LOCUS       NM_198219               4697 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens inhibitor of growth family member 1 (ING1), transcript
            variant 1, mRNA.
ACCESSION   NM_198219
VERSION     NM_198219.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4697)
  AUTHORS   Yang,Y., Ma,B., Djamshidi,M., Zhang,Q., Sarkar,A., Chanda,A.,
            Tran,U., Soh,J., Sandall,C., Chen,H.M., MacDonald,J.A., Bonni,S.,
            Sensen,C.W., Zheng,J. and Riabowol,K.
  TITLE     ING1 inhibits Twist1 expression to block EMT and is antagonized by
            the HDAC inhibitor vorinostat
  JOURNAL   Eur J Cell Biol 102 (3), 151341 (2023)
   PUBMED   37459799
  REMARK    GeneRIF: ING1 inhibits Twist1 expression to block EMT and is
            antagonized by the HDAC inhibitor vorinostat.
REFERENCE   2  (bases 1 to 4697)
  AUTHORS   Melekhova,A. and Baniahmad,A.
  TITLE     ING Tumour Suppressors and ING Splice Variants as Coregulators of
            the Androgen Receptor Signalling in Prostate Cancer
  JOURNAL   Cells 10 (10), 2599 (2021)
   PUBMED   34685579
  REMARK    GeneRIF: ING Tumour Suppressors and ING Splice Variants as
            Coregulators of the Androgen Receptor Signalling in Prostate
            Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4697)
  AUTHORS   Rusu,A.D., Cornhill,Z.E., Coutino,B.C., Uribe,M.C., Lourdusamy,A.,
            Markus,Z., May,S.T., Rahman,R. and Georgiou,M.
  TITLE     CG7379 and ING1 suppress cancer cell invasion by maintaining
            cell-cell junction integrity
  JOURNAL   Open Biol 11 (9), 210077 (2021)
   PUBMED   34493070
  REMARK    GeneRIF: CG7379 and ING1 suppress cancer cell invasion by
            maintaining cell-cell junction integrity.
REFERENCE   4  (bases 1 to 4697)
  AUTHORS   Gao,Z., Zhou,L., Hua,S., Wu,H., Luo,L., Li,L., Wang,S., Liu,Y.,
            Zhou,Z. and Chen,X.
  TITLE     miR-24-3p promotes colon cancer progression by targeting ING1
  JOURNAL   Signal Transduct Target Ther 5 (1), 171 (2020)
   PUBMED   32843621
  REMARK    GeneRIF: miR-24-3p promotes colon cancer progression by targeting
            ING1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4697)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4697)
  AUTHORS   Zeremski,M., Horrigan,S.K., Grigorian,I.A., Westbrook,C.A. and
            Gudkov,A.V.
  TITLE     Localization of the candidate tumor suppressor gene ING1 to human
            chromosome 13q34
  JOURNAL   Somat Cell Mol Genet 23 (3), 233-236 (1997)
   PUBMED   9330636
REFERENCE   7  (bases 1 to 4697)
  AUTHORS   Helbing,C.C., Veillette,C., Riabowol,K., Johnston,R.N. and
            Garkavtsev,I.
  TITLE     A novel candidate tumor suppressor, ING1, is involved in the
            regulation of apoptosis
  JOURNAL   Cancer Res 57 (7), 1255-1258 (1997)
   PUBMED   9102209
REFERENCE   8  (bases 1 to 4697)
  AUTHORS   Garkavtsev,I. and Riabowol,K.
  TITLE     Extension of the replicative life span of human diploid fibroblasts
            by inhibition of the p33ING1 candidate tumor suppressor
  JOURNAL   Mol Cell Biol 17 (4), 2014-2019 (1997)
   PUBMED   9121449
REFERENCE   9  (bases 1 to 4697)
  AUTHORS   Garkavtsev,I., Demetrick,D. and Riabowol,K.
  TITLE     Cellular localization and chromosome mapping of a novel candidate
            tumor suppressor gene (ING1)
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 176-178 (1997)
   PUBMED   9186514
REFERENCE   10 (bases 1 to 4697)
  AUTHORS   Garkavtsev,I., Kazarov,A., Gudkov,A. and Riabowol,K.
  TITLE     Suppression of the novel growth inhibitor p33ING1 promotes
            neoplastic transformation
  JOURNAL   Nat Genet 14 (4), 415-420 (1996)
   PUBMED   8944021
  REMARK    Erratum:[Nat Genet 1999 Nov;23(3):373]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157820.27.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_198219.2.
            
            Summary: This gene encodes a tumor suppressor protein that can
            induce cell growth arrest and apoptosis. The encoded protein is a
            nuclear protein that physically interacts with the tumor suppressor
            protein TP53 and is a component of the p53 signaling pathway.
            Reduced expression and rearrangement of this gene have been
            detected in various cancers. Multiple alternatively spliced
            transcript variants encoding distinct isoforms have been reported.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' end-region,
            which includes part of the coding region, compared to variant 4.
            The resulting isoform (A) has a distinct and shorter N-terminus, as
            compared to isoform D.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB024401.1, SRR1803614.255879.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333219.9/ ENSP00000328436.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-586               AL157820.27        51839-52424
            587-4697            AL157820.27        57368-61478
FEATURES             Location/Qualifiers
     source          1..4697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..4697
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="inhibitor of growth family member 1"
                     /db_xref="GeneID:3621"
                     /db_xref="HGNC:HGNC:6062"
                     /db_xref="MIM:601566"
     exon            1..586
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..1290
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="isoform A is encoded by transcript variant 1; tumor
                     suppressor ING1; growth inhibitor ING1; inhibitor of
                     growth protein 1; growth inhibitory protein ING1"
                     /codon_start=1
                     /product="inhibitor of growth protein 1 isoform A"
                     /protein_id="NP_937862.1"
                     /db_xref="CCDS:CCDS9516.1"
                     /db_xref="GeneID:3621"
                     /db_xref="HGNC:HGNC:6062"
                     /db_xref="MIM:601566"
                     /translation="MLSPANGEQLHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKY
                     QEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENR
                     TRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRE
                     NASSNHDHDDGASGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQV
                     SYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERA
                     YNR"
     exon            587..4697
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1514..1519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="hexamer: AATATA"
     polyA_site      1533
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="major polyA site"
     regulatory      2108..2113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="hexamer: AATAAA"
     polyA_site      2129
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="major polyA site"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="hexamer: AATAAA"
     polyA_site      2432
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="major polyA site"
     regulatory      3688..3693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="hexamer: AATAAA"
     polyA_site      3712
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
     regulatory      4674..4679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
                     /note="hexamer: AATAAA"
     polyA_site      4697
                     /gene="ING1"
                     /gene_synonym="p24ING1c; p33; p33ING1; p33ING1b; p47;
                     p47ING1a"
ORIGIN      
        1 gggttttcca cgttggacaa gtgcggctcg gcggccagcg gagcgcgccc cttcccgctg
       61 cccgctccgc tcctctcttc tacccagccc agtgggcgag tgggcagcgg cggccgcggc
      121 gctgggccct ctcccgccgg tgtgtgcgcg ctcgtacgcg cggcccccgg cgccagcccc
      181 gccgcctgag agggggcctg cgccgccggc cggggcgtgc gcccgggagc caccgccacc
      241 gcggcccgcg ccctcaggcg ctggggtccc cgcggacccg gaggcggcgg acgggctcgg
      301 cagatgtagc cgccgggccg aagcaggagc cggcgggggg gcgccgggag agcgagggct
      361 ttgcattttg cagtgctatt ttttgagggg ggcggggggt ggaggaagcg gaaagccgcg
      421 ccgagtcgcc ggggacctcc ggggtgaacc atgttgagtc ctgccaacgg ggagcagctc
      481 cacctggtga actatgtgga ggactacctg gactccatcg agtccctgcc tttcgacttg
      541 cagagaaatg tctcgctgat gcgggagatc gacgcgaaat accaagagat cctgaaggag
      601 ctagacgagt gctacgagcg cttcagtcgc gagacagacg gggcgcagaa gcggcggatg
      661 ctgcactgtg tgcagcgcgc gctgatccgc agccaggagc tgggcgacga gaagatccag
      721 atcgtgagcc agatggtgga gctggtggag aaccgcacgc ggcaggtgga cagccacgtg
      781 gagctgttcg aggcgcagca ggagctgggc gacacagcgg gcaacagcgg caaggctggc
      841 gcggacaggc ccaaaggcga ggcggcagcg caggctgaca agcccaacag caagcgctca
      901 cggcggcagc gcaacaacga gaaccgtgag aacgcgtcca gcaaccacga ccacgacgac
      961 ggcgcctcgg gcacacccaa ggagaagaag gccaagacct ccaagaagaa gaagcgctcc
     1021 aaggccaagg cggagcgaga ggcgtcccct gccgacctcc ccatcgaccc caacgaaccc
     1081 acgtactgtc tgtgcaacca ggtctcctat ggggagatga tcggctgcga caacgacgag
     1141 tgccccatcg agtggttcca cttctcgtgc gtggggctca atcataaacc caagggcaag
     1201 tggtactgtc ccaagtgccg gggggagaac gagaagacca tggacaaagc cctggagaaa
     1261 tccaaaaaag agagggctta caacaggtag tttgtggaca ggcgcctggt gtgaggagga
     1321 caaaataaac cgtgtattta ttacattgct gcctttgttg aggtgcaagg agtgtaaaat
     1381 gtatattttt aaagaatgtt agtaaaggaa ccattccttt catagggatg gcagtgattc
     1441 tgtttgcctt ttgttttcat tggtacacgt gtaacaagaa agtggtctgt ggatcagcat
     1501 tttagaaact acaaatatag gtttgattca acacttaagt ctcagactga tttcttgcgg
     1561 gaggaggggg actaaactca acctaacaca ttaaatgtgg aaggaaaata tttcatttag
     1621 cttttttatt ttaatacaag taatattatt actttatgaa caattttttt taattggcca
     1681 tgtcgccaaa aatacagcct atagtaaatg tgtttcttgc tgccatgatg tatatccata
     1741 taacaattca gtaacaaagg tttaaagttt gaagattatt ttttaaaaag gtaaatggtt
     1801 aaattttaca tgacagatat tttatctatt ggcctgttcc ccaaatggcc attttaaaat
     1861 gcttgggtac acttctctta agtggtctag tcaaggaacc tcaagtcatg cttttgctat
     1921 caccaatcat agtgtaccca tctttaattt atatcaggtg tataaatgta catttccaaa
     1981 tgaacttgca cttgttatat tataattgga agtgcagtca gcagatgctg ttgtgaagct
     2041 aatgtcacaa ttatgtgcaa aggtgtgctt cctgctgtat gtgagctgta aaaatgttac
     2101 gtgaagaaat aaatgaaact tggccagttt gttcctctag tagtatattt aattttgaca
     2161 taagtaactt ttaaaatttg tcttaaaaat ttatacacca gcaatttaga caaagcctta
     2221 agcaaatttt gtattattgt tctcacttat tattaataat gaagtagaag ttacttaatt
     2281 gccagcaaat aaatacgtgt caaaaaagaa tctgtattca gaccctgggt caggaaatta
     2341 ctgcccactt gtcaagttca gcccaccatc tgtttgaaga ttatatgaag tttaaattct
     2401 agtgtccata aataaagttt cagcggaaca cagccgtgct tatgtgcgta tgtattgtct
     2461 gactgctttt gcaaaacggc agagttcaat agttgcacct gaaaccattt gacttgacaa
     2521 gccaaaacta ttttctggcc ctctgcagaa agggtttgct gacctctgat ttagactagc
     2581 atctaacatt gatttgccca catattgaaa gggtcagtgg agttttcatt tattattttt
     2641 tatttttttg agattgagtt ccaggctgga gtgcaatagc gcaatcttgg ctcaccgcaa
     2701 cctccgcctc ccaggttcaa gcgattgtcc tgcctcagcc tccccagtag ctaggattac
     2761 aggcatgcac caccacgcct ggctaatttt gtattttcag tagagacgcg gtttctccat
     2821 gttggtcatg gctggtctcg cactcccgac ctcaggtgat ccacctgcct cagccttcca
     2881 aagtgctggg attacaggtg tgagccaccg tgcccggctg gagttttcat tttttttttt
     2941 tttttttttt ctgagatgga gtctcactct gtctccaggc tagagtgcag tggcccagtc
     3001 ttggctcact gcaacctctg cctctcgggt tcaagcgatt ctcttgcctc agcctcccga
     3061 gtagctggga ctacaggtgc gtgccaccat gcccagctaa tttttgtatt tttagtagag
     3121 atgggttttc accatgttgg ccagtatggt ctcgagctct tgaccatgat ccgcccacct
     3181 cggcctccca cagtgctggg attacaggcg tgagccaccg tgcgctgagt gatacgtggt
     3241 tccctttaac ttcgcacatg gtaaaatcag tttctttcca tgatctgttt cacagtctct
     3301 gtgaagctac ctaccacaaa gaagtagtga gtgatgactt tctagaatct aagtatatgg
     3361 catgtattta ttataagtaa aacattaagt ttgctgattg tttacttgtg ataaacaatt
     3421 attgtgaact ttatttgtgc tggacataag tgtctgtttt acagtgaaat tccattatag
     3481 agggttactt ggtagagaaa tgcaaattgt agttggtcat atactaaaat ttgaactttt
     3541 tacatatcaa tacttacaaa taggtgttta ttttcccaca aaactccaga acatttaaga
     3601 gtctcgggtg tttaaatttg atgagattta cccaaacaaa tagtgaacaa aaggtttatg
     3661 aaaataagtt atgaaactaa aatacttaat aaacatccag tgacaataaa aatagcttga
     3721 gtctttgctt atataaaatt tcatgctaat ttttcacttc tatattaatt ggaggtaata
     3781 atgcaaatta agttatagaa atgaagattc aatgaaatgc agttgctcat cctggatttc
     3841 ttcatattca gttttggtgt agacaactgg tgaagagaga tggctcagag gccaagcctt
     3901 gcaatctagg agcccagccc tgtcctttaa gggcttgatc ttgaataaat tgcttaacag
     3961 ttggtctata gttctacact tttaaagtat gtttcacaga gggtggttcc aataaataaa
     4021 tgcactggca tattcaaatg ttggataatt tttctctagc tttcttcaag tttctcataa
     4081 ggacaggtgg gtagccactt attctttaaa aaaaaataga tacaatacag agtcgtgttg
     4141 gactggcagt cttaaatcac tcttgttatt tccagtggac attaaaaaaa aatcacagat
     4201 aagtacttaa aacactcaag atttgggatt tagatcatga ttagatacaa tagaaagatc
     4261 ctggaatccc gacatgagga caaaaatggt actgaattct ttttgaaaaa tagattactg
     4321 aaaagcgatc taatatagaa cagttgcttt tacttagatg ttcaatgcat atttgttgta
     4381 taataaccaa gttattacag ttcagataaa gggtccaaag tgttttcgtt atgatataat
     4441 actttctatt gtaaactgga ctaaagaaac gttgtatgtt caaggaagtg ttgagcagcc
     4501 atggtgttcc tgggacaggc tccccaggtg ctgagagagg tgctgcagga gtcacagacc
     4561 tgcaggcacg cacttgccag tgactgggac gttggctggt ggttctcttt tggtgtgatt
     4621 agagctatgt gagttgtctc aatacttgag actgtcggtg gttgccaatg ctgaataaag
     4681 catttatcaa agtaaaa
//
