LOCUS       NM_001394789            1051 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens inhibitor of CDK, cyclin A1 interacting protein 1
            (INCA1), transcript variant 6, mRNA.
ACCESSION   NM_001394789 XM_005256627
VERSION     NM_001394789.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1051)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1051)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1051)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1051)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 1051)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 1051)
  AUTHORS   Baumer,N., Tickenbrock,L., Tschanter,P., Lohmeyer,L.,
            Diederichs,S., Baumer,S., Skryabin,B.V., Zhang,F.,
            Agrawal-Singh,S., Kohler,G., Berdel,W.E., Serve,H., Koschmieder,S.
            and Muller-Tidow,C.
  TITLE     Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin
            A1 (INCA1) regulates proliferation and is repressed by oncogenic
            signaling
  JOURNAL   J Biol Chem 286 (32), 28210-28222 (2011)
   PUBMED   21540187
  REMARK    GeneRIF: Inhibitor of cyclin-dependent kinase (CDK) interacting
            with cyclin A1 (INCA1) regulates proliferation and is repressed by
            oncogenic signaling
REFERENCE   7  (bases 1 to 1051)
  AUTHORS   Chen,X., Hu,T., Liang,G., Yang,M., Zong,S., Miao,S., Koide,S.S. and
            Wang,L.
  TITLE     A novel testis protein, RSB-66, interacting with INCA1 (inhibitor
            of Cdk interacting with cyclin A1)
  JOURNAL   Biochem Cell Biol 86 (4), 345-351 (2008)
   PUBMED   18756329
REFERENCE   8  (bases 1 to 1051)
  AUTHORS   Kang,S., Li,H., Rao,A. and Hogan,P.G.
  TITLE     Inhibition of the calcineurin-NFAT interaction by small organic
            molecules reflects binding at an allosteric site
  JOURNAL   J Biol Chem 280 (45), 37698-37706 (2005)
   PUBMED   16148011
REFERENCE   9  (bases 1 to 1051)
  AUTHORS   Diederichs,S., Baumer,N., Schultz,N., Hamra,F.K., Schrader,M.G.,
            Sandstede,M.L., Berdel,W.E., Serve,H. and Muller-Tidow,C.
  TITLE     Expression patterns of mitotic and meiotic cell cycle regulators in
            testicular cancer and development
  JOURNAL   Int J Cancer 116 (2), 207-217 (2005)
   PUBMED   15800920
REFERENCE   10 (bases 1 to 1051)
  AUTHORS   Diederichs,S., Baumer,N., Ji,P., Metzelder,S.K., Idos,G.E.,
            Cauvet,T., Wang,W., Moller,M., Pierschalski,S., Gromoll,J.,
            Schrader,M.G., Koeffler,H.P., Berdel,W.E., Serve,H. and
            Muller-Tidow,C.
  TITLE     Identification of interaction partners and substrates of the cyclin
            A1-CDK2 complex
  JOURNAL   J Biol Chem 279 (32), 33727-33741 (2004)
   PUBMED   15159402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004771.1.
            
            On May 5, 2021 this sequence version replaced XM_005256627.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3893038.1,
                                           SRR5189652.50734.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695324.1/ ENSP00000511805.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC004771.1         67158-67184         c
            28-109              AC004771.1         64056-64137         c
            110-223             AC004771.1         59814-59927         c
            224-263             AC004771.1         59552-59591         c
            264-460             AC004771.1         59090-59286         c
            461-626             AC004771.1         58441-58606         c
            627-1051            AC004771.1         57792-58216         c
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1051
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /note="inhibitor of CDK, cyclin A1 interacting protein 1"
                     /db_xref="GeneID:388324"
                     /db_xref="HGNC:HGNC:32224"
                     /db_xref="MIM:617374"
     exon            1..27
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /inference="alignment:Splign:2.1.0"
     exon            28..109
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..776
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /note="isoform 1 is encoded by transcript variant 6;
                     protein INCA1"
                     /codon_start=1
                     /product="protein INCA1 isoform 1"
                     /protein_id="NP_001381718.1"
                     /db_xref="CCDS:CCDS54074.1"
                     /db_xref="GeneID:388324"
                     /db_xref="HGNC:HGNC:32224"
                     /db_xref="MIM:617374"
                     /translation="MQVQDDGVNLIPFAKCSRVVSRSPPPRLPSQSLRPMPQRYGDVF
                     WKNLNQRPTPTWLEEQHIPPMLRATGCSQLGLYPPEQLPPPEMLWRRKKRRPCLEGMQ
                     QQGLGGVPARVRAVTYHLEDLRRRQSIINELKKAQWGSSGAASEPVVLGEEGCGFPST
                     NEYPDLEEERATYPQEEDRFLTPGRAQLLWSPWSPLDQEEACASRQLHSLASFSTVTA
                     RRNPLHNPWGMELAASEE"
     exon            110..223
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /inference="alignment:Splign:2.1.0"
     exon            224..263
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /inference="alignment:Splign:2.1.0"
     exon            264..460
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /inference="alignment:Splign:2.1.0"
     exon            461..626
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /inference="alignment:Splign:2.1.0"
     exon            627..1051
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1031..1036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /note="hexamer: ATTAAA"
     polyA_site      1051
                     /gene="INCA1"
                     /gene_synonym="HSD45"
                     /note="major polyA site"
ORIGIN      
        1 ctagaattcg ccgcgcagct gcttcagcac caaaaaggag actaactacc cagccccgtc
       61 cagtcatgca ggtgcaggat gatggagtca acctcatccc ctttgccaag tgttccaggg
      121 tggtcagccg atctccaccc ccaaggttgc cttcccagag cctcagaccc atgccccagc
      181 gttatggaga tgtcttctgg aagaacctta atcaaaggcc cacccccact tggctggagg
      241 agcagcacat tccacccatg ctgagagcca ctggttgctc ccagcttggt ctgtatcctc
      301 ctgagcagct cccaccccct gaaatgcttt ggagaagaaa gaagaggagg ccatgtttgg
      361 aaggaatgca gcagcagggc cttgggggag tccccgcccg ggtgagggct gtcacttacc
      421 acctggagga cctaagaagg cgtcagagca tcatcaacga actgaagaag gcccagtggg
      481 gcagctctgg ggctgcatct gagccagtgg tgcttggcga agagggctgt ggattcccca
      541 gcaccaatga ataccctgat ctggaagagg agagagcaac ctatccacag gaagaggacc
      601 gttttctcac tcctggcagg gcccagctgc tttggtctcc ctggagcccc ctggatcagg
      661 aggaggcttg tgcctccagg cagctgcact ctctggcctc gttcagcact gtcacagcca
      721 gaaggaaccc ccttcacaat ccctggggga tggagttggc agcgtctgaa gagtaaggag
      781 aaaccaccga tgccgagagg ctagtggtgc cccagggacc caagactagt tccgtcacta
      841 gagtcaccct cattgctgac atgaaggcgt ttccccttcc ttcgtctctc caactgcctt
      901 tcccatcctc tgaactaggc attaacagcc cccgtgggct cccatctcaa cccaccgctc
      961 tcacaggagc accccaagtc ctgttttcct ccaggccccg ctcctggcct tgtattctct
     1021 ctgctctgtt attaaaaagc aagcaagtgg a
//
