LOCUS       NM_017620               6017 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens interleukin enhancer binding factor 3 (ILF3),
            transcript variant 4, mRNA.
ACCESSION   NM_017620
VERSION     NM_017620.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6017)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6017)
  AUTHORS   Hou,Y.M., Xu,B.H., Zhang,Q.T., Cheng,J., Zhang,X., Yang,H.R.,
            Wang,Z.Y., Wang,P. and Zhang,M.X.
  TITLE     Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis
  JOURNAL   J Mol Cell Cardiol 190, 62-75 (2024)
   PUBMED   38583797
  REMARK    GeneRIF: Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis.
REFERENCE   3  (bases 1 to 6017)
  AUTHORS   Wang,W., Xu,R., He,P., Xiong,Y., Zhao,H., Fu,X., Lin,J. and Ye,L.
  TITLE     Role of ATF3 triggering M2 macrophage polarization to protect
            against the inflammatory injury of sepsis through ILF3/NEAT1 axis
  JOURNAL   Mol Med 30 (1), 30 (2024)
   PUBMED   38395749
  REMARK    GeneRIF: Role of ATF3 triggering M2 macrophage polarization to
            protect against the inflammatory injury of sepsis through
            ILF3/NEAT1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6017)
  AUTHORS   Wang,D.D., Zhang,L.Z., Pang,C.J. and Ye,J.Z.
  TITLE     Astragaloside IV promotes keratinocyte proliferation and migration
            through upregulating lncRNA H19 recruited ILF3 to enhance the
            stability of CDK4 mRNA
  JOURNAL   Kaohsiung J Med Sci 39 (8), 811-823 (2023)
   PUBMED   37132584
  REMARK    GeneRIF: Astragaloside IV promotes keratinocyte proliferation and
            migration through upregulating lncRNA H19 recruited ILF3 to enhance
            the stability of CDK4 mRNA.
REFERENCE   5  (bases 1 to 6017)
  AUTHORS   Zhang,J., Ma,Q., Yu,Q., Xiao,F., Zhang,Z., Feng,H. and Liang,C.
  TITLE     PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation
            and migration
  JOURNAL   Biol Direct 18 (1), 33 (2023)
   PUBMED   37337223
  REMARK    GeneRIF: PSMD3-ILF3 signaling cascade drives lung cancer cell
            proliferation and migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6017)
  AUTHORS   Marcoulatos,P., Avgerinos,E., Tsantzalos,D.V. and
            Vamvakopoulos,N.C.
  TITLE     Mapping interleukin enhancer binding factor 3 gene (ILF3) to human
            chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain
            reaction amplification of human-rodent somatic cell hybrid DNA
            templates
  JOURNAL   J Interferon Cytokine Res 18 (5), 351-355 (1998)
   PUBMED   9620363
REFERENCE   7  (bases 1 to 6017)
  AUTHORS   Ting,N.S., Kao,P.N., Chan,D.W., Lintott,L.G. and Lees-Miller,S.P.
  TITLE     DNA-dependent protein kinase interacts with antigen receptor
            response element binding proteins NF90 and NF45
  JOURNAL   J Biol Chem 273 (4), 2136-2145 (1998)
   PUBMED   9442054
REFERENCE   8  (bases 1 to 6017)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   9  (bases 1 to 6017)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
REFERENCE   10 (bases 1 to 6017)
  AUTHORS   St Johnston,D., Brown,N.H., Gall,J.G. and Jantsch,M.
  TITLE     A conserved double-stranded RNA-binding domain
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10979-10983 (1992)
   PUBMED   1438302
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC320902.1, BC064836.1,
            AJ271744.1, AF167570.1 and AJ271747.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_017620.2.
            
            Summary: This gene encodes a double-stranded RNA (dsRNA) binding
            protein that complexes with other proteins, dsRNAs, small noncoding
            RNAs, and mRNAs to regulate gene expression and stabilize mRNAs.
            This protein (NF90, ILF3) forms a heterodimer with a 45 kDa
            transcription factor (NF45, ILF2) required for T-cell expression of
            interleukin 2. This complex has been shown to affect the
            redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45
            or NF90 protein retards cell growth, possibly by inhibition of mRNA
            stabilization. In contrast, an isoform (NF110) of this gene that is
            predominantly restricted to the nucleus has only minor effects on
            cell growth when its levels are reduced. Alternative splicing
            results in multiple transcript variants encoding distinct
            isoforms.[provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (d). Variants 4 and 6-8 all encode the same isoform (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10324.1, SRR11853567.15079.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000588657.6/ ENSP00000468181.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               DC320902.1         89-496
            409-2286            BC064836.1         427-2304
            2287-2303           AJ271744.1         1655-1671
            2304-3340           AF167570.1         2060-3096
            3341-3560           AJ271747.1         2188-2407
            3561-6017           AJ271747.1         2410-4866
FEATURES             Location/Qualifiers
     source          1..6017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..6017
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:3609"
                     /db_xref="HGNC:HGNC:6038"
                     /db_xref="MIM:603182"
     exon            1..142
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            143..235
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2929
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="isoform d is encoded by transcript variant 4;
                     M-phase phosphoprotein 4; nuclear factor of activated
                     T-cells, 90 kD; translational control protein 80;
                     double-stranded RNA-binding protein, 76 kD; nuclear factor
                     associated with dsRNA; dsRNA binding protein NFAR-2/MPP4;
                     nuclear factor of activated T-cells 90 kDa; interleukin
                     enhancer binding factor 3, 90kD; nuclear factor of
                     activated T-cells 110 kDa; M phase phosphoprotein 4,
                     nuclear factor associated with DS RNA; interleukin
                     enhancer binding factor 3, 90kDa"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform d"
                     /protein_id="NP_060090.2"
                     /db_xref="CCDS:CCDS45965.1"
                     /db_xref="GeneID:3609"
                     /db_xref="HGNC:HGNC:6038"
                     /db_xref="MIM:603182"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAA
                     FPSDATAENVKQQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVD
                     GQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHN
                     PGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYG
                     GNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQP
                     HGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPG
                     GGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGG
                     YSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR"
     exon            236..465
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            466..643
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            644..791
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            792..883
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            884..979
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1091
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1189
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1301
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1412
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1612
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1780
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1918
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2095
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2249
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2303
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2666
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2795
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..6017
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3445..3450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="hexamer: AATAAA"
     polyA_site      3464
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="major polyA site"
     regulatory      5995..6000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="hexamer: AATAAA"
     polyA_site      6017
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
ORIGIN      
        1 actcctcctc ctcctcttct cgccattgca gttggaccca gcagcccggc gcgcaccgcg
       61 tggcttttgg gggcagaccc cggcgggctg tggcaggagg gcggcggcgg cggctgcggt
      121 cgaagaaggg gacgccgaca agagttgaag tattgataac accaaggaac tctatcacaa
      181 tttgaaaaga taagcaaaag tttgatttcc agacactaca gaagaagtaa aaatgcgtcc
      241 aatgcgaatt tttgtgaatg atgaccgcca tgtgatggca aagcattctt ccgtttatcc
      301 aacacaagag gagctggagg cagtccagaa catggtgtcc cacacggagc gggcgctcaa
      361 agctgtgtcc gactggatag acgagcagga aaagggtagc agcgagcagg cagagtccga
      421 taacatggat gtgcccccag aggacgacag taaagaaggg gctggggaac agaagacgga
      481 gcacatgacc agaaccctgc ggggagtgat gcgggtgggc ctggtggcaa agggcctcct
      541 actcaagggg gacttggatc tggagctggt gctgctgtgt aaggagaagc ccacaaccgc
      601 cctcctggac aaggtggccg acaacctggc catccagctt gctgctgtaa cagaagacaa
      661 gtacgaaata ctgcaatctg tcgacgatgc tgcgattgtg ataaaaaaca caaaagagcc
      721 tccattgtcc ctgaccatcc acctgacatc ccctgttgtc agagaagaaa tggagaaagt
      781 attagctgga gaaacgctat cagtcaacga ccccccggac gttctggaca ggcagaaatg
      841 ccttgctgcc ttggcgtccc tccgacacgc caagtggttc caggccagag ccaacgggct
      901 gaagtcttgt gtcattgtga tccgggtctt gagggacctg tgcactcgcg tgcccacctg
      961 gggtcccctc cgaggctggc ctctcgagct cctgtgtgag aaatccattg gcacggccaa
     1021 cagaccgatg ggtgctggcg aggccctgcg gagagtgctg gagtgcctgg cgtcgggcat
     1081 cgtgatgcca gatggttctg gcatttatga cccttgtgaa aaagaagcca ctgatgctat
     1141 tgggcatcta gacagacagc aacgggaaga tatcacacag agtgcgcagc acgcactgcg
     1201 gctcgctgcc ttcggccagc tccataaagt cctaggcatg gaccctctgc cttccaagat
     1261 gcccaagaaa ccaaagaatg aaaacccagt ggactacacc gttcagatcc caccaagcac
     1321 cacctatgcc attacgccca tgaaacgccc aatggaggag gacggggagg agaagtcgcc
     1381 cagcaaaaag aagaagaaga ttcagaagaa agaggagaag gcagagcccc cccaggctat
     1441 gaatgccctg atgcggttga accagctgaa gccagggctg cagtacaagc tggtgtccca
     1501 gactgggccc gtccatgccc ccatctttac catgtctgtg gaggttgatg gcaattcatt
     1561 cgaggcctct gggccctcca aaaagacggc caagctgcac gtggccgtta aggtgttaca
     1621 ggacatgggc ttgccgacgg gtgctgaagg cagggactcg agcaaggggg aggactcggc
     1681 tgaggagacc gaggcgaagc cagcagtggt ggcccctgcc ccagtggtag aagctgtctc
     1741 cacccctagt gcggcctttc cctcagatgc cactgccgag aacgtaaaac agcaggggcc
     1801 gatcctgaca aagcacggca agaacccagt catggagctg aacgagaaga ggcgtgggct
     1861 caagtacgag ctcatctccg agaccggggg cagccacgac aagcgcttcg tcatggaggt
     1921 cgaagtggat ggacagaagt tccaaggtgc tggttccaac aaaaaggtgg cgaaggccta
     1981 cgctgctctt gctgccctag aaaagctttt ccctgacacc cctctcgccc ttgatgccaa
     2041 caaaaagaag agagccccag tacccgtcag agggggaccg aaatttgctg ctaagccaca
     2101 taaccctggc ttcggcatgg gaggccccat gcacaacgaa gtgcccccac cccccaacct
     2161 tcgagggcgg ggaagaggcg ggagcatccg gggacgaggg cgcgggcgag gatttggtgg
     2221 cgccaaccat ggaggctaca tgaatgccgg tgctgggtat ggaagctatg ggtacggagg
     2281 caactcggcg acagcaggct acagtcagtt ctacagcaac ggagggcatt ctgggaatgc
     2341 cagtggcggt ggcggcgggg gcggtggtgg ctcctccggc tatggctcct actaccaagg
     2401 tgacaactac aactcaccgg tgcccccaaa acacgctggg aagaagcagc cgcacggggg
     2461 ccagcagaag ccctcctacg gctcgggcta ccagtcccac cagggccagc agcagtccta
     2521 caaccagagc ccctacagca actatggccc tccacagggc aagcagaaag gctataacca
     2581 tggacaaggc agctactcct actcgaactc ctacaactct cccgggggcg ggggcggatc
     2641 cgactacaac tacgagagca aattcaacta cagtggtagt ggaggccgaa gcggcgggaa
     2701 cagctacggc tcaggcgggg catcctacaa cccagggtca cacgggggct acggcggagg
     2761 ttctgggggc ggctcctcat accaaggcaa acaaggaggc tactcacagt cgaactacaa
     2821 ctccccgggg tccggccaga actacagtgg ccctcccagc tcctaccagt cctcacaagg
     2881 cggctatggc agaaacgcag accacagcat gaactaccag tacagataag cccccgcggg
     2941 gcggagattt ctaccttctg cacttactcc ccatcagaag atcgagtttt atgcatcaca
     3001 gttaacatgt cagctggccc tccaggcccc cgcccccatc ccgtccacgt tgctgtgtcg
     3061 tgaggtgcag cgggtcaccc tgtggcccgt cctgtgaccc atatttagcc gtgtttggga
     3121 ctccgtgtct tcaatggttt gttagttgcc attacaactt tgtctgggta gagtttttga
     3181 gtttttgcag ttcagtatcc ctctgtctat tcacacttcg tgttagtggt aactcagttt
     3241 gtctttaaat agttacagaa gggatacgtc atttgttaat gcttttgtga agtgagttaa
     3301 acgagctttc tgtattttaa tgctttagtg tttcagtttt ataagtgaag attttatttt
     3361 aaaaaccagt gggaaagagt ggggggtttc tttttatgtc tgggtcattc aggcagtaca
     3421 tctgaattaa gctgaatgta gacaaataaa gaaaaacaaa actgcgcccg tcttaggcct
     3481 gggtgtctga cccaccagca gtgcaatggg caggtttccc cactctattc ctgctcttgg
     3541 gaaagcagcg tgggccatca ggatggtccc tggtccttag agagggtcca gttcaggctt
     3601 ctagacattt tactcatgct cagcgaaggc tggttcctgg tcccctgggc tgtgtagacc
     3661 cggtgtccca ccaggctcca ggctcccacc atctacagag gggcttacag cgcccattct
     3721 ggtcttgggg aacccatcac aaaataggct ttttctgctc cccgattctg gtgtagttct
     3781 aagtacacag tgatgtcctc tgtaggggcg tgcctgtggt ggaacataac gcagttacaa
     3841 aagaaagggc aggtgaggcc tgggtaaccc cagccatgga ccgtcagtgg ctggagggag
     3901 cttcgtgtct gtgctggagc tgcagcctgc tcgccatctg gaggctcagt ggagtgggga
     3961 gttggggttc tcataccagc agatttccct agagcgtgat tctcccatct gaggcaatct
     4021 tgcctcccag gggaaatttt gcaatgtttg gaggatgttg tcacagctag tagcgggtgc
     4081 tctgggatct ggtggataga tgccaaggat gctgtcaagc atactgtact gcccagaaca
     4141 gtggcccata gcagggacct gccctatcaa aatatcaggt gtatggaggt ggagtcccaa
     4201 cgctagagca gcccttctca gctccaccct gcccggggag ggaggaggag ctctggtttc
     4261 agagcagtgc cgggattgcc tttccccagg atctgtgtcg gccatccagg aagaactgta
     4321 ctggccaagc ctgggaccac acgtctgcag agatcctgct ctgctggcct gagccccagg
     4381 ccttggcctc ctgtgcttgg gtaaccatgg ccactgggaa aagcaaggac cgtgtttgac
     4441 tttcttggag aggtgaaaga ggtgaaagaa caagttgtgt gctagaaaac ttttgaggaa
     4501 ttcttatttg tgttagagca gaggaggtcc cagataccaa gtggcgcctc ccaggaaagg
     4561 ctgggagaag aggtggcctg gagtaccccg agatcccagc agcgcacaca gtggagggat
     4621 gaggatggat gggtcctaac ccctgatttt gatgggatgt gttcatgtcc tatctcctct
     4681 cctggacaca ttaaggggtt gggacaagaa gagactcctg tgagatcagc agacctcgtg
     4741 tttaaggaga gaatgcctgc ctgcaacact catggagagg gacacttcct ggccccacct
     4801 gctaaatacc tccaaactct gggcaggcgc ctgcattctc aacacaggac ttcccttaac
     4861 agtttccgga tcagtgacca ccaccacgtt caggtttctg aatgcagacc caccacgagg
     4921 gatggattcc acccgcccgc cctgctgcag atacatgcgg cacagcaggc acgtgcctgg
     4981 agagaacagc tcctgagcac agcacccttg gagccctcac cccgctcacg atcctcacca
     5041 gtgctgatga tgccgtcatg ctgctggcct gagacagtat cccagctaca acaggacgac
     5101 accgggttca ggaatatgtg gctatcacct tgagcactga cagtggcctt ccaggctagt
     5161 tgccttccaa acgcaggtag ccgacctgca ggagggccta caaacgggcc cagcaagagc
     5221 tgggcaacag ctggcttgtg aaatgagaca ccttgaccaa tatgctttgg gtggacggtc
     5281 tcctacatgt tcagtggagg ccaccaggag catccatgag cggggaaggg gtccacaccc
     5341 ttacatggca agttgatacg atggggtgct tggtggatgg gccatggagg tccgtgagct
     5401 ggaactgggc acacgccatc ccagagggct caggatgccc caggaaggaa agaagggcaa
     5461 cagactacac gattggacgt gtgtggttga ctgggatgaa gttggaggga ggggcagggc
     5521 cttgcagggg attggtactg atcccaggga ggaagtgttg gggcttcatg aactaggatg
     5581 aaaggaggcc cctgagccat gacaaggggc acatccagga tttccgccac cctgaattta
     5641 gtagagctag taggccctgg tcgtcactct gggcagggat gccgtcagcc ttgagggtcg
     5701 ccacccacct gtgtgttgcc ctctgtcctg gcagggaaac atacacccct tgtctcacca
     5761 ccaaccttgc ttgtgtagtc agcagggctg gccctgcccc aaggactcac tgcatgtacc
     5821 cggaccccta ggcctggcct ttgcagcata gttgggagct tctggattcc atctgcacct
     5881 gtgagcccca tgctggctgt gcactgcgcg ggcctgagac tgctggatac aatgttgggc
     5941 aacaactcag ccagcctgat ggcagcctca gaggcttact ctaacccatc ccagaataaa
     6001 tggagacttc atgtgtt
//
