LOCUS       NM_000600               1127 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 6 (IL6), transcript variant 1, mRNA.
ACCESSION   NM_000600
VERSION     NM_000600.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1127)
  AUTHORS   Abuelnadar,E.H., Ramadan,L.M., Shahin,H.E., Alakilli,S.Y.M.,
            Wahsh,E., El-Beltagy,N.S., Salem,E.T., Hatata,A.S., El-Said,A.M.
            and Alhelf,M.
  TITLE     Association of IL-6 G-174C (rs1800795) variant with the
            susceptibility to hepatocellular carcinoma in patients with chronic
            hepatitis
  JOURNAL   J Egypt Natl Canc Inst 36 (1), 32 (2024)
   PUBMED   39428452
  REMARK    GeneRIF: Association of IL-6 G-174C (rs1800795) variant with the
            susceptibility to hepatocellular carcinoma in patients with chronic
            hepatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1127)
  AUTHORS   Mora,P., Laisne,M., Bourguignon,C., Rouault,P., Jaspard-Vinassa,B.,
            Maitre,M., Gadeau,A.P., Renault,M.A., Horng,S., Couffinhal,T. and
            Chapouly,C.
  TITLE     Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation
            via the IL-6-STAT3 axis
  JOURNAL   J Neuroinflammation 21 (1), 258 (2024)
   PUBMED   39390606
  REMARK    GeneRIF: Astrocytic DLL4-NOTCH1 signaling pathway promotes
            neuroinflammation via the IL-6-STAT3 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1127)
  AUTHORS   Kraaijenhof,J.M., Nurmohamed,N.S., Tzolos,E., Meah,M., Geers,J.,
            Kaiser,Y., Kroon,J., Hovingh,G.K., Stroes,E.S.G. and Dweck,M.R.
  TITLE     Interleukin 6 plasma levels are associated with progression of
            coronary plaques
  JOURNAL   Open Heart 11 (2), e002773 (2024)
   PUBMED   39304297
  REMARK    GeneRIF: Interleukin 6 plasma levels are associated with
            progression of coronary plaques.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1127)
  AUTHORS   Boussouf,F.Z., Medjdoub,A., Tahari,Z., Messatfa,M., Bouras,N.,
            Dahmani,C.A., Seddiki,S.A. and Sahraoui,T.
  TITLE     Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria
  JOURNAL   Pol J Pathol 75 (3), 205-214 (2024)
   PUBMED   39451175
  REMARK    GeneRIF: Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria.
REFERENCE   5  (bases 1 to 1127)
  AUTHORS   Kikkert,R., de Groot,E.R. and Aarden,L.A.
  TITLE     Cytokine induction by pyrogens: comparison of whole blood,
            mononuclear cells, and TLR-transfectants
  JOURNAL   J Immunol Methods 336 (1), 45-55 (2008)
   PUBMED   18456276
REFERENCE   6  (bases 1 to 1127)
  AUTHORS   Dinarello,C.A.
  TITLE     Infection, fever, and exogenous and endogenous pyrogens: some
            concepts have changed
  JOURNAL   J Endotoxin Res 10 (4), 201-222 (2004)
   PUBMED   15373964
  REMARK    Review article
REFERENCE   7  (bases 1 to 1127)
  AUTHORS   Chen,Q.Y.
  TITLE     [Stable and efficient expression of human interleukin-6 cDNA in
            mammalian cells after gene transfer]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 14 (5), 340-344 (1992)
   PUBMED   1291290
REFERENCE   8  (bases 1 to 1127)
  AUTHORS   May,L.T. and Sehgal,P.B.
  TITLE     Phosphorylation of interleukin-6 at serine54: an early event in the
            secretory pathway in human fibroblasts
  JOURNAL   Biochem Biophys Res Commun 185 (2), 524-530 (1992)
   PUBMED   1610348
REFERENCE   9  (bases 1 to 1127)
  AUTHORS   May,L.T., Shaw,J.E., Khanna,A.K., Zabriskie,J.B. and Sehgal,P.B.
  TITLE     Marked cell-type-specific differences in glycosylation of human
            interleukin-6
  JOURNAL   Cytokine 3 (3), 204-211 (1991)
   PUBMED   1883960
REFERENCE   10 (bases 1 to 1127)
  AUTHORS   Sandler,N.H.
  TITLE     A case of meningitis admitted as schizophrenia
  JOURNAL   J Ky Med Assoc 73 (1), 25-26 (1975)
   PUBMED   1113021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301141.1 and BC015511.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 7, 2018 this sequence version replaced NM_000600.4.
            
            Summary: This gene encodes a cytokine that functions in
            inflammation and the maturation of B cells. In addition, the
            encoded protein has been shown to be an endogenous pyrogen capable
            of inducing fever in people with autoimmune diseases or infections.
            The protein is primarily produced at sites of acute and chronic
            inflammation, where it is secreted into the serum and induces a
            transcriptional inflammatory response through interleukin 6
            receptor, alpha. The functioning of this gene is implicated in a
            wide variety of inflammation-associated disease states, including
            suspectibility to diabetes mellitus and systemic juvenile
            rheumatoid arthritis. Elevated levels of the encoded protein have
            been found in virus infections, including COVID-19 (disease caused
            by SARS-CoV-2). [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015511.1, M14584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for COVID-19 prognosis
            MANE Ensembl match     :: ENST00000258743.10/ ENSP00000258743.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK301141.1         54-67
            15-1127             BC015511.1         1-1113
FEATURES             Location/Qualifiers
     source          1..1127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..1127
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /note="interleukin 6"
                     /db_xref="GeneID:3569"
                     /db_xref="HGNC:HGNC:6018"
                     /db_xref="MIM:147620"
     exon            1..82
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..702
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hybridoma growth factor; interleukin BSF-2;
                     B-cell differentiation factor; CTL differentiation factor;
                     interferon beta-2; B-cell stimulatory factor 2"
                     /codon_start=1
                     /product="interleukin-6 isoform 1 precursor"
                     /protein_id="NP_000591.1"
                     /db_xref="CCDS:CCDS5375.1"
                     /db_xref="GeneID:3569"
                     /db_xref="HGNC:HGNC:6018"
                     /db_xref="MIM:147620"
                     /translation="MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHR
                     QPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCF
                     QSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKN
                     LDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM"
     exon            83..273
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     exon            274..387
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     exon            388..534
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1127
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1103..1108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /note="hexamer: AATAAA"
     polyA_site      1127
                     /gene="IL6"
                     /gene_synonym="BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2;
                     IFNB2; IL-6"
                     /note="major polyA site"
ORIGIN      
        1 attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca
       61 gctatgaact ccttctccac aagcgccttc ggtccagttg ccttctccct ggggctgctc
      121 ctggtgttgc ctgctgcctt ccctgcccca gtacccccag gagaagattc caaagatgta
      181 gccgccccac acagacagcc actcacctct tcagaacgaa ttgacaaaca aattcggtac
      241 atcctcgacg gcatctcagc cctgagaaag gagacatgta acaagagtaa catgtgtgaa
      301 agcagcaaag aggcactggc agaaaacaac ctgaaccttc caaagatggc tgaaaaagat
      361 ggatgcttcc aatctggatt caatgaggag acttgcctgg tgaaaatcat cactggtctt
      421 ttggagtttg aggtatacct agagtacctc cagaacagat ttgagagtag tgaggaacaa
      481 gccagagctg tgcagatgag tacaaaagtc ctgatccagt tcctgcagaa aaaggcaaag
      541 aatctagatg caataaccac ccctgaccca accacaaatg ccagcctgct gacgaagctg
      601 caggcacaga accagtggct gcaggacatg acaactcatc tcattctgcg cagctttaag
      661 gagttcctgc agtccagcct gagggctctt cggcaaatgt agcatgggca cctcagattg
      721 ttgttgttaa tgggcattcc ttcttctggt cagaaacctg tccactgggc acagaactta
      781 tgttgttctc tatggagaac taaaagtatg agcgttagga cactatttta attattttta
      841 atttattaat atttaaatat gtgaagctga gttaatttat gtaagtcata tttatatttt
      901 taagaagtac cacttgaaac attttatgta ttagttttga aataataatg gaaagtggct
      961 atgcagtttg aatatccttt gtttcagagc cagatcattt cttggaaagt gtaggcttac
     1021 ctcaaataaa tggctaactt atacatattt ttaaagaaat atttatattg tatttatata
     1081 atgtataaat ggtttttata ccaataaatg gcattttaaa aaattca
//
