttattcc tcatttcttc ctaatctgat
     2221 gatcttgatt ctttttgatt aacatgaaaa atcctgtctg cttgttttgg gaaaaaaaaa
     2281 tgcttttttt ctcttctagc tctcctgtgt gacttttagg catgtcattt caccttgtct
     2341 gggtgtcagg tcattcacct gtaaaatgag ttggcttaaa tatctccgag attccttgga
     2401 aatttctact atttgcacta tagtgaggat tttaataatg acatgacttc tcttttca
//
