LOCUS       NM_002186               2038 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interleukin 9 receptor (IL9R), transcript variant 1,
            mRNA.
ACCESSION   NM_002186
VERSION     NM_002186.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Ercolano,G., Trabanelli,S., Jandus,C. and Jandus,P.
  TITLE     IL-9R Loss in Type 2 Innate Lymphoid Cells Reflects Treg Impairment
            in Patients With Mastocytosis
  JOURNAL   J Investig Allergol Clin Immunol 33 (2), 129-131 (2023)
   PUBMED   35416152
  REMARK    GeneRIF: IL-9R Loss in Type 2 Innate Lymphoid Cells Reflects Treg
            Impairment in Patients With Mastocytosis.
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Jehn,L.B., Costabel,U., Boerner,E., Wessendorf,T.E., Theegarten,D.,
            Taube,C. and Bonella,F.
  TITLE     IL-9 and IL-9 receptor expression in lymphocytes from
            bronchoalveolar lavage fluid of patients with interstitial lung
            disease
  JOURNAL   Immunobiology 227 (5), 152258 (2022)
   PUBMED   35998415
  REMARK    GeneRIF: IL-9 and IL-9 receptor expression in lymphocytes from
            bronchoalveolar lavage fluid of patients with interstitial lung
            disease.
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   Sun,Y., Liu,S., Hu,R., Zhou,Q. and Li,X.
  TITLE     Decreased placental IL9 and IL9R in preeclampsia impair trophoblast
            cell proliferation, invasion, and angiogenesis
  JOURNAL   Hypertens Pregnancy 39 (3), 228-235 (2020)
   PUBMED   32329646
  REMARK    GeneRIF: Decreased placental IL9 and IL9R in preeclampsia impair
            trophoblast cell proliferation, invasion, and angiogenesis.
REFERENCE   4  (bases 1 to 2038)
  AUTHORS   Raychaudhuri,S.K., Abria,C., Maverakis,E.M. and Raychaudhuri,S.P.
  TITLE     IL-9 receptor: Regulatory role on FLS and pannus formation
  JOURNAL   Cytokine 111, 58-62 (2018)
   PUBMED   30114630
  REMARK    GeneRIF: Thus the IL-9/IL-9R system is a new contributing factor in
            the cytokine network of psoriatic arthritis and rheumatoid
            arthritis.
REFERENCE   5  (bases 1 to 2038)
  AUTHORS   Vermeesch,J.R., Petit,P., Kermouni,A., Renauld,J.C., Van Den
            Berghe,H. and Marynen,P.
  TITLE     The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal
            region, has an autosomal origin, escapes X inactivation and is
            expressed from the Y
  JOURNAL   Hum Mol Genet 6 (1), 1-8 (1997)
   PUBMED   9002663
REFERENCE   6  (bases 1 to 2038)
  AUTHORS   Demoulin,J.B., Uyttenhove,C., Van Roost,E., DeLestre,B.,
            Donckers,D., Van Snick,J. and Renauld,J.C.
  TITLE     A single tyrosine of the interleukin-9 (IL-9) receptor is required
            for STAT activation, antiapoptotic activity, and growth regulation
            by IL-9
  JOURNAL   Mol Cell Biol 16 (9), 4710-4716 (1996)
   PUBMED   8756628
REFERENCE   7  (bases 1 to 2038)
  AUTHORS   Kermouni,A., Van Roost,E., Arden,K.C., Vermeesch,J.R., Weiss,S.,
            Godelaine,D., Flint,J., Lurquin,C., Szikora,J.P., Higgs,D.R. et al.
  TITLE     The IL-9 receptor gene (IL9R): genomic structure, chromosomal
            localization in the pseudoautosomal region of the long arm of the
            sex chromosomes, and identification of IL9R pseudogenes at 9qter,
            10pter, 16pter, and 18pter
  JOURNAL   Genomics 29 (2), 371-382 (1995)
   PUBMED   8666384
REFERENCE   8  (bases 1 to 2038)
  AUTHORS   Kimura,Y., Takeshita,T., Kondo,M., Ishii,N., Nakamura,M., Van
            Snick,J. and Sugamura,K.
  TITLE     Sharing of the IL-2 receptor gamma chain with the functional IL-9
            receptor complex
  JOURNAL   Int Immunol 7 (1), 115-120 (1995)
   PUBMED   7718508
REFERENCE   9  (bases 1 to 2038)
  AUTHORS   Chang,M.S., Engel,G., Benedict,C., Basu,R. and McNinch,J.
  TITLE     Isolation and characterization of the human interleukin-9 receptor
            gene
  JOURNAL   Blood 83 (11), 3199-3205 (1994)
   PUBMED   8193355
REFERENCE   10 (bases 1 to 2038)
  AUTHORS   Renauld,J.C., Druez,C., Kermouni,A., Houssiau,F., Uyttenhove,C.,
            Van Roost,E. and Van Snick,J.
  TITLE     Expression cloning of the murine and human interleukin 9 receptor
            cDNAs
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5690-5694 (1992)
   PUBMED   1376929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M84747.1 and BC025298.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002186.2.
            
            Summary: The protein encoded by this gene is a cytokine receptor
            that specifically mediates the biological effects of interleukin 9
            (IL9). The functional IL9 receptor complex requires this protein as
            well as the interleukin 2 receptor, gamma (IL2RG), a common gamma
            subunit shared by the receptors of many different cytokines. The
            ligand binding of this receptor leads to the activation of various
            JAK kinases and STAT proteins, which connect to different biologic
            responses. This gene is located at the pseudoautosomal regions of X
            and Y chromosomes. Genetic studies suggested an association of this
            gene with the development of asthma. Multiple pseudogenes on
            chromosome 9, 10, 16, and 18 have been described. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M84747.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244174.11/ ENSP00000244174.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1054              M84747.1           116-1169
            1055-2038           BC025298.1         1049-2032
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="Xq28 and Yq12"
     gene            1..2038
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /note="interleukin 9 receptor"
                     /db_xref="GeneID:3581"
                     /db_xref="HGNC:HGNC:6030"
                     /db_xref="MIM:300007"
     exon            1..92
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1630
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-9 receptor"
                     /codon_start=1
                     /product="interleukin-9 receptor isoform 1 precursor"
                     /protein_id="NP_002177.2"
                     /db_xref="CCDS:CCDS14771.4"
                     /db_xref="GeneID:3581"
                     /db_xref="HGNC:HGNC:6030"
                     /db_xref="MIM:300007"
                     /translation="MGLGRCIWEGWTLESEALRRDMGTWLLACICICTCVCLGVSVTG
                     EGQGPRSRTFTCLTNNILRIDCHWSAPELGQGSSPWLLFTSNQAPGGTHKCILRGSEC
                     TVVLPPEAVLVPSDNFTITFHHCMSGREQVSLVDPEYLPRRHVKLDPPSDLQSNISSG
                     HCILTWSISPALEPMTTLLSYELAFKKQEEAWEQAQHRDHIVGVTWLILEAFELDPGF
                     IHEARLRVQMATLEDDVVEEERYTGQWSEWSQPVCFQAPQRQGPLIPPWGWPGNTLVA
                     VSIFLLLTGPTYLLFKLSPRVKRIFYQNVPSPAMFFQPLYSVHNGNFQTWMGAHGAGV
                     LLSQDCAGTPQGALEPCVQEATALLTCGPARPWKSVALEEEQEGPGTRLPGNLSSEDV
                     LPAGCTEWRVQTLAYLPQEDWAPTSLTRPAPPDSEGSRSSSSSSSSNNNNYCALGCYG
                     GWHLSALPGNTQSSGPIPALACGLSCDHQGLETQQGVAWVLAGHCQRPGLHEDLQGML
                     LPSVLSKARSWTF"
     exon            93..206
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
     exon            207..318
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
     exon            319..497
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
     exon            498..643
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
     exon            644..845
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
     exon            846..951
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1036
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..2038
                     /gene="IL9R"
                     /gene_synonym="CD129; IL-9R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtgcacc cagagatagt tgggtgacaa atcacctcca ggttggggat gcctcagact
       61 tgtgatggga ctgggcagat gcatctggga aggctggacc ttggagagtg aggccctgag
      121 gcgagacatg ggcacctggc tcctggcctg catctgcatc tgcacctgtg tctgcttggg
      181 agtctctgtc acaggggaag gacaagggcc aaggtctaga accttcacct gcctcaccaa
      241 caacattctc aggatcgatt gccactggtc tgccccagag ctgggacagg gctccagccc
      301 ctggctcctc ttcaccagca accaggctcc tggcggcaca cataagtgca tcttgcgggg
      361 cagtgagtgc accgtcgtgc tgccacctga ggcagtgctc gtgccatctg acaatttcac
      421 catcactttc caccactgca tgtctgggag ggagcaggtc agcctggtgg acccggagta
      481 cctgccccgg agacacgtta agctggaccc gccctctgac ttgcagagca acatcagttc
      541 tggccactgc atcctgacct ggagcatcag tcctgccttg gagccaatga ccacacttct
      601 cagctatgag ctggccttca agaagcagga agaggcctgg gagcaggccc agcacaggga
      661 tcacattgtc ggggtgacct ggcttatact tgaagccttt gagctggacc ctggctttat
      721 ccatgaggcc aggctgcgtg tccagatggc cacactggag gatgatgtgg tagaggagga
      781 gcgttataca ggccagtgga gtgagtggag ccagcctgtg tgcttccagg ctccccagag
      841 acaaggccct ctgatcccac cctgggggtg gccaggcaac acccttgttg ctgtgtccat
      901 ctttctcctg ctgactggcc cgacctacct cctgttcaag ctgtcgccca gggtgaagag
      961 aatcttctac cagaacgtgc cctctccagc gatgttcttc cagcccctct acagtgtaca
     1021 caatgggaac ttccagactt ggatgggggc ccacggggcc ggtgtgctgt tgagccagga
     1081 ctgtgctggc accccacagg gagccttgga gccctgcgtc caggaggcca ctgcactgct
     1141 cacttgtggc ccagcgcgtc cttggaaatc tgtggccctg gaggaggaac aggagggccc
     1201 tgggaccagg ctcccgggga acctgagctc agaggatgtg ctgccagcag ggtgtacgga
     1261 gtggagggta cagacgcttg cctatctgcc acaggaggac tgggccccca cgtccctgac
     1321 taggccggct cccccagact cagagggcag caggagcagc agcagcagca gcagcagcaa
     1381 caacaacaac tactgtgcct tgggctgcta tgggggatgg cacctctcag ccctcccagg
     1441 aaacacacag agctctgggc ccatcccagc cctggcctgt ggcctttctt gtgaccatca
     1501 gggcctggag acccagcaag gagttgcctg ggtgctggct ggtcactgcc agaggcctgg
     1561 gctgcatgag gacctccagg gcatgttgct cccttctgtc ctcagcaagg ctcggtcctg
     1621 gacattctag gtccctgact cgccagatgc atcatgtcca ttttgggaaa atggactgaa
     1681 gtttctggag cccttgtctg agactgaacc tcctgagaag gggcccctag cagcggtcag
     1741 aggtcctgtc tggatggagg ctggaggctc ccccctcaac ccctctgctc agtgcctgtg
     1801 gggagcagcc tctaccctca gcatcctggc cacaagttct tccttccatt gtcccttttc
     1861 tttatccctg acctctctga gaagtggggt gtggtctctc agctgttctg ccctcatacc
     1921 cttaaagggc cagcctgggc ccagtggaca caggtaaggc accatgacca cctggtgtga
     1981 cctctctgtg ccttactgag gcacctttct agagattaaa aggggcttga tggctgtt
//
