LOCUS       NM_001142569            4132 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens innate immunity activator (INAVA), transcript variant
            2, mRNA.
ACCESSION   NM_001142569
VERSION     NM_001142569.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4132)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4132)
  AUTHORS   Chang,D., Luong,P., Li,Q., LeBarron,J., Anderson,M., Barrett,L. and
            Lencer,W.I.
  TITLE     Small-molecule modulators of INAVA cytosolic condensate and
            cell-cell junction assemblies
  JOURNAL   J Cell Biol 220 (9) (2021)
   PUBMED   34251416
  REMARK    GeneRIF: Small-molecule modulators of INAVA cytosolic condensate
            and cell-cell junction assemblies.
REFERENCE   3  (bases 1 to 4132)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4132)
  AUTHORS   Luong,P., Hedl,M., Yan,J., Zuo,T., Fu,T.M., Jiang,X.,
            Thiagarajah,J.R., Hansen,S.H., Lesser,C.F., Wu,H., Abraham,C. and
            Lencer,W.I.
  TITLE     INAVA-ARNO complexes bridge mucosal barrier function with
            inflammatory signaling
  JOURNAL   Elife 7, e38539 (2018)
   PUBMED   30355448
  REMARK    GeneRIF: INAVA-CUPID exhibits dual functions, coordinated directly
            by ARNO, that bridge epithelial barrier function with extracellular
            signals and inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4132)
  AUTHORS   Manzanillo,P., Mouchess,M., Ota,N., Dai,B., Ichikawa,R., Wuster,A.,
            Haley,B., Alvarado,G., Kwon,Y., Caothien,R., Roose-Girma,M.,
            Warming,S., McKenzie,B.S., Keir,M.E., Scherl,A., Ouyang,W. and
            Yi,T.
  TITLE     Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates
            Intestinal Epithelial Permeability
  JOURNAL   Immunohorizons 2 (5), 164-171 (2018)
   PUBMED   31022698
  REMARK    GeneRIF: Study identifies C1ORF106 as an epithelial cell junction
            protein, and the loss of C1ORF106 augments TNF-alpha-induced
            intestinal epithelial leakage and diarrhea that may play a critical
            role in the development of inflammatory bowel disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4132)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   7  (bases 1 to 4132)
  AUTHORS   Sawcer,S., Hellenthal,G., Pirinen,M., Spencer,C.C.,
            Patsopoulos,N.A., Moutsianas,L., Dilthey,A., Su,Z., Freeman,C.,
            Hunt,S.E., Edkins,S., Gray,E., Booth,D.R., Potter,S.C., Goris,A.,
            Band,G., Oturai,A.B., Strange,A., Saarela,J., Bellenguez,C.,
            Fontaine,B., Gillman,M., Hemmer,B., Gwilliam,R., Zipp,F.,
            Jayakumar,A., Martin,R., Leslie,S., Hawkins,S., Giannoulatou,E.,
            D'alfonso,S., Blackburn,H., Martinelli Boneschi,F., Liddle,J.,
            Harbo,H.F., Perez,M.L., Spurkland,A., Waller,M.J., Mycko,M.P.,
            Ricketts,M., Comabella,M., Hammond,N., Kockum,I., McCann,O.T.,
            Ban,M., Whittaker,P., Kemppinen,A., Weston,P., Hawkins,C.,
            Widaa,S., Zajicek,J., Dronov,S., Robertson,N., Bumpstead,S.J.,
            Barcellos,L.F., Ravindrarajah,R., Abraham,R., Alfredsson,L.,
            Ardlie,K., Aubin,C., Baker,A., Baker,K., Baranzini,S.E.,
            Bergamaschi,L., Bergamaschi,R., Bernstein,A., Berthele,A.,
            Boggild,M., Bradfield,J.P., Brassat,D., Broadley,S.A., Buck,D.,
            Butzkueven,H., Capra,R., Carroll,W.M., Cavalla,P., Celius,E.G.,
            Cepok,S., Chiavacci,R., Clerget-Darpoux,F., Clysters,K., Comi,G.,
            Cossburn,M., Cournu-Rebeix,I., Cox,M.B., Cozen,W., Cree,B.A.,
            Cross,A.H., Cusi,D., Daly,M.J., Davis,E., de Bakker,P.I.,
            Debouverie,M., D'hooghe,M.B., Dixon,K., Dobosi,R., Dubois,B.,
            Ellinghaus,D., Elovaara,I., Esposito,F., Fontenille,C., Foote,S.,
            Franke,A., Galimberti,D., Ghezzi,A., Glessner,J., Gomez,R.,
            Gout,O., Graham,C., Grant,S.F., Guerini,F.R., Hakonarson,H.,
            Hall,P., Hamsten,A., Hartung,H.P., Heard,R.N., Heath,S., Hobart,J.,
            Hoshi,M., Infante-Duarte,C., Ingram,G., Ingram,W., Islam,T.,
            Jagodic,M., Kabesch,M., Kermode,A.G., Kilpatrick,T.J., Kim,C.,
            Klopp,N., Koivisto,K., Larsson,M., Lathrop,M., Lechner-Scott,J.S.,
            Leone,M.A., Leppa,V., Liljedahl,U., Bomfim,I.L., Lincoln,R.R.,
            Link,J., Liu,J., Lorentzen,A.R., Lupoli,S., Macciardi,F., Mack,T.,
            Marriott,M., Martinelli,V., Mason,D., McCauley,J.L., Mentch,F.,
            Mero,I.L., Mihalova,T., Montalban,X., Mottershead,J., Myhr,K.M.,
            Naldi,P., Ollier,W., Page,A., Palotie,A., Pelletier,J., Piccio,L.,
            Pickersgill,T., Piehl,F., Pobywajlo,S., Quach,H.L., Ramsay,P.P.,
            Reunanen,M., Reynolds,R., Rioux,J.D., Rodegher,M., Roesner,S.,
            Rubio,J.P., Ruckert,I.M., Salvetti,M., Salvi,E., Santaniello,A.,
            Schaefer,C.A., Schreiber,S., Schulze,C., Scott,R.J., Sellebjerg,F.,
            Selmaj,K.W., Sexton,D., Shen,L., Simms-Acuna,B., Skidmore,S.,
            Sleiman,P.M., Smestad,C., Sorensen,P.S., Sondergaard,H.B.,
            Stankovich,J., Strange,R.C., Sulonen,A.M., Sundqvist,E.,
            Syvanen,A.C., Taddeo,F., Taylor,B., Blackwell,J.M., Tienari,P.,
            Bramon,E., Tourbah,A., Brown,M.A., Tronczynska,E., Casas,J.P.,
            Tubridy,N., Corvin,A., Vickery,J., Jankowski,J., Villoslada,P.,
            Markus,H.S., Wang,K., Mathew,C.G., Wason,J., Palmer,C.N.,
            Wichmann,H.E., Plomin,R., Willoughby,E., Rautanen,A.,
            Winkelmann,J., Wittig,M., Trembath,R.C., Yaouanq,J.,
            Viswanathan,A.C., Zhang,H., Wood,N.W., Zuvich,R., Deloukas,P.,
            Langford,C., Duncanson,A., Oksenberg,J.R., Pericak-Vance,M.A.,
            Haines,J.L., Olsson,T., Hillert,J., Ivinson,A.J., De Jager,P.L.,
            Peltonen,L., Stewart,G.J., Hafler,D.A., Hauser,S.L., McVean,G.,
            Donnelly,P. and Compston,A.
  CONSRTM   International Multiple Sclerosis Genetics Consortium; Wellcome
            Trust Case Control Consortium 2
  TITLE     Genetic risk and a primary role for cell-mediated immune mechanisms
            in multiple sclerosis
  JOURNAL   Nature 476 (7359), 214-219 (2011)
   PUBMED   21833088
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4132)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   9  (bases 1 to 4132)
  AUTHORS   Franke,A., McGovern,D.P., Barrett,J.C., Wang,K.,
            Radford-Smith,G.L., Ahmad,T., Lees,C.W., Balschun,T., Lee,J.,
            Roberts,R., Anderson,C.A., Bis,J.C., Bumpstead,S., Ellinghaus,D.,
            Festen,E.M., Georges,M., Green,T., Haritunians,T., Jostins,L.,
            Latiano,A., Mathew,C.G., Montgomery,G.W., Prescott,N.J.,
            Raychaudhuri,S., Rotter,J.I., Schumm,P., Sharma,Y., Simms,L.A.,
            Taylor,K.D., Whiteman,D., Wijmenga,C., Baldassano,R.N., Barclay,M.,
            Bayless,T.M., Brand,S., Buning,C., Cohen,A., Colombel,J.F.,
            Cottone,M., Stronati,L., Denson,T., De Vos,M., D'Inca,R.,
            Dubinsky,M., Edwards,C., Florin,T., Franchimont,D., Gearry,R.,
            Glas,J., Van Gossum,A., Guthery,S.L., Halfvarson,J.,
            Verspaget,H.W., Hugot,J.P., Karban,A., Laukens,D., Lawrance,I.,
            Lemann,M., Levine,A., Libioulle,C., Louis,E., Mowat,C., Newman,W.,
            Panes,J., Phillips,A., Proctor,D.D., Regueiro,M., Russell,R.,
            Rutgeerts,P., Sanderson,J., Sans,M., Seibold,F., Steinhart,A.H.,
            Stokkers,P.C., Torkvist,L., Kullak-Ublick,G., Wilson,D.,
            Walters,T., Targan,S.R., Brant,S.R., Rioux,J.D., D'Amato,M.,
            Weersma,R.K., Kugathasan,S., Griffiths,A.M., Mansfield,J.C.,
            Vermeire,S., Duerr,R.H., Silverberg,M.S., Satsangi,J.,
            Schreiber,S., Cho,J.H., Annese,V., Hakonarson,H., Daly,M.J. and
            Parkes,M.
  TITLE     Genome-wide meta-analysis increases to 71 the number of confirmed
            Crohn's disease susceptibility loci
  JOURNAL   Nat Genet 42 (12), 1118-1125 (2010)
   PUBMED   21102463
REFERENCE   10 (bases 1 to 4132)
  AUTHORS   Barrett,J.C., Lee,J.C., Lees,C.W., Prescott,N.J., Anderson,C.A.,
            Phillips,A., Wesley,E., Parnell,K., Zhang,H., Drummond,H.,
            Nimmo,E.R., Massey,D., Blaszczyk,K., Elliott,T., Cotterill,L.,
            Dallal,H., Lobo,A.J., Mowat,C., Sanderson,J.D., Jewell,D.P.,
            Newman,W.G., Edwards,C., Ahmad,T., Mansfield,J.C., Satsangi,J.,
            Parkes,M., Mathew,C.G., Donnelly,P., Peltonen,L., Blackwell,J.M.,
            Bramon,E., Brown,M.A., Casas,J.P., Corvin,A., Craddock,N.,
            Deloukas,P., Duncanson,A., Jankowski,J., Markus,H.S., Mathew,C.G.,
            McCarthy,M.I., Palmer,C.N., Plomin,R., Rautanen,A., Sawcer,S.J.,
            Samani,N., Trembath,R.C., Viswanathan,A.C., Wood,N., Spencer,C.C.,
            Barrett,J.C., Bellenguez,C., Davison,D., Freeman,C., Strange,A.,
            Donnelly,P., Langford,C., Hunt,S.E., Edkins,S., Gwilliam,R.,
            Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M., Gray,E.,
            Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J., Perez,M.L.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M., Waller,M., Weston,P.,
            Widaa,S., Whittaker,P., Deloukas,P., Peltonen,L., Mathew,C.G.,
            Blackwell,J.M., Brown,M.A., Corvin,A., McCarthy,M.I., Spencer,C.C.,
            Attwood,A.P., Stephens,J., Sambrook,J., Ouwehand,W.H.,
            McArdle,W.L., Ring,S.M. and Strachan,D.P.
  CONSRTM   UK IBD Genetics Consortium; Wellcome Trust Case Control Consortium
            2
  TITLE     Genome-wide association study of ulcerative colitis identifies
            three new susceptibility loci, including the HNF4A region
  JOURNAL   Nat Genet 41 (12), 1330-1334 (2009)
   PUBMED   19915572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK316510.1, AK303885.1, AK001583.1 and AC099756.2.
            
            On Nov 20, 2018 this sequence version replaced NM_001142569.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1732796.1,
                                           SRR7346977.1790751.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413687.3/ ENSP00000392105.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-605               AK316510.1         80-684
            606-1638            AK303885.1         586-1618
            1639-4123           AK001583.1         299-2783
            4124-4132           AC099756.2         97855-97863
FEATURES             Location/Qualifiers
     source          1..4132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..4132
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /note="innate immunity activator"
                     /db_xref="GeneID:55765"
                     /db_xref="HGNC:HGNC:25599"
                     /db_xref="MIM:618051"
     exon            1..188
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            189..337
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..2019
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C1orf106; innate immunity
                     activator protein"
                     /codon_start=1
                     /product="innate immunity activator protein isoform 2"
                     /protein_id="NP_001136041.1"
                     /db_xref="CCDS:CCDS44292.1"
                     /db_xref="GeneID:55765"
                     /db_xref="HGNC:HGNC:25599"
                     /db_xref="MIM:618051"
                     /translation="MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEAR
                     LEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPL
                     SSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRN
                     SEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEG
                     LQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASS
                     LWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRS
                     AFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDVSSISHPTSPGSSSPDI
                     SFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAGRYVVVAESPLPPGEW
                     ELRRAAPGPAYEEEGTPLRYQRLVPSRSRIVRTPSLKDSPAGRGLSKAAVSEELKWWH
                     ERARLRSTRPHSLDRQGAFRVRSLPLGREGFGRALGPRAQVPTVCVLRRSPDGAPVQV
                     FVPEKGEIISQV"
     exon            338..462
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            463..579
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            580..802
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            803..856
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1067
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1241
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1926
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..4132
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4098..4103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /note="hexamer: AATAAA"
     polyA_site      4132
                     /gene="INAVA"
                     /gene_synonym="C1orf106"
                     /note="major polyA site"
ORIGIN      
        1 ggcagcctgg gagggacggc aaggtaggca ggtgagccga gacggacgga cggccagcag
       61 ctccgtcagc tggagagaga gcacaggcct gtggcttggg agaccctgag gcgacatgtg
      121 agggccctga gccccctgac tggaagcagg ggctgttttt caactcctgg actaaagccc
      181 agaagcagct ggggaagctc caggctacct acacaacctg gcccaggctg gtcacggtgt
      241 cccccctccc tgctctgtgc cctctccttc cagaaatcca ccatggagag taaggatgag
      301 gtcagcgaca ccgacagtgg catcatcctg cagtctggcc ccgacagccc ggtctcccca
      361 atgaaggagc tgacccatgc agtgcacaag cagcagaggg ccctggaagc gaggctggag
      421 gcctgcctgg aggagctgag gagactctgc cttcgggaag cggagctgac gggcaccttg
      481 ccagcggagt atcccctcaa accaggggaa aaggccccca aggttcgccg caggatcgga
      541 gcggcttaca aactggatga ctgggccttg cacagagagg accccctaag cagcctggag
      601 cgccagctgg ccctgcagct gcagatcaca gaggcagccc gtcggctgtg cctggaggag
      661 aacctcagca ggcaggctcg gcggcagcgg aagcactcca tgctgcagga ggagaagaag
      721 ctgcaggagc tccagcgctg cctggtcgag cggcggcgca atagcgagcc acctccggct
      781 gctgctctcc ccctgggccg agagctcagt gcctctgatg acagctccct gtcagatggg
      841 ctcctcctgg aggaagagga atcccaagtg ccaaaacctc ctccagagtc tccagcccca
      901 ccttctcggc ctctcccacc ccaaaccctt gagggtctgc agccaacagg acctgaggct
      961 gggagcccag aacgggctcc agtccagaac agcccctgga aggaaaccag cctggaccac
     1021 ccctatgaga agcccaggaa gtcttctgag ccctggagcg agtccagcag cccagccacc
     1081 acaccacagg atgggcccag tgcctccagc ctgtggcttc tggagcctgc ctcctaccac
     1141 gtggttccca tccgtggtgt tcctggccag tggcagggcc gcaccagtgc cccagccacc
     1201 cctgagatac aggggaggag gggccagtcg cagtctctga gggtggattc cttccgggcg
     1261 ggtcctgagg gccgaggtcg cagcgccttt ccccgccgcc gccccactca ctacacggtg
     1321 acagtgccag attcctgctt tcccgcgacc aagcccccgc tgccccacgc cgcctgccac
     1381 tcctgctcag aagacagtgg ctctgacgtc tccagcatct cccaccccac ttcgccgggc
     1441 agcagcagcc ccgacatctc ctttctgcag cctctctccc ctcccaagac ccatcgtcac
     1501 cgcggggcct gggtcccagc cggcagcaga gagctggtcg cccaccaccc caagctactg
     1561 ctgccgcctg gctatttccc ggcggggcgg tacgtggtgg tggctgagag ccccctgccg
     1621 cctggcgagt gggagctgcg ccgcgcagcc ccgggccctg cttacgagga ggagggcact
     1681 cccctgcgct accagcgtct ggtgccctcc cgcagccgca tcgtgcggac gccctccctg
     1741 aaggacagcc cggcaggccg ggggctcagc aaggccgccg tgtccgagga gctcaagtgg
     1801 tggcacgagc gtgcacgcct ccggagcacc cgcccccact cactggaccg ccaaggagct
     1861 ttccgggtca ggagcctgcc ccttgggaga gagggcttcg gacgagccct gggaccccgg
     1921 gcacaggtgc ccacagtttg tgtgctgcgg agatcgcctg atggggcccc tgtgcaagtc
     1981 tttgtacctg aaaaaggaga gatcatcagc caggtgtaac tctgcgcccc acgctggaaa
     2041 aaactgtttc atagaggggc tgggctgaga cccccccacc cctgagtgcc tctttcagct
     2101 cccccatccc catcgcaggc cgatgacctg gagctgagac cttttattat ttttttttta
     2161 cacgactttt ttcagaagcc ctgacctaag gatttatata tgtggattgt cctcaatacc
     2221 cctgtgatat gattatgttt tatcccccag agtttggcct actggactta aggccttgcc
     2281 tgtctgactg acagcctcta tctccttata taagacaagt ggcaggggac gagtgaagca
     2341 gagtgagcca ccttgggagt tctccaacgc tctgtgctct ggttctaaga aattccctgg
     2401 ggaactgccc ctggccctcc tgtcccacta ttgctggagg ctggacatgg tacatactca
     2461 tgcacatgac tctcccccat ttcccaggtc tctgggtacc ccagcctggg ctgggggaga
     2521 atctcttccc ccttttctaa tgtgctctgt gatgcacaca ccaagtggta ggtcaaaggt
     2581 cagtatatcc cggtggtgta ttgtcttgct agaccctgct attttcctga ccccctaaat
     2641 cctctttagg gacccagtca ctataccctg tctatgccct gtgggctccc agacccctga
     2701 gctttgagtc agtggcatca cagtttgtag cctcaggggg tctggctggg ggctggtcca
     2761 tgcttgtggt tagtggacag cagccaccct ttgacagcta cctctgggca tctcaagggc
     2821 ttgcagcccc actgctcctt ctaacatttt gtttgttttt gagatggagt ctcgctctgt
     2881 cgcccaggct ggaatgctgt agcaagattt cggctcactg caacccccgt ctcccgggtt
     2941 caagcgaatc tcctgcctca gccttccgag tagctgggat tacaggcaag caccaccatg
     3001 cctgctaatt ttttattttt agtagagatg gggtttcatc atgttggcca ggctggtctc
     3061 gaactcctga cctcaagtga tccacctgcc ttggcctttc aaagtgctgg gattacaggc
     3121 atgagccacc gcacctggcc cttctaacgt tttttcatca tagtcccaaa aaccaatact
     3181 ttacaagtgg ttttggaaag gcaccacttt tgtggcatgt tctggttggg agagggagtc
     3241 acagttccta ctccccccac cagctatgct tctgctctga gaaggtggtt atttatacaa
     3301 acatggacat actcactccc aagggctgat gagatgctga attttctttg ggggcattca
     3361 ttaattgtcc cagctgcagc gactggagca agtctggaag ctgcctgtgc taagaccacc
     3421 cagctgtccc tgggttctca tcctagggcc ttctttgctt ccaggtcagg ggacctgctt
     3481 caatgagaaa gcaactgaat tgaggctagg agaggtaggg agagctgagt tctgacttca
     3541 cctgtgcaga actctctgcc cccatgttac ctggactgga acagactgtg aatatagcag
     3601 aaggttccaa gaactctggt gtctgaccta gaagaggcac agttctctct actggaaaga
     3661 aaacgatgta gccgattgca caagggtgcc aagggaagac ccaggatggc ccatcaaagg
     3721 aacctggggg aggatgcagg aggctgaagg gatgcacctg gcatttctct cactgtgctc
     3781 ttaccgcatc agcaaccccc aacttttggg cctactctgc cccccatgcg tgaataccct
     3841 gcttggatgc tgtgcttttc cggtttgtct ctaagcccct ttctccaggg catgttggtt
     3901 tccctggcct ctcagtgtcc taactggagc ccagagtgcc ttgttctgag ccaggagacg
     3961 gctgagcact ggccctccac acctaagcgt cctttacatt aacttattgg tcttgtataa
     4021 cacctggtgc cattgccaag tggctgtgtc ctcagctaca gagctggaat tgtgtggggt
     4081 ttagtgctaa atacttcaat aaagtctgtt ttttgtgatt ggctgagctg gg
//
