LOCUS       NP_001555                280 aa            linear   PRI 09-FEB-2025
DEFINITION  inhibitor of growth protein 2 isoform 1 [Homo sapiens].
ACCESSION   NP_001555
VERSION     NP_001555.1
DBSOURCE    REFSEQ: accession NM_001564.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 280)
  AUTHORS   Ricordel,C., Chaillot,L., Blondel,A., Archambeau,J., Jouan,F.,
            Mouche,A., Tiercin,M., Burel,A., Lena,H., Desrues,B.,
            Guillaudeux,T. and Pedeux,R.
  TITLE     ING2 tumor suppressive protein translocates into mitochondria and
            is involved in cellular metabolism homeostasis
  JOURNAL   Oncogene 40 (24), 4111-4123 (2021)
   PUBMED   34017078
  REMARK    GeneRIF: ING2 tumor suppressive protein translocates into
            mitochondria and is involved in cellular metabolism homeostasis.
REFERENCE   2  (residues 1 to 280)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 280)
  AUTHORS   Ma,Y., Yan,R., Wan,Q., Lv,B., Yang,Y., Lv,T. and Xin,W.
  TITLE     Inhibitor of growth 2 regulates the high glucose-induced cell cycle
            arrest and epithelial-to-mesenchymal transition in renal proximal
            tubular cells
  JOURNAL   J Physiol Biochem 76 (3), 373-382 (2020)
   PUBMED   32424454
  REMARK    GeneRIF: Inhibitor of growth 2 regulates the high glucose-induced
            cell cycle arrest and epithelial-to-mesenchymal transition in renal
            proximal tubular cells.
            Erratum:[J Physiol Biochem. 2020 Aug;76(3):483. doi:
            10.1007/s13105-020-00752-2.. PMID: 32562166]
REFERENCE   4  (residues 1 to 280)
  AUTHORS   Cheng,S., Li,C., Xie,W., Miao,Y., Guo,J., Wang,J. and Zhang,Y.
  TITLE     Integrated analysis of DNA methylation and mRNA expression profiles
            to identify key genes involved in the regrowth of clinically
            non-functioning pituitary adenoma
  JOURNAL   Aging (Albany NY) 12 (3), 2408-2427 (2020)
   PUBMED   32015217
  REMARK    GeneRIF: Integrated analysis of DNA methylation and mRNA expression
            profiles to identify key genes involved in the regrowth of
            clinically non-functioning pituitary adenoma.
REFERENCE   5  (residues 1 to 280)
  AUTHORS   Tao,X.C., Zhang,X.Y., Sun,S.B. and Wu,D.Q.
  TITLE     miR-92a contributes to cell proliferation, apoptosis and
            doxorubicin chemosensitivity in gastric carcinoma cells
  JOURNAL   Oncol Rep 42 (1), 313-320 (2019)
   PUBMED   31180538
  REMARK    GeneRIF: Findings provide evidence that ING2 is a direct target of
            miR92a.
REFERENCE   6  (residues 1 to 280)
  AUTHORS   Gozani,O., Karuman,P., Jones,D.R., Ivanov,D., Cha,J.,
            Lugovskoy,A.A., Baird,C.L., Zhu,H., Field,S.J., Lessnick,S.L.,
            Villasenor,J., Mehrotra,B., Chen,J., Rao,V.R., Brugge,J.S.,
            Ferguson,C.G., Payrastre,B., Myszka,D.G., Cantley,L.C., Wagner,G.,
            Divecha,N., Prestwich,G.D. and Yuan,J.
  TITLE     The PHD finger of the chromatin-associated protein ING2 functions
            as a nuclear phosphoinositide receptor
  JOURNAL   Cell 114 (1), 99-111 (2003)
   PUBMED   12859901
REFERENCE   7  (residues 1 to 280)
  AUTHORS   Kuzmichev,A., Zhang,Y., Erdjument-Bromage,H., Tempst,P. and
            Reinberg,D.
  TITLE     Role of the Sin3-histone deacetylase complex in growth regulation
            by the candidate tumor suppressor p33(ING1)
  JOURNAL   Mol Cell Biol 22 (3), 835-848 (2002)
   PUBMED   11784859
REFERENCE   8  (residues 1 to 280)
  AUTHORS   Nagashima,M., Shiseki,M., Miura,K., Hagiwara,K., Linke,S.P.,
            Pedeux,R., Wang,X.W., Yokota,J., Riabowol,K. and Harris,C.C.
  TITLE     DNA damage-inducible gene p33ING2 negatively regulates cell
            proliferation through acetylation of p53
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9671-9676 (2001)
   PUBMED   11481424
  REMARK    GeneRIF: p33ING2/ING1L is a DNA damage-inducible gene that
            negatively regulates cell proliferation through activation of p53
            by enhancing its acetylation.
REFERENCE   9  (residues 1 to 280)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   10 (residues 1 to 280)
  AUTHORS   Shimada,Y., Saito,A., Suzuki,M., Takahashi,E. and Horie,M.
  TITLE     Cloning of a novel gene (ING1L) homologous to ING1, a candidate
            tumor suppressor
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 232-235 (1998)
   PUBMED   10072587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314000.1, AB012853.1, BC030128.2 and AC107214.5.
            
            Summary: This gene is a member of the inhibitor of growth (ING)
            family. Members of the ING family associate with and modulate the
            activity of histone acetyltransferase (HAT) and histone deacetylase
            (HDAC) complexes and function in DNA repair and apoptosis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.149145.1,
                                           SRR1803612.196524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302327.4/ ENSP00000307183.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     Protein         1..280
                     /product="inhibitor of growth protein 2 isoform 1"
                     /note="inhibitor of growth protein 2; p32; ING1Lp;
                     inhibitor of growth 1-like protein"
                     /calculated_mol_wt=32677
     Region          32..119
                     /region_name="ING_ING2"
                     /note="Inhibitor of growth (ING) domain of inhibitor of
                     growth protein 2 (ING2); cd16861"
                     /db_xref="CDD:341094"
     Site            order(35,38..40,43,46,49,53,60,63..64,83..84,87,90..91,94,
                     97..98,101,104,107..108,111..112,114..115,118..119)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:341094"
     Region          122..204
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H160.2)"
     Region          213..261
                     /region_name="PHD_ING2"
                     /note="PHD finger found in inhibitor of growth protein 2
                     (ING2); cd15683"
                     /db_xref="CDD:277153"
     Site            order(214,221..229,236..237,240,248..249,251)
                     /site_type="other"
                     /note="H3K4me3 binding site [polypeptide binding]"
                     /db_xref="CDD:277153"
     Site            214
                     /site_type="other"
                     /note="Histone H3K4me3 binding.
                     /evidence=ECO:0000250|UniProtKB:Q9UK53; propagated from
                     UniProtKB/Swiss-Prot (Q9H160.2)"
     Site            225
                     /site_type="other"
                     /note="Histone H3K4me3 binding.
                     /evidence=ECO:0000250|UniProtKB:Q9UK53; propagated from
                     UniProtKB/Swiss-Prot (Q9H160.2)"
     Site            229
                     /site_type="other"
                     /note="Histone H3K4me3 binding.
                     /evidence=ECO:0000250|UniProtKB:Q9UK53; propagated from
                     UniProtKB/Swiss-Prot (Q9H160.2)"
     Site            237
                     /site_type="other"
                     /note="Histone H3K4me3 binding.
                     /evidence=ECO:0000250|UniProtKB:Q9UK53; propagated from
                     UniProtKB/Swiss-Prot (Q9H160.2)"
     Region          258..280
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H160.2)"
     Region          264..280
                     /region_name="PBR. /evidence=ECO:0000269|PubMed:16728974"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H160.2)"
     CDS             1..280
                     /gene="ING2"
                     /gene_synonym="ING1L; p33ING2"
                     /coded_by="NM_001564.4:139..981"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS3833.1"
                     /db_xref="GeneID:3622"
                     /db_xref="HGNC:HGNC:6063"
                     /db_xref="MIM:604215"
ORIGIN      
        1 mlgqqqqqly ssaalltger srlltcyvqd ylecveslph dmqrnvsvlr eldnkyqetl
       61 keiddvyeky kkeddlnqkk rlqqllqral insqelgdek iqivtqmlel venrarqmel
      121 hsqcfqdpae serasdkakm dssqperssr rprrqrtses rdlchmangi edcddqppke
      181 kksksakkkk rskakqerea spvefaidpn eptyclcnqv sygemigcdn eqcpiewfhf
      241 scvsltykpk gkwycpkcrg dnektmdkst ektkkdrrsr
//
