LOCUS       NM_000418               3624 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens interleukin 4 receptor (IL4R), transcript variant 1,
            mRNA.
ACCESSION   NM_000418
VERSION     NM_000418.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3624)
  AUTHORS   Alvarez-Argote,S., Almeida,V.A., Knas,M.C., Buday,S.L.,
            Patterson,M. and O'Meara,C.C.
  TITLE     Global IL4Ralpha blockade exacerbates heart failure after an
            ischemic event in mice and humans
  JOURNAL   Am J Physiol Heart Circ Physiol 326 (5), H1080-H1093 (2024)
   PUBMED   38426866
  REMARK    GeneRIF: Global IL4Ralpha blockade exacerbates heart failure after
            an ischemic event in mice and humans.
REFERENCE   2  (bases 1 to 3624)
  AUTHORS   Williams,D., Hargrove-Wiley,E., Bindeman,W., Valent,D.,
            Miranda,A.X., Beckstead,J. and Fingleton,B.
  TITLE     Type II Interleukin-4 Receptor Activation in Basal Breast Cancer
            Cells Promotes Tumor Progression via Metabolic and Epigenetic
            Modulation
  JOURNAL   Int J Mol Sci 25 (9), 4647 (2024)
   PUBMED   38731867
  REMARK    GeneRIF: Type II Interleukin-4 Receptor Activation in Basal Breast
            Cancer Cells Promotes Tumor Progression via Metabolic and
            Epigenetic Modulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3624)
  AUTHORS   Nelson,M.R., Zhang,X., Podgaetz,E., Wang,X., Zhang,Q., Pan,Z.,
            Spechler,S.J. and Souza,R.F.
  TITLE     Th2 cytokine signaling through IL-4Ralpha increases eotaxin-3
            secretion and tension in human esophageal smooth muscle
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (1), G38-G52 (2024)
   PUBMED   37933466
  REMARK    GeneRIF: Th2 cytokine signaling through IL-4Ralpha increases
            eotaxin-3 secretion and tension in human esophageal smooth muscle.
REFERENCE   4  (bases 1 to 3624)
  AUTHORS   K,J., Joshi,J.L., Kansal,H., Chopra,V., Garg,K., Girdhar,N.,
            Sharma,K., Deshwal,R. and Sharma,S.
  TITLE     Association of IL4RA and IL-8 polymorphism in predicting
            susceptibility to tuberculosis
  JOURNAL   Monaldi Arch Chest Dis 94 (2) (2023)
   PUBMED   37565285
  REMARK    GeneRIF: Association of IL4RA and IL-8 polymorphism in predicting
            susceptibility to tuberculosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3624)
  AUTHORS   Bergin,A.M., Balder,B., Kishore,S., Sward,K., Hahn-Zoric,M.,
            Lowhagen,O., Hanson,L.A. and Padyukov,L.
  TITLE     Common variations in the IL4R gene affect splicing and influence
            natural expression of the soluble isoform
  JOURNAL   Hum Mutat 27 (10), 990-998 (2006)
   PUBMED   16917945
  REMARK    GeneRIF: Results show sequence variations as a possible way of
            altering alternative splicing selection of IL4R in vivo.
REFERENCE   6  (bases 1 to 3624)
  AUTHORS   Puri,R.K. and Aggarwal,B.B.
  TITLE     Human immunodeficiency virus type 1 tat gene up-regulates
            interleukin 4 receptors on a human B-lymphoblastoid cell line
  JOURNAL   Cancer Res 52 (13), 3787-3790 (1992)
   PUBMED   1617647
REFERENCE   7  (bases 1 to 3624)
  AUTHORS   Pritchard,M.A., Baker,E., Whitmore,S.A., Sutherland,G.R.,
            Idzerda,R.L., Park,L.S., Cosman,D., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. et al.
  TITLE     The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in
            human and to the distal region of mouse chromosome 7
  JOURNAL   Genomics 10 (3), 801-806 (1991)
   PUBMED   1679753
REFERENCE   8  (bases 1 to 3624)
  AUTHORS   Donnelly,R.P., Fenton,M.J., Finbloom,D.S. and Gerrard,T.L.
  TITLE     Differential regulation of IL-1 production in human monocytes by
            IFN-gamma and IL-4
  JOURNAL   J Immunol 145 (2), 569-575 (1990)
   PUBMED   2114443
REFERENCE   9  (bases 1 to 3624)
  AUTHORS   Idzerda,R.L., March,C.J., Mosley,B., Lyman,S.D., Vanden Bos,T.,
            Gimpel,S.D., Din,W.S., Grabstein,K.H., Widmer,M.B., Park,L.S. et
            al.
  TITLE     Human interleukin 4 receptor confers biological responsiveness and
            defines a novel receptor superfamily
  JOURNAL   J Exp Med 171 (3), 861-873 (1990)
   PUBMED   2307934
REFERENCE   10 (bases 1 to 3624)
  AUTHORS   Galizzi,J.P., Zuber,C.E., Harada,N., Gorman,D.M., Djossou,O.,
            Kastelein,R., Banchereau,J., Howard,M. and Miyajima,A.
  TITLE     Molecular cloning of a cDNA encoding the human interleukin 4
            receptor
  JOURNAL   Int Immunol 2 (7), 669-675 (1990)
   PUBMED   2278997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA492909.1, X52425.1 and
            BC110343.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000418.3.
            
            Summary: This gene encodes the alpha chain of the interleukin-4
            receptor, a type I transmembrane protein that can bind interleukin
            4 and interleukin 13 to regulate IgE production. The encoded
            protein also can bind interleukin 4 to promote differentiation of
            Th2 cells. A soluble form of the encoded protein can be produced by
            proteolysis of the membrane-bound protein, and this soluble form
            can inhibit IL4-mediated cell proliferation and IL5 upregulation by
            T-cells. Allelic variations in this gene have been associated with
            atopy, a condition that can manifest itself as allergic rhinitis,
            sinusitus, asthma, or eczema. Polymorphisms in this gene are also
            associated with resistance to human immunodeficiency virus type-1
            infection. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52425.1, AK223591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395762.7/ ENSP00000379111.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA492909.1         66-88
            24-3620             X52425.1           1-3597
            3621-3624           BC110343.1         3496-3499
FEATURES             Location/Qualifiers
     source          1..3624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..3624
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /note="interleukin 4 receptor"
                     /db_xref="GeneID:3566"
                     /db_xref="HGNC:HGNC:6015"
                     /db_xref="MIM:147781"
     exon            1..47
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            48..180
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            181..268
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2676
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; interleukin-4 receptor alpha chain;
                     interleukin-4 receptor subunit alpha; IL-4 receptor
                     subunit alpha; interleukin 13 receptor"
                     /codon_start=1
                     /product="interleukin-4 receptor subunit alpha isoform a
                     precursor"
                     /protein_id="NP_000409.1"
                     /db_xref="CCDS:CCDS10629.1"
                     /db_xref="GeneID:3566"
                     /db_xref="HGNC:HGNC:6015"
                     /db_xref="MIM:147781"
                     /translation="MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTC
                     EWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLD
                     LWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYA
                     VNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPS
                     TKWHNSYREPFEQHLLLGVSVSCIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVA
                     IIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQ
                     GSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSR
                     DDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPS
                     AGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSP
                     CPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAA
                     PVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGA
                     SSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEP
                     GEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMA
                     SPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPA
                     PGNAQSSSQTPKIVNFVSVGPTYMRVS"
     exon            269..407
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            408..559
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            560..711
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            712..868
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            869..968
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1047
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1097
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..3624
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3602..3607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /note="hexamer: AATAAA"
     polyA_site      3624
                     /gene="IL4R"
                     /gene_synonym="CD124; IL-4RA; IL4RA"
                     /note="major polyA site"
ORIGIN      
        1 acttcccgct tgggcgcccg gacggcgaat ggagcagggg cgcgcagata attaaagatt
       61 tacacacagc tggaagaaat catagagaag ccgggcgtgg tggctcatgc ctataatccc
      121 agcacttttg gaggctgagg cgggcagatc acttgagatc aggagttcga gaccagcctg
      181 gtgccttggc atctcccaat ggggtggctt tgctctgggc tcctgttccc tgtgagctgc
      241 ctggtcctgc tgcaggtggc aagctctggg aacatgaagg tcttgcagga gcccacctgc
      301 gtctccgact acatgagcat ctctacttgc gagtggaaga tgaatggtcc caccaattgc
      361 agcaccgagc tccgcctgtt gtaccagctg gtttttctgc tctccgaagc ccacacgtgt
      421 atccctgaga acaacggagg cgcggggtgc gtgtgccacc tgctcatgga tgacgtggtc
      481 agtgcggata actatacact ggacctgtgg gctgggcagc agctgctgtg gaagggctcc
      541 ttcaagccca gcgagcatgt gaaacccagg gccccaggaa acctgacagt tcacaccaat
      601 gtctccgaca ctctgctgct gacctggagc aacccgtatc cccctgacaa ttacctgtat
      661 aatcatctca cctatgcagt caacatttgg agtgaaaacg acccggcaga tttcagaatc
      721 tataacgtga cctacctaga accctccctc cgcatcgcag ccagcaccct gaagtctggg
      781 atttcctaca gggcacgggt gagggcctgg gctcagtgct ataacaccac ctggagtgag
      841 tggagcccca gcaccaagtg gcacaactcc tacagggagc ccttcgagca gcacctcctg
      901 ctgggcgtca gcgtttcctg cattgtcatc ctggccgtct gcctgttgtg ctatgtcagc
      961 atcaccaaga ttaagaaaga atggtgggat cagattccca acccagcccg cagccgcctc
     1021 gtggctataa taatccagga tgctcagggg tcacagtggg agaagcggtc ccgaggccag
     1081 gaaccagcca agtgcccaca ctggaagaat tgtcttacca agctcttgcc ctgttttctg
     1141 gagcacaaca tgaaaaggga tgaagatcct cacaaggctg ccaaagagat gcctttccag
     1201 ggctctggaa aatcagcatg gtgcccagtg gagatcagca agacagtcct ctggccagag
     1261 agcatcagcg tggtgcgatg tgtggagttg tttgaggccc cggtggagtg tgaggaggag
     1321 gaggaggtag aggaagaaaa agggagcttc tgtgcatcgc ctgagagcag cagggatgac
     1381 ttccaggagg gaagggaggg cattgtggcc cggctaacag agagcctgtt cctggacctg
     1441 ctcggagagg agaatggggg cttttgccag caggacatgg gggagtcatg ccttcttcca
     1501 ccttcgggaa gtacgagtgc tcacatgccc tgggatgagt tcccaagtgc agggcccaag
     1561 gaggcacctc cctggggcaa ggagcagcct ctccacctgg agccaagtcc tcctgccagc
     1621 ccgacccaga gtccagacaa cctgacttgc acagagacgc ccctcgtcat cgcaggcaac
     1681 cctgcttacc gcagcttcag caactccctg agccagtcac cgtgtcccag agagctgggt
     1741 ccagacccac tgctggccag acacctggag gaagtagaac ccgagatgcc ctgtgtcccc
     1801 cagctctctg agccaaccac tgtgccccaa cctgagccag aaacctggga gcagatcctc
     1861 cgccgaaatg tcctccagca tggggcagct gcagcccccg tctcggcccc caccagtggc
     1921 tatcaggagt ttgtacatgc ggtggagcag ggtggcaccc aggccagtgc ggtggtgggc
     1981 ttgggtcccc caggagaggc tggttacaag gccttctcaa gcctgcttgc cagcagtgct
     2041 gtgtccccag agaaatgtgg gtttggggct agcagtgggg aagaggggta taagcctttc
     2101 caagacctca ttcctggctg ccctggggac cctgccccag tccctgtccc cttgttcacc
     2161 tttggactgg acagggagcc acctcgcagt ccgcagagct cacatctccc aagcagctcc
     2221 ccagagcacc tgggtctgga gccgggggaa aaggtagagg acatgccaaa gcccccactt
     2281 ccccaggagc aggccacaga cccccttgtg gacagcctgg gcagtggcat tgtctactca
     2341 gcccttacct gccacctgtg cggccacctg aaacagtgtc atggccagga ggatggtggc
     2401 cagacccctg tcatggccag tccttgctgt ggctgctgct gtggagacag gtcctcgccc
     2461 cctacaaccc ccctgagggc cccagacccc tctccaggtg gggttccact ggaggccagt
     2521 ctgtgtccgg cctccctggc accctcgggc atctcagaga agagtaaatc ctcatcatcc
     2581 ttccatcctg cccctggcaa tgctcagagc tcaagccaga cccccaaaat cgtgaacttt
     2641 gtctccgtgg gacccacata catgagggtc tcttaggtgc atgtcctctt gttgctgagt
     2701 ctgcagatga ggactagggc ttatccatgc ctgggaaatg ccacctcctg gaaggcagcc
     2761 aggctggcag atttccaaaa gacttgaaga accatggtat gaaggtgatt ggccccactg
     2821 acgttggcct aacactgggc tgcagagact ggaccccgcc cagcattggg ctgggctcgc
     2881 cacatcccat gagagtagag ggcactgggt cgccgtgccc cacggcaggc ccctgcagga
     2941 aaactgaggc ccttgggcac ctcgacttgt gaacgagttg ttggctgctc cctccacagc
     3001 ttctgcagca gactgtccct gttgtaactg cccaaggcat gttttgccca ccagatcatg
     3061 gcccacgtgg aggcccacct gcctctgtct cactgaacta gaagccgagc ctagaaacta
     3121 acacagccat caagggaatg acttgggcgg ccttgggaaa tcgatgagaa attgaacttc
     3181 agggagggtg gtcattgcct agaggtgctc attcatttaa cagagcttcc ttaggttgat
     3241 gctggaggca gaatcccggc tgtcaagggg tgttcagtta aggggagcaa cagaggacat
     3301 gaaaaattgc tatgactaaa gcagggacaa tttgctgcca aacacccatg cccagctgta
     3361 tggctggggg ctcctcgtat gcatggaacc cccagaataa atatgctcag ccaccctgtg
     3421 ggccgggcaa tccagacagc aggcataagg caccagttac cctgcatgtt ggcccagacc
     3481 tcaggtgcta gggaaggcgg gaaccttggg ttgagtaatg ctcgtctgtg tgttttagtt
     3541 tcatcacctg ttatctgtgt ttgctgagga gagtggaaca gaaggggtgg agttttgtat
     3601 aaataaagtt tctttgtctc ttta
//
