LOCUS       NM_014214               1449 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens inositol monophosphatase 2 (IMPA2), mRNA.
ACCESSION   NM_014214
VERSION     NM_014214.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1449)
  AUTHORS   Lei,X., Liao,R., Chen,X., Wang,Z., Cao,Q., Bai,L., Ma,C., Deng,X.,
            Ma,Y., Wu,X., Li,J., Dai,Z. and Dong,C.
  TITLE     IMPA2 promotes basal-like breast cancer aggressiveness by a
            MYC-mediated positive feedback loop
  JOURNAL   Cancer Lett 582, 216527 (2024)
   PUBMED   38048842
  REMARK    GeneRIF: IMPA2 promotes basal-like breast cancer aggressiveness by
            a MYC-mediated positive feedback loop.
REFERENCE   2  (bases 1 to 1449)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1449)
  AUTHORS   Zhang,K., Liu,L., Wang,M., Yang,M., Li,X., Xia,X., Tian,J., Tan,S.
            and Luo,L.
  TITLE     A novel function of IMPA2, plays a tumor-promoting role in cervical
            cancer
  JOURNAL   Cell Death Dis 11 (5), 371 (2020)
   PUBMED   32409648
  REMARK    GeneRIF: A novel function of IMPA2, plays a tumor-promoting role in
            cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1449)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1449)
  AUTHORS   Lin,Y.F., Chou,J.L., Chang,J.S., Chiu,I.J., Chiu,H.W. and Lin,Y.F.
  TITLE     Dysregulation of the miR-25-IMPA2 axis promotes metastatic
            progression in clear cell renal cell carcinoma
  JOURNAL   EBioMedicine 45, 220-230 (2019)
   PUBMED   31202813
  REMARK    GeneRIF: We conclude that miR-25-mediated IMPA2 downregulation
            constitutes a novel signature for cancer metastasis and poor
            outcomes in clear cell renal cell carcinoma (ccRCC). We further
            postulate that the therapeutic targeting of miR-25 can be useful
            for preventing the metastatic progression of ccRCC associated with
            IMPA2 downregulation.
REFERENCE   6  (bases 1 to 1449)
  AUTHORS   Arai,R., Ito,K., Ohnishi,T., Ohba,H., Akasaka,R., Bessho,Y.,
            Hanawa-Suetsugu,K., Yoshikawa,T., Shirouzu,M. and Yokoyama,S.
  TITLE     Crystal structure of human myo-inositol monophosphatase 2, the
            product of the putative susceptibility gene for bipolar disorder,
            schizophrenia, and febrile seizures
  JOURNAL   Proteins 67 (3), 732-742 (2007)
   PUBMED   17340635
  REMARK    GeneRIF: The crystal structures of human IMPA2 are useful for
            understanding the effect of nonsynonymous polymorphism reported in
            IMPA2, and will contribute to further functional analyses of IMPA2.
REFERENCE   7  (bases 1 to 1449)
  AUTHORS   Yoshikawa,T., Kikuchi,M., Saito,K., Watanabe,A., Yamada,K.,
            Shibuya,H., Nankai,M., Kurumaji,A., Hattori,E., Ishiguro,H.,
            Shimizu,H., Okubo,Y., Toru,M. and Detera-Wadleigh,S.D.
  TITLE     Evidence for association of the myo-inositol monophosphatase 2
            (IMPA2) gene with schizophrenia in Japanese samples
  JOURNAL   Mol Psychiatry 6 (2), 202-210 (2001)
   PUBMED   11317223
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1449)
  AUTHORS   Sjoholt,G., Gulbrandsen,A.K., Lovlie,R., Berle,J.O., Molven,A. and
            Steen,V.M.
  TITLE     A human myo-inositol monophosphatase gene (IMPA2) localized in a
            putative susceptibility region for bipolar disorder on chromosome
            18p11.2: genomic structure and polymorphism screening in
            manic-depressive patients
  JOURNAL   Mol Psychiatry 5 (2), 172-180 (2000)
   PUBMED   10822345
REFERENCE   9  (bases 1 to 1449)
  AUTHORS   Yoshikawa,T., Padigaru,M., Karkera,J.D., Sharma,M.,
            Berrettini,W.H., Esterling,L.E. and Detera-Wadleigh,S.D.
  TITLE     Genomic structure and novel variants of myo-inositol
            monophosphatase 2 (IMPA2)
  JOURNAL   Mol Psychiatry 5 (2), 165-171 (2000)
   PUBMED   10822344
REFERENCE   10 (bases 1 to 1449)
  AUTHORS   Yoshikawa,T., Turner,G., Esterling,L.E., Sanders,A.R. and
            Detera-Wadleigh,S.D.
  TITLE     A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a
            susceptibility region for bipolar disorder
  JOURNAL   Mol Psychiatry 2 (5), 393-397 (1997)
   PUBMED   9322233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001269.4 and BC017176.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014214.2.
            
            Summary: This locus encodes an inositol monophosphatase. The
            encoded protein catalyzes the dephosphoylration of inositol
            monophosphate and plays an important role in phosphatidylinositol
            signaling. This locus may be associated with susceptibility to
            bipolar disorder. [provided by RefSeq, Jan 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.98649.1, AF014398.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269159.8/ ENSP00000269159.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AP001269.4         116802-116882
            82-1449             BC017176.1         1-1368
FEATURES             Location/Qualifiers
     source          1..1449
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..1449
                     /gene="IMPA2"
                     /note="inositol monophosphatase 2"
                     /db_xref="GeneID:3613"
                     /db_xref="HGNC:HGNC:6051"
                     /db_xref="MIM:605922"
     exon            1..259
                     /gene="IMPA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1030
                     /gene="IMPA2"
                     /EC_number="3.1.3.25"
                     /note="inosine monophosphatase 2; IMP 2; IMPase 2;
                     myo-inositol monophosphatase A2; inositol(myo)-1(or
                     4)-monophosphatase 2; myo-inositol monophosphatase 2"
                     /codon_start=1
                     /product="inositol monophosphatase 2"
                     /protein_id="NP_055029.1"
                     /db_xref="CCDS:CCDS11855.1"
                     /db_xref="GeneID:3613"
                     /db_xref="HGNC:HGNC:6051"
                     /db_xref="MIM:605922"
                     /translation="MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRV
                     STKTSAADLVTETDHLVEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDP
                     IDGTCNFVHRFPTVAVSIGFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVS
                     GETDLSKALVLTEIGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGA
                     ADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQA
                     LQTINYGRDDEK"
     exon            260..393
                     /gene="IMPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            394..498
                     /gene="IMPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..544
                     /gene="IMPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..653
                     /gene="IMPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..762
                     /gene="IMPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..914
                     /gene="IMPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1449
                     /gene="IMPA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMPA2"
                     /note="hexamer: AATAAA"
     polyA_site      1449
                     /gene="IMPA2"
                     /note="major polyA site"
ORIGIN      
        1 tgcccttccc gccagcgcag gtgtgggacg ggcggcggac taggcacaga gctgcgggag
       61 caggcacagg gagtgtggag cctggcggcg ggacggcggg atccggtggg agccggagtc
      121 ccgccgaggg gggctggagg tggaggggcc cggcgaggcc gcgatgaagc cgagcggcga
      181 ggaccaggcg gcgctggcgg ccggcccctg ggaggagtgc ttccaggcgg ccgtgcagct
      241 ggcgctgcgg gcaggacaga tcatcagaaa agcccttact gaggaaaaac gtgtctcaac
      301 aaaaacatca gctgcagatc ttgtgacaga aacagatcac cttgtggaag atttaattat
      361 ttctgagttg cgagagaggt ttccttcaca caggttcatt gcagaagagg ccgcggcttc
      421 tggggccaag tgtgtgctca cccacagccc gacgtggatc atcgacccca tcgacggcac
      481 ctgcaatttt gtgcacagat tcccgactgt ggcggttagc attggatttg ctgttcgaca
      541 agagcttgaa ttcggagtga tttaccactg cacagaggag cggctgtaca cgggccggcg
      601 gggtcggggc gccttctgca atggccagcg gctccgggtc tccggggaga cagatctctc
      661 aaaggccttg gttctgacag aaattggccc caaacgtgac cctgcgaccc tgaagctgtt
      721 cctgagtaac atggagcggc tgctgcatgc caaggcgcat ggggtccgag tgattggaag
      781 ctccacattg gcactctgcc acctggcctc aggggccgcg gatgcctatt accagtttgg
      841 cctgcactgc tgggatctgg cggctgccac agtcatcatc agagaagcag gcggcatcgt
      901 gatagacact tcgggtggac ccctcgacct catggcttgc agagtggttg cggccagcac
      961 ccgggagatg gcgatgctca tagctcaggc cttacagacg attaactatg ggcgggatga
     1021 tgagaagtga ctgcggctga ggcaaagctg ctcccaaggc ctccctgggc tgctgtgggc
     1081 tcctggggag gtggccctcg tggcccacgc tccatgccag tggctcacgc tctgctcctg
     1141 gctaccccag agggagttgt cacgctacag tgagtggctg gccttttaaa tcgacgtctc
     1201 tctcaccagg atttggtgtt tagctgtttc tctctttaat ctcacgtagc ctttttcagg
     1261 ttagtacgtg ttcttctgtc agggccaaaa ctcaaatctc ctgtgaaata cgtattgata
     1321 atccaatctt gatttttccc cccagaatat aaatctcagg taataaggct ttagaactgc
     1381 tgataaagcg gatcgttctc aggccctccc cccggagtac ttcagaatgc aataaatcaa
     1441 aataatggc
//
