LOCUS       NM_018439               3734 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens impact RWD domain protein (IMPACT), mRNA.
ACCESSION   NM_018439
VERSION     NM_018439.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3734)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3734)
  AUTHORS   Habibi,D., Jalili,R.B., Forouzandeh,F., Ong,C.J. and Ghahary,A.
  TITLE     High expression of IMPACT protein promotes resistance to
            indoleamine 2,3-dioxygenase-induced cell death
  JOURNAL   J Cell Physiol 225 (1), 196-205 (2010)
   PUBMED   20648630
  REMARK    GeneRIF: Data suggest that high expression of protein IMPACT
            homolog in non-immune cells acts as a protective mechanism against
            indoleamine 2,3-dioxygenase (IDO)-induced GCN2 activation, making
            them resistant to the amino acid-deprived environment caused by
            IDO.
REFERENCE   3  (bases 1 to 3734)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3734)
  AUTHORS   Pereira,C.M., Sattlegger,E., Jiang,H.Y., Longo,B.M., Jaqueta,C.B.,
            Hinnebusch,A.G., Wek,R.C., Mello,L.E. and Castilho,B.A.
  TITLE     IMPACT, a protein preferentially expressed in the mouse brain,
            binds GCN1 and inhibits GCN2 activation
  JOURNAL   J Biol Chem 280 (31), 28316-28323 (2005)
   PUBMED   15937339
REFERENCE   5  (bases 1 to 3734)
  AUTHORS   Okamura,K., Sakaki,Y. and Ito,T.
  TITLE     Comparative genomics approach toward critical determinants for the
            imprinting of an evolutionarily conserved gene Impact
  JOURNAL   Biochem Biophys Res Commun 329 (3), 824-830 (2005)
   PUBMED   15752730
  REMARK    GeneRIF: It thus seems that lineage-specific enhancement of gene
            expression rather than the tandem repeat per se played a critical
            role in the evolution of imprinting of Impact.
REFERENCE   6  (bases 1 to 3734)
  AUTHORS   Okamura,K., Yamada,Y., Sakaki,Y. and Ito,T.
  TITLE     An evolutionary scenario for genomic imprinting of Impact lying
            between nonimprinted neighbors
  JOURNAL   DNA Res 11 (6), 381-390 (2004)
   PUBMED   15871461
  REMARK    GeneRIF: segmental duplication followed by enhancement of the
            promoter activity is responsible for the species-specific
            imprinting of Impact
REFERENCE   7  (bases 1 to 3734)
  AUTHORS   Kosaki,K., Suzuki,T., Kosaki,R., Yoshihashi,H., Itoh,M., Goto,Y.
            and Matsuo,N.
  TITLE     Human homolog of the mouse imprinted gene Impact resides at the
            pericentric region of chromosome 18 within the critical region for
            bipolar affective disorder
  JOURNAL   Mol Psychiatry 6 (1), 87-91 (2001)
   PUBMED   11244491
REFERENCE   8  (bases 1 to 3734)
  AUTHORS   Okamura,K., Hagiwara-Takeuchi,Y., Li,T., Vu,T.H., Hirai,M.,
            Hattori,M., Sakaki,Y., Hoffman,A.R. and Ito,T.
  TITLE     Comparative genome analysis of the mouse imprinted gene impact and
            its nonimprinted human homolog IMPACT: toward the structural basis
            for species-specific imprinting
  JOURNAL   Genome Res 10 (12), 1878-1889 (2000)
   PUBMED   11116084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007922.13.
            
            On Nov 23, 2018 this sequence version replaced NM_018439.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.493146.1,
                                           SRR1803611.81555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284202.9/ ENSP00000284202.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC007922.13        110496-110618       c
            124-252             AC007922.13        109241-109369       c
            253-305             AC007922.13        108367-108419       c
            306-368             AC007922.13        106904-106966       c
            369-454             AC007922.13        99248-99333         c
            455-577             AC007922.13        96670-96792         c
            578-681             AC007922.13        94136-94239         c
            682-755             AC007922.13        91822-91895         c
            756-846             AC007922.13        89105-89195         c
            847-981             AC007922.13        87335-87469         c
            982-3734            AC007922.13        83757-86509         c
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..3734
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /note="impact RWD domain protein"
                     /db_xref="GeneID:55364"
                     /db_xref="HGNC:HGNC:20387"
                     /db_xref="MIM:615319"
     exon            1..123
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1050
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /note="imprinted and ancient gene protein homolog; Impact
                     homolog; RWD domain containing 5"
                     /codon_start=1
                     /product="protein IMPACT"
                     /protein_id="NP_060909.2"
                     /db_xref="CCDS:CCDS11886.1"
                     /db_xref="GeneID:55364"
                     /db_xref="HGNC:HGNC:20387"
                     /db_xref="MIM:615319"
                     /translation="MAEGDAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDD
                     IDDPKWTLCLQVMLPNEYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESIL
                     YLWVEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDDLILACQPESSLKALDFDISE
                     TRTEVEVEELPPIDHGIPITDRRSTFQAHLAPVVCPKQVKMVLSKLYENKKIASATHN
                     IYAYRIYCEDKQTFLQDCEDDGETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPD
                     RFKHINNCARNILVEKNYTNSPEESSKALGKNKKVRKDKKRNEH"
     exon            124..252
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            253..305
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            306..368
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            369..454
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            455..577
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            578..681
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            682..755
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            756..846
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            847..981
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            982..3734
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1759..1764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /note="hexamer: AATAAA"
     polyA_site      1799
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /note="major polyA site"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /note="hexamer: AATAAA"
     polyA_site      3734
                     /gene="IMPACT"
                     /gene_synonym="RWDD5"
                     /note="major polyA site"
ORIGIN      
        1 agccagctct cggctcgcag ccgcagcgcc ccgcccccgc gctccggacc tggcaggcgg
       61 cggctgcagg gcaggtccag gggccacatg gctgaggggg acgcagggag cgaccagagg
      121 cagaatgagg aaattgaagc aatggcagcc atttatggcg aggagtggtg tgtcattgat
      181 gactgtgcca aaatattttg tattagaatt agcgacgata tagatgaccc caaatggaca
      241 ctttgcttgc aggtgatgct gccgaatgaa tacccaggta cagctccacc tatctaccag
      301 ttgaatgctc cttggcttaa agggcaagaa cgtgcggatt tatcaaatag ccttgaggaa
      361 atatatattc agaatatcgg tgaaagtatt ctttacctgt gggtggagaa aataagagat
      421 gttcttatac aaaaatctca gatgacagaa ccaggcccag atgtaaagaa gaaaactgaa
      481 gaggaagatg ttgaatgtga agatgatctc attttagcat gtcagccgga aagttcgctt
      541 aaagcattgg attttgatat cagtgaaact cggacagaag tagaagtaga agaattacct
      601 ccgattgatc atggcattcc tattacagac cgaagaagta cttttcaggc acacttggct
      661 ccagtggttt gtcccaaaca ggtgaaaatg gttctttcca aattgtatga gaataagaaa
      721 atagctagtg ccacccacaa catctatgcc tacagaatat attgtgagga taaacagacc
      781 ttcttacagg attgtgagga tgatggggaa acagcagctg gtgggcgtct tcttcatctc
      841 atggagattt tgaatgtgaa gaatgtcatg gtggtagtat cacgctggta tggagggatt
      901 ctgctaggac cagatcgctt taaacatatc aacaactgtg ccagaaacat actagtggaa
      961 aagaactaca caaattcacc tgaggagtca tctaaggctt tgggaaagaa caaaaaagta
     1021 agaaaagaca agaagaggaa tgaacattaa tacctgaaac tataggaaag gttaatttgc
     1081 ctataattat atatacattc catagtcatc aaggaatata ttgtgcagag agagtatcct
     1141 tgactgctta agtcagccag ttcagcatgg ataccaacat tagcttttct tcttggttat
     1201 atcatctgcc aaaaatagag aacttatgat ctattcatgt gtgtttcagg cttatttggg
     1261 agaactaatt tgaacttaat caccacttca tctaatttta gcaaggtaac agttgcccag
     1321 ggcagtacct gaattaactg tccatttcag tacatgtcaa gtgcctttgt taggtggaga
     1381 agaaatgtct ctagaggaat ataaatacct gatttcttgt catcgagatt cttgtactgt
     1441 taaatgaata ttgcctttta ctgctcttta tggcttattg gaataggagc tcatttaaga
     1501 ttgatcttgg agagtttctt cttgtgattt tagttcataa gtatgtcacc tttcatttta
     1561 tagtgttcat cattgagtaa tggattaagt gaaaatccag gagtatccat ctgcagttat
     1621 gtgctgaggt gataattcat ccaacatatt tgttagcata aatattatgc ttcagtttct
     1681 gttgcaaatt ggtgattgtg aaattacaga aagtgatttt ctagtctgct ttttttgttt
     1741 aattcttgta atgtaagcaa taaatatgga gtgtcagtag tctccttcca ccccagaaat
     1801 gtgttggtgt aacattctcg tttcttttaa caacctggaa gtacctttct tgtgatcttc
     1861 actgaggaat tagaactatg atagaagtta ggctgtggca aatgggacat tcgtagagtg
     1921 ggatagaggt ggcagaatga acctggtgta gggcaggagt atgttgtgta gttacatcaa
     1981 tttgatgcat gctttccatc tgcactccag acggctttct cagttccaag attttgcaga
     2041 gagaaggagc aaaccttttc attggaaaaa cagaaacaac cctccccccc attttttccc
     2101 ctctattcat caaaccttta tgtatctttc atcttccagt tacctctagg catttagata
     2161 gtgaaattta cctttgagat ataacaataa gtgattaact gttcactttc agatgtaatg
     2221 gcaaacaatt gttaaaagtt attaactgat cacagatttg cctggacttc ccttcccagg
     2281 gagggaacag aagttaggag gcaactttgg gatggtgcta gagcatggaa agcacagaga
     2341 attggacaaa caggtctttt tctcttttct ctgatgtttt acctttaaaa gatccaacat
     2401 ccttaccgtt ggtattttta gtaaggttat agtaaatagc tttacaccag gatggattct
     2461 gaaatataaa ttctaaatta tatttgttat aactatattt tatgttgtat gttatcagga
     2521 gccatcagag aatgaccttt ttgtgtttgg aacacttggt tccatgaaaa gtatgctttg
     2581 tgttttaact gttaaaataa tttaaaaatt aattatttta cataattaaa gaagttaaaa
     2641 actattaaca ttaaataatt tcacaatttc aacatgtcaa acctatgaag ggagatagga
     2701 aacaatgaga aacttacttt tgctccttta tacagaatta ttaactatat tttactaact
     2761 aaaaaactct agtattcttt acctaaagtc aattggctgg taagagggag agatgcaaaa
     2821 ttctccagct ctgaacttgg agctacttca cactctactc ttaatggaaa cttgaactaa
     2881 tgatagatag tatttttttc ctctatttaa aatttttgtc ttgattagga gatttttcag
     2941 ttctccatat aataattttc tacaatcaga tctatgctgt ggcatatttt gctttattta
     3001 aaaatttttt tttagagatg agttcttgct ctgtcaccta ggctggagtg cagtggcatg
     3061 atcatggctc actgcagcct tgaccttcca gcctgccaag tagctgggat tacagacagg
     3121 catgtgctat tacacctggc taatttttaa agtttttttt gtaaagatag ggtctttcta
     3181 tgttgcccag gctcgtcttg agctcctggc ctcaatcgat cttcctgcca aggttttgga
     3241 attacaggtg tgagccacca tgcctggcct gctttgacat attttatagt gtgttaatta
     3301 caaatagtct tcatatgcca gaatataaga gcaagtgtta tctacttttt agatgggaat
     3361 tgcagaagct gcatcaaaag tatgctttga ggtatatata gtgaaacaga gcctttctga
     3421 agagaattat atcaaactaa ttacaaccaa gaaataatag tatgaagcgg atgctgtttg
     3481 gaggacagga aaatttatcg ggaaaattac ataatccctc tgattccact atccagagat
     3541 agccattatt attaatattt ggtatgtaca tccttatatt atttttttct tatgcatgat
     3601 tttgtatata tggttatttt tctttccata aaaatggtat taaactgtat atactgtttt
     3661 gtagcctaca tatttcatat agaagtatat tgttaacatt ttccatgtca ataaatattc
     3721 ttctatggct taaa
//
