LOCUS       NM_000590                605 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens interleukin 9 (IL9), mRNA.
ACCESSION   NM_000590
VERSION     NM_000590.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 605)
  AUTHORS   Radpour,R., Simillion,C., Wang,B., Abbas,H.A., Riether,C. and
            Ochsenbein,A.F.
  TITLE     IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T
            cells, which promote their expansion
  JOURNAL   Blood 144 (8), 888-903 (2024)
   PUBMED   38941612
  REMARK    GeneRIF: IL-9 secreted by leukemia stem cells induces Th1-skewed
            CD4+ T cells, which promote their expansion.
REFERENCE   2  (bases 1 to 605)
  AUTHORS   Garcia-Jimenez,I., Sans-de San Nicolas,L., Curto-Barredo,L.,
            Bertolin-Colilla,M., Sensada-Lopez,E., Figueras-Nart,I.,
            Bonfill-Orti,M., Guilabert-Vidal,A., Ryzhkova,A., Ferran,M.,
            Damiani,G., Czarnowicki,T., Pujol,R.M. and Santamaria-Babi,L.F.
  TITLE     Heterogeneous IL-9 Production by Circulating Skin-Tropic and
            Extracutaneous Memory T Cells in Atopic Dermatitis Patients
  JOURNAL   Int J Mol Sci 25 (16), 8569 (2024)
   PUBMED   39201262
  REMARK    GeneRIF: Heterogeneous IL-9 Production by Circulating Skin-Tropic
            and Extracutaneous Memory T Cells in Atopic Dermatitis Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 605)
  AUTHORS   Son,A., Baral,I., Falduto,G.H. and Schwartz,D.M.
  TITLE     Locus of (IL-9) control: IL9 epigenetic regulation in cellular
            function and human disease
  JOURNAL   Exp Mol Med 56 (6), 1331-1339 (2024)
   PUBMED   38825637
  REMARK    GeneRIF: Locus of (IL-9) control: IL9 epigenetic regulation in
            cellular function and human disease.
            Review article
REFERENCE   4  (bases 1 to 605)
  AUTHORS   Guo,X., Zhu,X., Zhou,S. and Dong,X.
  TITLE     Serum levels of IL-9 and IL-11 serve as predictors for the
            occurrence of early neurologic deterioration in patients with
            cerebral infarction
  JOURNAL   Clin Chim Acta 558, 119683 (2024)
   PUBMED   38643817
  REMARK    GeneRIF: Serum levels of IL-9 and IL-11 serve as predictors for the
            occurrence of early neurologic deterioration in patients with
            cerebral infarction.
REFERENCE   5  (bases 1 to 605)
  AUTHORS   Yao,Q., Song,Z., Wang,B., Du,P., Qin,Q., Zhao,J. and Zhang,J.A.
  TITLE     Increased interleukin-9 and Th9 cells in patients with refractory
            Graves' disease and interleukin-9 polymorphisms are associated with
            autoimmune thyroid diseases
  JOURNAL   Front Immunol 15, 1341749 (2024)
   PUBMED   38605942
  REMARK    GeneRIF: Increased interleukin-9 and Th9 cells in patients with
            refractory Graves' disease and interleukin-9 polymorphisms are
            associated with autoimmune thyroid diseases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 605)
  AUTHORS   Merz,H., Houssiau,F.A., Orscheschek,K., Renauld,J.C., Fliedner,A.,
            Herin,M., Noel,H., Kadin,M., Mueller-Hermelink,H.K., Van Snick,J.
            et al.
  TITLE     Interleukin-9 expression in human malignant lymphomas: unique
            association with Hodgkin's disease and large cell anaplastic
            lymphoma
  JOURNAL   Blood 78 (5), 1311-1317 (1991)
   PUBMED   1908723
REFERENCE   7  (bases 1 to 605)
  AUTHORS   Kelleher,K., Bean,K., Clark,S.C., Leung,W.Y., Yang-Feng,T.L.,
            Chen,J.W., Lin,P.F., Luo,W. and Yang,Y.C.
  TITLE     Human interleukin-9: genomic sequence, chromosomal location, and
            sequences essential for its expression in human T-cell leukemia
            virus (HTLV)-I-transformed human T cells
  JOURNAL   Blood 77 (7), 1436-1441 (1991)
   PUBMED   1901233
REFERENCE   8  (bases 1 to 605)
  AUTHORS   Modi,W.S., Pollock,D.D., Mock,B.A., Banner,C., Renauld,J.C. and Van
            Snick,J.
  TITLE     Regional localization of the human glutaminase (GLS) and
            interleukin-9 (IL9) genes by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 114-116 (1991)
   PUBMED   1680606
REFERENCE   9  (bases 1 to 605)
  AUTHORS   Renauld,J.C., Goethals,A., Houssiau,F., Merz,H., Van Roost,E. and
            Van Snick,J.
  TITLE     Human P40/IL-9. Expression in activated CD4+ T cells, genomic
            organization, and comparison with the mouse gene
  JOURNAL   J Immunol 144 (11), 4235-4241 (1990)
   PUBMED   1971295
REFERENCE   10 (bases 1 to 605)
  AUTHORS   Renauld,J.C., Goethals,A., Houssiau,F., Van Roost,E. and Van
            Snick,J.
  TITLE     Cloning and expression of a cDNA for the human homolog of mouse T
            cell and mast cell growth factor P40
  JOURNAL   Cytokine 2 (1), 9-12 (1990)
   PUBMED   2129501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002428.1 and S63356.1.
            
            On May 17, 2019 this sequence version replaced NM_000590.1.
            
            Summary: The protein encoded by this gene is a cytokine that acts
            as a regulator of a variety of hematopoietic cells. This cytokine
            stimulates cell proliferation and prevents apoptosis. It functions
            through the interleukin 9 receptor (IL9R), which activates
            different signal transducer and activator (STAT) proteins and thus
            connects this cytokine to various biological processes. The gene
            encoding this cytokine has been identified as a candidate gene for
            asthma. Genetic studies on a mouse model of asthma demonstrated
            that this cytokine is a determining factor in the pathogenesis of
            bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S63356.1, M30134.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274520.2/ ENSP00000274520.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC002428.1         124095-124108
            15-605              S63356.1           1-591
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..605
                     /gene="IL9"
                     /gene_synonym="HP40; IL-9; P40"
                     /note="interleukin 9"
                     /db_xref="GeneID:3578"
                     /db_xref="HGNC:HGNC:6029"
                     /db_xref="MIM:146931"
     exon            1..139
                     /gene="IL9"
                     /gene_synonym="HP40; IL-9; P40"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..460
                     /gene="IL9"
                     /gene_synonym="HP40; IL-9; P40"
                     /note="p40 T-cell and mast cell growth factor; T-cell
                     growth factor p40; p40 cytokine; homolog of mouse T cell
                     and mast cell growth factor 40; cytokine P40"
                     /codon_start=1
                     /product="interleukin-9 precursor"
                     /protein_id="NP_000581.1"
                     /db_xref="CCDS:CCDS4189.1"
                     /db_xref="GeneID:3578"
                     /db_xref="HGNC:HGNC:6029"
                     /db_xref="MIM:146931"
                     /translation="MLLAMVLTSALLLCSVAGQGCPTLAGILDINFLINKMQEDPASK
                     CHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNN
                     KCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI"
     exon            140..175
                     /gene="IL9"
                     /gene_synonym="HP40; IL-9; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            176..208
                     /gene="IL9"
                     /gene_synonym="HP40; IL-9; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            209..340
                     /gene="IL9"
                     /gene_synonym="HP40; IL-9; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            341..605
                     /gene="IL9"
                     /gene_synonym="HP40; IL-9; P40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcgagctc cagtccgctg tcaagatgct tctggccatg gtccttacct ctgccctgct
       61 cctgtgctcc gtggcaggcc aggggtgtcc aaccttggcg gggatcctgg acatcaactt
      121 cctcatcaac aagatgcagg aagatccagc ttccaagtgc cactgcagtg ctaatgtgac
      181 cagttgtctc tgtttgggca ttccctctga caactgcacc agaccatgct tcagtgagag
      241 actgtctcag atgaccaata ccaccatgca aacaagatac ccactgattt tcagtcgggt
      301 gaaaaaatca gttgaagtac taaagaacaa caagtgtcca tatttttcct gtgaacagcc
      361 atgcaaccaa accacggcag gcaacgcgct gacatttctg aagagtcttc tggaaatttt
      421 ccagaaagaa aagatgagag ggatgagagg caagatatga agatgaaata ttatttatcc
      481 tatttattaa atttaaaaag ctttctcttt aagttgctac aatttaaaaa tcaagtaagc
      541 tactctaaat cagtatcagt tgtgattatt tgtttaacat tgtatgtctt tattttgaaa
      601 taaat
//
