LOCUS       NM_005536               3369 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant
            1, mRNA.
ACCESSION   NM_005536
VERSION     NM_005536.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3369)
  AUTHORS   Yang,S.Y., Xie,Y.F., Zhang,T.M., Deng,L., Liao,L., Hu,S.Y.,
            Zhang,Y.L., Zhang,F.L. and Li,D.Q.
  TITLE     Inositol monophosphatase 1 (IMPA1) promotes triple-negative breast
            cancer progression through regulating mTOR pathway and EMT process
  JOURNAL   Cancer Med 12 (2), 1602-1615 (2023)
   PUBMED   35796646
  REMARK    GeneRIF: Inositol monophosphatase 1 (IMPA1) promotes
            triple-negative breast cancer progression through regulating mTOR
            pathway and EMT process.
REFERENCE   2  (bases 1 to 3369)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3369)
  AUTHORS   Figueiredo,T., Mendes,A.P.D., Moreira,D.P., Goulart,E.,
            Oliveira,D., Kobayashi,G.S., Stern,S., Kok,F., Marchetto,M.C.,
            Santos,R., Gage,F.H. and Zatz,M.
  TITLE     Inositol monophosphatase 1 (IMPA1) mutation in intellectual
            disability patients impairs neurogenesis but not gliogenesis
  JOURNAL   Mol Psychiatry 26 (7), 3558-3571 (2021)
   PUBMED   32839513
  REMARK    GeneRIF: Inositol monophosphatase 1 (IMPA1) mutation in
            intellectual disability patients impairs neurogenesis but not
            gliogenesis.
REFERENCE   4  (bases 1 to 3369)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3369)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3369)
  AUTHORS   Bone,R., Frank,L., Springer,J.P. and Atack,J.R.
  TITLE     Structural studies of metal binding by inositol monophosphatase:
            evidence for two-metal ion catalysis
  JOURNAL   Biochemistry 33 (32), 9468-9476 (1994)
   PUBMED   8068621
REFERENCE   7  (bases 1 to 3369)
  AUTHORS   Bone,R., Frank,L., Springer,J.P., Pollack,S.J., Osborne,S.A.,
            Atack,J.R., Knowles,M.R., McAllister,G., Ragan,C.I., Broughton,H.B.
            et al.
  TITLE     Structural analysis of inositol monophosphatase complexes with
            substrates
  JOURNAL   Biochemistry 33 (32), 9460-9467 (1994)
   PUBMED   8068620
REFERENCE   8  (bases 1 to 3369)
  AUTHORS   Bone,R., Springer,J.P. and Atack,J.R.
  TITLE     Structure of inositol monophosphatase, the putative target of
            lithium therapy
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10031-10035 (1992)
   PUBMED   1332026
REFERENCE   9  (bases 1 to 3369)
  AUTHORS   McAllister,G., Whiting,P., Hammond,E.A., Knowles,M.R., Atack,J.R.,
            Bailey,F.J., Maigetter,R. and Ragan,C.I.
  TITLE     cDNA cloning of human and rat brain myo-inositol monophosphatase.
            Expression and characterization of the human recombinant enzyme
  JOURNAL   Biochem J 284 (Pt 3) (Pt 3), 749-754 (1992)
   PUBMED   1377913
REFERENCE   10 (bases 1 to 3369)
  AUTHORS   Hallcher,L.M. and Sherman,W.R.
  TITLE     The effects of lithium ion and other agents on the activity of
            myo-inositol-1-phosphatase from bovine brain
  JOURNAL   J Biol Chem 255 (22), 10896-10901 (1980)
   PUBMED   6253491
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC375686.1, AF042729.2,
            BC008381.1, AI921211.1, AC090255.4 and DB299262.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_005536.3.
            
            Summary: This gene encodes an enzyme that dephosphorylates
            myo-inositol monophosphate to generate free myo-inositol, a
            precursor of phosphatidylinositol, and is therefore an important
            modulator of intracellular signal transduction via the production
            of the second messengers myoinositol 1,4,5-trisphosphate and
            diacylglycerol. This enzyme can also use
            myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate,
            scyllo-inositol-phosphate, glucose-1-phosphate,
            glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate,
            and 2'-AMP as substrates. This enzyme shows magnesium-dependent
            phosphatase activity and is inhibited by therapeutic concentrations
            of lithium. Inhibition of inositol monophosphate hydroylosis and
            subsequent depletion of inositol for phosphatidylinositol synthesis
            may explain the anti-manic and anti-depressive effects of lithium
            administered to treat bipolar disorder. Alternative splicing
            results in multiple transcript variants encoding distinct isoforms.
            A pseudogene of this gene is also present on chromosome 8q21.13.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF042729.2, SRR1660805.82085.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256108.10/ ENSP00000256108.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               DC375686.1         30-132
            104-2127            AF042729.2         104-2127
            2128-2327           BC008381.1         2123-2322
            2328-2670           AI921211.1         2-344               c
            2671-2940           AC090255.4         36028-36297
            2941-3367           DB299262.1         1-427               c
            3368-3369           AC090255.4         36725-36726
FEATURES             Location/Qualifiers
     source          1..3369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..3369
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /note="inositol monophosphatase 1"
                     /db_xref="GeneID:3612"
                     /db_xref="HGNC:HGNC:6050"
                     /db_xref="MIM:602064"
     exon            1..74
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     exon            75..161
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..932
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /EC_number="3.1.3.25"
                     /EC_number="3.1.3.94"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lithium-sensitive myo-inositol monophosphatase A1; IMP 1;
                     IMPase 1; inositol-1(or 4)-monophosphatase 1; D-galactose
                     1-phosphate phosphatase; inositol(myo)-1(or
                     4)-monophosphatase 1; myo-inositol monophosphatase 1;
                     testicular tissue protein Li 94"
                     /codon_start=1
                     /product="inositol monophosphatase 1 isoform 1"
                     /protein_id="NP_005527.1"
                     /db_xref="CCDS:CCDS6231.1"
                     /db_xref="GeneID:3612"
                     /db_xref="HGNC:HGNC:6050"
                     /db_xref="MIM:602064"
                     /translation="MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVT
                     ATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRF
                     PFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLV
                     TELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHC
                     WDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDE
                     D"
     exon            162..295
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     exon            296..400
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     exon            401..446
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     exon            447..555
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     exon            556..664
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     exon            665..816
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     exon            817..3369
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /note="hexamer: AATAAA"
     polyA_site      2330
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /note="major polyA site"
     regulatory      2647..2652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /note="hexamer: ATTAAA"
     polyA_site      2669
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
     regulatory      3348..3353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
                     /note="hexamer: AATATA"
     polyA_site      3369
                     /gene="IMPA1"
                     /gene_synonym="IMP; IMPA; MRT59"
ORIGIN      
        1 agcccctcta cctccggaag agacgagtgc ggtaacaccg ttcacagagc tagccggacg
       61 tcctccgact caagatattt gtcaaatatt ttcagaagat ggctgatcct tggcaggaat
      121 gcatggatta tgcagtaact ctagcaagac aagctggaga ggtagtttgt gaagctataa
      181 aaaatgaaat gaatgttatg ctgaaaagtt ctccagttga tttggtaact gctacggacc
      241 aaaaagttga aaaaatgctt atctcttcca taaaggaaaa gtatccatct cacagtttca
      301 ttggtgaaga atctgtggca gctggggaaa aaagtatctt aaccgacaac cccacatgga
      361 tcattgaccc tattgatgga acaactaact ttgtacatag atttcctttt gtagctgttt
      421 caattggctt tgctgtaaat aaaaagatag aatttggagt tgtgtacagt tgtgtggaag
      481 gcaagatgta cactgccaga aaaggaaaag gtgccttttg taatggtcaa aaactacaag
      541 tttcacaaca agaagatatt accaaatctc tcttggtgac tgagttgggc tcttccagaa
      601 caccagagac tgtgagaatg gttctttcta atatggaaaa gcttttttgc attcctgttc
      661 atgggatccg gagtgttgga acagcagctg ttaatatgtg ccttgtggca actggcggag
      721 cagatgcata ttatgaaatg ggaattcact gctgggatgt tgcaggagct ggcattattg
      781 ttactgaagc tggtggcgtg ctaatggatg ttacaggtgg accatttgat ttgatgtcac
      841 gaagagtaat tgctgcaaat aatagaatat tagcagaaag gatagctaaa gaaattcagg
      901 ttataccttt gcaacgagac gacgaagatt aattaaggca gcctcatagt caatcccagt
      961 tgcttttccc cagatttggt gactcatcaa tggatatgtg ttttggatgt atgatatgct
     1021 tggtttaaat tctctttgtc caggtcaaaa atttggaact tgtttcttat tttactatgt
     1081 ctaggtttgc aagaattgac ataatgtttg tttcactgat ttaaaaaatt ttgcatgtaa
     1141 gaatgtactt taggaaacat acccaggaag tacagttgat aaatataaca tcaactgaaa
     1201 tagtcaatta gcaattttgt gtttctaaat atctatggtc ccctgaaatt ttgacttagt
     1261 atataggtgc agagacaccc acttagaaag ttaactgttt ggaaaaacat ttctctttag
     1321 tttcaaaaac catatataat taaatttgta aggatatact gagtacccta ggccaacttt
     1381 tttttctttg cagagaacct tttttgtttt attcttcagt gttcatatag cacctggccc
     1441 attacatatc taggcaacta aaaacaaaca ttgtaagaat gaatattttt aatgtagtaa
     1501 ttcctagtta caatagatac ataaagtaat gaactcagca ttctgtactt ttgcttcagg
     1561 tttgaagtaa aaattatcta gttaaatttt ttttatttca cgttaccatg ccatttcaca
     1621 ttaccatacc atcagatagc atggcttatt gtgggcattt ctgcagtgaa tacattttcc
     1681 aaaacagtta aattgtctgt ttggatttgc tttaaagtct tgtgtaagag agaagaaact
     1741 atttctataa taaaaagcac tctcatcaga tatctgacat aattagatac aatataacat
     1801 tttactaagt tcagtattca tgttttaaag gtgtttatac tgatttgatt gtgctggcaa
     1861 atatactgta ttgttaatat tgaactgttt atttttctct tagtcttctt atttaattaa
     1921 cttcattgcc gctggattct gttcagcctt taaaaatatt tcttagtggt cattgctctg
     1981 cagaactcaa aaagaaaatt gtacttgttc atagacattt ttaaagggtt aatttattgt
     2041 tcagccttat cccttggcac gtaaacagac tactagactt attgtaggtt cgtttgagct
     2101 ttgtgttgta aaattaaaaa tgcttctgta aagttttcaa ggtagggagt gattttatta
     2161 ttgtgtatat ctaatatatt aagtatgtgt gatactaagg tttgactgct ataattattt
     2221 gtactgttga tcacatgtac ttaaaacatc tgatactgta ttctaagaca ggttgttttt
     2281 gcaattaaat ttattttaat aagacgatca tgaataaaac tttaaattga tatttttatt
     2341 attattacca ttatcattat tattattttt agattcaggg tctcgctctg ttgcccaggg
     2401 tctgtctctg actgtgctgt ggtgcagtca tagctcactg tatccttaaa ttcctgggct
     2461 caagtgatcc tcctctttca gtctcctgag tagctgggac tataagttca tgccaccatg
     2521 ccctactaat gttttaattt tatttttgta aagatgggat cttcctatgt tttccaggcc
     2581 ccttggcctc ccaaagtgct gggattacag atgtgagcca ccgagccagg ccatgatatt
     2641 tacattatta aagttaatag ttcaaactac ttttagaggc tttgttttgt ttttgttttt
     2701 tgaagacagt gtcttgctct tctgctcaaa cagtaatgca gtggcatgat caccattcat
     2761 tgcagtctca accttctggg ctcaagcagt cctcccacct cagcctccct agtaactgga
     2821 accacaggca catgccacca tgcctggcta attttttagt ttttgtagag acagaatctt
     2881 cctatgttgc ttaggctggt ctcattgggc tcaagtgatc ctcctgcctc agccttctaa
     2941 agtgctggga ttacagatgt gagccattgc acccaacata cttttagagg tttttgtgtt
     3001 gagttacaaa tatttgaaac ttgcaaatgt aatttaatat atgttcttat tttttgcctg
     3061 taatctttcc aacttttcta aaaacctata tttttttcta caatagcttt tccatctgtt
     3121 tattctaaat gcagttgcat attttgtgtc tgaaatttct ttagatgctg aaaaaggatg
     3181 atcgacaagt gaattatcta ataatatttg aaaatatttc tttgagtaac aggacttctt
     3241 agacttaaca tgtatatttt gtatcagggt atattatctt tctgcatgtg gatacataca
     3301 cagatacata cataaatata cataaatata tgtacttgaa cacataaaat atatgtactt
     3361 gccttttaa
//
