LOCUS       NM_001371096            1058 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 6 (IL6), transcript variant 3, mRNA.
ACCESSION   NM_001371096
VERSION     NM_001371096.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1058)
  AUTHORS   Abuelnadar,E.H., Ramadan,L.M., Shahin,H.E., Alakilli,S.Y.M.,
            Wahsh,E., El-Beltagy,N.S., Salem,E.T., Hatata,A.S., El-Said,A.M.
            and Alhelf,M.
  TITLE     Association of IL-6 G-174C (rs1800795) variant with the
            susceptibility to hepatocellular carcinoma in patients with chronic
            hepatitis
  JOURNAL   J Egypt Natl Canc Inst 36 (1), 32 (2024)
   PUBMED   39428452
  REMARK    GeneRIF: Association of IL-6 G-174C (rs1800795) variant with the
            susceptibility to hepatocellular carcinoma in patients with chronic
            hepatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1058)
  AUTHORS   Mora,P., Laisne,M., Bourguignon,C., Rouault,P., Jaspard-Vinassa,B.,
            Maitre,M., Gadeau,A.P., Renault,M.A., Horng,S., Couffinhal,T. and
            Chapouly,C.
  TITLE     Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation
            via the IL-6-STAT3 axis
  JOURNAL   J Neuroinflammation 21 (1), 258 (2024)
   PUBMED   39390606
  REMARK    GeneRIF: Astrocytic DLL4-NOTCH1 signaling pathway promotes
            neuroinflammation via the IL-6-STAT3 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1058)
  AUTHORS   Kraaijenhof,J.M., Nurmohamed,N.S., Tzolos,E., Meah,M., Geers,J.,
            Kaiser,Y., Kroon,J., Hovingh,G.K., Stroes,E.S.G. and Dweck,M.R.
  TITLE     Interleukin 6 plasma levels are associated with progression of
            coronary plaques
  JOURNAL   Open Heart 11 (2), e002773 (2024)
   PUBMED   39304297
  REMARK    GeneRIF: Interleukin 6 plasma levels are associated with
            progression of coronary plaques.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1058)
  AUTHORS   Boussouf,F.Z., Medjdoub,A., Tahari,Z., Messatfa,M., Bouras,N.,
            Dahmani,C.A., Seddiki,S.A. and Sahraoui,T.
  TITLE     Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria
  JOURNAL   Pol J Pathol 75 (3), 205-214 (2024)
   PUBMED   39451175
  REMARK    GeneRIF: Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria.
REFERENCE   5  (bases 1 to 1058)
  AUTHORS   Kikkert,R., de Groot,E.R. and Aarden,L.A.
  TITLE     Cytokine induction by pyrogens: comparison of whole blood,
            mononuclear cells, and TLR-transfectants
  JOURNAL   J Immunol Methods 336 (1), 45-55 (2008)
   PUBMED   18456276
REFERENCE   6  (bases 1 to 1058)
  AUTHORS   Dinarello,C.A.
  TITLE     Infection, fever, and exogenous and endogenous pyrogens: some
            concepts have changed
  JOURNAL   J Endotoxin Res 10 (4), 201-222 (2004)
   PUBMED   15373964
  REMARK    Review article
REFERENCE   7  (bases 1 to 1058)
  AUTHORS   Chen,Q.Y.
  TITLE     [Stable and efficient expression of human interleukin-6 cDNA in
            mammalian cells after gene transfer]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 14 (5), 340-344 (1992)
   PUBMED   1291290
REFERENCE   8  (bases 1 to 1058)
  AUTHORS   May,L.T. and Sehgal,P.B.
  TITLE     Phosphorylation of interleukin-6 at serine54: an early event in the
            secretory pathway in human fibroblasts
  JOURNAL   Biochem Biophys Res Commun 185 (2), 524-530 (1992)
   PUBMED   1610348
REFERENCE   9  (bases 1 to 1058)
  AUTHORS   May,L.T., Shaw,J.E., Khanna,A.K., Zabriskie,J.B. and Sehgal,P.B.
  TITLE     Marked cell-type-specific differences in glycosylation of human
            interleukin-6
  JOURNAL   Cytokine 3 (3), 204-211 (1991)
   PUBMED   1883960
REFERENCE   10 (bases 1 to 1058)
  AUTHORS   Sandler,N.H.
  TITLE     A case of meningitis admitted as schizophrenia
  JOURNAL   J Ky Med Assoc 73 (1), 25-26 (1975)
   PUBMED   1113021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073072.11.
            
            Summary: This gene encodes a cytokine that functions in
            inflammation and the maturation of B cells. In addition, the
            encoded protein has been shown to be an endogenous pyrogen capable
            of inducing fever in people with autoimmune diseases or infections.
            The protein is primarily produced at sites of acute and chronic
            inflammation, where it is secreted into the serum and induces a
            transcriptional inflammatory response through interleukin 6
            receptor, alpha. The functioning of this gene is implicated in a
            wide variety of inflammation-associated disease states, including
            suspectibility to diabetes mellitus and systemic juvenile
            rheumatoid arthritis. Elevated levels of the encoded protein have
            been found in virus infections, including COVID-19 (disease caused
            by SARS-CoV-2). [provided by RefSeq, Aug 2020].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE787841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920, SAMEA2163105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: relevant for COVID-19 prognosis
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC073072.11        11236-11317
            83-204              AC073072.11        11549-11670
            205-318             AC073072.11        12729-12842
            319-465             AC073072.11        13550-13696
            466-1058            AC073072.11        15442-16034
FEATURES             Location/Qualifiers
     source          1..1058
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..1058
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /note="interleukin 6"
                     /db_xref="GeneID:3569"
                     /db_xref="HGNC:HGNC:6018"
                     /db_xref="MIM:147620"
     exon            1..82
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..633
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /note="isoform 3 is encoded by transcript variant 3;
                     hybridoma growth factor; interleukin BSF-2; B-cell
                     differentiation factor; CTL differentiation factor;
                     interferon beta-2; B-cell stimulatory factor 2"
                     /codon_start=1
                     /product="interleukin-6 isoform 3"
                     /protein_id="NP_001358025.1"
                     /db_xref="CCDS:CCDS94066.1"
                     /db_xref="GeneID:3569"
                     /db_xref="HGNC:HGNC:6018"
                     /db_xref="MIM:147620"
                     /translation="MNSFSTIPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISAL
                     RKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVY
                     LEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQN
                     QWLQDMTTHLILRSFKEFLQSSLRALRQM"
     exon            83..204
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     exon            205..318
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     exon            319..465
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     exon            466..1058
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1034..1039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /note="hexamer: AATAAA"
     polyA_site      1058
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /note="major polyA site"
ORIGIN      
        1 attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca
       61 gctatgaact ccttctccac aataccccca ggagaagatt ccaaagatgt agccgcccca
      121 cacagacagc cactcacctc ttcagaacga attgacaaac aaattcggta catcctcgac
      181 ggcatctcag ccctgagaaa ggagacatgt aacaagagta acatgtgtga aagcagcaaa
      241 gaggcactgg cagaaaacaa cctgaacctt ccaaagatgg ctgaaaaaga tggatgcttc
      301 caatctggat tcaatgagga gacttgcctg gtgaaaatca tcactggtct tttggagttt
      361 gaggtatacc tagagtacct ccagaacaga tttgagagta gtgaggaaca agccagagct
      421 gtgcagatga gtacaaaagt cctgatccag ttcctgcaga aaaaggcaaa gaatctagat
      481 gcaataacca cccctgaccc aaccacaaat gccagcctgc tgacgaagct gcaggcacag
      541 aaccagtggc tgcaggacat gacaactcat ctcattctgc gcagctttaa ggagttcctg
      601 cagtccagcc tgagggctct tcggcaaatg tagcatgggc acctcagatt gttgttgtta
      661 atgggcattc cttcttctgg tcagaaacct gtccactggg cacagaactt atgttgttct
      721 ctatggagaa ctaaaagtat gagcgttagg acactatttt aattattttt aatttattaa
      781 tatttaaata tgtgaagctg agttaattta tgtaagtcat atttatattt ttaagaagta
      841 ccacttgaaa cattttatgt attagttttg aaataataat ggaaagtggc tatgcagttt
      901 gaatatcctt tgtttcagag ccagatcatt tcttggaaag tgtaggctta cctcaaataa
      961 atggctaact tatacatatt tttaaagaaa tatttatatt gtatttatat aatgtataaa
     1021 tggtttttat accaataaat ggcattttaa aaaattca
//
