LOCUS       NP_000580                153 aa            linear   PRI 12-NOV-2024
DEFINITION  interleukin-4 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_000580
VERSION     NP_000580.1
DBSOURCE    REFSEQ: accession NM_000589.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 153)
  AUTHORS   de Juan,A., Tabtim-On,D., Coillard,A., Becher,B., Goudot,C. and
            Segura,E.
  TITLE     The aryl hydrocarbon receptor shapes monocyte transcriptional
            responses to interleukin-4 by prolonging STAT6 binding to promoters
  JOURNAL   Sci Signal 17 (858), eadn6324 (2024)
   PUBMED   39405377
  REMARK    GeneRIF: The aryl hydrocarbon receptor shapes monocyte
            transcriptional responses to interleukin-4 by prolonging STAT6
            binding to promoters.
REFERENCE   2  (residues 1 to 153)
  AUTHORS   Aydin,S., Darko,K., Detchou,D. and Barrie,U.
  TITLE     A call for clinical trials in glioblastoma multiforme for
            interleukin 4, interleukin 6, interleukin 13 and CD40
  JOURNAL   Neurosurg Rev 47 (1), 571 (2024)
   PUBMED   39242402
  REMARK    GeneRIF: A call for clinical trials in glioblastoma multiforme for
            interleukin 4, interleukin 6, interleukin 13 and CD40.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 153)
  AUTHORS   Che,M., Xu,Y., Zang,Y., Zhang,R., Hu,J., Liu,S. and Zhang,J.
  TITLE     Association of NLRP3 and IL-4 VNTR polymorphisms and genetic
            susceptibility to preeclampsia: A case-control study
  JOURNAL   Pregnancy Hypertens 37, 101142 (2024)
   PUBMED   38959653
  REMARK    GeneRIF: Association of NLRP3 and IL-4 VNTR polymorphisms and
            genetic susceptibility to preeclampsia: A case-control study.
REFERENCE   4  (residues 1 to 153)
  AUTHORS   Keshavarz,F., Mokhtari,M.J. and Poursadeghfard,M.
  TITLE     Increased level of GATA3-AS1 long non-coding RNA is correlated with
            the upregulation of GATA3 and IL-4 genes in multiple sclerosis
            patients
  JOURNAL   Mol Biol Rep 51 (1), 874 (2024)
   PUBMED   39080124
  REMARK    GeneRIF: Increased level of GATA3-AS1 long non-coding RNA is
            correlated with the upregulation of GATA3 and IL-4 genes in
            multiple sclerosis patients.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 153)
  AUTHORS   Zeng,X., Li,J., Liu,J., Mo,L., Liu,Y., Zhang,A., Yang,P. and
            Kong,H.
  TITLE     Nasal mucosal fibroblasts produce IL-4 to induce Th2 response
  JOURNAL   Innate Immun 30 (2-4), 55-65 (2024)
   PUBMED   38725177
  REMARK    GeneRIF: Nasal mucosal fibroblasts produce IL-4 to induce Th2
            response.
REFERENCE   6  (residues 1 to 153)
  AUTHORS   Walter,M.R., Cook,W.J., Zhao,B.G., Cameron,R.P. Jr., Ealick,S.E.,
            Walter,R.L. Jr., Reichert,P., Nagabhushan,T.L., Trotta,P.P. and
            Bugg,C.E.
  TITLE     Crystal structure of recombinant human interleukin-4
  JOURNAL   J Biol Chem 267 (28), 20371-20376 (1992)
   PUBMED   1400355
REFERENCE   7  (residues 1 to 153)
  AUTHORS   Wlodawer,A., Pavlovsky,A. and Gustchina,A.
  TITLE     Crystal structure of human recombinant interleukin-4 at 2.25 A
            resolution
  JOURNAL   FEBS Lett 309 (1), 59-64 (1992)
   PUBMED   1511746
  REMARK    Erratum:[FEBS Lett. 2006 May 29;580(13):3340. Wlodaver, A
            [corrected to Wlodawer, A]]
REFERENCE   8  (residues 1 to 153)
  AUTHORS   Garrett,D.S., Powers,R., March,C.J., Frieden,E.A., Clore,G.M. and
            Gronenborn,A.M.
  TITLE     Determination of the secondary structure and folding topology of
            human interleukin-4 using three-dimensional heteronuclear magnetic
            resonance spectroscopy
  JOURNAL   Biochemistry 31 (17), 4347-4353 (1992)
   PUBMED   1567881
REFERENCE   9  (residues 1 to 153)
  AUTHORS   Powers,R., Garrett,D.S., March,C.J., Frieden,E.A., Gronenborn,A.M.
            and Clore,G.M.
  TITLE     1H, 15N, 13C, and 13CO assignments of human interleukin-4 using
            three-dimensional double- and triple-resonance heteronuclear
            magnetic resonance spectroscopy
  JOURNAL   Biochemistry 31 (17), 4334-4346 (1992)
   PUBMED   1567880
REFERENCE   10 (residues 1 to 153)
  AUTHORS   Milne,L.J. and Crompton,G.K.
  TITLE     Oropharyngeal thrush and beclomethasone dipropionate
  JOURNAL   Postgrad Med J 51 Suppl 4, 53 (1975)
   PUBMED   1197194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC067514.1, M13982.1 and
            CD640452.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a pleiotropic cytokine
            produced by activated T cells. This cytokine is a ligand for
            interleukin 4 receptor. The interleukin 4 receptor also binds to
            IL13, which may contribute to many overlapping functions of this
            cytokine and IL13. STAT6, a signal transducer and activator of
            transcription, has been shown to play a central role in mediating
            the immune regulatory signal of this cytokine. This gene, IL3, IL5,
            IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with
            this gene particularly close to IL13. This gene, IL13 and IL5 are
            found to be regulated coordinately by several long-range regulatory
            elements in an over 120 kilobase range on the chromosome. IL4 is
            considered an important cytokine for tissue repair,
            counterbalancing the effects of proinflammatory type 1 cytokines,
            however, it also promotes allergic airway inflammation. Moreover,
            IL-4, a type 2 cytokine, mediates and regulates a variety of human
            host responses such as allergic, anti-parasitic, wound healing, and
            acute inflammation. This cytokine has been reported to promote
            resolution of neutrophil-mediated acute lung injury. In an allergic
            response, IL-4 has an essential role in the production of
            allergen-specific immunoglobin (Ig) E. This pro-inflammatory
            cytokine has been observed to be increased in COVID-19 (Coronavirus
            disease 2019) patients, but is not necessarily associated with
            severe COVID-19 pathology. Two alternatively spliced transcript
            variants of this gene encoding distinct isoforms have been
            reported. [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070123.1, M13982.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for disease process
            MANE Ensembl match     :: ENST00000231449.7/ ENSP00000231449.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..153
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     Protein         1..153
                     /product="interleukin-4 isoform 1 precursor"
                     /note="B cell growth factor 1; B_cell stimulatory factor
                     1; lymphocyte stimulatory factor 1; binetrakin;
                     pitrakinra"
                     /calculated_mol_wt=14963
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2547
     mat_peptide     25..153
                     /product="Interleukin-4. /id=PRO_0000015532"
                     /note="propagated from UniProtKB/Swiss-Prot (P05112.1)"
                     /calculated_mol_wt=14963
     Region          26..149
                     /region_name="IL4"
                     /note="Interleukin 4; pfam00727"
                     /db_xref="CDD:459916"
     Site            62
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:1993171; propagated from
                     UniProtKB/Swiss-Prot (P05112.1)"
     CDS             1..153
                     /gene="IL4"
                     /gene_synonym="BCGF-1; BCGF1; BSF-1; BSF1; IL-4"
                     /coded_by="NM_000589.4:63..524"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS4158.1"
                     /db_xref="GeneID:3565"
                     /db_xref="HGNC:HGNC:6014"
                     /db_xref="MIM:147780"
ORIGIN      
        1 mgltsqllpp lffllacagn fvhghkcdit lqeiiktlns lteqktlcte ltvtdifaas
       61 kntteketfc raatvlrqfy shhekdtrcl gataqqfhrh kqlirflkrl drnlwglagl
      121 nscpvkeanq stlenflerl ktimrekysk css
//
