LOCUS       NM_000589                615 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 4 (IL4), transcript variant 1, mRNA.
ACCESSION   NM_000589
VERSION     NM_000589.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 615)
  AUTHORS   de Juan,A., Tabtim-On,D., Coillard,A., Becher,B., Goudot,C. and
            Segura,E.
  TITLE     The aryl hydrocarbon receptor shapes monocyte transcriptional
            responses to interleukin-4 by prolonging STAT6 binding to promoters
  JOURNAL   Sci Signal 17 (858), eadn6324 (2024)
   PUBMED   39405377
  REMARK    GeneRIF: The aryl hydrocarbon receptor shapes monocyte
            transcriptional responses to interleukin-4 by prolonging STAT6
            binding to promoters.
REFERENCE   2  (bases 1 to 615)
  AUTHORS   Aydin,S., Darko,K., Detchou,D. and Barrie,U.
  TITLE     A call for clinical trials in glioblastoma multiforme for
            interleukin 4, interleukin 6, interleukin 13 and CD40
  JOURNAL   Neurosurg Rev 47 (1), 571 (2024)
   PUBMED   39242402
  REMARK    GeneRIF: A call for clinical trials in glioblastoma multiforme for
            interleukin 4, interleukin 6, interleukin 13 and CD40.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 615)
  AUTHORS   Che,M., Xu,Y., Zang,Y., Zhang,R., Hu,J., Liu,S. and Zhang,J.
  TITLE     Association of NLRP3 and IL-4 VNTR polymorphisms and genetic
            susceptibility to preeclampsia: A case-control study
  JOURNAL   Pregnancy Hypertens 37, 101142 (2024)
   PUBMED   38959653
  REMARK    GeneRIF: Association of NLRP3 and IL-4 VNTR polymorphisms and
            genetic susceptibility to preeclampsia: A case-control study.
REFERENCE   4  (bases 1 to 615)
  AUTHORS   Keshavarz,F., Mokhtari,M.J. and Poursadeghfard,M.
  TITLE     Increased level of GATA3-AS1 long non-coding RNA is correlated with
            the upregulation of GATA3 and IL-4 genes in multiple sclerosis
            patients
  JOURNAL   Mol Biol Rep 51 (1), 874 (2024)
   PUBMED   39080124
  REMARK    GeneRIF: Increased level of GATA3-AS1 long non-coding RNA is
            correlated with the upregulation of GATA3 and IL-4 genes in
            multiple sclerosis patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 615)
  AUTHORS   Zeng,X., Li,J., Liu,J., Mo,L., Liu,Y., Zhang,A., Yang,P. and
            Kong,H.
  TITLE     Nasal mucosal fibroblasts produce IL-4 to induce Th2 response
  JOURNAL   Innate Immun 30 (2-4), 55-65 (2024)
   PUBMED   38725177
  REMARK    GeneRIF: Nasal mucosal fibroblasts produce IL-4 to induce Th2
            response.
REFERENCE   6  (bases 1 to 615)
  AUTHORS   Walter,M.R., Cook,W.J., Zhao,B.G., Cameron,R.P. Jr., Ealick,S.E.,
            Walter,R.L. Jr., Reichert,P., Nagabhushan,T.L., Trotta,P.P. and
            Bugg,C.E.
  TITLE     Crystal structure of recombinant human interleukin-4
  JOURNAL   J Biol Chem 267 (28), 20371-20376 (1992)
   PUBMED   1400355
REFERENCE   7  (bases 1 to 615)
  AUTHORS   Wlodawer,A., Pavlovsky,A. and Gustchina,A.
  TITLE     Crystal structure of human recombinant interleukin-4 at 2.25 A
            resolution
  JOURNAL   FEBS Lett 309 (1), 59-64 (1992)
   PUBMED   1511746
  REMARK    Erratum:[FEBS Lett. 2006 May 29;580(13):3340. Wlodaver, A
            [corrected to Wlodawer, A]]
REFERENCE   8  (bases 1 to 615)
  AUTHORS   Garrett,D.S., Powers,R., March,C.J., Frieden,E.A., Clore,G.M. and
            Gronenborn,A.M.
  TITLE     Determination of the secondary structure and folding topology of
            human interleukin-4 using three-dimensional heteronuclear magnetic
            resonance spectroscopy
  JOURNAL   Biochemistry 31 (17), 4347-4353 (1992)
   PUBMED   1567881
REFERENCE   9  (bases 1 to 615)
  AUTHORS   Powers,R., Garrett,D.S., March,C.J., Frieden,E.A., Gronenborn,A.M.
            and Clore,G.M.
  TITLE     1H, 15N, 13C, and 13CO assignments of human interleukin-4 using
            three-dimensional double- and triple-resonance heteronuclear
            magnetic resonance spectroscopy
  JOURNAL   Biochemistry 31 (17), 4334-4346 (1992)
   PUBMED   1567880
REFERENCE   10 (bases 1 to 615)
  AUTHORS   Milne,L.J. and Crompton,G.K.
  TITLE     Oropharyngeal thrush and beclomethasone dipropionate
  JOURNAL   Postgrad Med J 51 Suppl 4, 53 (1975)
   PUBMED   1197194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC067514.1, M13982.1 and
            CD640452.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000589.3.
            
            Summary: The protein encoded by this gene is a pleiotropic cytokine
            produced by activated T cells. This cytokine is a ligand for
            interleukin 4 receptor. The interleukin 4 receptor also binds to
            IL13, which may contribute to many overlapping functions of this
            cytokine and IL13. STAT6, a signal transducer and activator of
            transcription, has been shown to play a central role in mediating
            the immune regulatory signal of this cytokine. This gene, IL3, IL5,
            IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with
            this gene particularly close to IL13. This gene, IL13 and IL5 are
            found to be regulated coordinately by several long-range regulatory
            elements in an over 120 kilobase range on the chromosome. IL4 is
            considered an important cytokine for tissue repair,
            counterbalancing the effects of proinflammatory type 1 cytokines,
            however, it also promotes allergic airway inflammation. Moreover,
            IL-4, a type 2 cytokine, mediates and regulates a variety of human
            host responses such as allergic, anti-parasitic, wound healing, and
            acute inflammation. This cytokine has been reported to promote
            resolution of neutrophil-mediated acute lung injury. In an allergic
            response, IL-4 has an essential role in the production of
            allergen-specific immunoglobin (Ig) E. This pro-inflammatory
            cytokine has been observed to be increased in COVID-19 (Coronavirus
            disease 2019) patients, but is not necessarily associated with
            severe COVID-19 pathology. Two alternatively spliced transcript
            variants of this gene encoding distinct isoforms have been
            reported. [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070123.1, M13982.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for disease process
            MANE Ensembl match     :: ENST00000231449.7/ ENSP00000231449.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               BC067514.1         4-528
            526-613             M13982.1           527-614
            614-615             CD640452.1         617-618
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..615
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /note="interleukin 4"
                     /db_xref="GeneID:3565"
                     /db_xref="HGNC:HGNC:6014"
                     /db_xref="MIM:147780"
     exon            1..197
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..524
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B cell growth factor 1; B_cell stimulatory
                     factor 1; lymphocyte stimulatory factor 1; binetrakin;
                     pitrakinra"
                     /codon_start=1
                     /product="interleukin-4 isoform 1 precursor"
                     /protein_id="NP_000580.1"
                     /db_xref="CCDS:CCDS4158.1"
                     /db_xref="GeneID:3565"
                     /db_xref="HGNC:HGNC:6014"
                     /db_xref="MIM:147780"
                     /translation="MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQ
                     KTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQ
                     LIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS"
     exon            198..245
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            246..422
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            423..615
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      593..598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /note="hexamer: AATAAA"
     polyA_site      615
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /note="major polyA site"
ORIGIN      
        1 atcgttagct tctcctgata aactaattgc ctcacattgt cactgcaaat cgacacctat
       61 taatgggtct cacctcccaa ctgcttcccc ctctgttctt cctgctagca tgtgccggca
      121 actttgtcca cggacacaag tgcgatatca ccttacagga gatcatcaaa actttgaaca
      181 gcctcacaga gcagaagact ctgtgcaccg agttgaccgt aacagacatc tttgctgcct
      241 ccaagaacac aactgagaag gaaaccttct gcagggctgc gactgtgctc cggcagttct
      301 acagccacca tgagaaggac actcgctgcc tgggtgcgac tgcacagcag ttccacaggc
      361 acaagcagct gatccgattc ctgaaacggc tcgacaggaa cctctggggc ctggcgggct
      421 tgaattcctg tcctgtgaag gaagccaacc agagtacgtt ggaaaacttc ttggaaaggc
      481 taaagacgat catgagagag aaatattcaa agtgttcgag ctgaatattt taatttatga
      541 gtttttgata gctttatttt ttaagtattt atatatttat aactcatcat aaaataaagt
      601 atatatagaa tctaa
//
