LOCUS       NM_001394827            3210 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens interleukin enhancer binding factor 3 (ILF3),
            transcript variant 25, mRNA.
ACCESSION   NM_001394827
VERSION     NM_001394827.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Hou,Y.M., Xu,B.H., Zhang,Q.T., Cheng,J., Zhang,X., Yang,H.R.,
            Wang,Z.Y., Wang,P. and Zhang,M.X.
  TITLE     Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis
  JOURNAL   J Mol Cell Cardiol 190, 62-75 (2024)
   PUBMED   38583797
  REMARK    GeneRIF: Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis.
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Wang,W., Xu,R., He,P., Xiong,Y., Zhao,H., Fu,X., Lin,J. and Ye,L.
  TITLE     Role of ATF3 triggering M2 macrophage polarization to protect
            against the inflammatory injury of sepsis through ILF3/NEAT1 axis
  JOURNAL   Mol Med 30 (1), 30 (2024)
   PUBMED   38395749
  REMARK    GeneRIF: Role of ATF3 triggering M2 macrophage polarization to
            protect against the inflammatory injury of sepsis through
            ILF3/NEAT1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Wang,D.D., Zhang,L.Z., Pang,C.J. and Ye,J.Z.
  TITLE     Astragaloside IV promotes keratinocyte proliferation and migration
            through upregulating lncRNA H19 recruited ILF3 to enhance the
            stability of CDK4 mRNA
  JOURNAL   Kaohsiung J Med Sci 39 (8), 811-823 (2023)
   PUBMED   37132584
  REMARK    GeneRIF: Astragaloside IV promotes keratinocyte proliferation and
            migration through upregulating lncRNA H19 recruited ILF3 to enhance
            the stability of CDK4 mRNA.
REFERENCE   5  (bases 1 to 3210)
  AUTHORS   Zhang,J., Ma,Q., Yu,Q., Xiao,F., Zhang,Z., Feng,H. and Liang,C.
  TITLE     PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation
            and migration
  JOURNAL   Biol Direct 18 (1), 33 (2023)
   PUBMED   37337223
  REMARK    GeneRIF: PSMD3-ILF3 signaling cascade drives lung cancer cell
            proliferation and migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3210)
  AUTHORS   Marcoulatos,P., Avgerinos,E., Tsantzalos,D.V. and
            Vamvakopoulos,N.C.
  TITLE     Mapping interleukin enhancer binding factor 3 gene (ILF3) to human
            chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain
            reaction amplification of human-rodent somatic cell hybrid DNA
            templates
  JOURNAL   J Interferon Cytokine Res 18 (5), 351-355 (1998)
   PUBMED   9620363
REFERENCE   7  (bases 1 to 3210)
  AUTHORS   Ting,N.S., Kao,P.N., Chan,D.W., Lintott,L.G. and Lees-Miller,S.P.
  TITLE     DNA-dependent protein kinase interacts with antigen receptor
            response element binding proteins NF90 and NF45
  JOURNAL   J Biol Chem 273 (4), 2136-2145 (1998)
   PUBMED   9442054
REFERENCE   8  (bases 1 to 3210)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   9  (bases 1 to 3210)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
REFERENCE   10 (bases 1 to 3210)
  AUTHORS   St Johnston,D., Brown,N.H., Gall,J.G. and Jantsch,M.
  TITLE     A conserved double-stranded RNA-binding domain
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10979-10983 (1992)
   PUBMED   1438302
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011475.6.
            
            Summary: This gene encodes a double-stranded RNA (dsRNA) binding
            protein that complexes with other proteins, dsRNAs, small noncoding
            RNAs, and mRNAs to regulate gene expression and stabilize mRNAs.
            This protein (NF90, ILF3) forms a heterodimer with a 45 kDa
            transcription factor (NF45, ILF2) required for T-cell expression of
            interleukin 2. This complex has been shown to affect the
            redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45
            or NF90 protein retards cell growth, possibly by inhibition of mRNA
            stabilization. In contrast, an isoform (NF110) of this gene that is
            predominantly restricted to the nucleus has only minor effects on
            cell growth when its levels are reduced. Alternative splicing
            results in multiple transcript variants encoding distinct
            isoforms.[provided by RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2496577.1,
                                           SRR14038196.2687958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC011475.6         73439-73580         c
            143-235             AC011475.6         57318-57410         c
            236-465             AC011475.6         56723-56952         c
            466-643             AC011475.6         56391-56568         c
            644-791             AC011475.6         50616-50763         c
            792-883             AC011475.6         49222-49313         c
            884-979             AC011475.6         48734-48829         c
            980-1091            AC011475.6         47999-48110         c
            1092-1189           AC011475.6         47483-47580         c
            1190-1301           AC011475.6         46796-46907         c
            1302-1412           AC011475.6         46597-46707         c
            1413-1612           AC011475.6         45734-45933         c
            1613-1780           AC011475.6         45222-45389         c
            1781-1918           AC011475.6         44664-44801         c
            1919-2095           AC011475.6         44384-44560         c
            2096-2249           AC011475.6         44137-44290         c
            2250-2303           AC011475.6         43956-44009         c
            2304-3210           AC011475.6         42161-43067         c
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3210
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:3609"
                     /db_xref="HGNC:HGNC:6038"
                     /db_xref="MIM:603182"
     exon            1..142
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            143..235
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2317
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="isoform l is encoded by transcript variant 25;
                     M-phase phosphoprotein 4; nuclear factor of activated
                     T-cells, 90 kD; translational control protein 80;
                     double-stranded RNA-binding protein, 76 kD; nuclear factor
                     associated with dsRNA; dsRNA binding protein NFAR-2/MPP4;
                     nuclear factor of activated T-cells 90 kDa; interleukin
                     enhancer binding factor 3, 90kD; nuclear factor of
                     activated T-cells 110 kDa; M phase phosphoprotein 4,
                     nuclear factor associated with DS RNA; interleukin
                     enhancer binding factor 3, 90kDa"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform l"
                     /protein_id="NP_001381756.1"
                     /db_xref="GeneID:3609"
                     /db_xref="HGNC:HGNC:6038"
                     /db_xref="MIM:603182"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAA
                     FPSDATAENVKQQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVD
                     GQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHN
                     PGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYG
                     GNSATAGYTGFV"
     exon            236..465
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            466..643
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            644..791
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            792..883
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            884..979
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1091
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1189
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1301
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1412
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1612
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1780
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1918
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2095
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2249
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2303
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..3210
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3191..3196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="hexamer: AATACA"
     polyA_site      3210
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="major polyA site"
ORIGIN      
        1 actcctcctc ctcctcttct cgccattgca gttggaccca gcagcccggc gcgcaccgcg
       61 tggcttttgg gggcagaccc cggcgggctg tggcaggagg gcggcggcgg cggctgcggt
      121 cgaagaaggg gacgccgaca agagttgaag tattgataac accaaggaac tctatcacaa
      181 tttgaaaaga taagcaaaag tttgatttcc agacactaca gaagaagtaa aaatgcgtcc
      241 aatgcgaatt tttgtgaatg atgaccgcca tgtgatggca aagcattctt ccgtttatcc
      301 aacacaagag gagctggagg cagtccagaa catggtgtcc cacacggagc gggcgctcaa
      361 agctgtgtcc gactggatag acgagcagga aaagggtagc agcgagcagg cagagtccga
      421 taacatggat gtgcccccag aggacgacag taaagaaggg gctggggaac agaagacgga
      481 gcacatgacc agaaccctgc ggggagtgat gcgggtgggc ctggtggcaa agggcctcct
      541 actcaagggg gacttggatc tggagctggt gctgctgtgt aaggagaagc ccacaaccgc
      601 cctcctggac aaggtggccg acaacctggc catccagctt gctgctgtaa cagaagacaa
      661 gtacgaaata ctgcaatctg tcgacgatgc tgcgattgtg ataaaaaaca caaaagagcc
      721 tccattgtcc ctgaccatcc acctgacatc ccctgttgtc agagaagaaa tggagaaagt
      781 attagctgga gaaacgctat cagtcaacga ccccccggac gttctggaca ggcagaaatg
      841 ccttgctgcc ttggcgtccc tccgacacgc caagtggttc caggccagag ccaacgggct
      901 gaagtcttgt gtcattgtga tccgggtctt gagggacctg tgcactcgcg tgcccacctg
      961 gggtcccctc cgaggctggc ctctcgagct cctgtgtgag aaatccattg gcacggccaa
     1021 cagaccgatg ggtgctggcg aggccctgcg gagagtgctg gagtgcctgg cgtcgggcat
     1081 cgtgatgcca gatggttctg gcatttatga cccttgtgaa aaagaagcca ctgatgctat
     1141 tgggcatcta gacagacagc aacgggaaga tatcacacag agtgcgcagc acgcactgcg
     1201 gctcgctgcc ttcggccagc tccataaagt cctaggcatg gaccctctgc cttccaagat
     1261 gcccaagaaa ccaaagaatg aaaacccagt ggactacacc gttcagatcc caccaagcac
     1321 cacctatgcc attacgccca tgaaacgccc aatggaggag gacggggagg agaagtcgcc
     1381 cagcaaaaag aagaagaaga ttcagaagaa agaggagaag gcagagcccc cccaggctat
     1441 gaatgccctg atgcggttga accagctgaa gccagggctg cagtacaagc tggtgtccca
     1501 gactgggccc gtccatgccc ccatctttac catgtctgtg gaggttgatg gcaattcatt
     1561 cgaggcctct gggccctcca aaaagacggc caagctgcac gtggccgtta aggtgttaca
     1621 ggacatgggc ttgccgacgg gtgctgaagg cagggactcg agcaaggggg aggactcggc
     1681 tgaggagacc gaggcgaagc cagcagtggt ggcccctgcc ccagtggtag aagctgtctc
     1741 cacccctagt gcggcctttc cctcagatgc cactgccgag aacgtaaaac agcaggggcc
     1801 gatcctgaca aagcacggca agaacccagt catggagctg aacgagaaga ggcgtgggct
     1861 caagtacgag ctcatctccg agaccggggg cagccacgac aagcgcttcg tcatggaggt
     1921 cgaagtggat ggacagaagt tccaaggtgc tggttccaac aaaaaggtgg cgaaggccta
     1981 cgctgctctt gctgccctag aaaagctttt ccctgacacc cctctcgccc ttgatgccaa
     2041 caaaaagaag agagccccag tacccgtcag agggggaccg aaatttgctg ctaagccaca
     2101 taaccctggc ttcggcatgg gaggccccat gcacaacgaa gtgcccccac cccccaacct
     2161 tcgagggcgg ggaagaggcg ggagcatccg gggacgaggg cgcgggcgag gatttggtgg
     2221 cgccaaccat ggaggctaca tgaatgccgg tgctgggtat ggaagctatg ggtacggagg
     2281 caactcggcg acagcaggct acacaggttt tgtatgaatt tttaaccttt taacaaactc
     2341 ccaaatctgg ttgatgcctt tgacagtgat gaaaacgatt tcaccacatc tgaatccaga
     2401 gaaaccggct ttttttctta ttgcgagcat gttaaaacgt tgggaacatg tggggaattg
     2461 tatattgcgc tgaattaact tctcccgcct cttgtaatgc tctggtgggt tcttgtttgg
     2521 gaatgcgata ttttgtggct ggtttagcta gagagtgaac tctcaaaggt atcaaaactg
     2581 tgcttccatt attagtgcaa gaaacagaca ggctttaagg ggtagatgac gtgaaatttt
     2641 gcaagtctta attacagctg cagatgcatg ggattctgga tttttttgtt gctttttagt
     2701 ttaatgggac tttaaaagta attgaggaga aagaaccgtg atgttccctg tttctccagt
     2761 aaaggactgg cttttgcttg ggcagaggtg gtgctgctgg gtgtgcagct gccacagact
     2821 ccaaaggcgt agaagtttgt gccaacacac ggagtcattc tggctctctg ctgaggcccc
     2881 tgttttctgg caggtgccct ccttggaaac tggttttggc tctgatcagc ggttcttttt
     2941 gcagcaaagc ctgcatctgt gttgacttgc aagattttgc gtttattcag gcaaaaactg
     3001 gtcaaaatgg ttactacatg atttgttccc agaggtttga aacattcagt gaaacttttt
     3061 aaaactttga ttgcatgatg tatttttttt ttagaaagtt attgtttgag aataatgtct
     3121 ttttatacca ggaaaatagt tatcctgaat gacgttgaaa actccccctc ccctttattt
     3181 ttttttaatc aatacatgtg aaagtaacaa
//
