LOCUS       NM_152899               1795 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens interleukin 4 induced 1 (IL4I1), transcript variant 1,
            mRNA.
ACCESSION   NM_152899
VERSION     NM_152899.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1795)
  AUTHORS   Ye,F., Wang,L., Li,Y., Dong,C., Zhou,L. and Xu,J.
  TITLE     IL4I1 in M2-like macrophage promotes glioma progression and is a
            promising target for immunotherapy
  JOURNAL   Front Immunol 14, 1338244 (2024)
   PUBMED   38250074
  REMARK    GeneRIF: IL4I1 in M2-like macrophage promotes glioma progression
            and is a promising target for immunotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1795)
  AUTHORS   Run,L., Tian,Z., Xu,L., Du,J., Li,N., Wang,Q. and Sun,H.
  TITLE     Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance
            in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through
            AHR Activation
  JOURNAL   Appl Biochem Biotechnol 195 (11), 6694-6707 (2023)
   PUBMED   36913096
  REMARK    GeneRIF: Knockdown of IL4I1 Improved High Glucose-evoked Insulin
            Resistance in HepG2 Cells by Alleviating Inflammation and
            Lipotoxicity Through AHR Activation.
REFERENCE   3  (bases 1 to 1795)
  AUTHORS   Zeitler,L. and Murray,P.J.
  TITLE     IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus
            in cancer
  JOURNAL   J Biol Chem 299 (6), 104827 (2023)
   PUBMED   37196768
  REMARK    GeneRIF: IL4i1 and IDO1: Oxidases that control a tryptophan
            metabolic nexus in cancer.
            Review article
REFERENCE   4  (bases 1 to 1795)
  AUTHORS   Luo,J.M., Zhang,T.T., He,Y.Y., Luo,H.N., Hong,Y.Q. and Yang,Z.M.
  TITLE     Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1
            (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon
            Receptor
  JOURNAL   Int J Mol Sci 24 (4), 3163 (2023)
   PUBMED   36834576
  REMARK    GeneRIF: Human Chorionic Gonadotropin-Stimulated
            Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via
            Aryl Hydrocarbon Receptor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1795)
  AUTHORS   Gatineau,J., Nidercorne,C., Dupont,A., Puiffe,M.L., Cohen,J.L.,
            Molinier-Frenkel,V., Niedergang,F. and Castellano,F.
  TITLE     IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike
  JOURNAL   Front Immunol 13, 982839 (2022)
   PUBMED   36131918
  REMARK    GeneRIF: IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2
            spike.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1795)
  AUTHORS   Wiemann,S., Kolb-Kokocinski,A. and Poustka,A.
  TITLE     Alternative pre-mRNA processing regulates cell-type specific
            expression of the IL4l1 and NUP62 genes
  JOURNAL   BMC Biol 3, 16 (2005)
   PUBMED   16029492
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1795)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 1795)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1795)
  AUTHORS   Copie-Bergman,C., Boulland,M.L., Dehoulle,C., Moller,P.,
            Farcet,J.P., Dyer,M.J., Haioun,C., Romeo,P.H., Gaulard,P. and
            Leroy,K.
  TITLE     Interleukin 4-induced gene 1 is activated in primary mediastinal
            large B-cell lymphoma
  JOURNAL   Blood 101 (7), 2756-2761 (2003)
   PUBMED   12446450
  REMARK    GeneRIF: is activated in primary mediastinal large B-cell lymphoma,
            which might be due to a constitutive activation of a cytokine
            signaling pathway
REFERENCE   10 (bases 1 to 1795)
  AUTHORS   Chavan,S.S., Tian,W., Hsueh,K., Jawaheer,D., Gregersen,P.K. and
            Chu,C.C.
  TITLE     Characterization of the human homolog of the IL-4 induced gene-1
            (Fig1)
  JOURNAL   Biochim Biophys Acta 1576 (1-2), 70-80 (2002)
   PUBMED   12031486
  REMARK    GeneRIF: genomic structure, cDNA sequence, chromosome location and
            RNA expression in immune tissues
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF293462.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152899.1.
            
            Summary: This gene encodes a secreted L-amino acid oxidase protein
            which primarily catabolizes L-phenylalanine and, to a lesser
            extent, L-arginine. The expression of this gene is induced by the
            cytokine interleukin 4 in B cells. This gene is also expressed in
            macrophages and dendritic cells. This protein may play a role
            immune system escape as it is expressed in tumor-associated
            macrophages and suppresses T-cell responses. This protein also
            contains domains thought to be involved in the binding of flavin
            adenine dinucleotide (FAD) cofactor. Multiple transcript variants
            encoding different isoforms have been found for this gene. Some
            transcripts of this gene share a promoter and exons of the 5' UTR
            with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            coding region, compared to variant 2, and is expressed from a
            different promoter. The resulting isoform (1) contains a distinct
            and shorter N-terminus, as compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF293462.1, AY358933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391826.7/ ENSP00000375702.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1795              AF293462.1         4-1798
FEATURES             Location/Qualifiers
     source          1..1795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1795
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /note="interleukin 4 induced 1"
                     /db_xref="GeneID:259307"
                     /db_xref="HGNC:HGNC:19094"
                     /db_xref="MIM:609742"
     exon            1..53
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /inference="alignment:Splign:2.1.0"
     exon            54..88
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1779
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /EC_number="1.4.3.2"
                     /EC_number="1.4.3.25"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin four induced 1; Fig-1 protein;
                     L-amino-acid oxidase; IL4-induced protein 1"
                     /codon_start=1
                     /product="L-amino-acid oxidase isoform 1 precursor"
                     /protein_id="NP_690863.1"
                     /db_xref="CCDS:CCDS12787.1"
                     /db_xref="GeneID:259307"
                     /db_xref="HGNC:HGNC:19094"
                     /db_xref="MIM:609742"
                     /translation="MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQDPDYEQ
                     LLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTYR
                     DQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVE
                     KVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGE
                     GNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSS
                     LSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSP
                     PLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGA
                     LLLASYTWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHS
                     QGGFVVQPPALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRK
                     GPASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTS
                     H"
     exon            89..327
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /inference="alignment:Splign:2.1.0"
     exon            328..440
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /inference="alignment:Splign:2.1.0"
     exon            441..642
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /inference="alignment:Splign:2.1.0"
     exon            643..711
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /inference="alignment:Splign:2.1.0"
     exon            712..848
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1795
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1775..1780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /note="hexamer: ATTAAA"
     polyA_site      1795
                     /gene="IL4I1"
                     /gene_synonym="FIG1; hIL4I1; LAAO; LAO"
                     /note="major polyA site"
ORIGIN      
        1 agtggagggc agtggagagg accgcgctgt cctgctgtca ccaagagctg gagacaccat
       61 ctcccaccga gagtcatggc cccattggcc ctgcacctcc tcgtcctcgt ccccatcctc
      121 ctcagcctgg tggcctccca ggactggaag gctgaacgca gccaagaccc cttcgagaaa
      181 tgcatgcagg atcctgacta tgagcagctg ctcaaggtgg tgacctgggg gctcaatcgg
      241 accctgaagc cccagagggt gattgtggtt ggcgctggtg tggccgggct ggtggccgcc
      301 aaggtgctca gcgatgctgg acacaaggtc accatcctgg aggcagataa caggatcggg
      361 ggccgcatct tcacctaccg ggaccagaac acgggctgga ttggggagct gggagccatg
      421 cgcatgccca gctctcacag gatcctccac aagctctgcc agggcctggg gctcaacctg
      481 accaagttca cccagtacga caagaacacg tggacggagg tgcacgaagt gaagctgcgc
      541 aactatgtgg tggagaaggt gcccgagaag ctgggctacg ccttgcgtcc ccaggaaaag
      601 ggccactcgc ccgaagacat ctaccagatg gctctcaacc aggccctcaa agacctcaag
      661 gcactgggct gcagaaaggc gatgaagaag tttgaaaggc acacgctctt ggaatatctt
      721 ctcggggagg ggaacctgag ccggccggcc gtgcagcttc tgggagacgt gatgtccgag
      781 gatggcttct tctatctcag cttcgccgag gccctccggg cccacagctg cctcagcgac
      841 agactccagt acagccgcat cgtgggtggc tgggacctgc tgccgcgcgc gctgctgagc
      901 tcgctgtccg ggcttgtgct gttgaacgcg cccgtggtgg cgatgaccca gggaccgcac
      961 gatgtgcacg tgcagatcga gacctctccc ccggcgcgga atctgaaggt gctgaaggcc
     1021 gacgtggtgc tgctgacggc gagcggaccg gcggtgaagc gcatcacctt ctcgccgccg
     1081 ctgccccgcc acatgcagga ggcgctgcgg aggctgcact acgtgccggc caccaaggtg
     1141 ttcctaagct tccgcaggcc cttctggcgc gaggagcaca ttgaaggcgg ccactcaaac
     1201 accgatcgcc cgtcgcgcat gattttctac ccgccgccgc gcgagggcgc gctgctgctg
     1261 gcctcgtaca cgtggtcgga cgcggcggca gcgttcgccg gcttgagccg ggaagaggcg
     1321 ttgcgcttgg cgctcgacga cgtggcggca ttgcacgggc ctgtcgtgcg ccagctctgg
     1381 gacggcaccg gcgtcgtcaa gcgttgggcg gaggaccagc acagccaggg tggctttgtg
     1441 gtacagccgc cggcgctctg gcaaaccgaa aaggatgact ggacggtccc ttatggccgc
     1501 atctactttg ccggcgagca caccgcctac ccgcacggct gggtggagac ggcggtcaag
     1561 tcggcgctgc gcgccgccat caagatcaac agccggaagg ggcctgcatc ggacacggcc
     1621 agccccgagg ggcacgcatc tgacatggag gggcaggggc atgtgcatgg ggtggccagc
     1681 agcccctcgc atgacctggc aaaggaagaa ggcagccacc ctccagtcca aggccagtta
     1741 tctctccaaa acacgaccca cacgaggacc tcgcattaaa gtattttcgg aaaaa
//
