LOCUS       NM_199351              13360 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens immunoglobulin like domain containing receptor 2
            (ILDR2), transcript variant 1, mRNA.
ACCESSION   NM_199351 XR_108301 XR_111960 XR_114930
VERSION     NM_199351.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13360)
  AUTHORS   Hecht,I., Toporik,A., Podojil,J.R., Vaknin,I., Cojocaru,G.,
            Oren,A., Aizman,E., Liang,S.C., Leung,L., Dicken,Y., Novik,A.,
            Marbach-Bar,N., Elmesmari,A., Tange,C., Gilmour,A., McIntyre,D.,
            Kurowska-Stolarska,M., McNamee,K., Leitner,J., Greenwald,S.,
            Dassa,L., Levine,Z., Steinberger,P., Williams,R.O., Miller,S.D.,
            McInnes,I.B., Neria,E. and Rotman,G.
  TITLE     ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell
            Responses
  JOURNAL   J Immunol 200 (6), 2025-2037 (2018)
   PUBMED   29431694
REFERENCE   2  (bases 1 to 13360)
  AUTHORS   Watanabe,K., Nakayama,K., Ohta,S., Tago,K., Boonvisut,S.,
            Millings,E.J., Fischer,S.G., LeDuc,C.A., Leibel,R.L. and Iwamoto,S.
  TITLE     ZNF70, a novel ILDR2-interacting protein, contributes to the
            regulation of HES1 gene expression
  JOURNAL   Biochem Biophys Res Commun 477 (4), 712-716 (2016)
   PUBMED   27353377
  REMARK    GeneRIF: We demonstrated that ZNF70 interacts with ZFP64 and
            activates HES1 transcription by binding to the HES1 promoter. In
            addition, HES1 gene expression is increased in ILDR2-knockdown
            HepG2 cells, in which ZNF70 is translocated from the cytoplasm to
            the nucleus, suggesting that ZNF70 migration to the nucleus after
            dissociating from the ILDR2-ZNF70 complex activates HES1
            transcription. These results support a novel link betwee
REFERENCE   3  (bases 1 to 13360)
  AUTHORS   Li,Q., Wojciechowski,R., Simpson,C.L., Hysi,P.G., Verhoeven,V.J.,
            Ikram,M.K., Hohn,R., Vitart,V., Hewitt,A.W., Oexle,K., Makela,K.M.,
            MacGregor,S., Pirastu,M., Fan,Q., Cheng,C.Y., St Pourcain,B.,
            McMahon,G., Kemp,J.P., Northstone,K., Rahi,J.S., Cumberland,P.M.,
            Martin,N.G., Sanfilippo,P.G., Lu,Y., Wang,Y.X., Hayward,C.,
            Polasek,O., Campbell,H., Bencic,G., Wright,A.F., Wedenoja,J.,
            Zeller,T., Schillert,A., Mirshahi,A., Lackner,K., Yip,S.P.,
            Yap,M.K., Ried,J.S., Gieger,C., Murgia,F., Wilson,J.F., Fleck,B.,
            Yazar,S., Vingerling,J.R., Hofman,A., Uitterlinden,A.,
            Rivadeneira,F., Amin,N., Karssen,L., Oostra,B.A., Zhou,X.,
            Teo,Y.Y., Tai,E.S., Vithana,E., Barathi,V., Zheng,Y., Siantar,R.G.,
            Neelam,K., Shin,Y., Lam,J., Yonova-Doing,E., Venturini,C.,
            Hosseini,S.M., Wong,H.S., Lehtimaki,T., Kahonen,M., Raitakari,O.,
            Timpson,N.J., Evans,D.M., Khor,C.C., Aung,T., Young,T.L.,
            Mitchell,P., Klein,B., van Duijn,C.M., Meitinger,T., Jonas,J.B.,
            Baird,P.N., Mackey,D.A., Wong,T.Y., Saw,S.M., Parssinen,O.,
            Stambolian,D., Hammond,C.J., Klaver,C.C., Williams,C.,
            Paterson,A.D., Bailey-Wilson,J.E. and Guggenheim,J.A.
  CONSRTM   CREAM Consortium
  TITLE     Genome-wide association study for refractive astigmatism reveals
            genetic co-determination with spherical equivalent refractive
            error: the CREAM consortium
  JOURNAL   Hum Genet 134 (2), 131-146 (2015)
   PUBMED   25367360
REFERENCE   4  (bases 1 to 13360)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 13360)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum Mol Genet 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 13360)
  AUTHORS   Roni,V., Carpio,R. and Wissinger,B.
  TITLE     Mapping of transcription start sites of human retina expressed
            genes
  JOURNAL   BMC Genomics 8, 42 (2007)
   PUBMED   17286855
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL009182.17 and AF503509.1.
            
            On Nov 23, 2018 this sequence version replaced NM_199351.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF503509.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271417.8/ ENSP00000271417.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AL009182.17        102974-103189       c
            217-2788            AF503509.1         1-2572
            2789-13360          AL009182.17        35836-46407         c
FEATURES             Location/Qualifiers
     source          1..13360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.1"
     gene            1..13360
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /note="immunoglobulin like domain containing receptor 2"
                     /db_xref="GeneID:387597"
                     /db_xref="HGNC:HGNC:18131"
                     /db_xref="MIM:618081"
     exon            1..318
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2192
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; angulin-3"
                     /codon_start=1
                     /product="immunoglobulin-like domain-containing receptor 2
                     isoform 1 precursor"
                     /protein_id="NP_955383.1"
                     /db_xref="CCDS:CCDS1256.1"
                     /db_xref="GeneID:387597"
                     /db_xref="HGNC:HGNC:18131"
                     /db_xref="MIM:618081"
                     /translation="MDRVLLRWISLFWLTAMVEGLQVTVPDKKKVAMLFQPTVLRCHF
                     STSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRV
                     VASKQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDS
                     VELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGVFLFFVLVGICWCQCCPHSCCC
                     YVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDK
                     PHPPPLAPSDSTGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNN
                     TISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAME
                     YNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHE
                     ARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDA
                     HLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYY
                     AWSPPGTYKAGSSQDDQEDASDDALPPYSELELTRGPSYRGRDLPYHSNSEKKRKKEP
                     AKKTNDFPTRMSLVV"
     exon            319..651
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..771
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..828
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..975
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1152
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1266
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1483
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..2156
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..13360
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8323..8328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /note="hexamer: AATAAA"
     polyA_site      8343
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /note="major polyA site"
     regulatory      13337..13342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
                     /note="hexamer: AATAAA"
     polyA_site      13360
                     /gene="ILDR2"
                     /gene_synonym="C1orf32; dJ782G3.1"
ORIGIN      
        1 gagacgctcg ccccgtgccg cgctgcctgg gcatgcggat gcgccgccga gcgctgcgcg
       61 gaccccggaa gcccgcggca gcgcgcgctc agccggcggc gcgatccagc ccccggcccc
      121 gcctgcgcgg ccggcccggc gggcgctgcg cccagggacg cccggtgccc gccgctccgc
      181 cgccgcccgc tgccgcgggg tgacagcgat ccttctgttc cagccatttc ccactttcct
      241 cactccgtaa ttcggctggg aagttgggga agatggatag ggtcttgctg aggtggattt
      301 ctctcttctg gctaacagcc atggtcgaag gccttcaggt cacagtgccc gacaagaaga
      361 aggtggccat gctcttccag cccactgtgc ttcgctgcca cttctcaaca tcctcccatc
      421 agcctgcagt tgtgcagtgg aagttcaagt cctactgcca ggatcgcatg ggagaatcct
      481 tgggcatgtc ctctacccgg gcccaatctc tcagcaagag aaacctggaa tgggacccct
      541 acttggattg tttggacagc aggaggactg ttcgagtagt agcttcaaaa cagggctcga
      601 ctgtcaccct gggagatttc tacaggggca gagagatcac gattgttcat gatgcagatc
      661 ttcaaattgg aaagcttatg tggggagaca gcggactcta ttactgtatt atcaccaccc
      721 cagatgacct ggaggggaaa aatgaggact cagtggaact gctggtgttg ggcaggacag
      781 ggctgcttgc tgatctcttg cccagttttg ctgtggagat tatgccagag tgggtgtttg
      841 ttggcctggt gctcctgggc gtcttcctct tcttcgtcct ggtggggatc tgctggtgcc
      901 agtgctgccc tcacagctgc tgctgctatg tccgctgccc atgctgccca gattcctgct
      961 gctgccctca agccttgtat gaagcaggga aagcagcaaa ggccgggtac cctccctctg
     1021 tctccggtgt ccccggccct tactccatcc cctctgtccc tttgggagga gccccctcat
     1081 ctggcatgct gatggacaag ccgcatccac ctcccttggc accaagtgac tccactggag
     1141 gaagccacag tgttcgcaaa ggttaccgga tccaggctga caaagagaga gactccatga
     1201 aggtcctgta ctatgttgag aaggagctgg ctcagtttga tccagccaga aggatgagag
     1261 gcagatataa caacaccatc tcagaactca gctccctaca tgaggaggac agcaatttcc
     1321 gccagtcttt ccatcagatg agaagcaagc agttccctgt gtctggggac ttggagagca
     1381 atcctgacta ttggtcaggt gtcatgggag gcagcagtgg ggcaagccgc gggccctcag
     1441 ccatggagta taacaaagag gatcgagaga gcttcaggca cagccagccg cgctccaagt
     1501 cggagatgct gtcgcggaag aacttcgcca cgggggtgcc ggccgtttcc atggacgagc
     1561 tggcggcctt cgctgactcc tacggccagc ggccccgccg ggcagacggc aacagtcacg
     1621 aggcgcgggg cgggagccgc ttcgagcgct cggagtcgcg ggcgcacagc ggcttctacc
     1681 aggacgactc cttggaggag tactacggtc agcgcagccg cagccgcgag cccctgaccg
     1741 atgctgaccg cggctgggcc ttcagccccg cgcgccgcag acccgccgag gacgcgcacc
     1801 tgccgcggct ggtgagccgc acgccaggca ccgcacccaa atacgaccac tcgtacctgg
     1861 gcagcgcgcg ggagcgccag gcgcggcccg agggcgccag ccgcggtggc agcctggaga
     1921 cgccatccaa gcggagcgcg cagctcggcc cgcgcagcgc ctcctactac gcttggtcgc
     1981 cgcccggcac ctacaaggcc ggctcgtcgc aggacgacca ggaggacgcg tccgacgacg
     2041 cgctgccgcc ctacagcgag ctggagctga cccgcggccc gtcctaccgc ggccgcgacc
     2101 tgccctacca cagcaactcg gagaagaaga ggaaaaagga gcccgccaag aaaaccaatg
     2161 actttccaac caggatgtcc cttgtggtct gatgttgtca acatttctct ggataatgag
     2221 aaatcagaca tggactacgg ggacaagaca caaatctaag aaccagcagg cccaggacct
     2281 tctctggcca tcaccttgga agatttgctg atctctgctt tggcaaggga tggcaggcag
     2341 cctttaaggg aggctgattt caaacctctg tgcccatcta actagtttga gaagcttacc
     2401 aagaaagcaa gaatgtgtga gaacattcct acatacagag tttctcaact atagcgttta
     2461 tcctgcccag cctcctccct taacagaacc aggactccat ttgcaattct gaaagagagt
     2521 tagctctgga ctgctaaact ccagaaattg cctatgccta caatatgctt ttctatacct
     2581 cctgtgctat acttagagac agaagaattt attactacta ttagaaggcc ttcttctgac
     2641 aagggaagat agcttcaagt caaaatatac cttttatccc catcacttta cagtcactag
     2701 tcaatgactg ttgttacact aaaatcaaaa ggcctttggt gagctcagtg acagtgacct
     2761 ctgggacaat cacagaaatg acttcactgc tgttctgaat gacaattctt aagtggctag
     2821 gacaaagcaa aagcgagtat acctttttga aaagctgtct aagtggtatt tccttttcca
     2881 ttctgagaac gtaaactgct ttttcctttt ctgctgcaca tgtcaatatc ggagtcttag
     2941 acattaaggg ctcttctctt cctcccctct cctggacttc ccacaggttg gtgccacaca
     3001 cacagccctg cctccctctg cactctgatt agattgtcat tgaatgcctt gtgataaatg
     3061 cttaaaatat acacatgaaa gagaagaggg aggaaagagg agaaagcagt aatgcatata
     3121 gaaaagaatg agaaggaatt taaaagggaa ataacatcat ctcattatat tttgaatgtg
     3181 gaccatttca cccacaaact tcactcagtc ttttccggtt ttgtgcttca cttgccgtta
     3241 attgtttctg ccatcccagt tctgccattc taggacatgg gggatgtgga acatacagca
     3301 tttggcctga ctagactgcc actatggctg ctttcaagag attagagata ctgctttctc
     3361 aggaaggagt acttcctatt cccacccttg cctaaatgat agattttgcc taaatcccaa
     3421 agctagatct ctggatttta tcgtttgtgt agatagcaaa aatggccacg aactctttcc
     3481 ttctcatcaa gaggtgccat cttttttcca accccttgaa tctggagttg gctatgtgat
     3541 ttgatttagc cagtagccca acaaatgtga cacaagcaga gacttgaaaa gttcttgtgc
     3601 atggggcttg tcctcttttg ctgctcttgg gaaccttgca actaccatca ggtgaacaag
     3661 cctggactat cctgctgcat gacaaaagaa aagggcccag ttacccttgt caccctatct
     3721 gacagcccgt caacttccag ctgatgcaga catgggtgag tccaggtgat accaatagaa
     3781 gaactgccta gctgaaccca gcccaaattt ctgattccta ctcgaggcgt gagaagttgg
     3841 tgcattcttt atgttcattt ctctttaaga acaaacctga ctcgttcttg tctgaatgtt
     3901 catccctgaa cctcttaatc catccaaact tgtgtttctc atagcctcca ctattgttga
     3961 caaattttta tcaaagcttt tcaccctgca ctcttgtgga gtggaggata atgcttgact
     4021 ttgctatccc ttaatccagc agtggtttct tccctgtcta tggatccgtg gacaacctct
     4081 gaagatctct tctttaccat ccttttggtc ttctccagag ccaccctact ggggctagac
     4141 cctattctca aagtaccatt cctctagtat ccatttgtac ttcatgacat ttccaaaaaa
     4201 agtcctatgt ttgcaatgaa ataagaaagt ggctgggtga gggtcggagg gatgagctgg
     4261 tatgtgtcat tgcttggaga attgacctac caaaggactt ccgtgttgct ttggccagtc
     4321 ccagagaaat caggagaaca gttgaaccca gtgctggcac ttccaagggc tggaagacac
     4381 aagccataac cctggtgctg agttttagac ttgctggtgt ccctggcctc tgaaagccta
     4441 ggtctagcct gtctgtttgg accccagttc agatggaaaa gatgataaaa aacatttctt
     4501 agtcaccagc tttggatttc aacttgctca ggcaattttg gagaatattg ggtagctgtg
     4561 gtagctatta tcgctttata ctgagcactg tgtcaggctt ttcaccacca aagagcctca
     4621 tagcaccagc tgcagagacc aaaaataatg tttttttaaa gctacggacg tatgattttg
     4681 gtgaaggttg agggtagcaa tgggaaagaa agaattatta aaattggaaa cctgcaattc
     4741 caaagacaac aaaactacag atagactgaa aagtacaaag aagatagcag gctactgaat
     4801 taaccttggg agttgggacc aggttgtcct ttgtagaact ggataaatca ttcagacttc
     4861 caggctttca gtagagagaa aaagcagttg tttctgggta tatggacagg agttaaggct
     4921 gagttgacaa gtcaaaactt cttgtcctca gcacccctga ctttcctcta tgtgtccttt
     4981 tgtttcttct cctttgaata gtgtgtcctg cacaggaaat ggttatattt gttagcttct
     5041 ttcctaggtc ttattggagt acaaagtaaa tcttgtgtaa gacataatct ctgtccacta
     5101 ggaccccgta atttaatagg ggaaataaga catgctcaag aaaggagatt ttatacatag
     5161 agtatgaaat agtgctatgg ataaattata ataaaaccag agatttagtt tttttaaaaa
     5221 atgagaatac tttgatatta aagtgttgta tgtgtttgtc catcatctta tttaaacata
     5281 gacttggtga tctgaaaagc caatactcaa aagtctgaac tgaaaagagg tgaattagga
     5341 tcgggaaagg gtgagcagca ggggtcccag ggggatgatg cataagctgc tgtgcttgcc
     5401 tgtgagtcac tactgagtca ggaacacgct ggaggaggga gtgtggatgc aggtggcagg
     5461 gaggtgtccc ctggtagatg agctgcttct ctaggccatg catggattca ttaggaagtt
     5521 ggagacaatg gccatggacc tggtgcatgg cagctattcc atccaagcac gttcacaggg
     5581 gagctcagcg tggctgctcc tggggctcag ttctgcggct gtgagtgctg ctgcccatat
     5641 tcaccaacac agggcaggcc tcacggagat gctaggcctc acatccccct tctcatgatc
     5701 ctcactgtgc acttgacata ggattaggca tactggagat gagaaaaggc tgccacccaa
     5761 acccaaggca cctgaccaca tctgtaaata tttctgaata gtccacaaaa tttcacatag
     5821 gtagtctgat tagatcttgc ctttgagaga agctgaagtc acagatactg ttgtaattta
     5881 ccaccgcccc tcacccaatt ttttttaata ggtgaagaaa ccatcactgc cattaatgaa
     5941 gtcacaaacc tattaggtct ttagactccc aacctctgga tcttttctgc tgattagtgt
     6001 ttcccaaaat tgcctaacca caagaattaa cttgatagct gctgttaaaa aggtattgtt
     6061 ggaccctgtt ttggagattg attgggtggg tctagagcca gaattcatat ttttaatatg
     6121 cattccagga gactcctgtg atcagatgca tttggaaatc attgcactaa gtcatacctc
     6181 tgggtactcc aaacagctag tcctgaggct tccttgggcc ttagaatttt ttcttcaaat
     6241 gtcctggtga ggtccctctc aatcctttgg ggctggctgt ggtgagtcac tcagaagtct
     6301 ggctgtgacc tggatgggct caccagagta cgctagtggt agtgggaaaa caggcagaga
     6361 gaaaggagtg tcaggagcac tcccagggag gctgttgtag atatttccat tcccagaaca
     6421 gtgatctatt gtgacagtct cagaacagac aacaagaatt acaggtaatt ttctcattct
     6481 cttgatatat ttttagcaaa acttaaatca tgaatagaag gaaaagatgc cattggggaa
     6541 atagaaaaac tcaatcattt tataaagcat acaaatcata aggatgactg gccaatagca
     6601 ctcccacttt ggtcttacct aaagttgggt ggacaagaat aataaaagtc ctcattttat
     6661 atccttccaa aatcagattt aaatgctgcc agcatcttaa tggaagtctg aaattgattg
     6721 ataggatgta gaaatccaaa ttcactaaaa tagggggcca gctacataaa gtcctagaag
     6781 gaaaaagtgc ctcgcttttt tctgccatta tcctaccccc tagtcatctg gggaattgat
     6841 ctatgaagct tgaagaaggg gcatttaaca tcagagtggt gcaagggcag tgttgagatg
     6901 ctttaagcag cagcctgagc tttagcacta tttgaagggg agaaggttaa tactaataat
     6961 atttgtgtta tttttatgat atattactgt ttacagaaca ctttcatttg atcccaacat
     7021 caactgctgt gatagaggca gggcagatgt tgtggtctca ttacatagaa tgtaaaactg
     7081 aggttgaaaa atactaagtg acttgtctgt agtcaaatgg tttttaaaat tataaagcca
     7141 ggccttctga ctgtcttgtc tggtgtcctt tccaattcct taaatactca tgggactgga
     7201 atctgggtat tccagattcc agtttctctt cacagccaga catctggtga gaagagccgt
     7261 agacttgatg cttgttcata tgtcatggat gtggcgaagc catgaagaca gatactgttg
     7321 ctgcttcatc caactaagca ccattcattc ctcaaatgct aatctaagag ggagttgtag
     7381 cttcactcaa ggagagtttc gttttctttt tctttctttt tttttttttt gagacagggt
     7441 cttgctctgt ggcccatggt gcagtgcagt gcagtggtgc tatcagctca ctgcagtctc
     7501 aaactcctag ctcaagcaat cctcctccct cagcctccca agtaggtagg actacagata
     7561 tatgccacca cgtccagcaa attttgtttg tttgtagaga tggggtcttg ctatatttcc
     7621 caggcttgtc tcaaactcct ggcctcaagt gatcctccca ccttggctgc ctaaagtgct
     7681 ggtattacag acatgagcca ctgaacccag ctgagagcct cactttcatc acctgtgctg
     7741 tgaggggtaa tatatgcttc aggttttctg gagaatcctt cttgcagaga agtttctgaa
     7801 tgaaacgaca gattcatctg gattcagaac tccaggcaga agctgcttaa cagcaaaaat
     7861 ctggcatctt cactacattt taagatttta ggtagaacta agagggatca gatatagagg
     7921 aataaggaat gtgagaagga aaaagatata gtagtttagc taaatttttc ttagagtttc
     7981 ttggtggggc tggccatgaa gtaactagtc tgactcattt cttctgggaa ggctaaaaga
     8041 gacacagata gcttctcttt taccttggct ttaaggaaaa gccattttat taacaaaagt
     8101 attagacacg actgcataag aaatttgctg tgtgagaata aagaacaagg gagtaggagg
     8161 gtgggacaga gaagggtgag aagttggctt cgtgagggcc acctgtcagt tgtctttgtg
     8221 ccttgtgaca tcaaaactga aatgtttgta ttactgttgt ccatgacttt ttttttctgt
     8281 gtcagacata caaattgaat ttggttgtaa tgttttaaac gtaataaaga attcttacct
     8341 acatttgtta ccaagaactc ataattaaca caactatggt taatcatgat ctgacattaa
     8401 atggcctcag caagagaaag aatcatatga tacatgtcct tctctgattg ttgtaagtac
     8461 agtaatagag gaatacatat tgtggggtta cagagggggc tggtactgac agagcaaaag
     8521 gtatgctttt acagattgta ataagctaga taaattctgt tgtcactctt actgctctcc
     8581 acagactgta acattcagaa ggagatgaag ggtaggaaag gtggttggat aaggtgatgg
     8641 tacctagctc atttccaaga ggggcacaag catatgcctg ctagaaatta cacttgggga
     8701 agggaggaag gaagctattc gtgggaggac atttcaagtt ctgttaagat ttgagaaatt
     8761 ccacagcacc ataattaaga ggaggcaatt aaaaaccttt gttagcaaaa gaagtgataa
     8821 atacctctga gaactattaa tcctgttttg gatggctaag ccctctcaag ggaattccag
     8881 attttagtgg ccttgtcaag cagaaaatct gtttttgctt gaagcatctg ggctcaattt
     8941 tttttaagta gttaacttaa aaatgttaac atgtagattt aacttaaaga tagactctaa
     9001 aacagtttga ttacctctgg attttgtatt attttgtgtt ttaattccat ttaggttttt
     9061 cagctttata aaatattttt gtttttattt ataaagtatt tgtttagaat cacccacgtg
     9121 ttttttctac acatcttttt ttcctatatt tcagatcttc cttttgaaat attttctttc
     9181 tgaaggaagt ttacttcagt aatgatttgt tggtaggata ctcatcagtc tttgttgatg
     9241 taaaagtctt tatttcattc ttgttcttga aagataattt cactgattat gattctagat
     9301 tgatagttat tttctttcag gacattgaag ttattattac actcccttct gacttttatt
     9361 tttgctttta agaagtcaat taccagttta attatccttc ctaatctgtc tggtctctct
     9421 gactgttcta aagatttttt tgtctctagt gttctttggt ttaattaaca tgtgaccagg
     9481 tgtggatttc tttttattta tccaaattag gatttgtggt gtttcctaaa tccgtggatt
     9541 ggatttccca ttaaatatgg aaaactctca gctatattaa cacatcaaat atttcctctt
     9601 ctttttaaac tctctcttga gaattccaat tgttagattt tttttcattc tatgccccat
     9661 attgtttaat ctatattttg tatttcctct ctctgtgttt tctattccct attcaggtaa
     9721 atttcttcag gtttatcttc cagctcacta attttctttt cagctagctc taatctcctt
     9781 tatttgagtt ttaattttaa ttaatatgta tttcatttct aggagtttag ttctttttca
     9841 aatttacata gtccctgttg tcttgtgact tactcttttt ttttttttac aatgccctct
     9901 tatttatctg aatatcttaa agatactaac ttaaaatttt atatccagta attccaatat
     9961 ctacagtctt tgtgggtcta cttttagagt ttgttacttc tgctaacttt cactcacagt
    10021 tttttgtttc tttatgggtt ttatagtttt ttattttaag ctcatgtgtg gtgcaatgcc
    10081 atattacatt gtgccagtca agaaaaacct ttcttgctcc ttatctgcct tacatttctc
    10141 cataatgact ctatatatac acagcaaccc tggggaagcc aggaagagtg aatgattgag
    10201 taaggaagaa gtaagtgtgc taaatgggaa aaaatgaaaa aggcacacat acacgcattg
    10261 tgcatttctt tctaatgcaa cctgtagact gcaaacaaaa tcttaagatg gggagggcaa
    10321 gaggctttaa ctttacatat tctttagagt ttgataatat aagagaatgg ctgtcttaat
    10381 tatagacata gactgtttta gggtttaaga gtgaacagaa ggctgttaat tgttaagagt
    10441 ggccaaataa attatggatg tagatttcat tcaagaggca aggaaggccg ggccctgtgg
    10501 ctcacacctg aaatcccaac agttagggag acaaaggtgg gaggatagct tgagccagga
    10561 gttcaagacc tacctgggca gtatagtgag atcccatcct ccacaaaaag gtaaaaattt
    10621 aaaaagacaa gaaaaaaaag aagcagcaag gaaggactag actcatagga tggattaaaa
    10681 ttaggcaaaa caaataattc atttttccct atgattatct aattctaatc caatttttat
    10741 atgctttcat ttcaagaaat aagaagtagg ctaatttcag gttctcttag aaaatcttgg
    10801 cagagacatc ctaatcatac tcatcacacc acttaggtga aaattatatt ttctgctgaa
    10861 ttggttataa gcatttcctg aatacttatc aggtggccta agatgactca ccaaaaatgg
    10921 catgaggtgt agaagtagct aggaagttgc ttagaggtga gtgagttggt ctgacacgcc
    10981 atctagtggc acacatccaa gagagtgact ctattgctaa ccttccagta ttggatggag
    11041 gtgtgcctca cattacttaa gggaaaagct acatatgaat ttatatagct tattttaatg
    11101 ctatatatga atttatatag atgaatttgg cttttgaaaa acaaattaag tgcattagga
    11161 attttttctt taaaagtgat atgtttttct tacactttgc aagtttagaa cttgccatat
    11221 tatgtttttg aggcaggctt ctgtggatat aatgtgggga aaaccatgag gtttttgctt
    11281 gggatcaagt gggatttagg tgcatgcctt ttgtgattta aagctatttt aaagtgtgct
    11341 tttaacacca tggaattaca attgttttct gaagtcaggt caggactctg attctgcaga
    11401 attatggtga agccagtttc tctttaacaa gcaaaaaccg tgtcatcaaa ctgtacaacc
    11461 aaaggaccta aatagtccat tccctagtct tcagctgtac aaagatgaat caatctctct
    11521 gtctcttgtt ctctctctca ctgtctctaa aaaccaagca gaggagaaaa ttccagacat
    11581 gttaaaacac tttacttttt tttaaaacaa tccttgctct ctggagatat tttctcacat
    11641 tttgttacaa attttgtgta gaagcatagc cacagtggat tttttctggc tctttttctt
    11701 tctctgagac gttaatgtcc agtagagcaa agctagaagg atatatatat atatatatat
    11761 atataaatat atatatttat atatatttat atatatatat atatatatat gtatgtatac
    11821 acacacacat atatatgtca atttctatta accttgtttt tggaaaaacg ctttgttcaa
    11881 ctgaatgtag ttaaattata atggacatta atatacaacc ccaccctccc agcctctttt
    11941 tgttgctggt atgacttagg cacctagctt ttctcattcc ctcaggccaa ggcgatagcc
    12001 tcttatgttt cattcctttg gcagctgtat tagtaaaaaa atttttggtt gcaaatgaca
    12061 ggaagatagc tcagactagc ttaagaacaa gaaaaggaga aatggagctc atctattaga
    12121 gagatcctgg agtagctcac aggctggaag agctgtagga actgagaaca aacctgggtc
    12181 tcaatgtagt aagatttaag attccctgtc catcatccac acctacttgt gtttttacat
    12241 caatacattt tctcagtgag gatagactta ctccaaaagg caggaatata gccactagca
    12301 gtctgagagt cacaactttc cagctcattt gaccaagcag gcaaaaggct ttactcatga
    12361 gaacaatcct ggagaaagac tgcagtcaac tcatattgag tcatgtgccc atatctgagc
    12421 taatcatgtg gccagagatg tggcaagtct gtttatgacc aggaaggtga gactgcgatg
    12481 gactggatag tgggatagga agatttctcc aaagagagaa gagagttgtt attaatagaa
    12541 gaagtgagaa tagtgatgct gggcagacaa aacacataca caacaccaac agctatctgc
    12601 tactgcatcc gaaaagattc tttatctgca gccacagagc cctgaacaac cagcctttcc
    12661 ggcttccttt tgttgccaat tccctcacac gtattattcc aacccaaggc ttcagggagg
    12721 ctgtttttac cacagttcag tgacaaatcc taccagagcc ttccatatac cagtgaatgt
    12781 ccttggttat acttgtctcg ttctgaattt agaaatccat ctctgtgtca ctgccttcat
    12841 taggaccttt cgtctcctcc ctggattctt ctggtaccct catttcttgt ctcctacttc
    12901 ctgttgtctc ctaattattc accttctact ttttttgtta gaggttccag acagtttcaa
    12961 gaaaaatact taatgctggg caaggtgctt ctcccttcct ctctaagttc catagaacag
    13021 gggacatttt gcttctctgt tgctatggac tgagtgtttt gtgtcttccc caaattttta
    13081 tgtcaaaatc ctaatcctaa tgtgatggta tttgggcatg aggcctttgg gaggtgatta
    13141 ggtcagtagg gtggagctct tatgatggaa ttagtgtcct tataagaaga gacaggagag
    13201 agattacttc ctctctttct ctgccatgtg aggatacagc aaggtatctg tctgcaaacc
    13261 aggaaaagga ccttcgccag gaactgaatg tattggtgca ctgagcttgg acttcccaga
    13321 ttctagaact gtgagaaata aatttctgat atttaagcca
//
