LOCUS       NM_000879                815 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens interleukin 5 (IL5), mRNA.
ACCESSION   NM_000879
VERSION     NM_000879.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 815)
  AUTHORS   Adrizain,R., Nagari,M.V., Setiabudi,D., Berbudi,A. and
            Setiabudiawan,B.
  TITLE     The association of 25(OH)D, interleukin-4, interleukin-5, and
            interleukin-13 levels with the burden of soil-transmitted helminth
            infection in stunted children aged 24-59 months
  JOURNAL   Autoimmunity 57 (1), 2330394 (2024)
   PUBMED   38497343
  REMARK    GeneRIF: The association of 25(OH)D, interleukin-4, interleukin-5,
            and interleukin-13 levels with the burden of soil-transmitted
            helminth infection in stunted children aged 24-59 months.
REFERENCE   2  (bases 1 to 815)
  AUTHORS   Motataianu,A., Andone,S., Stoian,A., Balasa,R., Hutanu,A. and
            Sarmasan,E.
  TITLE     A Potential Role of Interleukin-5 in the Pathogenesis and
            Progression of Amyotrophic Lateral Sclerosis: A New Molecular
            Perspective
  JOURNAL   Int J Mol Sci 25 (7), 3782 (2024)
   PUBMED   38612591
  REMARK    GeneRIF: A Potential Role of Interleukin-5 in the Pathogenesis and
            Progression of Amyotrophic Lateral Sclerosis: A New Molecular
            Perspective.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 815)
  AUTHORS   Junior,J.D.E.S., de Souza,J.L., da Silva,L.S., da Silva,C.C., do
            Nascimento,T.A., de Souza,M.L.G., da Cunha,A.F., Batista,J.D.S.,
            Neto,J.P.M., Guerra,M.V.F. and Ramasawmy,R.
  TITLE     A fine mapping of single nucleotide variants and haplotype analysis
            of IL13 gene in patients with Leishmania guyanensis-cutaneous
            leishmaniasis and plasma cytokines IL-4, IL-5, and IL-13
  JOURNAL   Front Immunol 14, 1232488 (2023)
   PUBMED   37908348
  REMARK    GeneRIF: A fine mapping of single nucleotide variants and haplotype
            analysis of IL13 gene in patients with Leishmania
            guyanensis-cutaneous leishmaniasis and plasma cytokines IL-4, IL-5,
            and IL-13.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 815)
  AUTHORS   Milburn,M.V., Hassell,A.M., Lambert,M.H., Jordan,S.R.,
            Proudfoot,A.E., Graber,P. and Wells,T.N.
  TITLE     A novel dimer configuration revealed by the crystal structure at
            2.4 A resolution of human interleukin-5
  JOURNAL   Nature 363 (6425), 172-176 (1993)
   PUBMED   8483502
REFERENCE   5  (bases 1 to 815)
  AUTHORS   Tavernier,J., Tuypens,T., Plaetinck,G., Verhee,A., Fiers,W. and
            Devos,R.
  TITLE     Molecular basis of the membrane-anchored and two soluble isoforms
            of the human interleukin 5 receptor alpha subunit
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 7041-7045 (1992)
   PUBMED   1495999
REFERENCE   6  (bases 1 to 815)
  AUTHORS   Tavernier,J., Devos,R., Cornelis,S., Tuypens,T., Van der Heyden,J.,
            Fiers,W. and Plaetinck,G.
  TITLE     A human high affinity interleukin-5 receptor (IL5R) is composed of
            an IL5-specific alpha chain and a beta chain shared with the
            receptor for GM-CSF
  JOURNAL   Cell 66 (6), 1175-1184 (1991)
   PUBMED   1833065
REFERENCE   7  (bases 1 to 815)
  AUTHORS   Lopez,A.F., Eglinton,J.M., Lyons,A.B., Tapley,P.M., To,L.B.,
            Park,L.S., Clark,S.C. and Vadas,M.A.
  TITLE     Human interleukin-3 inhibits the binding of granulocyte-macrophage
            colony-stimulating factor and interleukin-5 to basophils and
            strongly enhances their functional activity
  JOURNAL   J Cell Physiol 145 (1), 69-77 (1990)
   PUBMED   1698795
REFERENCE   8  (bases 1 to 815)
  AUTHORS   Takahashi,M., Yoshida,M.C., Satoh,H., Hilgers,J., Yaoita,Y. and
            Honjo,T.
  TITLE     Chromosomal mapping of the mouse IL-4 and human IL-5 genes
  JOURNAL   Genomics 4 (1), 47-52 (1989)
   PUBMED   2563351
REFERENCE   9  (bases 1 to 815)
  AUTHORS   Tanabe,T., Konishi,M., Mizuta,T., Noma,T. and Honjo,T.
  TITLE     Molecular cloning and structure of the human interleukin-5 gene
  JOURNAL   J Biol Chem 262 (34), 16580-16584 (1987)
   PUBMED   2824500
REFERENCE   10 (bases 1 to 815)
  AUTHORS   Campbell,H.D., Tucker,W.Q., Hort,Y., Martinson,M.E., Mayo,G.,
            Clutterbuck,E.J., Sanderson,C.J. and Young,I.G.
  TITLE     Molecular cloning, nucleotide sequence, and expression of the gene
            encoding human eosinophil differentiation factor (interleukin 5)
  JOURNAL   Proc Natl Acad Sci U S A 84 (19), 6629-6633 (1987)
   PUBMED   3498940
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC116366.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_000879.2.
            
            Summary: This gene encodes a cytokine that acts as a growth and
            differentiation factor for both B cells and eosinophils. The
            encoded cytokine plays a major role in the regulation of eosinophil
            formation, maturation, recruitment and survival. The increased
            production of this cytokine may be related to pathogenesis of
            eosinophil-dependent inflammatory diseases. This cytokine functions
            by binding to its receptor, which is a heterodimer, whose beta
            subunit is shared with the receptors for interleukine 3 (IL3) and
            colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on
            chromosome 5 within a cytokine gene cluster which includes
            interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene,
            IL4, and IL13 may be regulated coordinately by long-range
            regulatory elements spread over 120 kilobases on chromosome 5q31.
            [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X04688.1, X12705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231454.6/ ENSP00000231454.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC116366.2         154892-155079       c
            189-221             AC116366.2         154651-154683       c
            222-350             AC116366.2         153572-153700       c
            351-815             AC116366.2         153002-153466       c
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..815
                     /gene="IL5"
                     /gene_synonym="EDF; IL-5; TRF"
                     /note="interleukin 5"
                     /db_xref="GeneID:3567"
                     /db_xref="HGNC:HGNC:6016"
                     /db_xref="MIM:147850"
     exon            1..188
                     /gene="IL5"
                     /gene_synonym="EDF; IL-5; TRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..449
                     /gene="IL5"
                     /gene_synonym="EDF; IL-5; TRF"
                     /note="eosinophil differentiation factor; T-cell replacing
                     factor; B-cell differentiation factor I;
                     colony-stimulating factor, eosinophil"
                     /codon_start=1
                     /product="interleukin-5 precursor"
                     /protein_id="NP_000870.1"
                     /db_xref="CCDS:CCDS4156.1"
                     /db_xref="GeneID:3567"
                     /db_xref="HGNC:HGNC:6016"
                     /db_xref="MIM:147850"
                     /translation="MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLL
                     IANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQK
                     KKCGEERRRVNQFLDYLQEFLGVMNTEWIIES"
     exon            189..221
                     /gene="IL5"
                     /gene_synonym="EDF; IL-5; TRF"
                     /inference="alignment:Splign:2.1.0"
     exon            222..350
                     /gene="IL5"
                     /gene_synonym="EDF; IL-5; TRF"
                     /inference="alignment:Splign:2.1.0"
     exon            351..815
                     /gene="IL5"
                     /gene_synonym="EDF; IL-5; TRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      791..796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL5"
                     /gene_synonym="EDF; IL-5; TRF"
                     /note="hexamer: AATAAA"
     polyA_site      815
                     /gene="IL5"
                     /gene_synonym="EDF; IL-5; TRF"
                     /note="major polyA site"
ORIGIN      
        1 atgcactttc tttgccaaag gcaaacgcag aacgtttcag agccatgagg atgcttctgc
       61 atttgagttt gctagctctt ggagctgcct acgtgtatgc catccccaca gaaattccca
      121 caagtgcatt ggtgaaagag accttggcac tgctttctac tcatcgaact ctgctgatag
      181 ccaatgagac tctgaggatt cctgttcctg tacataaaaa tcaccaactg tgcactgaag
      241 aaatctttca gggaataggc acactggaga gtcaaactgt gcaagggggt actgtggaaa
      301 gactattcaa aaacttgtcc ttaataaaga aatacattga cggccaaaaa aaaaagtgtg
      361 gagaagaaag acggagagta aaccaattcc tagactacct gcaagagttt cttggtgtaa
      421 tgaacaccga gtggataata gaaagttgag actaaactgg tttgttgcag ccaaagattt
      481 tggaggagaa ggacatttta ctgcagtgag aatgagggcc aagaaagagt caggccttaa
      541 ttttcagtat aatttaactt cagagggaaa gtaaatattt caggcatact gacactttgc
      601 cagaaagcat aaaattctta aaatatattt cagatatcag aatcattgaa gtattttcct
      661 ccaggcaaaa ttgatatact tttttcttat ttaacttaac attctgtaaa atgtctgtta
      721 acttaatagt atttatgaaa tggttaagaa tttggtaaat tagtatttat ttaatgttat
      781 gttgtgttct aataaaacaa aaatagacaa ctgtt
//
