LOCUS       NM_000880               2016 bp    mRNA    linear   PRI 09-DEC-2024
DEFINITION  Homo sapiens interleukin 7 (IL7), transcript variant 1, mRNA.
ACCESSION   NM_000880
VERSION     NM_000880.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Wu,H., Xu,Z., Qi,M., Liu,P., Zhang,B., Wang,Z., Chen,G., Liu,X.,
            Liu,J., Wei,W., Duan,W. and Chen,Z.
  TITLE     Interleukin-7 expression by CAR-T cells improves CAR-T cell
            survival and efficacy in chordoma
  JOURNAL   Cancer Immunol Immunother 73 (10), 188 (2024)
   PUBMED   39093440
  REMARK    GeneRIF: Interleukin-7 expression by CAR-T cells improves CAR-T
            cell survival and efficacy in chordoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Kaiser,F.M.P., Janowska,I., Menafra,R., de Gier,M.,
            Korzhenevich,J., Pico-Knijnenburg,I., Khatri,I., Schulz,A.,
            Kuijpers,T.W., Lankester,A.C., Konstantinidis,L., Erlacher,M.,
            Kloet,S., van Schouwenburg,P.A., Rizzi,M. and van der Burg,M.
  TITLE     IL-7 receptor signaling drives human B-cell progenitor
            differentiation and expansion
  JOURNAL   Blood 142 (13), 1113-1130 (2023)
   PUBMED   37369082
  REMARK    GeneRIF: IL-7 receptor signaling drives human B-cell progenitor
            differentiation and expansion.
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Hesari,M., Attar,Z., Soltani-Shirazi,S., Keshavarzian,O.,
            Taheri,R., Tabrizi,R. and Fouladseresht,H.
  TITLE     The Therapeutic Values of IL-7/IL-7R and the Recombinant
            Derivatives in Glioma: A Narrative Review
  JOURNAL   J Interferon Cytokine Res 43 (8), 319-334 (2023)
   PUBMED   37566474
  REMARK    GeneRIF: The Therapeutic Values of IL-7/IL-7R and the Recombinant
            Derivatives in Glioma: A Narrative Review.
            Review article
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Martin-Nares,E., Hernandez-Molina,G., Lima,G.,
            Hernandez-Ramirez,D.F., Chan-Campos,I., Saavedra-Gonzalez,V. and
            Llorente,L.
  TITLE     Tear levels of IL-7, IL-1alpha, and IL-1beta may differentiate
            between IgG4-related disease and Sjogren's syndrome
  JOURNAL   Clin Rheumatol 42 (4), 1101-1105 (2023)
   PUBMED   36627528
  REMARK    GeneRIF: Tear levels of IL-7, IL-1alpha, and IL-1beta may
            differentiate between IgG4-related disease and Sjogren's syndrome.
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Issaoui,H. and Ricci,J.E.
  TITLE     IL-7 germline variant: setting the stage for immune-related adverse
            events
  JOURNAL   Mol Oncol 17 (3), 384-386 (2023)
   PUBMED   36748568
  REMARK    GeneRIF: IL-7 germline variant: setting the stage for
            immune-related adverse events.
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Chi,Y., Ge,Y., Wu,B., Zhang,W., Wu,T., Wen,T., Liu,J., Guo,X.,
            Huang,C., Jiao,Y., Zhu,F., Zhu,B. and Cui,L.
  TITLE     Serum Cytokine and Chemokine Profile in Relation to the Severity of
            Coronavirus Disease 2019 in China
  JOURNAL   J Infect Dis 222 (5), 746-754 (2020)
   PUBMED   32563194
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Lupton,S.D., Gimpel,S., Jerzy,R., Brunton,L.L., Hjerrild,K.A.,
            Cosman,D. and Goodwin,R.G.
  TITLE     Characterization of the human and murine IL-7 genes
  JOURNAL   J Immunol 144 (9), 3592-3601 (1990)
   PUBMED   2329282
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Brunton,L.L. and Lupton,S.D.
  TITLE     An STS in the human IL7 gene located at 8q12-13
  JOURNAL   Nucleic Acids Res 18 (5), 1315 (1990)
   PUBMED   2320434
  REMARK    Erratum:[Nucleic Acids Res 1990 May 11;18(9):2852]
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Sutherland,G.R., Baker,E., Fernandez,K.E., Callen,D.F.,
            Goodwin,R.G., Lupton,S., Namen,A.E., Shannon,M.F. and Vadas,M.A.
  TITLE     The gene for human interleukin 7 (IL7) is at 8q12-13
  JOURNAL   Hum Genet 82 (4), 371-372 (1989)
   PUBMED   2786840
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Goodwin,R.G., Lupton,S., Schmierer,A., Hjerrild,K.J., Jerzy,R.,
            Clevenger,W., Gillis,S., Cosman,D. and Namen,A.E.
  TITLE     Human interleukin 7: molecular cloning and growth factor activity
            on human and murine B-lineage cells
  JOURNAL   Proc Natl Acad Sci U S A 86 (1), 302-306 (1989)
   PUBMED   2643102
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291538.1, J04156.1 and
            BC047698.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000880.3.
            
            Summary: The protein encoded by this gene is a cytokine important
            for B and T cell development. This cytokine and the hepatocyte
            growth factor (HGF) form a heterodimer that functions as a
            pre-pro-B cell growth-stimulating factor. IL7 is found to be a
            cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB)
            during early T cell development. This cytokine can be produced
            locally by intestinal epithelial and epithelial goblet cells, and
            may serve as a regulatory factor for intestinal mucosal
            lymphocytes. IL7 plays an essential role in lymphoid cell survival,
            and in the maintenance of naive and memory T cells. Alternative
            splicing results in multiple transcript variants encoding distinct
            isoforms. Additional splice variants have been described but their
            presence in normal tissues has not been confirmed. Severe acute
            respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a
            potent inducer of proinflammatory cytokines and chemokines which
            may defend against the infection, but may also mediate destructive
            lung injury. Elevated serum IL7 levels, together with several other
            circulating cytokines and chemokines, has been found to be
            associated with the severity of Coronavirus Disease 19 (COVID-19).
            [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047698.1, SRR1660805.214593.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000263851.9/ ENSP00000263851.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AK291538.1         61-217
            158-1746            J04156.1           1-1589
            1747-2016           BC047698.1         1795-2064
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..2016
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /note="interleukin 7"
                     /db_xref="GeneID:3574"
                     /db_xref="HGNC:HGNC:6023"
                     /db_xref="MIM:146660"
     exon            1..551
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..1075
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="interleukin-7 isoform 1 precursor"
                     /protein_id="NP_000871.1"
                     /db_xref="CCDS:CCDS6224.1"
                     /db_xref="GeneID:3574"
                     /db_xref="HGNC:HGNC:6023"
                     /db_xref="MIM:146660"
                     /translation="MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVS
                     IDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDL
                     HLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLL
                     QEIKTCWNKILMGTKEH"
     exon            552..688
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /inference="alignment:Splign:2.1.0"
     exon            689..769
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /inference="alignment:Splign:2.1.0"
     exon            770..901
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /inference="alignment:Splign:2.1.0"
     exon            902..955
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /inference="alignment:Splign:2.1.0"
     exon            956..2016
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /note="hexamer: ATTAAA"
     polyA_site      1421
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /note="major polyA site"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /note="hexamer: AATAAA"
     polyA_site      1789
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="IL7"
                     /gene_synonym="IL-7; IMD130"
                     /note="major polyA site"
ORIGIN      
        1 acacttgtgg cttccgtgca cacattaaca actcatggtt ctagctccca gtcgccaagc
       61 gttgccaagg cgttgagaga tcatctggga agtcttttac ccagaattgc tttgattcag
      121 gccagctggt ttttcctgcg gtgattcgga aattcgcgaa ttcctctggt cctcatccag
      181 gtgcgcggga agcaggtgcc caggagagag gggataatga agattccatg ctgatgatcc
      241 caaagattga acctgcagac caagcgcaaa gtagaaactg aaagtacact gctggcggat
      301 cctacggaag ttatggaaaa ggcaaagcgc agagccacgc cgtagtgtgt gccgcccccc
      361 ttgggatgga tgaaactgca gtcgcggcgt gggtaagagg aaccagctgc agagatcacc
      421 ctgcccaaca cagactcggc aactccgcgg aagaccaggg tcctgggagt gactatgggc
      481 ggtgagagct tgctcctgct ccagttgcgg tcatcatgac tacgcccgcc tcccgcagac
      541 catgttccat gtttctttta ggtatatctt tggacttcct cccctgatcc ttgttctgtt
      601 gccagtagca tcatctgatt gtgatattga aggtaaagat ggcaaacaat atgagagtgt
      661 tctaatggtc agcatcgatc aattattgga cagcatgaaa gaaattggta gcaattgcct
      721 gaataatgaa tttaactttt ttaaaagaca tatctgtgat gctaataagg aaggtatgtt
      781 tttattccgt gctgctcgca agttgaggca atttcttaaa atgaatagca ctggtgattt
      841 tgatctccac ttattaaaag tttcagaagg cacaacaata ctgttgaact gcactggcca
      901 ggttaaagga agaaaaccag ctgccctggg tgaagcccaa ccaacaaaga gtttggaaga
      961 aaataaatct ttaaaggaac agaaaaaact gaatgacttg tgtttcctaa agagactatt
     1021 acaagagata aaaacttgtt ggaataaaat tttgatgggc actaaagaac actgaaaaat
     1081 atggagtggc aatatagaaa cacgaacttt agctgcatcc tccaagaatc tatctgctta
     1141 tgcagttttt cagagtggaa tgcttcctag aagttactga atgcaccatg gtcaaaacgg
     1201 attagggcat ttgagaaatg catattgtat tactagaaga tgaatacaaa caatggaaac
     1261 tgaatgctcc agtcaacaaa ctatttctta tatatgtgaa catttatcaa tcagtataat
     1321 tctgtactga tttttgtaag acaatccatg taaggtatca gttgcaataa tacttctcaa
     1381 acctgtttaa atatttcaag acattaaatc tatgaagtat ataatggttt caaagattca
     1441 aaattgacat tgctttactg tcaaaataat tttatggctc actatgaatc tattatactg
     1501 tattaagagt gaaaattgtc ttcttctgtg ctggagatgt tttagagtta acaatgatat
     1561 atggataatg ccggtgagaa taagagagtc ataaacctta agtaagcaac agcataacaa
     1621 ggtccaagat acctaaaaga gatttcaaga gatttaatta atcatgaatg tgtaacacag
     1681 tgccttcaat aaatggtata gcaaatgttt tgacatgaaa aaaggacaat ttcaaaaaaa
     1741 taaaataaaa taaaaataaa ttcacctagt ctaaggatgc taaaccttag tactgagtta
     1801 cattgtcatt tatatagatt ataacttgtc taaataagtt tgcaatttgg gagatatatt
     1861 tttaagataa taatatatgt ttacctttta attaatgaaa tatctgtatt taattttgac
     1921 actatatctg tatataaaat attttcatac agcattacaa attgcttact ttggaataca
     1981 tttctccttt gataaaataa atgagctatg tattaa
//
