LOCUS       NM_001394824            3799 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens interleukin enhancer binding factor 3 (ILF3),
            transcript variant 22, mRNA.
ACCESSION   NM_001394824
VERSION     NM_001394824.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3799)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3799)
  AUTHORS   Hou,Y.M., Xu,B.H., Zhang,Q.T., Cheng,J., Zhang,X., Yang,H.R.,
            Wang,Z.Y., Wang,P. and Zhang,M.X.
  TITLE     Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis
  JOURNAL   J Mol Cell Cardiol 190, 62-75 (2024)
   PUBMED   38583797
  REMARK    GeneRIF: Deficiency of smooth muscle cell ILF3 alleviates intimal
            hyperplasia via HMGB1 mRNA degradation-mediated regulation of the
            STAT3/DUSP16 axis.
REFERENCE   3  (bases 1 to 3799)
  AUTHORS   Wang,W., Xu,R., He,P., Xiong,Y., Zhao,H., Fu,X., Lin,J. and Ye,L.
  TITLE     Role of ATF3 triggering M2 macrophage polarization to protect
            against the inflammatory injury of sepsis through ILF3/NEAT1 axis
  JOURNAL   Mol Med 30 (1), 30 (2024)
   PUBMED   38395749
  REMARK    GeneRIF: Role of ATF3 triggering M2 macrophage polarization to
            protect against the inflammatory injury of sepsis through
            ILF3/NEAT1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3799)
  AUTHORS   Wang,D.D., Zhang,L.Z., Pang,C.J. and Ye,J.Z.
  TITLE     Astragaloside IV promotes keratinocyte proliferation and migration
            through upregulating lncRNA H19 recruited ILF3 to enhance the
            stability of CDK4 mRNA
  JOURNAL   Kaohsiung J Med Sci 39 (8), 811-823 (2023)
   PUBMED   37132584
  REMARK    GeneRIF: Astragaloside IV promotes keratinocyte proliferation and
            migration through upregulating lncRNA H19 recruited ILF3 to enhance
            the stability of CDK4 mRNA.
REFERENCE   5  (bases 1 to 3799)
  AUTHORS   Zhang,J., Ma,Q., Yu,Q., Xiao,F., Zhang,Z., Feng,H. and Liang,C.
  TITLE     PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation
            and migration
  JOURNAL   Biol Direct 18 (1), 33 (2023)
   PUBMED   37337223
  REMARK    GeneRIF: PSMD3-ILF3 signaling cascade drives lung cancer cell
            proliferation and migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3799)
  AUTHORS   Marcoulatos,P., Avgerinos,E., Tsantzalos,D.V. and
            Vamvakopoulos,N.C.
  TITLE     Mapping interleukin enhancer binding factor 3 gene (ILF3) to human
            chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain
            reaction amplification of human-rodent somatic cell hybrid DNA
            templates
  JOURNAL   J Interferon Cytokine Res 18 (5), 351-355 (1998)
   PUBMED   9620363
REFERENCE   7  (bases 1 to 3799)
  AUTHORS   Ting,N.S., Kao,P.N., Chan,D.W., Lintott,L.G. and Lees-Miller,S.P.
  TITLE     DNA-dependent protein kinase interacts with antigen receptor
            response element binding proteins NF90 and NF45
  JOURNAL   J Biol Chem 273 (4), 2136-2145 (1998)
   PUBMED   9442054
REFERENCE   8  (bases 1 to 3799)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   9  (bases 1 to 3799)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
REFERENCE   10 (bases 1 to 3799)
  AUTHORS   St Johnston,D., Brown,N.H., Gall,J.G. and Jantsch,M.
  TITLE     A conserved double-stranded RNA-binding domain
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10979-10983 (1992)
   PUBMED   1438302
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011475.6.
            
            Summary: This gene encodes a double-stranded RNA (dsRNA) binding
            protein that complexes with other proteins, dsRNAs, small noncoding
            RNAs, and mRNAs to regulate gene expression and stabilize mRNAs.
            This protein (NF90, ILF3) forms a heterodimer with a 45 kDa
            transcription factor (NF45, ILF2) required for T-cell expression of
            interleukin 2. This complex has been shown to affect the
            redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45
            or NF90 protein retards cell growth, possibly by inhibition of mRNA
            stabilization. In contrast, an isoform (NF110) of this gene that is
            predominantly restricted to the nucleus has only minor effects on
            cell growth when its levels are reduced. Alternative splicing
            results in multiple transcript variants encoding distinct
            isoforms.[provided by RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1666094.1,
                                           SRR18074967.664539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC011475.6         73439-73580         c
            143-300             AC011475.6         61277-61434         c
            301-393             AC011475.6         57318-57410         c
            394-623             AC011475.6         56723-56952         c
            624-801             AC011475.6         56391-56568         c
            802-949             AC011475.6         50616-50763         c
            950-1041            AC011475.6         49222-49313         c
            1042-1137           AC011475.6         48734-48829         c
            1138-1249           AC011475.6         47999-48110         c
            1250-1347           AC011475.6         47483-47580         c
            1348-1459           AC011475.6         46796-46907         c
            1460-1570           AC011475.6         46597-46707         c
            1571-1770           AC011475.6         45734-45933         c
            1771-1938           AC011475.6         45222-45389         c
            1939-2064           AC011475.6         44664-44789         c
            2065-2241           AC011475.6         44384-44560         c
            2242-2395           AC011475.6         44137-44290         c
            2396-2449           AC011475.6         43956-44009         c
            2450-3799           AC011475.6         42161-43510         c
FEATURES             Location/Qualifiers
     source          1..3799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3799
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:3609"
                     /db_xref="HGNC:HGNC:6038"
                     /db_xref="MIM:603182"
     exon            1..142
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            143..300
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            301..393
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..2499
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="isoform b is encoded by transcript variant 22;
                     M-phase phosphoprotein 4; nuclear factor of activated
                     T-cells, 90 kD; translational control protein 80;
                     double-stranded RNA-binding protein, 76 kD; nuclear factor
                     associated with dsRNA; dsRNA binding protein NFAR-2/MPP4;
                     nuclear factor of activated T-cells 90 kDa; interleukin
                     enhancer binding factor 3, 90kD; nuclear factor of
                     activated T-cells 110 kDa; M phase phosphoprotein 4,
                     nuclear factor associated with DS RNA; interleukin
                     enhancer binding factor 3, 90kDa"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3 isoform b"
                     /protein_id="NP_001381753.1"
                     /db_xref="CCDS:CCDS12247.1"
                     /db_xref="GeneID:3609"
                     /db_xref="HGNC:HGNC:6038"
                     /db_xref="MIM:603182"
                     /translation="MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKA
                     VSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGL
                     LLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNT
                     KEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQA
                     RANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVL
                     ECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVL
                     GMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQK
                     KEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSK
                     KTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAA
                     FPSDATAEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKF
                     QGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHNPGFG
                     MGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNSA
                     TAGYSDFFTDCYGYHDFGSS"
     exon            394..623
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            624..801
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            802..949
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1041
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1137
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1249
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1347
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1459
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1570
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1770
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1938
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2064
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2241
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2395
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2449
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..3799
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3780..3785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="hexamer: AATACA"
     polyA_site      3799
                     /gene="ILF3"
                     /gene_synonym="CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4;
                     MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b;
                     NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2;
                     NFAR90; TCP110; TCP80"
                     /note="major polyA site"
ORIGIN      
        1 actcctcctc ctcctcttct cgccattgca gttggaccca gcagcccggc gcgcaccgcg
       61 tggcttttgg gggcagaccc cggcgggctg tggcaggagg gcggcggcgg cggctgcggt
      121 cgaagaaggg gacgccgaca agccagtggg acacctcaca agtcagctcc gatgtcctca
      181 ggacaagact gctatagtca ccagtgcttt gttgctttct ggcgctccgg taggatccag
      241 gctcacttgg tatatcccct gctgcagatt acggtccact tctcccggga gctgctttca
      301 agttgaagta ttgataacac caaggaactc tatcacaatt tgaaaagata agcaaaagtt
      361 tgatttccag acactacaga agaagtaaaa atgcgtccaa tgcgaatttt tgtgaatgat
      421 gaccgccatg tgatggcaaa gcattcttcc gtttatccaa cacaagagga gctggaggca
      481 gtccagaaca tggtgtccca cacggagcgg gcgctcaaag ctgtgtccga ctggatagac
      541 gagcaggaaa agggtagcag cgagcaggca gagtccgata acatggatgt gcccccagag
      601 gacgacagta aagaaggggc tggggaacag aagacggagc acatgaccag aaccctgcgg
      661 ggagtgatgc gggtgggcct ggtggcaaag ggcctcctac tcaaggggga cttggatctg
      721 gagctggtgc tgctgtgtaa ggagaagccc acaaccgccc tcctggacaa ggtggccgac
      781 aacctggcca tccagcttgc tgctgtaaca gaagacaagt acgaaatact gcaatctgtc
      841 gacgatgctg cgattgtgat aaaaaacaca aaagagcctc cattgtccct gaccatccac
      901 ctgacatccc ctgttgtcag agaagaaatg gagaaagtat tagctggaga aacgctatca
      961 gtcaacgacc ccccggacgt tctggacagg cagaaatgcc ttgctgcctt ggcgtccctc
     1021 cgacacgcca agtggttcca ggccagagcc aacgggctga agtcttgtgt cattgtgatc
     1081 cgggtcttga gggacctgtg cactcgcgtg cccacctggg gtcccctccg aggctggcct
     1141 ctcgagctcc tgtgtgagaa atccattggc acggccaaca gaccgatggg tgctggcgag
     1201 gccctgcgga gagtgctgga gtgcctggcg tcgggcatcg tgatgccaga tggttctggc
     1261 atttatgacc cttgtgaaaa agaagccact gatgctattg ggcatctaga cagacagcaa
     1321 cgggaagata tcacacagag tgcgcagcac gcactgcggc tcgctgcctt cggccagctc
     1381 cataaagtcc taggcatgga ccctctgcct tccaagatgc ccaagaaacc aaagaatgaa
     1441 aacccagtgg actacaccgt tcagatccca ccaagcacca cctatgccat tacgcccatg
     1501 aaacgcccaa tggaggagga cggggaggag aagtcgccca gcaaaaagaa gaagaagatt
     1561 cagaagaaag aggagaaggc agagcccccc caggctatga atgccctgat gcggttgaac
     1621 cagctgaagc cagggctgca gtacaagctg gtgtcccaga ctgggcccgt ccatgccccc
     1681 atctttacca tgtctgtgga ggttgatggc aattcattcg aggcctctgg gccctccaaa
     1741 aagacggcca agctgcacgt ggccgttaag gtgttacagg acatgggctt gccgacgggt
     1801 gctgaaggca gggactcgag caagggggag gactcggctg aggagaccga ggcgaagcca
     1861 gcagtggtgg cccctgcccc agtggtagaa gctgtctcca cccctagtgc ggcctttccc
     1921 tcagatgcca ctgccgagca ggggccgatc ctgacaaagc acggcaagaa cccagtcatg
     1981 gagctgaacg agaagaggcg tgggctcaag tacgagctca tctccgagac cgggggcagc
     2041 cacgacaagc gcttcgtcat ggaggtcgaa gtggatggac agaagttcca aggtgctggt
     2101 tccaacaaaa aggtggcgaa ggcctacgct gctcttgctg ccctagaaaa gcttttccct
     2161 gacacccctc tcgcccttga tgccaacaaa aagaagagag ccccagtacc cgtcagaggg
     2221 ggaccgaaat ttgctgctaa gccacataac cctggcttcg gcatgggagg ccccatgcac
     2281 aacgaagtgc ccccaccccc caaccttcga gggcggggaa gaggcgggag catccgggga
     2341 cgagggcgcg ggcgaggatt tggtggcgcc aaccatggag gctacatgaa tgccggtgct
     2401 gggtatggaa gctatgggta cggaggcaac tcggcgacag caggctacag tgactttttc
     2461 acagactgct acggctatca tgattttggg tcttcctaga gcgtctaaaa gtattgcaca
     2521 caaaatcaac tttttactcc aatttcctcc aactccaaaa cccaaagtgt ccgtgctgtg
     2581 tccctgtgct tcactgggtt tctcaaccgt ggcttttcac cgcagcttgt ctgaaactct
     2641 tagcctgcag aatttaagac aatggcagtt tttatcgtga tttgcctttg aacttggtcc
     2701 tattgaagtt cacaataagt ggaaaacaat tttttcagag aatgtatttt tgtgcagaat
     2761 tgcacagaat tctagagaca gcgttgttcg gcatcaaggc aaaagcccac ctttgctttt
     2821 tatggaaagc attactttat ttaaagagac agacaatgac gcattttaat ctacctttgt
     2881 cttaatttac agcaggtttt gtatgaattt ttaacctttt aacaaactcc caaatctggt
     2941 tgatgccttt gacagtgatg aaaacgattt caccacatct gaatccagag aaaccggctt
     3001 tttttcttat tgcgagcatg ttaaaacgtt gggaacatgt ggggaattgt atattgcgct
     3061 gaattaactt ctcccgcctc ttgtaatgct ctggtgggtt cttgtttggg aatgcgatat
     3121 tttgtggctg gtttagctag agagtgaact ctcaaaggta tcaaaactgt gcttccatta
     3181 ttagtgcaag aaacagacag gctttaaggg gtagatgacg tgaaattttg caagtcttaa
     3241 ttacagctgc agatgcatgg gattctggat ttttttgttg ctttttagtt taatgggact
     3301 ttaaaagtaa ttgaggagaa agaaccgtga tgttccctgt ttctccagta aaggactggc
     3361 ttttgcttgg gcagaggtgg tgctgctggg tgtgcagctg ccacagactc caaaggcgta
     3421 gaagtttgtg ccaacacacg gagtcattct ggctctctgc tgaggcccct gttttctggc
     3481 aggtgccctc cttggaaact ggttttggct ctgatcagcg gttctttttg cagcaaagcc
     3541 tgcatctgtg ttgacttgca agattttgcg tttattcagg caaaaactgg tcaaaatggt
     3601 tactacatga tttgttccca gaggtttgaa acattcagtg aaacttttta aaactttgat
     3661 tgcatgatgt attttttttt tagaaagtta ttgtttgaga ataatgtctt tttataccag
     3721 gaaaatagtt atcctgaatg acgttgaaaa ctccccctcc cctttatttt tttttaatca
     3781 atacatgtga aagtaacaa
//
