LOCUS       NM_018285               1132 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens IMP U3 small nucleolar ribonucleoprotein 3 (IMP3),
            mRNA.
ACCESSION   NM_018285
VERSION     NM_018285.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Wang,Z., Zhang,H., Li,F. and Huang,C.
  TITLE     Knockdown of RNA-binding protein IMP3 suppresses oral squamous cell
            carcinoma proliferation by destabilizing E2F5 transcript
  JOURNAL   Aging (Albany NY) 16 (2), 1897-1910 (2024)
   PUBMED   38271139
REFERENCE   2  (bases 1 to 1132)
  AUTHORS   Sasaki,M., Sato,Y. and Nakanuma,Y.
  TITLE     Bile duct adenoma and small-sized small duct type intrahepatic
            cholangiocarcinoma show distinct differences in genetic
            alterations, expression of IMP3 and EZH2 and stromal and
            inflammatory components
  JOURNAL   Histopathology 83 (2), 298-309 (2023)
   PUBMED   37140546
REFERENCE   3  (bases 1 to 1132)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1132)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   5  (bases 1 to 1132)
  AUTHORS   Zhang,M., Zhao,S., Tan,C., Gu,Y., He,X., Du,X., Li,D. and Wei,P.
  TITLE     RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling
            pathway in the progression of colorectal Cancer through the
            stabilization of MEKK1 mRNA
  JOURNAL   J Exp Clin Cancer Res 40 (1), 200 (2021)
   PUBMED   34154626
  REMARK    GeneRIF: RNA-binding protein IMP3 is a novel regulator of MEK1/ERK
            signaling pathway in the progression of colorectal Cancer through
            the stabilization of MEKK1 mRNA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1132)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1132)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   8  (bases 1 to 1132)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 1132)
  AUTHORS   Granneman,S., Gallagher,J.E., Vogelzangs,J., Horstman,W., van
            Venrooij,W.J., Baserga,S.J. and Pruijn,G.J.
  TITLE     The human Imp3 and Imp4 proteins form a ternary complex with
            hMpp10, which only interacts with the U3 snoRNA in 60-80S
            ribonucleoprotein complexes
  JOURNAL   Nucleic Acids Res 31 (7), 1877-1887 (2003)
   PUBMED   12655004
REFERENCE   10 (bases 1 to 1132)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105020.18.
            
            On Apr 29, 2020 this sequence version replaced NM_018285.3.
            
            Summary: This gene encodes the human homolog of the yeast Imp3
            protein. The protein localizes to the nucleoli and interacts with
            the U3 snoRNP complex. The protein contains an S4 domain. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK223121.1, BC006487.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403490.3/ ENSP00000385217.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1132              AC105020.18        74191-75322
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..1132
                     /gene="IMP3"
                     /gene_synonym="BRMS2; C15orf12; MRPS4"
                     /note="IMP U3 small nucleolar ribonucleoprotein 3"
                     /db_xref="GeneID:55272"
                     /db_xref="HGNC:HGNC:14497"
                     /db_xref="MIM:612980"
     exon            1..1132
                     /gene="IMP3"
                     /gene_synonym="BRMS2; C15orf12; MRPS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..611
                     /gene="IMP3"
                     /gene_synonym="BRMS2; C15orf12; MRPS4"
                     /note="U3 snoRNP protein 3 homolog; U3 snoRNP protein
                     IMP3; IMP3, U3 small nucleolar ribonucleoprotein, homolog"
                     /codon_start=1
                     /product="U3 small nucleolar ribonucleoprotein protein
                     IMP3"
                     /protein_id="NP_060755.1"
                     /db_xref="CCDS:CCDS10282.1"
                     /db_xref="GeneID:55272"
                     /db_xref="HGNC:HGNC:14497"
                     /db_xref="MIM:612980"
                     /translation="MVRKLKFHEQKLLKQVDFLNWEVTDHNLHELRVLRRYRLQRRED
                     YTRYNQLSRAVRELARRLRDLPERDQFRVRASAALLDKLYALGLVPTRGSLELCDFVT
                     ASSFCRRRLPTVLLKLRMAQHLQAAVAFVEQGHVRVGPDVVTDPAFLVTRSMEDFVTW
                     VDSSKIKRHVLEYNEERDDFDLEA"
     regulatory      1102..1107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IMP3"
                     /gene_synonym="BRMS2; C15orf12; MRPS4"
                     /note="hexamer: AATAAA"
     polyA_site      1132
                     /gene="IMP3"
                     /gene_synonym="BRMS2; C15orf12; MRPS4"
                     /note="major polyA site"
ORIGIN      
        1 gcggatgcca gaacgcgctc tcagcttcgg gtcctgcggc tgcggctgcc gccatcatgg
       61 tgcggaagct taagttccac gagcagaagc tgctgaagca ggtggacttc ctgaactggg
      121 aggtcaccga ccacaacctg cacgagctgc gcgtgctgcg gcgttaccgg ctgcagcggc
      181 gggaggacta cacgcgctac aaccagctga gccgtgccgt gcgtgagctg gcgcggcgcc
      241 tgcgcgacct gcccgaacgc gaccagttcc gcgtgcgcgc ttcggccgcg ctgctggaca
      301 agctgtatgc tctcggcttg gtgcccacgc gcggttcgct ggagctctgc gacttcgtca
      361 cggcctcgtc cttctgccgc cgccgcctcc ccaccgtgct cctcaagctg cgcatggcgc
      421 agcaccttca ggctgccgtg gcctttgtgg agcaagggca cgtacgcgtg ggccctgacg
      481 tggttaccga ccccgccttc cttgtcacgc gcagcatgga ggactttgtc acttgggtgg
      541 actcgtccaa gatcaagcgg cacgtgctag agtacaatga ggagcgcgat gacttcgatc
      601 tggaagccta gcggatctcc cactttgcat ggctgtcttt tacagatggg aaaactgagg
      661 cctgatgctg gagattctat gagggtgctc tcctcaaggg tatcagacgg tcgtaggttc
      721 ttaagaattt gattcatcag tggcaggcca tgcatagagc cacgggaggt gcgtccttgt
      781 tttccaggga atgttcttag aacttggact actgattatt aattgactgt gccttgggaa
      841 acagtgggaa gtaacttggt gcagcactgg ggtattgttg gcttcttgtg ttggaaactt
      901 tgtaatgtaa aaggaaaaac tggaaatccc cacgccctgt ttccctttat cgtcttgtgg
      961 ttggactggt tcaattcgtt taactcgaat tcttgctcct ggccgtggtt aagctgtgta
     1021 cagatgatgg agagtttggc ctcaagtttt tataaactga gcgagactag tgttcaggat
     1081 ctcctccctt gtttaaatgt caataaatgc cccaactgct ttgtaagtgc aa
//
