LOCUS       NM_175726               5739 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens interleukin 5 receptor subunit alpha (IL5RA),
            transcript variant 4, mRNA.
ACCESSION   NM_175726
VERSION     NM_175726.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5739)
  AUTHORS   Caveney,N.A., Rodriguez,G.E., Pollmann,C., Meyer,T., Borowska,M.T.,
            Wilson,S.C., Wang,N., Xiang,X., Householder,K.D., Tao,P., Su,L.L.,
            Saxton,R.A., Piehler,J. and Garcia,K.C.
  TITLE     Structure of the interleukin-5 receptor complex exemplifies the
            organizing principle of common beta cytokine signaling
  JOURNAL   Mol Cell 84 (10), 1995-2005 (2024)
   PUBMED   38614096
  REMARK    GeneRIF: Structure of the interleukin-5 receptor complex
            exemplifies the organizing principle of common beta cytokine
            signaling.
REFERENCE   2  (bases 1 to 5739)
  AUTHORS   Chen,S., Zhao,T., Xie,S. and Wan,X.
  TITLE     Epithelial IL5RA promotes epithelial-mesenchymal transition in
            pulmonary fibrosis via Jak2/STAT3 cascade
  JOURNAL   Pulm Pharmacol Ther 84, 102286 (2024)
   PUBMED   38191068
  REMARK    GeneRIF: Epithelial IL5RA promotes epithelial-mesenchymal
            transition in pulmonary fibrosis via Jak2/STAT3 cascade.
REFERENCE   3  (bases 1 to 5739)
  AUTHORS   Li,S., Lin,L., Zhao,J., Yang,Z., Zhong,Y., Huang,L., Chen,J.,
            Zhang,L., Ding,Y. and Xie,T.
  TITLE     The Study of the Influence of IL5RA Variants on Chronic Obstructive
            Pulmonary Disease
  JOURNAL   COPD 20 (1), 338-347 (2023)
   PUBMED   37905709
  REMARK    GeneRIF: The Study of the Influence of IL5RA Variants on Chronic
            Obstructive Pulmonary Disease.
REFERENCE   4  (bases 1 to 5739)
  AUTHORS   Xu,C., Gao,M., Zhang,J. and Fu,Y.
  TITLE     IL5RA as an immunogenic cell death-related predictor in progression
            and therapeutic response of multiple myeloma
  JOURNAL   Sci Rep 13 (1), 8528 (2023)
   PUBMED   37236993
  REMARK    GeneRIF: IL5RA as an immunogenic cell death-related predictor in
            progression and therapeutic response of multiple myeloma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5739)
  AUTHORS   Laffey,K.G., Du,J., Schrum,A.G. and Ackerman,S.J.
  TITLE     Transcriptional Regulation of the Human IL5RA Gene through
            Alternative Promoter Usage during Eosinophil Development
  JOURNAL   Int J Mol Sci 22 (19), 10245 (2021)
   PUBMED   34638583
  REMARK    GeneRIF: Transcriptional Regulation of the Human IL5RA Gene through
            Alternative Promoter Usage during Eosinophil Development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5739)
  AUTHORS   Isobe,M., Kumura,Y., Murata,Y., Takaki,S., Tominaga,A., Takatsu,K.
            and Ogita,Z.
  TITLE     Localization of the gene encoding the alpha subunit of human
            interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26
  JOURNAL   Genomics 14 (3), 755-758 (1992)
   PUBMED   1427903
REFERENCE   7  (bases 1 to 5739)
  AUTHORS   Tuypens,T., Plaetinck,G., Baker,E., Sutherland,G., Brusselle,G.,
            Fiers,W., Devos,R. and Tavernier,J.
  TITLE     Organization and chromosomal localization of the human interleukin
            5 receptor alpha-chain gene
  JOURNAL   Eur Cytokine Netw 3 (5), 451-459 (1992)
   PUBMED   1477296
REFERENCE   8  (bases 1 to 5739)
  AUTHORS   Tavernier,J., Tuypens,T., Plaetinck,G., Verhee,A., Fiers,W. and
            Devos,R.
  TITLE     Molecular basis of the membrane-anchored and two soluble isoforms
            of the human interleukin 5 receptor alpha subunit
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 7041-7045 (1992)
   PUBMED   1495999
REFERENCE   9  (bases 1 to 5739)
  AUTHORS   Murata,Y., Takaki,S., Migita,M., Kikuchi,Y., Tominaga,A. and
            Takatsu,K.
  TITLE     Molecular cloning and expression of the human interleukin 5
            receptor
  JOURNAL   J Exp Med 175 (2), 341-351 (1992)
   PUBMED   1732409
REFERENCE   10 (bases 1 to 5739)
  AUTHORS   Tavernier,J., Devos,R., Cornelis,S., Tuypens,T., Van der Heyden,J.,
            Fiers,W. and Plaetinck,G.
  TITLE     A human high affinity interleukin-5 receptor (IL5R) is composed of
            an IL5-specific alpha chain and a beta chain shared with the
            receptor for GM-CSF
  JOURNAL   Cell 66 (6), 1175-1184 (1991)
   PUBMED   1833065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK304256.1, DB222974.1,
            X61176.1, M96652.1, AC022002.5 and BX118481.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_175726.3.
            
            Summary: The protein encoded by this gene is an interleukin 5
            specific subunit of a heterodimeric cytokine receptor. The receptor
            is comprised of a ligand specific alpha subunit and a signal
            transducing beta subunit shared by the receptors for interleukin 3
            (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5
            (IL5). The binding of this protein to IL5 depends on the beta
            subunit. The beta subunit is activated by the ligand binding, and
            is required for the biological activities of IL5. This protein has
            been found to interact with syndecan binding protein (syntenin),
            which is required for IL5 mediated activation of the transcription
            factor SOX4. Several alternatively spliced transcript variants
            encoding four distinct isoforms have been reported. [provided by
            RefSeq, Jul 2011].
            
            Transcript Variant: This variant (4) lacks an internal segment
            within the 5' UTR, as compared to variant 1. Variants 1 and 4
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X61176.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2144333, SAMEA2156099 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446632.7/ ENSP00000412209.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AK304256.1         1-341
            342-514             DB222974.1         339-511
            515-959             X61176.1           1-445
            960-1208            M96652.1           634-882
            1209-2288           X61176.1           695-1774
            2289-5496           AC022002.5         155071-158278       c
            5497-5739           BX118481.1         1-243
FEATURES             Location/Qualifiers
     source          1..5739
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.2"
     gene            1..5739
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /note="interleukin 5 receptor subunit alpha"
                     /db_xref="GeneID:3568"
                     /db_xref="HGNC:HGNC:6017"
                     /db_xref="MIM:147851"
     exon            1..430
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            431..572
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            573..657
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     CDS             576..1838
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; interleukin 5 receptor type 3; interleukin-5
                     receptor alpha chain; CD125 antigen; IL-5R subunit alpha;
                     IL-5 receptor subunit alpha; interleukin 5 receptor,
                     alpha"
                     /codon_start=1
                     /product="interleukin-5 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_783853.1"
                     /db_xref="CCDS:CCDS2559.1"
                     /db_xref="GeneID:3568"
                     /db_xref="HGNC:HGNC:6017"
                     /db_xref="MIM:147851"
                     /translation="MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTGLA
                     QVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTIL
                     QNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVG
                     TDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGS
                     SKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKI
                     HNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGND
                     EHKPLREWFVIVIMATICFILLILSLICKICHLWIKLFPPIPAPKSNIKDLFVTTNYE
                     KAGSSETEIEVICYIEKPGVETLEDSVF"
     exon            658..803
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            804..942
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1096
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1284
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1430
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1569
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1666
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1751
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..5739
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5718..5723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /note="hexamer: ATTAAA"
     polyA_site      5739
                     /gene="IL5RA"
                     /gene_synonym="CD125; CDw125; HSIL5R3; IL5R"
                     /note="major polyA site"
ORIGIN      
        1 aaacaaaaca gaaatgcaac gctttagagt acccacggaa aacttgttta ccttgtcacc
       61 atgagtaaaa gttaattccc actcctgaag agagcaaacc aactctgaaa gagagtgaaa
      121 atgcagacaa gacagttatc agataatggc tatctggacg agagattctt tcgtttgaca
      181 gcagtttggt tgttgggagt tccagttcag ctcctgcaca gttgctctgt acaaatcctc
      241 ctccatattt gcttagagaa aacgtgttgc catcccatca tgaaggaagc tgcctgagag
      301 tttttaacca ttacagccgt gatgatgaaa gagtgaagaa ccgcctctaa gttaaaaagt
      361 gcacccagag ataaggttcg ttctcaatgc cctgccgctg cttctcatcg catggccacc
      421 gcatttctca ggccaggcac attgagcatt ggtcctgtgc ctgacgctat gctagatgct
      481 ggggttgcag ccacgagcat agacacgaca gacacggtcc tcgccatctt ctgttgagta
      541 ctggtcggaa caagaggatc gtctgtagac aggatatgat catcgtggcg catgtattac
      601 tcatcctttt gggggccact gagatactgc aagctgactt acttcctgat gaaaagattt
      661 cacttctccc acctgtcaat ttcaccatta aagttactgg tttggctcaa gttcttttac
      721 aatggaaacc aaatcctgat caagagcaaa ggaatgttaa tctagaatat caagtgaaaa
      781 taaacgctcc aaaagaagat gactatgaaa ccagaatcac tgaaagcaaa tgtgtaacca
      841 tcctccacaa aggcttttca gcaagtgtgc ggaccatcct gcagaacgac cactcactac
      901 tggccagcag ctgggcttct gctgaacttc atgccccacc agggtctcct ggaacctcaa
      961 ttgtgaattt aacttgcacc acaaacacta cagaagacaa ttattcacgt ttaaggtcat
     1021 accaagtttc ccttcactgc acctggcttg ttggcacaga tgcccctgag gacacgcagt
     1081 attttctcta ctataggtat ggctcttgga ctgaagaatg ccaagaatac agcaaagaca
     1141 cactggggag aaatatcgca tgctggtttc ccaggacttt tatcctcagc aaagggcgtg
     1201 actggcttgc ggtgcttgtt aacggctcca gcaagcactc tgctatcagg ccctttgatc
     1261 agctgtttgc ccttcacgcc attgatcaaa taaatcctcc actgaatgtc acagcagaga
     1321 ttgaaggaac tcgtctctct atccaatggg agaaaccagt gtctgctttt ccaatccatt
     1381 gctttgatta tgaagtaaaa atacacaata caaggaatgg atatttgcag atagaaaaat
     1441 tgatgaccaa tgcattcatc tcaataattg atgatctttc taagtacgat gttcaagtga
     1501 gagcagcagt gagctccatg tgcagagagg cagggctctg gagtgagtgg agccaaccta
     1561 tttatgtggg aaatgatgaa cacaagccct tgagagagtg gtttgtcatt gtgattatgg
     1621 caaccatctg cttcatcttg ttaattctct cgcttatctg taaaatatgt catttatgga
     1681 tcaagttgtt tccaccaatt ccagcaccaa aaagtaatat caaagatctc tttgtaacca
     1741 ctaactatga gaaagctggg tccagtgaga cggaaattga agtcatctgt tatatagaga
     1801 agcctggagt tgagaccctg gaggattctg tgttttgact gtcactttgg catcctctga
     1861 tgaactcaca catgcctcag tgcctcagtg aaaagaacag ggatgctggc tcttggctaa
     1921 gaggtgttca gaatttaggc aacactcaat ttacctgcga agcaatacac ccagacacac
     1981 cagtcttgta tctcttaaaa gtatggatgc ttcatccaaa tcgcctcacc tacagcaggg
     2041 aagttgactc atccaagcat tttgccatgt tttttctccc catgccgtac agggtagcac
     2101 ctcctcacct gccaatcttt gcaatttgct tgactcacct cagacttttc attcacaaca
     2161 gacagctttt aaggctaacg tccagctgta tttacttctg gctgtgcccg tttggctgtt
     2221 taagctgcca attgtagcac tcagctacca tctgaggaag aaagcatttt gcatcagcct
     2281 ggagtgaacc atgaacttgg attcaagact gtcttttcta tagcaagtga gagccacaaa
     2341 ttcctcaccc ccctacattc tagaatgatc tttttctagg tagattgtgt atgtgtgtgt
     2401 atgagagaga gagagagaga gagagagaga gaaattatct caagctccag aggcctgatc
     2461 caggatacat catttgaaac caactaattt aaaagcataa tagagctaat atatcacccc
     2521 atatcaaaag agacgacaga ttttgttcaa atattatatt cttgaaggaa gccttaatat
     2581 tctggaaatg tgctgaggaa gtcattgagc ataattcaat catgaaaggg accactgaat
     2641 caagaatgaa ctttctgaag agatgtttgc tgccaaagac ttcagaacaa cttgttggtc
     2701 aagtaatgcc agatcaatcc tagtctctca agtttggaaa agtttctaca aggccattcc
     2761 atcaaatatc ccaatataca cagaaattct tcttcctaac atcttcatat atgagtctgc
     2821 atccagattg gaggcctttg tggtgggtgg tggactgcag gtggaaccaa gcacaggtgt
     2881 gccctgggca gaggtgggca agaggaagga acccaaacag tgctgattcc acatggccct
     2941 tggtcaagaa gctgaaggcc tagaaaggag gtaacagtgc ccagaatccc cacctggcac
     3001 actctttaaa tgctttctgg aggtgtttta gtcagttttg atccatcggt ggggacacac
     3061 tgactaccat atatttccag gtttgtttgt tttcttaact aacctgtaat tatccactgt
     3121 aactagcaga gggttgaacc ctgggtaata ggcacagaaa catcttgaat cttgacaagc
     3181 ctgcactgtc ttatagtaat ctgtattact gtcccatttt atagttgcag ttactaaggt
     3241 tcagagaagt tgataggaaa tggcatagtg aggagttgaa taccaggctc aggtaaaagt
     3301 gaccccagaa atgtgcagag gagtgtcagg gaaagctgag gcctgcttag gggtgtggct
     3361 gagaaggcaa cacccatgga ggtgctgcaa tagttggcaa aatgtttaaa atgtttggtc
     3421 actcaaatga ttcataatct caaacctgtt tttgtttttt tttttttttt tttttgtggg
     3481 gtgggtggtg gagacagtct tgttctgtct cccaggctag agtgtagtga tgtgatctta
     3541 gctcactaca acctccctgt cctgggctca agccatcctc ctccctcacc ctcccaagta
     3601 gctgggacta caggtgcata acaccattcc cagctctttt ttgtattttt ttttgtaaag
     3661 ctggggtttt gccatgctgt ctaggttcat ctcgaactcc tgggctcaag cgatacaccg
     3721 gcctcagcct tccaaagtac tgggattaca ggcatgaacc accattcctg gccaggaaac
     3781 tgtatttgta atgaacacct taggtcagaa tcagaggcgc ctggagggct ccttaagaca
     3841 cagaggagtg ggctccattc ttagagtctc taactgaata ggtctgggtg aggtctgaaa
     3901 agctgcgttt ctaacaagtt ctcaggtgat gctcatgctg ctggtctcca ggacacactc
     3961 ggagaactgc tgctccagga gagtcttatg aataccaaaa tttgaaaatc agccgctgaa
     4021 ggaagatgtg acagaaaagt cctgtcccca gaaaactgtc cttttggggc ggcttggagc
     4081 accctgtctg atctctttca aaccacaacc cagacagttg gcattgtgga aactgcctct
     4141 gcttaggagg caggaacaga agcagggagc tccccctcca caaatgtggc cagctcttca
     4201 gtgcttggtg tggtgcccac ttcagactcc tccctccact cagcagccat agatcacctg
     4261 ggctctgtgg agctccttgc cacacttccc tgagctggta ccgttatctg gcccttggta
     4321 tatgtgtttc aggagcaaca caaagtagcc cattggcctc cttggtggat tgggaactcc
     4381 ttcctccctt cttgccctgt gcaactcata gtcattcttt gggaacccgt aaccatcatc
     4441 acttcctcca tgaagccttc aaaagcagag ttggttgatc ccgcctctgg attctcattc
     4501 tgggcctcat acccgtgtta gagctactgc attgtagaat ataccattaa cagctgggag
     4561 gcctcccctc tagactgcgg cttccaggag gatggagctt gtgtgaaata cgtcttttta
     4621 tctgcagtgt ctaggacagt atctgactta agaaaatata aatgtttctt aaaccctctg
     4681 tcagccctga tacggcacct tgtatatagg ttagactgaa cagtatttgg cagagatcct
     4741 caaggcctac aataatgaca gggggaggaa gctgggtatc taatgagaat gcggttagtt
     4801 agaagcaacc aggagacaca tgtgcctaac aactgggcta ctgcaacctg gatgtttttg
     4861 ctgccaaagt gtctaaatgg ttatgtataa attgctgtgt aagaggcatt tcagaagtgg
     4921 ctcactgtga gtggtctata ctgttctcac cagccttgtc atagcaagtc aaagagtttg
     4981 aaattcactt aacagtaaac accatcagca gcaggttgat gtaaggtaaa gtcatgatat
     5041 tggctcccat ctcttgccat ctctcactag gacgagtgta gagagtcact tttctcctag
     5101 agcctccaca gccacgggat cagaacaaac atgcttttcc aagatatccg ttccaatagg
     5161 gatttttagc ccaatttctt tccttggcat ttggaattca ctgcgtgcag catgggggag
     5221 tgctggggag actggagggt gaaggtcaca tttgccaaca gcccgaccac ctgagcctca
     5281 ttgaaatgcc tcagacctca agctattcat gcaggctggg gaagaatcca cgtgggcaaa
     5341 gaacatcctg attaaaaatc caaacgtttt catggtgaga cttctatgtg tcaggaccat
     5401 ctgctggtgg aattaagaag cctgaggtgc taatttgtta aagaaaaagt agatatctgg
     5461 aagtgagaac agagaactga aaacaatctc tgatggcaca agtaaaggtg aaaaacctaa
     5521 ttagaatagg acttggtgct agcctaagga ctgtagctat tcctgcttct acatccttca
     5581 aattgagtac cagggtgcaa attttttcaa aaccattcct tcctttggaa ttttgtattg
     5641 tactataaga caatcatgct tatctcctgt tttgtaggta atagatgtga atataaatat
     5701 gtttcagaat gagaaatatt aaacataaat gacagtgaa
//
