LOCUS       NM_001563               3543 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interphotoreceptor matrix proteoglycan 1 (IMPG1),
            transcript variant 1, mRNA.
ACCESSION   NM_001563
VERSION     NM_001563.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3543)
  AUTHORS   Olivier,G., Corton,M., Intartaglia,D., Verbakel,S.K.,
            Sergouniotis,P.I., Le Meur,G., Dhaenens,C.M., Naacke,H.,
            Avila-Fernandez,A., Hoyng,C.B., Klevering,J., Bocquet,B.,
            Roubertie,A., Senechal,A., Banfi,S., Muller,A., Hamel,C.L.,
            Black,G.C., Conte,I., Roosing,S., Zanlonghi,X., Ayuso,C.,
            Meunier,I. and Manes,G.
  TITLE     Pathogenic variants in IMPG1 cause autosomal dominant and autosomal
            recessive retinitis pigmentosa
  JOURNAL   J Med Genet 58 (8), 570-578 (2021)
   PUBMED   32817297
  REMARK    GeneRIF: Pathogenic variants in IMPG1 cause autosomal dominant and
            autosomal recessive retinitis pigmentosa.
REFERENCE   2  (bases 1 to 3543)
  AUTHORS   Felemban,M., Dorgau,B., Hunt,N.C., Hallam,D., Zerti,D., Bauer,R.,
            Ding,Y., Collin,J., Steel,D., Krasnogor,N., Al-Aama,J., Lindsay,S.,
            Mellough,C. and Lako,M.
  TITLE     Extracellular matrix component expression in human pluripotent stem
            cell-derived retinal organoids recapitulates retinogenesis in vivo
            and reveals an important role for IMPG1 and CD44 in the development
            of photoreceptors and interphotoreceptor matrix
  JOURNAL   Acta Biomater 74, 207-221 (2018)
   PUBMED   29777959
  REMARK    GeneRIF: Extracellular matrix component expression in human
            pluripotent stem cell-derived retinal organoids recapitulates
            retinogenesis in vivo and reveals an important role for IMPG1 and
            CD44 in the development of photoreceptors and interphotoreceptor
            matrix.
REFERENCE   3  (bases 1 to 3543)
  AUTHORS   Meunier,I., Manes,G., Bocquet,B., Marquette,V., Baudoin,C.,
            Puech,B., Defoort-Dhellemmes,S., Audo,I., Verdet,R., Arndt,C.,
            Zanlonghi,X., Le Meur,G., Dhaenens,C.M. and Hamel,C.P.
  TITLE     Frequency and clinical pattern of vitelliform macular dystrophy
            caused by mutations of interphotoreceptor matrix IMPG1 and IMPG2
            genes
  JOURNAL   Ophthalmology 121 (12), 2406-2414 (2014)
   PUBMED   25085631
  REMARK    GeneRIF: IMPG1 and IMPG2 are new causal genes of vitelliform
            dystrophy, involved in 8% of our families.
REFERENCE   4  (bases 1 to 3543)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   5  (bases 1 to 3543)
  AUTHORS   Roni,V., Carpio,R. and Wissinger,B.
  TITLE     Mapping of transcription start sites of human retina expressed
            genes
  JOURNAL   BMC Genomics 8, 42 (2007)
   PUBMED   17286855
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3543)
  AUTHORS   Kuehn,M.H. and Hageman,G.S.
  TITLE     Expression and characterization of the IPM 150 gene (IMPG1)
            product, a novel human photoreceptor cell-associated
            chondroitin-sulfate proteoglycan
  JOURNAL   Matrix Biol 18 (5), 509-518 (1999)
   PUBMED   10601738
  REMARK    GeneRIF: The gene product of IMPG1 (designated IPM 150) is a member
            of a group of neuronal proteoglycans and/ or glycoproteins
            suspected to be essential in retinal adhesion and photoreceptor
            cell survival.
REFERENCE   7  (bases 1 to 3543)
  AUTHORS   Acharya,S., Rodriguez,I.R., Moreira,E.F., Midura,R.J., Misono,K.,
            Todres,E. and Hollyfield,J.G.
  TITLE     SPACR, a novel interphotoreceptor matrix glycoprotein in human
            retina that interacts with hyaluronan
  JOURNAL   J Biol Chem 273 (47), 31599-31606 (1998)
   PUBMED   9813076
REFERENCE   8  (bases 1 to 3543)
  AUTHORS   Acharya,S., Rayborn,M.E. and Hollyfield,J.G.
  TITLE     Characterization of SPACR, a sialoprotein associated with cones and
            rods present in the interphotoreceptor matrix of the human retina:
            immunological and lectin binding analysis
  JOURNAL   Glycobiology 8 (10), 997-1006 (1998)
   PUBMED   9719680
REFERENCE   9  (bases 1 to 3543)
  AUTHORS   Gehrig,A., Felbor,U., Kelsell,R.E., Hunt,D.M., Maumenee,I.H. and
            Weber,B.H.
  TITLE     Assessment of the interphotoreceptor matrix proteoglycan-1 (IMPG1)
            gene localised to 6q13-q15 in autosomal dominant Stargardt-like
            disease (ADSTGD), progressive bifocal chorioretinal atrophy
            (PBCRA), and North Carolina macular dystrophy (MCDR1)
  JOURNAL   J Med Genet 35 (8), 641-645 (1998)
   PUBMED   9719369
REFERENCE   10 (bases 1 to 3543)
  AUTHORS   Felbor,U., Gehrig,A., Sauer,C.G., Marquardt,A., Kohler,M.,
            Schmid,M. and Weber,B.H.
  TITLE     Genomic organization and chromosomal localization of the
            interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate
            for 6q-linked retinopathies
  JOURNAL   Cytogenet Cell Genet 81 (1), 12-17 (1998)
   PUBMED   9691169
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356962.8, AF047492.2,
            AL392166.19 and BU728582.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001563.3.
            
            Summary: This gene encodes a protein that is a major component of
            the retinal interphotoreceptor matrix. The encoded protein is a
            proteoglycan that is thought to play a role in maintaining
            viability of photoreceptor cells and in adhesion of the neural
            retina to the retinal pigment epithelium. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047492.2, BC117450.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2145743 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369950.8/ ENSP00000358966.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AL356962.8         63286-63329         c
            45-2105             AF047492.2         1-2061
            2106-2106           AL392166.19        28759-28759         c
            2107-2591           AF047492.2         2063-2547
            2592-2592           AL392166.19        3398-3398           c
            2593-2753           AF047492.2         2549-2709
            2754-2754           AL392166.19        3236-3236           c
            2755-3312           AF047492.2         2711-3268
            3313-3543           BU728582.1         18-248              c
FEATURES             Location/Qualifiers
     source          1..3543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..3543
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /note="interphotoreceptor matrix proteoglycan 1"
                     /db_xref="GeneID:3617"
                     /db_xref="HGNC:HGNC:6055"
                     /db_xref="MIM:602870"
     exon            1..241
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2568
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sialoprotein associated with cones and rods;
                     interphotoreceptor matrix proteoglycan of 150 kDa"
                     /codon_start=1
                     /product="interphotoreceptor matrix proteoglycan 1 isoform
                     1 precursor"
                     /protein_id="NP_001554.2"
                     /db_xref="CCDS:CCDS4985.1"
                     /db_xref="GeneID:3617"
                     /db_xref="HGNC:HGNC:6055"
                     /db_xref="MIM:602870"
                     /translation="MYLETRRAIFVFWIFLQVQGTKDISINIYHSETKDIDNPPRNET
                     TESTEKMYKMSTMRRIFDLAKHRTKRSAFFPTGVKVCPQESMKQILDSLQAYYRLRVC
                     QEAVWEAYRIFLDRIPDTGEYQDWVSICQQETFCLFDIGKNFSNSQEHLDLLQQRIKQ
                     RSFPDRKDEISAEKTLGEPGETIVISTDVANVSLGPFPLTPDDTLLNEILDNTLNDTK
                     MPTTERETEFAVLEEQRVELSVSLVNQKFKAELADSQSPYYQELAGKSQLQMQKIFKK
                     LPGFKKIHVLGFRPKKEKDGSSSTEMQLTAIFKRHSAEAKSPASDLLSFDSNKIESEE
                     VYHGTMEEDKQPEIYLTATDLKRLISKALEEEQSLDVGTIQFTDEIAGSLPAFGPDTQ
                     SELPTSFAVITEDATLSPELPPVEPQLETVDGAEHGLPDTSWSPPAMASTSLSEAPPF
                     FMASSIFSLTDQGTTDTMATDQTMLVPGLTIPTSDYSAISQLALGISHPPASSDDSRS
                     SAGGEDMVRHLDEMDLSDTPAPSEVPELSEYVSVPDHFLEDTTPVSALQYITTSSMTI
                     APKGRELVVFFSLRVANMAFSNDLFNKSSLEYRALEQQFTQLLVPYLRSNLTGFKQLE
                     ILNFRNGSVIVNSKMKFAKSVPYNLTKAVHGVLEDFRSAAAQQLHLEIDSYSLNIEPA
                     DQADPCKFLACGEFAQCVKNERTEEAECRCKPGYDSQGSLDGLEPGLCGPGTKECEVL
                     QGKGAPCRLPDHSENQAYKTSVKKFQNQQNNKVISKRNSELLTVEYEEFNHQDWEGN"
     exon            242..475
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            476..642
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            643..671
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            672..736
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..840
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..981
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1040
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1061
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1309
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1386
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1465
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1998
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2218
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2417
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2490
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..3543
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3520..3525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /note="hexamer: AATAAA"
     polyA_site      3543
                     /gene="IMPG1"
                     /gene_synonym="GP147; IPM150; RP91; SPACR; VMD4"
                     /note="major polyA site"
ORIGIN      
        1 agacactgct acatgttctt cataaattaa caccctcata aaggtaaacc aagaaggtta
       61 tcctcaatca tctggtatca atatataatt atttttcaca tttctgttac tttttaatga
      121 gatttgaggt tgttctgtga ttgttatcag aattaccaat gcacaaaagc cagaatgtat
      181 ttggaaacta gaagagctat ttttgttttt tggatttttc tccaagttca aggaaccaaa
      241 gatatctcca ttaacatata ccattctgaa actaaagaca tagacaatcc cccaagaaat
      301 gaaacaactg aaagtactga aaaaatgtac aaaatgtcaa ctatgagacg aatattcgat
      361 ttggcaaagc atcgaacaaa aagatccgca tttttcccaa cgggggttaa agtctgtcca
      421 caggaatcca tgaaacagat tttagacagt cttcaagctt attatagatt gagagtgtgt
      481 caggaagcag tatgggaagc atatcggatc tttctggatc gcatccctga cacaggggaa
      541 tatcaggact gggtcagcat ctgccagcag gagaccttct gcctctttga cattggaaaa
      601 aacttcagca attcccagga gcacctggat cttctccagc agagaataaa acagagaagt
      661 ttccctgaca gaaaagatga aatatctgca gagaagacat tgggagagcc tggtgaaacc
      721 attgtcattt caacagatgt tgccaacgtc tcacttgggc ctttccctct cactcctgat
      781 gacaccctcc tcaatgaaat tctcgataat acactcaacg acaccaagat gcctacaaca
      841 gaaagagaaa cagaattcgc tgtgttggag gagcagaggg tggagctcag cgtctctctg
      901 gtaaaccaga agttcaaggc agagctcgct gactcccagt ccccatatta ccaggagcta
      961 gcaggaaagt cccaacttca gatgcaaaag atatttaaga aacttccagg attcaaaaaa
     1021 atccatgtgt taggatttag accaaagaaa gaaaaagatg gctcaagctc cacagagatg
     1081 caacttacgg ccatctttaa gagacacagt gcagaagcaa aaagccctgc aagtgacctc
     1141 ctgtcttttg attccaacaa aattgaaagt gaggaagtct atcatggaac catggaggag
     1201 gacaagcaac cagaaatcta tctcacagct acagacctca aaaggctgat cagcaaagca
     1261 ctagaggaag aacaatcttt ggatgtgggg acaattcagt tcactgatga aattgctgga
     1321 tcactgccag cctttggtcc tgacacccaa tcagagctgc ccacatcttt tgctgttata
     1381 acagaggatg ctactttgag tccagaactt cctcctgttg aaccccagct tgagacagtg
     1441 gacggagcag agcatggtct acctgacact tcttggtctc cacctgctat ggcctctacc
     1501 tccctgtcag aagctccacc tttctttatg gcatcaagca tcttctctct gactgatcaa
     1561 ggcaccacag atacaatggc cactgaccag acaatgctag taccagggct caccatcccc
     1621 accagtgatt attctgcaat cagccaactg gctctgggaa tttcacatcc acctgcatct
     1681 tcagatgaca gccgatcaag tgcaggtggc gaagatatgg tcagacacct agatgaaatg
     1741 gatctgtctg acactcctgc cccatctgag gtaccagagc tcagcgaata tgtttctgtc
     1801 ccagatcatt tcttggagga taccactcct gtctcagctt tacagtatat caccactagt
     1861 tctatgacca ttgcccccaa gggccgagag ctggtagtgt tcttcagtct gcgtgttgct
     1921 aacatggcct tctccaacga cctgttcaac aagagctctc tggagtaccg agctctggag
     1981 caacaattca cacagctgct ggttccatat ctacgatcca atcttacagg atttaagcaa
     2041 cttgaaatac ttaacttcag aaacgggagt gtgattgtga atagcaaaat gaagtttgct
     2101 aagtcagtgc cgtataacct caccaaggct gtgcacgggg tcttggagga ttttcgttct
     2161 gctgcagccc aacaactcca tctggaaata gacagctact ctctcaacat tgaaccagct
     2221 gatcaagcag atccctgcaa gttcctggcc tgcggcgaat ttgcccaatg tgtaaagaac
     2281 gaacggactg aggaagcgga gtgtcgctgc aaaccaggat atgacagcca ggggagcctg
     2341 gacggtctgg aaccaggcct ctgtggccct ggcacaaagg aatgcgaggt cctccaggga
     2401 aagggagctc catgcaggtt gccagatcac tctgaaaatc aagcatacaa aactagtgtt
     2461 aaaaagttcc aaaatcaaca aaataacaag gtaatcagta aaagaaattc tgaattactg
     2521 accgtagaat atgaagaatt taaccatcaa gattgggaag gaaattaaaa actgaaaatg
     2581 tacaattatc atttaggcta tctcaagaga gatgatttgc cttctcaagg aaaatggaga
     2641 caggcatatt catgggtcat caaaatccag acatacagtc aacactgaga atcagcacac
     2701 accatatttc aaatatagaa gagtcatgta cttggcaacc agtaaattct gaagaaaaag
     2761 acacttactt attattaaaa ccccaaatgc aatcagcgaa acatattttt actattcttg
     2821 gatgatagtc aaaatgatca taagccaggt ttgcttccac cttccctgaa aattttactc
     2881 acagatcatt tgcaacaagc atagcttact tattgtttag ggactgaaca atttattggg
     2941 aagcaaactc tttatatgct agaaagtaca tttaaaagat gactacttac gcagggagat
     3001 gcaggtctct ctaaacgcat gaatgtatgt agtgtgtagg cactgtagtg agtgtatata
     3061 tgctccacac tacgtctgat aaacacaaac ctcagtattc agttattagg cacactagtt
     3121 ttatacgcaa ctactgctta catagtagac tgttttgttg ccaataatct ttgaattgtt
     3181 ctttaaaaga aactgaggtt cagatacaca taccatggaa aaatcttact tttcttgtta
     3241 ctacacaaag ctattttaaa gaagatgcta tgttgggaga agggcgaagt tgtactatat
     3301 gacataatca attcctgtct tccaccacag atgaacaatg tcttcctata ataacttcag
     3361 aatatttcct cacaccaact ttagtgtgtg tatacctaga ctggcatcaa tgtaatccaa
     3421 ttcagtccat tttttatgtg ctgcttaatg aaaatgaatc tgtctctatc tctttcaaat
     3481 gttctaatat cagatatatt tgctacaaac cttaatttca ataaagtaaa agtgatatac
     3541 tca
//
