LOCUS       NM_000565               5764 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens interleukin 6 receptor (IL6R), transcript variant 1,
            mRNA.
ACCESSION   NM_000565
VERSION     NM_000565.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5764)
  AUTHORS   Al-Rashed,F., AlSaeed,H., Almansour,N., Al-Mulla,F., Hannun,Y.A.
            and Ahmad,R.
  TITLE     IL-6R (trans-signaling) is a key regulator of reverse cholesterol
            transport in lipid-laden macrophages
  JOURNAL   Clin Immunol 267, 110351 (2024)
   PUBMED   39216780
  REMARK    GeneRIF: IL-6R (trans-signaling) is a key regulator of reverse
            cholesterol transport in lipid-laden macrophages.
REFERENCE   2  (bases 1 to 5764)
  AUTHORS   Uciechowski,P. and Dempke,W.C.M.
  TITLE     Interleukin-6: A Masterplayer in the Cytokine Network
  JOURNAL   Oncology 98 (3), 131-137 (2020)
   PUBMED   31958792
  REMARK    Review article
REFERENCE   3  (bases 1 to 5764)
  AUTHORS   Schaper,F. and Rose-John,S.
  TITLE     Interleukin-6: Biology, signaling and strategies of blockade
  JOURNAL   Cytokine Growth Factor Rev 26 (5), 475-487 (2015)
   PUBMED   26189695
  REMARK    Review article
REFERENCE   4  (bases 1 to 5764)
  AUTHORS   Hunter,C.A. and Jones,S.A.
  TITLE     IL-6 as a keystone cytokine in health and disease
  JOURNAL   Nat Immunol 16 (5), 448-457 (2015)
   PUBMED   25898198
  REMARK    Review article
            Erratum:[Nat Immunol. 2017 Oct 18;18(11):1271. doi:
            10.1038/ni1117-1271b.. PMID: 29044237]
REFERENCE   5  (bases 1 to 5764)
  AUTHORS   Mihara,M., Hashizume,M., Yoshida,H., Suzuki,M. and Shiina,M.
  TITLE     IL-6/IL-6 receptor system and its role in physiological and
            pathological conditions
  JOURNAL   Clin Sci (Lond) 122 (4), 143-159 (2012)
   PUBMED   22029668
  REMARK    Review article
REFERENCE   6  (bases 1 to 5764)
  AUTHORS   Boulanger,M.J., Chow,D.C., Brevnova,E.E. and Garcia,K.C.
  TITLE     Hexameric structure and assembly of the interleukin-6/IL-6
            alpha-receptor/gp130 complex
  JOURNAL   Science 300 (5628), 2101-2104 (2003)
   PUBMED   12829785
  REMARK    GeneRIF: a structural model, derived from 3.65 A resolution
            crystallographic data of the complex between IL-6, the
            extracellular binding domains of IL-6R, and the extracellular
            activation and binding domains of gp130 is presented
            Erratum:[Science. 2003 Aug 15;301(5635):918]
REFERENCE   7  (bases 1 to 5764)
  AUTHORS   Kluck,P.M., Wiegant,J., Jansen,R.P., Bolk,M.W., Raap,A.K.,
            Willemze,R. and Landegent,J.E.
  TITLE     The human interleukin-6 receptor alpha chain gene is localized on
            chromosome 1 band q21
  JOURNAL   Hum Genet 90 (5), 542-544 (1993)
   PUBMED   8428753
REFERENCE   8  (bases 1 to 5764)
  AUTHORS   Schooltink,H., Stoyan,T., Roeb,E., Heinrich,P.C. and Rose-John,S.
  TITLE     Ciliary neurotrophic factor induces acute-phase protein expression
            in hepatocytes
  JOURNAL   FEBS Lett 314 (3), 280-284 (1992)
   PUBMED   1281789
REFERENCE   9  (bases 1 to 5764)
  AUTHORS   Szpirer,J., Szpirer,C., Riviere,M., Houart,C., Baumann,M.,
            Fey,G.H., Poli,V., Cortese,R., Islam,M.Q. and Levan,G.
  TITLE     The Interleukin-6-dependent DNA-binding protein gene (transcription
            factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3,
            the IL6 receptor locus (IL6R) to human chromosome 1 and rat
            chromosome 2, and the rat IL6 gene to rat chromosome 4
  JOURNAL   Genomics 10 (3), 539-546 (1991)
   PUBMED   1889804
REFERENCE   10 (bases 1 to 5764)
  AUTHORS   Yamasaki,K., Taga,T., Hirata,Y., Yawata,H., Kawanishi,Y., Seed,B.,
            Taniguchi,T., Hirano,T. and Kishimoto,T.
  TITLE     Cloning and expression of the human interleukin-6 (BSF-2/IFN beta
            2) receptor
  JOURNAL   Science 241 (4867), 825-828 (1988)
   PUBMED   3136546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X12830.1, BC132684.1,
            AL162591.16 and AA035377.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_000565.3.
            
            Summary: This gene encodes a subunit of the interleukin 6 (IL6)
            receptor complex. Interleukin 6 is a potent pleiotropic cytokine
            that regulates cell growth and differentiation and plays an
            important role in the immune response. The IL6 receptor is a
            protein complex consisting of this protein and interleukin 6 signal
            transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared
            by many other cytokines. Dysregulated production of IL6 and this
            receptor are implicated in the pathogenesis of many diseases, such
            as multiple myeloma, autoimmune diseases and prostate cancer.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been identified in this gene. A pseudogene of this
            gene is found on chromosome 9. [provided by RefSeq, Aug 2020].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4346137.1, X12830.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000368485.8/ ENSP00000357470.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                X12830.1           151-187
            38-1755             BC132684.1         1-1718
            1756-5695           AL162591.16        54505-58444         c
            5696-5764           AA035377.1         15-83               c
FEATURES             Location/Qualifiers
     source          1..5764
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..5764
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /note="interleukin 6 receptor"
                     /db_xref="GeneID:3570"
                     /db_xref="HGNC:HGNC:6019"
                     /db_xref="MIM:147880"
     exon            1..372
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1694
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD126 antigen; membrane glycoprotein 80; IL-6
                     receptor subunit alpha"
                     /codon_start=1
                     /product="interleukin-6 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_000556.1"
                     /db_xref="CCDS:CCDS1067.1"
                     /db_xref="GeneID:3570"
                     /db_xref="HGNC:HGNC:6019"
                     /db_xref="MIM:147880"
                     /translation="MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVT
                     LTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRP
                     AGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAED
                     FQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDP
                     PANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHH
                     CVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQAL
                     TTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTW
                     KLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDA
                     RDPRSPYDISNTDYFFPR"
     exon            373..621
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     exon            622..745
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     exon            746..927
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1094
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1236
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1283
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1353
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1447
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..5764
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5744..5749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /note="hexamer: AATAAA"
     polyA_site      5764
                     /gene="IL6R"
                     /gene_synonym="CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1;
                     IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ"
                     /note="major polyA site"
ORIGIN      
        1 aaatgttttc ctgcgttgcc aggaccgtcc gccgctctga gtcatgtgcg agtgggaagt
       61 cgcactgaca ctgagccggg ccagagggag aggagccgag cgcggcgcgg ggccgaggga
      121 ctcgcagtgt gtgtagagag ccgggctcct gcggatgggg gctgcccccg gggcctgagc
      181 ccgcctgccc gcccaccgcc ccgccccgcc cctgccaccc ctgccgcccg gttcccatta
      241 gcctgtccgc ctctgcggga ccatggagtg gtagccgagg aggaagcatg ctggccgtcg
      301 gctgcgcgct gctggctgcc ctgctggccg cgccgggagc ggcgctggcc ccaaggcgct
      361 gccctgcgca ggaggtggcg agaggcgtgc tgaccagtct gccaggagac agcgtgactc
      421 tgacctgccc gggggtagag ccggaagaca atgccactgt tcactgggtg ctcaggaagc
      481 cggctgcagg ctcccacccc agcagatggg ctggcatggg aaggaggctg ctgctgaggt
      541 cggtgcagct ccacgactct ggaaactatt catgctaccg ggccggccgc ccagctggga
      601 ctgtgcactt gctggtggat gttccccccg aggagcccca gctctcctgc ttccggaaga
      661 gccccctcag caatgttgtt tgtgagtggg gtcctcggag caccccatcc ctgacgacaa
      721 aggctgtgct cttggtgagg aagtttcaga acagtccggc cgaagacttc caggagccgt
      781 gccagtattc ccaggagtcc cagaagttct cctgccagtt agcagtcccg gagggagaca
      841 gctctttcta catagtgtcc atgtgcgtcg ccagtagtgt cgggagcaag ttcagcaaaa
      901 ctcaaacctt tcagggttgt ggaatcttgc agcctgatcc gcctgccaac atcacagtca
      961 ctgccgtggc cagaaacccc cgctggctca gtgtcacctg gcaagacccc cactcctgga
     1021 actcatcttt ctacagacta cggtttgagc tcagatatcg ggctgaacgg tcaaagacat
     1081 tcacaacatg gatggtcaag gacctccagc atcactgtgt catccacgac gcctggagcg
     1141 gcctgaggca cgtggtgcag cttcgtgccc aggaggagtt cgggcaaggc gagtggagcg
     1201 agtggagccc ggaggccatg ggcacgcctt ggacagaatc caggagtcct ccagctgaga
     1261 acgaggtgtc cacccccatg caggcactta ctactaataa agacgatgat aatattctct
     1321 tcagagattc tgcaaatgcg acaagcctcc cagtgcaaga ttcttcttca gtaccactgc
     1381 ccacattcct ggttgctgga gggagcctgg ccttcggaac gctcctctgc attgccattg
     1441 ttctgaggtt caagaagacg tggaagctgc gggctctgaa ggaaggcaag acaagcatgc
     1501 atccgccgta ctctttgggg cagctggtcc cggagaggcc tcgacccacc ccagtgcttg
     1561 ttcctctcat ctccccaccg gtgtccccca gcagcctggg gtctgacaat acctcgagcc
     1621 acaaccgacc agatgccagg gacccacgga gcccttatga catcagcaat acagactact
     1681 tcttccccag atagctggct gggtggcacc agcagcctgg accctgtgga tgataaaaca
     1741 caaacgggct cagcaaaaga tgcttctcac tgccatgcca gcttatctca ggggtgtgcg
     1801 gcctttggct tcacggaaga gccttgcgga aggttctacg ccaggggaaa atcagcctgc
     1861 tccagctgtt cagctggttg aggtttcaaa cctccctttc caaatgccca gcttaaaggg
     1921 gctagagtga acttgggcca ctgtgaagag aaccatatca agactctttg gacactcaca
     1981 cggacactca aaagctgggc aggttggtgg gggcctcggt gtggagaagc ggctggcagc
     2041 ccacccctca acacctctgc acaagctgca ccctcaggca ggtgggatgg atttccagcc
     2101 aaagcctcct ccagccgcca tgctcctggc ccactgcatc gtttcatctt ccaactcaaa
     2161 ctcttaaaac ccaagtgcct tagcaaattc tgtttttcta ggcctgggga cggcttttac
     2221 ttaaaccgcc aaggctgggg gaagaagctc tctcctccct ttcttcccta cagttgaaaa
     2281 acagctgagg gtgagtgggt gaataataca gtatctcagg gcctggtcgt tttcaacaga
     2341 attataatta gttcctcatt agcattttgc taaatgtgaa tgatgatcct aggcatttgc
     2401 tgaatacaga ggcaactgca ttggctttgg gttgcaggac ctcaggtgag aagcagagga
     2461 aggagaggag aggggcacag ggtctctacc atcccctgta gagtgggagc tgagtggggg
     2521 atcacagcct ctgaaaacca atgttctctc ttctccacct cccacaaagg agagctagca
     2581 gcagggaggg cttctgccat ttctgagatc aaaacggttt tactgcagct ttgtttgttg
     2641 tcagctgaac ctgggtaact agggaagata atattaagga agacaatgtg aaaagaaaaa
     2701 tgagcctggc aagaatgtgt ttaaacttgg tttttaaaaa actgctgact gttttctctt
     2761 gagagggtgg aatatccaat attcgctgtg tcagcataga agtaacttac ttaggtgtgg
     2821 gggaagcacc ataactttgt ttagcccaaa accaagtcaa gtgaaaaagg aggaagagaa
     2881 aaaatatttt cctgccaggc atggtggccc acgcacttcg ggaggtcgag gcaggaggat
     2941 cacttgagtc cagaagtttg agatcagcct gggcaatgtg ataaaacccc atctctacaa
     3001 aaagcataaa aattagccaa gtgtggtaga gtgtgcctga agtcccagat acttgggggg
     3061 ctgaggtggg aggatctctt gagcctggga ggtcaaggct gcagtgagcc gagattgcac
     3121 cactgcactc cagcctgggt gacagagcaa gtgagaccct gtctcaaaaa aagaaaaaga
     3181 aaaagaaaaa atattttccc tattagagaa gagattgtgg tttcattctg tattttgttt
     3241 ttgtcttaaa aagtggaaaa atagcctgcc tcttctctac tctagggaaa aaccagcgtg
     3301 tgactactcc cccaggtggt tatggagagg gtgtccggtc cctgtcccag tgccgagaag
     3361 gaagcctccc acgactgccc ggcagggtcc tagaaattcc ccaccctgaa agccctgagc
     3421 tttctgctat caaagaggtt ttaaaaaaat cccatttaaa aaaaatccct tacctcggtg
     3481 ccttcctctt tttatttagt tccttgagtt gattcagctc tgcaagaatt gaagcaggac
     3541 taaatgtcta gttgtaacac catgattaac cacttcagct gacttttctg tccgagcttt
     3601 gaaaattcag tggtgttagt ggttacccag ttagctctca agttatcagg gtattccaga
     3661 gtggggatat gatttaaatc agccgtgtaa ccatggaccc aatatttacc agaccacaaa
     3721 acttttctaa tactctaccc tcttagaaaa accaccacca tcaccagaca ggtgcgaaag
     3781 gatgaaagtg accatgtttt gtttacggtt ttccaggttt aagctgttac tgtcttcagt
     3841 aagccgtgat tttcattgct gggcttgtct gtagatttta gaccctattg ctgcttgagg
     3901 caactcatct taggttggca aaaaggcagg atggccgggc gcggtggctc acgcctgtaa
     3961 tcctagcact ttgggaggcc aaggtgggag gattgcttga gctcaggagt ttgagaccaa
     4021 cctgggtaac atagtgagac accatctcta ttatgaacaa taacagttaa gaaaaaaaaa
     4081 ggcaggcagg cggttatggt ggttccctcc catcccacca cataaagttt ctgagacttg
     4141 agaacagcaa aatgctgtta aagggaaata ttaagaatga gaatctgcag taagggtgat
     4201 tctgtgccca cagttcttca attctttata ccgttttacc cacatgtggt gttaccaaag
     4261 ccgggcagaa ccatgctagc ggaagatgtg aaatccagat agctcattat tgccaagagc
     4321 taggcagctt tgatctccaa attgttattg ctttcatttt tattgtaatg gaattgcttt
     4381 gttttgtttt tttgtttttg tattgaagag ggttgttttc cctttatttt tcataagcta
     4441 atgtaaatga agaaaaaatg tcttctctgg gctgtaggcc tggctcagcg tacacaggta
     4501 tacatcctaa gctctctatg ttctctaatc tgtggtgact gaacatgtgt ctcaatgcac
     4561 ggggcatttc tacctgtgtt tctgcagcac ccccactgcc ttgagtcccc agcagtgctg
     4621 ttatttgcct aacacctgta gccatctgcc acgcagccag acgtgaaacg ctgagacaga
     4681 gaccatttag gttaaatacg acagcttatc ctgctgggtg gggaaagtaa aaaatatgct
     4741 ggttcaaggc ctaaagtaaa atgatcaata atgtttgtag cattaatgaa atattttcaa
     4801 gaaatgtgtc caggggtagc actggctatg ttgacgaggc ctttggtaac tcagagagct
     4861 cttggccctg atggggactt gcccttacgc tttctttatc aggctctgag ttcacacgga
     4921 gcctctggca cttccctgct gtcttgggag aaaggaaact ggttgccgcg gcaggttgtg
     4981 gaatctgttg ctggaaccag gctggaagcc cacctggtag tgaacagggc ccagtggggc
     5041 aggctgggca tgttgtggtc tatgggtttg tttcctggag aatgttcagg aatgtcttcc
     5101 cagctgcttt ggtgctgagc tctattatct cacagcacgt ccagaaggct aacccaggtg
     5161 gggaggatgc tgacaccagc tccaggtgga gttggtggtc ttaatttgga gatgcagggg
     5221 caacctgtga ccctttgagg caagagccct gcacccagct gtcccgtgca gccgtgggca
     5281 ggggctgcac acggaggggc aggcgggcca gttcagggtc cgtgccaggc cctcctcagt
     5341 gccctgtgaa ggcctcctgt cctccgtgcg gctgggcacc agcaccaggg agtttctatg
     5401 gcaaccttag tgattattaa ggaacactgt cagttttatg aacatatgct caaatgaaat
     5461 tctactttag gaggaaagga ttggaacagc atgtcacaag gctgttaatt aacagagaga
     5521 ccttattgga tggagatcac atctgttaaa tagaatacct caactctacg ttgttttctt
     5581 ggagataaat aatagtttca agtttttgtt tgtttgtttt acctaattac ctgaaagcaa
     5641 ataccaaagg ctgatgtctg tatatggggc aaagggtcag tatatttttc agtgtttttt
     5701 tttctaccag ctattttgca tttaaagtga acattgtgtt tggaataaat actcttaaaa
     5761 aata
//
