LOCUS       NM_024294               4338 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens inflammation and lipid regulator with UBA-like and
            NBR1-like domains (ILRUN), transcript variant 1, mRNA.
ACCESSION   NM_024294
VERSION     NM_024294.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4338)
  AUTHORS   Tribolet,L., Alexander,M.R., Brice,A.M., van Vuren,P.J.,
            Rootes,C.L., Mara,K., McDonald,M., Bruce,K.L., Gough,T.J., Shi,S.,
            Cowled,C., Bean,A.G.D. and Stewart,C.R.
  TITLE     ILRUN Downregulates ACE2 Expression and Blocks Infection of Human
            Cells by SARS-CoV-2
  JOURNAL   J Virol 95 (15), e0032721 (2021)
   PUBMED   33963054
  REMARK    GeneRIF: ILRUN Downregulates ACE2 Expression and Blocks Infection
            of Human Cells by SARS-CoV-2.
REFERENCE   2  (bases 1 to 4338)
  AUTHORS   Ambrose,R.L., Brice,A.M., Caputo,A.T., Alexander,M.R., Tribolet,L.,
            Liu,Y.C., Adams,T.E., Bean,A.G.D. and Stewart,C.R.
  TITLE     Molecular characterisation of ILRUN, a novel inhibitor of
            proinflammatory and antimicrobial cytokines
  JOURNAL   Heliyon 6 (6), e04115 (2020)
   PUBMED   32518853
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4338)
  AUTHORS   Li,X., Dong,M., Zhou,J., Zhu,D., Zhao,J. and Sheng,W.
  TITLE     C6orf106 accelerates pancreatic cancer cell invasion and
            proliferation via activating ERK signaling pathway
  JOURNAL   Mol Cell Biochem 454 (1-2), 87-95 (2019)
   PUBMED   30311108
  REMARK    GeneRIF: C6orf106 facilitates invasion and proliferation of
            pancreatic cancer cells, likely via activating ERK-P90RSK signaling
            pathway.
REFERENCE   4  (bases 1 to 4338)
  AUTHORS   Riveros-McKay,F., Mistry,V., Bounds,R., Hendricks,A., Keogh,J.M.,
            Thomas,H., Henning,E., Corbin,L.J., O'Rahilly,S., Zeggini,E.,
            Wheeler,E., Barroso,I. and Farooqi,I.S.
  CONSRTM   Understanding Society Scientific Group
  TITLE     Genetic architecture of human thinness compared to severe obesity
  JOURNAL   PLoS Genet 15 (1), e1007603 (2019)
   PUBMED   30677029
  REMARK    GeneRIF: we detected a novel obesity and BMI-associated locus at
            PKHD1 and novel variants driving associations at previously
            established signals (e.g. rs205262 at the SNRPC/C6orf106 locus and
            rs112446794 at the PRDM6-CEP120 locus).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4338)
  AUTHORS   Zhang,M., Ferrari,R., Tartaglia,M.C., Keith,J., Surace,E.I.,
            Wolf,U., Sato,C., Grinberg,M., Liang,Y., Xi,Z., Dupont,K.,
            McGoldrick,P., Weichert,A., McKeever,P.M., Schneider,R.,
            McCorkindale,M.D., Manzoni,C., Rademakers,R., Graff-Radford,N.R.,
            Dickson,D.W., Parisi,J.E., Boeve,B.F., Petersen,R.C., Miller,B.L.,
            Seeley,W.W., van Swieten,J.C., van Rooij,J., Pijnenburg,Y., van der
            Zee,J., Van Broeckhoven,C., Le Ber,I., Van Deerlin,V., Suh,E.,
            Rohrer,J.D., Mead,S., Graff,C., Oijerstedt,L., Pickering-Brown,S.,
            Rollinson,S., Rossi,G., Tagliavini,F., Brooks,W.S.,
            Dobson-Stone,C., Halliday,G.M., Hodges,J.R., Piguet,O., Binetti,G.,
            Benussi,L., Ghidoni,R., Nacmias,B., Sorbi,S., Bruni,A.C.,
            Galimberti,D., Scarpini,E., Rainero,I., Rubino,E., Clarimon,J.,
            Lleo,A., Ruiz,A., Hernandez,I., Pastor,P., Diez-Fairen,M.,
            Borroni,B., Pasquier,F., Deramecourt,V., Lebouvier,T.,
            Perneczky,R., Diehl-Schmid,J., Grafman,J., Huey,E.D., Mayeux,R.,
            Nalls,M.A., Hernandez,D., Singleton,A., Momeni,P., Zeng,Z.,
            Hardy,J., Robertson,J., Zinman,L. and Rogaeva,E.
  CONSRTM   International FTD-Genomics Consortium (IFGC)
  TITLE     A C6orf10/LOC101929163 locus is associated with age of onset in
            C9orf72 carriers
  JOURNAL   Brain 141 (10), 2895-2907 (2018)
   PUBMED   30252044
REFERENCE   6  (bases 1 to 4338)
  AUTHORS   Jiang,B., Liang,P., Zhang,B., Huang,X. and Xiao,X.
  TITLE     Enhancement of PPAR-beta activity by repetitive low-grade H(2)O(2)
            stress protects human umbilical vein endothelial cells from
            subsequent oxidative stress-induced apoptosis
  JOURNAL   Free Radic Biol Med 46 (5), 555-563 (2009)
   PUBMED   19059477
  REMARK    GeneRIF: up-regulated expression by repetitive low-grade oxidative
            stress through p38MAPK or NF-kappaB pathways
REFERENCE   7  (bases 1 to 4338)
  AUTHORS   Song,H.J., Park,J., Seo,S.R., Kim,J., Paik,S.R. and Chung,K.C.
  TITLE     Down syndrome critical region 2 protein inhibits the
            transcriptional activity of peroxisome proliferator-activated
            receptor beta in HEK293 cells
  JOURNAL   Biochem Biophys Res Commun 376 (3), 478-482 (2008)
   PUBMED   18793612
  REMARK    GeneRIF: DSCR2 was found to interact with PPARbeta and to inhibit
            it.
REFERENCE   8  (bases 1 to 4338)
  AUTHORS   Weedon,M.N., Lango,H., Lindgren,C.M., Wallace,C., Evans,D.M.,
            Mangino,M., Freathy,R.M., Perry,J.R., Stevens,S., Hall,A.S.,
            Samani,N.J., Shields,B., Prokopenko,I., Farrall,M., Dominiczak,A.,
            Johnson,T., Bergmann,S., Beckmann,J.S., Vollenweider,P.,
            Waterworth,D.M., Mooser,V., Palmer,C.N., Morris,A.D.,
            Ouwehand,W.H., Zhao,J.H., Li,S., Loos,R.J., Barroso,I.,
            Deloukas,P., Sandhu,M.S., Wheeler,E., Soranzo,N., Inouye,M.,
            Wareham,N.J., Caulfield,M., Munroe,P.B., Hattersley,A.T.,
            McCarthy,M.I. and Frayling,T.M.
  CONSRTM   Diabetes Genetics Initiative; Wellcome Trust Case Control
            Consortium; Cambridge GEM Consortium
  TITLE     Genome-wide association analysis identifies 20 loci that influence
            adult height
  JOURNAL   Nat Genet 40 (5), 575-583 (2008)
   PUBMED   18391952
REFERENCE   9  (bases 1 to 4338)
  AUTHORS   Venkata,N.G., Aung,C.S., Cabot,P.J., Monteith,G.R. and
            Roberts-Thomson,S.J.
  TITLE     PPARalpha and PPARbeta are differentially affected by ethanol and
            the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell
            line
  JOURNAL   Toxicol Sci 102 (1), 120-128 (2008)
   PUBMED   18003597
  REMARK    GeneRIF: Ethanol, but not acetaldehyde, inhibited PPAR-beta
            transactivation.
REFERENCE   10 (bases 1 to 4338)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL451165.19 and AL031577.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024294.3.
            
            Summary: This gene encodes a protein with N-terminal
            ubiquitin-associated (UBA)-like and central neighbor of BRCA1 gene
            1 (NBR1)-like domains. The protein acts an inhibitor of antiviral
            and proinflammatory cytokine transcription and as a regulator of
            the renin-angiotensin-aldosterone system (RAAS). [provided by
            RefSeq, Jul 2021].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075810.1, SRR1803611.274431.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000374023.8/ ENSP00000363135.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               AL451165.19        6376-6697           c
            323-477             AL031577.1         37297-37451
            478-675             AL031577.1         45278-45475
            676-1025            AL031577.1         85172-85521
            1026-4338           AL031577.1         101476-104788
FEATURES             Location/Qualifiers
     source          1..4338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..4338
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /note="inflammation and lipid regulator with UBA-like and
                     NBR1-like domains"
                     /db_xref="GeneID:64771"
                     /db_xref="HGNC:HGNC:21215"
                     /db_xref="MIM:612217"
     exon            1..322
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1061
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /note="isoform a is encoded by transcript variant 1;
                     uncharacterized protein C6orf106; inflammation and lipid
                     regulator with UBA-like and NBR1-like domains protein;
                     protein ILRUN"
                     /codon_start=1
                     /product="protein ILRUN isoform a"
                     /protein_id="NP_077270.1"
                     /db_xref="CCDS:CCDS4796.1"
                     /db_xref="GeneID:64771"
                     /db_xref="HGNC:HGNC:21215"
                     /db_xref="MIM:612217"
                     /translation="MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGC
                     AFFLDMTNWNLQAAIGAYYDFESPNISVPSMSFVEDVTIGEGESIPPDTQFVKTWRIQ
                     NSGAEAWPPGVCLKYVGGDQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWR
                     MCTATGLYYGDVIWVILSVEVGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQK
                     NRQSDENNLKDPGGSEFDSISKNTWAPAPDTWAPAPDQTEQDQNRLSQNSVNLSPSSH
                     ANNLSVVTYSKGLHGPYPFGQS"
     exon            323..477
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /inference="alignment:Splign:2.1.0"
     exon            478..675
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1025
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..4338
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4312..4317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /note="hexamer: ATTAAA"
     polyA_site      4338
                     /gene="ILRUN"
                     /gene_synonym="C6orf106; dJ391O22.4; FP852"
                     /note="major polyA site"
ORIGIN      
        1 agagtgagtt tacccctatg agactgtgag aggcccgggg cctacctcaa aggagcgggg
       61 tcgcgaagct agctagcagc ggcccccctc caggtccccg ggcccggcgg cgcggcggcg
      121 gcttggttgt gaagaggcgg ggaagcgggt gtccggtccc cgccatggag ggcatggacg
      181 tagacctgga cccggagctg atgcagaagt tcagctgcct gggcaccacc gacaaggacg
      241 tgctcatctc cgagttccag aggctgctcg gcttccagct caatcctgcc ggttgcgcct
      301 tcttcctgga catgaccaac tggaacctac aagcagcaat tggcgcctat tatgactttg
      361 agagcccaaa catcagtgtg ccctctatgt cctttgttga agatgtcacc ataggagaag
      421 gggagtcaat acctccggat actcagtttg taaaaacatg gcggatccag aattctgggg
      481 cagaggcctg gcctccaggg gtttgtctta aatatgtcgg gggagaccaa tttggacatg
      541 tgaacatggt gatggtgaga tcgctagagc cccaagagat tgcagatgtc agcgtccaga
      601 tgtgcagccc cagcagagca ggaatgtatc agggacagtg gcggatgtgc actgctacag
      661 gactctacta tggagatgtc atctgggtga ttctcagtgt ggaggtgggt ggacttttag
      721 gagtaacgca gcagctgtca tcttttgaaa cggagttcaa cacacagccg catcgtaagg
      781 tagaaggaaa cttcaaccct tttgcctctc cccaaaagaa ccgacaatca gatgaaaaca
      841 acttaaaaga ccctgggggc tccgagttcg actcgatcag caaaaacaca tgggctcctg
      901 ctcctgacac atgggctcct gctcctgacc aaactgagca agaccagaat agactgtcac
      961 agaactctgt aaatctgtct cccagcagtc acgcaaacaa cttatcagta gtgacttaca
     1021 gtaaggggct ccatgggcct taccccttcg gccagtctta aacgggtgtc agcaagaaga
     1081 aaaattaaca aaagacagaa ggcctgactt tggggggtta gggcaagggg ttcctctgga
     1141 ttgcagacca catcgcacag acccctggct ctgaccccct ctcatcccgg aagaagagga
     1201 agaagcagaa cagactagtt ttgagtaaac tcagtatgca tgtgtgaatg ctgaatcaca
     1261 ggaatggtgt tgaggctacc aagaagaaat ccatgcagcc actttgggtt ttgttatagg
     1321 catcagtcta acaagtcatt aggtcactcg ggaaggggga aaaagtttaa aatgggggaa
     1381 aaaaagccat ctttttaaac aaaaattatt ttgcctacag aaaggttgta gttttgagca
     1441 catgttaatt tttttccctc tttccccact tttatttttt taaataaggg ataacatatt
     1501 ctttatagaa tagtgcttgt tctggaagag attcaggtga aaagttggcg tggcatgttt
     1561 gaggactctg cggatcagtg ctacaggagt acatctgccc tgccacatga ctccagaagt
     1621 ctctgacccc atttgttttt aatggcatca gccaatgagt tatcaccctt ttcctcctct
     1681 tttctcttta atcttctgtt gatttacacc tttgacattt gtattcgtca accctgtggc
     1741 ttgttagcat cagaacctct ctgaagacca aacttccctg tgtggccagc agaggaagcc
     1801 ttgaggatag atctcgggtg acgtgggatt ttctaagcct gagaggtgtc cttctgcaca
     1861 cccttgtaac aattaaaatt gcttttcttc catgtttctc ttggcagaga gaaatgccat
     1921 catgcttact gctcttttgg attcttcatg cagtggcttc ccatttgctc tgggaacagt
     1981 gcctctgtgc tggttatatg tatgcaccac atgtgcacac acgggtgttg gtgcaactca
     2041 ccagcaggtg tgcagtaggc aagcttgaag gtggcccatg cttctctgtt gtcacacaac
     2101 acctttccct gtttctcttc agttgtcctc tgatattttc acagcctgtt agtggcggct
     2161 gatctgtaga ggtatgaaaa tacagcccca aagggggaat ttgtcatggg gaagggccag
     2221 ccactgacta cttgatcttg gagaccacat ttagatggaa atgagaggac ctccacagcc
     2281 ccgcctccct gccaggatgc tagattattg gctgggaggt gggcaagtgg cagcccagct
     2341 gaagcaagag gctgattgac tggctgctca ctcaggcagg tggcctgccc tggcatcctg
     2401 tagattctga gcaggttgag atgtggatat ctccatggga agcttgaacc aggctagaac
     2461 agctgtctgc caaagataca agaatatgca aagtccctct tacccccctc cttccctcaa
     2521 gtcttagttg gtttgagagc cagggatatg gatccagggt gctgttgcag ggtcacctgc
     2581 ctgttaccac acccccatcc agctgggtgg tgggtgaggg tgtgagacag gcagggagac
     2641 caggtaatga gtggctgcaa ggagtcatat agcctgggtg tgggtgaggg tctgcctgcc
     2701 tgtttctgtc tgggtgtctg agttccaaaa aatgtgtgtt gtttgttcct cctcatcctc
     2761 ttctgagact gttgtttttt tagagcttga ttgtgggaga aaagcttgtg tgaaattccc
     2821 tcttcacctc cccacccccc aaaaaataaa agggggcata aactttattc cactggagaa
     2881 gccctggggg tggctggagc cagcctgctg agaagcgtgg tgcagctggg tctgggactt
     2941 cactagagct tactctggag cacctatttt ctgtgcacat gggagtgctc cactccctag
     3001 cagagcagag ggaagtctct gccaggtacc cacgccacag gcctcaggat ggctttttgt
     3061 ctgagggcct cattaggccc agactgctgc tgctggtacc agtctcctga gacactgcct
     3121 ccctggagcc catgcatgcc cagctgttct tactgcttag tagccttgaa gcagcacatc
     3181 tccactgtcc ctggcaggat tgtgggaggc ttcacaaccc ctgctttcct gacttcctct
     3241 tctgcccaac actgggtgcc ccttcccagt ttcccagcag gggcttcatg ggccaccgtc
     3301 agtgggtctg ggcctgccag agtcgtcttg ctcttcctct tgcttctagg caaccacact
     3361 tggcaagtta aatgtcccaa gcaccttgtc tcccttccca agaacaaacc atttctgtgc
     3421 acatccttgg aggcgagatg agctccttgc agagggccag agtaagtgca agtcatggag
     3481 tgcaggcaga ggggtccatg gcttccccag cccagggagg gtatcagtat cattcattct
     3541 ctctcccctc actggtatgg gttcagagca atgcctaggg cccctctctg ctcccctgcc
     3601 tagtggggtg gtagtggcta cctctcagcc ccaatagtcc ctgctcctct tagaatcttc
     3661 accaagtggc aggccacctc tgggcaggac cacctgcgtc tggcacccag gaggtgaggc
     3721 agacaccatg gttaggtgat agggtctgaa cccagttggg gagacagagg ggttcagact
     3781 tgggaagaat ctgtcagtgt gcatggagtg aggtgtgtgt gtgtggatgg atgtgcacgt
     3841 gtgcatgctt tttttctttt tgccgtgagg acagttgaat ttggggcatt tttctacaag
     3901 aagcagtcag ccttctctcc cccataagga ctggctgtaa ccttaagccc atcaaagtta
     3961 cttccagcct ggagagaacc tcaccaaaca gctggtgtgg cctgagggtg gccatggtgg
     4021 gaaatgggca tgagaataaa tacctcccca aattcaatct gagcccagca ggagaggatg
     4081 gtagggttgc cagggctcag aagtgcaagc tgattactca ccccaccctg cctcgccgca
     4141 cctttccttt gtttccttgg gtgaatgcag gagcagcagt ggctgccctt cccacctgga
     4201 cagtggtgtg tgtagaaagc cagctggatg tttgtggtgg ggcctcatgg tgcctaggag
     4261 gagataaaga tgaggaggtt tttccttatt gtataaatga atatttgtat gattaaatta
     4321 acacacacac caaaaaaa
//
