LOCUS       NM_033416               2411 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens IMP U3 small nucleolar ribonucleoprotein 4 (IMP4),
            transcript variant 1, mRNA.
ACCESSION   NM_033416
VERSION     NM_033416.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Liu,C., Tang,J., Duan,X., Du,Y., Wang,X. and Cui,Y.
  TITLE     DDX10 promotes human lung carcinoma proliferation by U3 small
            nucleolar ribonucleoprotein IMP4
  JOURNAL   Thorac Cancer 12 (12), 1873-1880 (2021)
   PUBMED   33973712
  REMARK    GeneRIF: DDX10 promotes human lung carcinoma proliferation by U3
            small nucleolar ribonucleoprotein IMP4.
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Leary,D.J., Terns,M.P. and Huang,S.
  TITLE     Components of U3 snoRNA-containing complexes shuttle between nuclei
            and the cytoplasm and differentially localize in nucleoli:
            implications for assembly and function
  JOURNAL   Mol Biol Cell 15 (1), 281-293 (2004)
   PUBMED   14565981
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Granneman,S., Gallagher,J.E., Vogelzangs,J., Horstman,W., van
            Venrooij,W.J., Baserga,S.J. and Pruijn,G.J.
  TITLE     The human Imp3 and Imp4 proteins form a ternary complex with
            hMpp10, which only interacts with the U3 snoRNA in 60-80S
            ribonucleoprotein complexes
  JOURNAL   Nucleic Acids Res 31 (7), 1877-1887 (2003)
   PUBMED   12655004
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Jakel,S., Mingot,J.M., Schwarzmaier,P., Hartmann,E. and Gorlich,D.
  TITLE     Importins fulfil a dual function as nuclear import receptors and
            cytoplasmic chaperones for exposed basic domains
  JOURNAL   EMBO J 21 (3), 377-386 (2002)
   PUBMED   11823430
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC132479.2.
            
            On Jul 23, 2019 this sequence version replaced NM_033416.2.
            
            Summary: The protein encoded by this gene, along with IMP3 and
            MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein
            (U3 snoRNP) complex. This complex is necessary for the early
            cleavage steps of pre-18S ribosomal RNA processing. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Feb 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289878.1, AK292345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259239.8/ ENSP00000259239.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC132479.2         18893-18931
            40-148              AC132479.2         19082-19190
            149-232             AC132479.2         20625-20708
            233-342             AC132479.2         21372-21481
            343-475             AC132479.2         21563-21695
            476-630             AC132479.2         21775-21929
            631-725             AC132479.2         22014-22108
            726-799             AC132479.2         22197-22270
            800-2411            AC132479.2         22352-23963
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..2411
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /note="IMP U3 small nucleolar ribonucleoprotein 4"
                     /db_xref="GeneID:92856"
                     /db_xref="HGNC:HGNC:30856"
                     /db_xref="MIM:612981"
     exon            1..39
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..912
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /note="isoform a is encoded by transcript variant 1; U3
                     snoRNP protein 4 homolog; U3 small nucleolar
                     ribonucleoprotein protein IMP4; U3 snoRNP protein IMP4;
                     brix domain-containing protein 4; IMP4, U3 small nucleolar
                     ribonucleoprotein, homolog; IMP4 homolog, U3 small
                     nucleolar ribonucleoprotein"
                     /codon_start=1
                     /product="U3 small nucleolar ribonucleoprotein protein
                     IMP4 isoform a"
                     /protein_id="NP_219484.1"
                     /db_xref="CCDS:CCDS2160.1"
                     /db_xref="GeneID:92856"
                     /db_xref="HGNC:HGNC:30856"
                     /db_xref="MIM:612981"
                     /translation="MLRREARLRREYLYRKAREEAQRSAQERKERLRRALEENRLIPT
                     ELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAK
                     ELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTA
                     YFTLCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDDSHRVI
                     TFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWH
                     PYTNTARKRVFLSTE"
     exon            40..148
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            149..232
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            233..342
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            343..475
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            476..630
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            631..725
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..799
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            800..2411
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1047..1052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /note="hexamer: AATAAA"
     polyA_site      1068
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /note="major polyA site"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /note="hexamer: AATAAA"
     polyA_site      2254
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
     regulatory      2388..2393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
                     /note="hexamer: AATACA"
     polyA_site      2411
                     /gene="IMP4"
                     /gene_synonym="BXDC4"
ORIGIN      
        1 agattctccc ggacccacgt ggaagcggca ctcaagatgc tgcgccgcga ggcccgcctg
       61 cgccgcgagt acctgtaccg caaggcccgg gaggaggcgc agcgctcagc ccaggagagg
      121 aaggagcggc tgcggcgcgc gctggaagaa aaccgcctga ttcccactga gttacgccga
      181 gaggctctgg ccttacaggg gtccctggag tttgatgatg ctggaggtga aggtgtgacc
      241 agccacgtgg atgatgaata ccgatgggca ggagtcgagg atcccaaggt tatgatcact
      301 acctcccgag accccagttc ccgcctcaag atgtttgcaa aggagctgaa gctggtgttc
      361 ccgggcgccc agcgaatgaa ccgaggtcga catgaagtgg gggcactggt gcgagcctgc
      421 aaagccaacg gcgtcaccga tctgctggtc gttcacgagc atcggggcac acctgtgggg
      481 ctcatcgtca gccacctgcc ctttggtcct actgcctact tcacgctgtg caatgtggtc
      541 atgcggcatg acatcccaga cctgggcacc atgtcggagg ccaagcccca cctcatcaca
      601 cacggcttct cctcccgcct gggcaagcgg gtctctgaca tcctccgata cctatttccc
      661 gtgcccaaag atgacagcca ccgggtcatc accttcgcaa accaggacga ctacatatca
      721 ttccggcacc atgtgtataa gaagacagac caccgcaacg tggagctcac tgaggtcggg
      781 ccccgctttg agctgaagct gtacatgatc cgtctgggca cgctggagca ggaggccaca
      841 gcagacgtgg agtggcgctg gcacccttac accaataccg cacgcaagag agtcttcctg
      901 agcaccgagt gagcacactc accactcagt caggacatgg acttggaact caggatgggg
      961 ctgtcataga cagacccacc agtaggaact gtcacagaat ggcctgctga actgggatgt
     1021 ggaactgtgg cgggtggaga ggtctgaata aaccgtctgt gtcatggccc cgcctgcctc
     1081 tgagtggtca ggccaagtct gcagggcaaa gcccatggga tccctttggg tggggacctg
     1141 atggctgtgg gacgtgcttg ggcctggagt cagtgtgggg gttaacagag agagagattt
     1201 gatgctaacg tcccctcaag agtgagggtc atatgagctc ttcagcaggc agatgtgggt
     1261 agcagggcca gcctgtgtca ggggcagccc accaagttaa ctcactgagt ggaagccgcc
     1321 agtgtgccaa cgcggagggg acaggccaca cccagtgctc agcagctgat tcctcatgta
     1381 agtggcatca tgtggtattt gttttgtgtc tggcttattt ctattaacat aatgttctcc
     1441 aggttcctcc atgttattgc aaatgatagg atttctttcc ttgtaaaaaa taacatgcca
     1501 cattttctta ccaatccgtc caccaataga cacttaggtc gttttcatag tttggcagtt
     1561 gtggaaatgc tgcagtaaac atgggagtat agctatcttt tgaagataat gatttcatct
     1621 cttttttata tgtataccca gaagtgggat tgctgcatca aatggtggtt ctatttttaa
     1681 ttttttgagg aaccgccata ctgttttcca taaaggctgt actaatttcc attctcacca
     1741 acagttcact agggttccct tttctccaca ttgttgccaa cattctttat cttgtgtttt
     1801 ttaataacag ctatcctaac aggtatgagg tgatctctct cattgcggtt ttgatttgca
     1861 tttccctaac ggttggtgat actgagcatt tttgcataca ccgggtcatt tgttctttgt
     1921 tgttgacttg agtcccttat atagtttgga tactgctgtg gcctgaatgt ttgtgtcccc
     1981 caaaaattcg tatattgaac tctcatccct aaggtcaaca gtttagggaa gcgattaggt
     2041 cctgaggact ctgccctctt gcatagaatt agtgctctta taaaagatgc ccgagggagc
     2101 tcttttgccc ctcctgccat gtgaggacac agctagaagc taccatctgt gaaccaggaa
     2161 gcccccctca ccagacactg aatctgctgg agccaccatc ttggacttcc cagcctccag
     2221 agctgtgaga aataaatgcc tgttgtttaa gctacccagt ctgtggtatt ttgttagaac
     2281 agcccaagtt gagacagata gtaacccttt accagataca tggtttgcaa atagtttttc
     2341 ccactctgta gatatagcca ttgagaagct cctcaagata gacattaaat acaaagaagc
     2401 atggtgtgaa a
//
