LOCUS       NM_001040694            4114 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens inner centromere protein (INCENP), transcript variant
            1, mRNA.
ACCESSION   NM_001040694
VERSION     NM_001040694.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Redouane,S., Charoute,H., Harmak,H., Malki,A., Barakat,A. and
            Rouba,H.
  TITLE     Computational study of the potential impact of AURKC missense SNPs
            on AURKC-INCENP interaction and their correlation to
            macrozoospermia
  JOURNAL   J Biomol Struct Dyn 41 (19), 9503-9522 (2023)
   PUBMED   36326488
  REMARK    GeneRIF: Computational study of the potential impact of AURKC
            missense SNPs on AURKC-INCENP interaction and their correlation to
            macrozoospermia.
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   Ibrahim,A., Miligy,I.M., Toss,M.S., Green,A.R. and Rakha,E.A.
  TITLE     High Inner Centromere Protein Expression Correlates with Aggressive
            Features and Predicts Poor Prognosis in Patients with Invasive
            Breast Cancer
  JOURNAL   Pathobiology 90 (6), 377-388 (2023)
   PUBMED   37031675
  REMARK    GeneRIF: High Inner Centromere Protein Expression Correlates with
            Aggressive Features and Predicts Poor Prognosis in Patients with
            Invasive Breast Cancer.
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4114)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4114)
  AUTHORS   Petsalaki,E. and Zachos,G.
  TITLE     An ATM-Chk2-INCENP pathway activates the abscission checkpoint
  JOURNAL   J Cell Biol 220 (2) (2021)
   PUBMED   33355621
  REMARK    GeneRIF: An ATM-Chk2-INCENP pathway activates the abscission
            checkpoint.
REFERENCE   6  (bases 1 to 4114)
  AUTHORS   Ainsztein,A.M., Kandels-Lewis,S.E., Mackay,A.M. and Earnshaw,W.C.
  TITLE     INCENP centromere and spindle targeting: identification of
            essential conserved motifs and involvement of heterochromatin
            protein HP1
  JOURNAL   J Cell Biol 143 (7), 1763-1774 (1998)
   PUBMED   9864353
REFERENCE   7  (bases 1 to 4114)
  AUTHORS   Li,F., Ambrosini,G., Chu,E.Y., Plescia,J., Tognin,S.,
            Marchisio,P.C. and Altieri,D.C.
  TITLE     Control of apoptosis and mitotic spindle checkpoint by survivin
  JOURNAL   Nature 396 (6711), 580-584 (1998)
   PUBMED   9859993
REFERENCE   8  (bases 1 to 4114)
  AUTHORS   Martineau-Thuillier,S., Andreassen,P.R. and Margolis,R.L.
  TITLE     Colocalization of TD-60 and INCENP throughout G2 and mitosis:
            evidence for their possible interaction in signalling cytokinesis
  JOURNAL   Chromosoma 107 (6-7), 461-470 (1998)
   PUBMED   9914378
REFERENCE   9  (bases 1 to 4114)
  AUTHORS   Earnshaw,W.C. and Mackay,A.M.
  TITLE     Role of nonhistone proteins in the chromosomal events of mitosis
  JOURNAL   FASEB J 8 (12), 947-956 (1994)
   PUBMED   8088460
  REMARK    Review article
REFERENCE   10 (bases 1 to 4114)
  AUTHORS   Earnshaw,W.C. and Cooke,C.A.
  TITLE     Analysis of the distribution of the INCENPs throughout mitosis
            reveals the existence of a pathway of structural changes in the
            chromosomes during metaphase and early events in cleavage furrow
            formation
  JOURNAL   J Cell Sci 98 (Pt 4), 443-461 (1991)
   PUBMED   1860899
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098576.1, CV569756.1, AW839685.1, BC111732.1 and AP002793.4.
            
            On Nov 22, 2018 this sequence version replaced NM_001040694.1.
            
            Summary: In mammalian cells, 2 broad groups of
            centromere-interacting proteins have been described: constitutively
            binding centromere proteins and 'passenger,' or transiently
            interacting, proteins (reviewed by Choo, 1997). The constitutive
            proteins include CENPA (centromere protein A; MIM 117139), CENPB
            (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term
            'passenger proteins' encompasses a broad collection of proteins
            that localize to the centromere during specific stages of the cell
            cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include
            CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213);
            cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838);
            and CENPF/mitosin (MIM 600236). The inner centromere proteins
            (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial
            members of the passenger protein group, display a broad
            localization along chromosomes in the early stages of mitosis but
            gradually become concentrated at centromeres as the cell cycle
            progresses into mid-metaphase. During telophase, the proteins are
            located within the midbody in the intercellular bridge, where they
            are discarded after cytokinesis (Cutts et al., 1999 [PubMed
            10369859]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394818.8/ ENSP00000378295.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               BC098576.1         39-309
            272-674             CV569756.1         221-623
            675-1351            BC098576.1         713-1389
            1352-1370           AW839685.1         75-93
            1371-2095           BC098576.1         1409-2133
            2096-2686           BC111732.1         1924-2514
            2687-2987           BC098576.1         2725-3025
            2988-4108           AP002793.4         72493-73613
            4109-4114           AP002793.4         73614-73619
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..4114
                     /gene="INCENP"
                     /note="inner centromere protein"
                     /db_xref="GeneID:3619"
                     /db_xref="HGNC:HGNC:6058"
                     /db_xref="MIM:604411"
     exon            1..153
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            154..304
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2921
                     /gene="INCENP"
                     /note="isoform 1 is encoded by transcript variant 1; inner
                     centromere protein INCENP; binds and activates aurora-B
                     and -C in vivo and in vitro; chromosomal passenger
                     protein; inner centromere protein antigens 135/155kDa"
                     /codon_start=1
                     /product="inner centromere protein isoform 1"
                     /protein_id="NP_001035784.1"
                     /db_xref="CCDS:CCDS44624.1"
                     /db_xref="GeneID:3619"
                     /db_xref="HGNC:HGNC:6058"
                     /db_xref="MIM:604411"
                     /translation="MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERM
                     FTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLR
                     SKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNH
                     TQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEES
                     TPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSP
                     WRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRR
                     ASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEV
                     PENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRK
                     RSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTP
                     TSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRR
                     LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAK
                     KKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK
                     RLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER
                     EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQS
                     PACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAII
                     HQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQGARVPSSLAYS
                     LKKH"
     exon            305..418
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            419..1227
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1279
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1337
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1455
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1507
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1625
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1757
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1769
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1879
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2000
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2123
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2368
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2447
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2555
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2706
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..4114
                     /gene="INCENP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3252..3257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INCENP"
                     /note="hexamer: AATAAA"
     polyA_site      3271
                     /gene="INCENP"
                     /note="major polyA site"
     regulatory      3775..3780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INCENP"
                     /note="hexamer: ATTAAA"
     polyA_site      3798
                     /gene="INCENP"
     regulatory      4082..4087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INCENP"
                     /note="hexamer: AATAAA"
     polyA_site      4114
                     /gene="INCENP"
ORIGIN      
        1 atagttttcg cccgcgctgc gccgcctggt tgctcctccc gtgcggtgag tcccgaaggc
       61 ccggagccaa gtgggtctgg gcaagcgggg ccttacctag ggataccacc ggacttggat
      121 cggagcagcc ttcaggggac gtggcgcagt cgaacagagc caccatgggg acgacggccc
      181 cagggcccat tcacctgctg gagctatgtg accagaagct catggagttt ctctgcaaca
      241 tggataataa ggacttggtg tggcttgagg aaatccaaga ggaggccgag cgcatgttca
      301 ccagagaatt cagcaaagag ccagagctga tgcccaaaac accttctcag aagaaccgac
      361 ggaagaagag acggatttct tatgttcagg atgaaaacag agatcccatc aggagaaggt
      421 tatcccgcag aaagtctcgg agcagccagc tgagctcccg acgcctccgc agcaaggaca
      481 gtgtagagaa gctggctaca gtggtcgggg agaacggctc cgtcctgcgg cgtgtgaccc
      541 gtgctgcggc tgcagctgcc gcggctacca tggcattggc tgcaccttct tcacccaccc
      601 ctgagtctcc cacgatgctg actaagaagc ccgaggataa ccacacccag tgccagctgg
      661 tgcctgtggt ggagatcggc atcagtgagc gccagaatgc tgagcagcat gtcacccagc
      721 tcatgtccac cgagcctctg ccccgcactc tgtccccgac tccagcttca gccacagctc
      781 caacctccca gggcatcccg acatcagatg aggaatcaac acctaagaag tcgaaggcca
      841 ggatactgga gtccatcaca gtgagctccc tgatggctac accccaggac cccaagggtc
      901 aaggggtcgg gacggggcgg tctgcgtcta agctcaggat tgcgcaggtc tcccctggcc
      961 cacgggactc gccagccttt ccagattctc catggcggga gcgggtgctg gctcccatcc
     1021 tgccggataa cttctccacg cccacgggct ctcgcacgga ctctcaatcg gtgcggcaca
     1081 gcccgatcgc cccgtcttcc ccgagtcccc aagtcttagc ccagaagtac tctctggtgg
     1141 ccaaacagga aagtgttgtc cgcagggcga gcagaaggct tgccaagaag actgccgaag
     1201 agccagctgc ctctggccgc atcatctgtc acagttacct ggagaggctc ctgaatgttg
     1261 aggtgcccca gaaagttggt tctgagcaga aggaaccccc cgaggaggct gagcctgtgg
     1321 cggcagctga gccagaggtc cctgagaaca atggaaataa ctcgtggccc cacaatgaca
     1381 cggagattgc caacagcaca cccaacccga agcctgcagc cagcagcccg gaaacaccct
     1441 ctgcagggca gcaagaggcc aagacggacc aagcagatgg acccagagag ccaccgcaga
     1501 gtgccaggag gaagcgcagc tacaagcagg ccgtgagtga gctggacgag gagcagcacc
     1561 tggaggatga ggagctgcag ccccccagga gcaagacccc ttcctcaccc tgcccagcca
     1621 gcaaggtggt acggcccctc cggacctttc tgcacacagt gcagaggaac cagatgctca
     1681 tgaccccgac ctcagcccca cgcagcgtca tgaagtcctt tattaagcgc aacactcccc
     1741 tgcgcatgga ccccaagtgc agcttcgtcg agaaggagcg gcagcgcctg gagaatctgc
     1801 ggcggaagga ggaggccgag cagctgcgca ggcagaaggt ggaggaggac aagcggcggc
     1861 ggctggagga ggtgaagctg aagcgtgagg aacgcctccg caaggtgctg caggcccgcg
     1921 agcgggtgga gcagatgaag gaggagaaga agaagcagat tgagcagaag tttgctcaga
     1981 tcgacgagaa gactgagaag gccaaggagg agcggctggc agaggagaag gccaagaaaa
     2041 aggcggcggc caagaagatg gaggaggtgg aagcacgcag gaagcaggaa gaggaggcac
     2101 gtaggctcag gtggctgcag caggaggagg aagagcggcg gcaccaagag ctgctgcaga
     2161 agaagaagga agaggagcag gagcggctgc ggaaggcggc cgaggctaag cggctggcag
     2221 agcagcggga gcaggagcgg cgggagcagg agcggcgcga gcaggagcgg cgcgagcagg
     2281 agcggcggga gcaggagcgg cgcgagcagg agcgacagct ggcagagcag gagcgtcggc
     2341 gggagcagga gcggctccag gccgagaggg agctgcagga gcgggagaag gccctgcggc
     2401 tgcagaagga gcagctgcag agggaactgg aggagaagaa gaagaaggaa gagcagcagc
     2461 gtctggctga gcggcagctg caggaggagc aagagaagaa agccaaggag gcagcagggg
     2521 ccagcaaggc cctgaatgtg actgtggacg tgcagtctcc agcttgtacc tcatatcaga
     2581 tgactccgca agggcacagg gcccctccca agatcaaccc agataactac gggatggatc
     2641 tgaatagcga cgactccacc gatgatgagg cccatccccg gaagcccatc cccacctggg
     2701 cccgaggcac cccgctcagc caggctatca ttcaccagta ctaccaccca ccgaaccttc
     2761 tggagctctt tggaaccatt ctcccactgg acttggagga tatcttcaag aagagcaagc
     2821 cccgctatca caagcgcacc agctctgctg tctggaactc accgcccctg cagggcgcca
     2881 gggtccccag cagcctggcc tacagcctga agaagcactg aggctggcct gcggccttct
     2941 tggcagcctc gcctcctgtc catgtctatc tgtctgtctg tcggtctctg tcttggtctg
     3001 ttgccctcct tcttggcatg ccattgtgga gggcttggcc aggtgtatat aaacgtcctc
     3061 tgtgctgggt gtttctgctg caggtggcag gtggccccag gcctgtttgg aggatgggct
     3121 gggtgggtgg gtggggaaga aatgggccca gccccacatg gcctgcagac agtgctctgt
     3181 aaatagttgt tttaatttag ctgaatgtta gcattttagt ctttggcatt ttagcgtttg
     3241 ggaggtagat taataaagta tattccttca agcctgctgt tgataccatg aagactgggc
     3301 gcctcagtcc cagccctgta gctgtgtgtc ttgggccacc agtggcctgc aggacgaagg
     3361 tactgttcca tcacctgcgg tgtgcctcag gatcaccagg tgcaggcccc caccctcgga
     3421 gatgctgctg cagtgagtgg ttccactgcc tggataaccc ttgaggaaca cgtcagttac
     3481 tgtcacgatg gggcaggtgg agctccttcc tattttttgg ggtgctccct gtttgtaaag
     3541 gggagtttgt tcattgggaa agacctgggt cttgacacgg ccctgccact tagtccccta
     3601 ccctctccat tccccaggct ccacccgtgc tgctcaggtg caaatggact tgagagcatc
     3661 tatgtgctgg tgaagcatga ggtctgagta gaaaaggggt atcccttgag accaccttgg
     3721 gaccagtgct tgcaagcagc gagatatttc cccagcaaaa ccaggcagct gctaattaaa
     3781 tgcttagaac caatgaaagc tggctgtggt cctgcctgtg agctgcctac tgctgccttc
     3841 tgaatgcata tatctgctac tgtagccccg ggttgtcaaa ctatggcctg tgggccaaat
     3901 ccagccacag tcggttcttt aaagttttat cgaaacacaa gcaatggaaa tgcccatttc
     3961 cattgttgtc tccagttgct ctgctccgag ggcagtgtta agttgtgcag cagaggcccc
     4021 tccatgcaaa gctgaatatg tttactattt gaactttttc agaagttctg cttaaggaca
     4081 aaataaagcc taaatccaag aacactttta aaaa
//
