LOCUS       NM_002183               1541 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 3 receptor subunit alpha (IL3RA),
            transcript variant 1, mRNA.
ACCESSION   NM_002183
VERSION     NM_002183.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1541)
  AUTHORS   Liu,K.M., Yang,C.F., H'ng,W.S., Chuang,H.P., Khor,E.H.X.,
            Tsai,P.C., Khosasih,V., Lu,L.S., Yeh,E.C., Lin,W.J., Hsieh,F.J.,
            Chen,C.H., Hwang,S.L. and Wu,J.Y.
  TITLE     Role of IL3RA in a Family with Lumbar Spinal Stenosis
  JOURNAL   Int J Mol Sci 25 (20), 10915 (2024)
   PUBMED   39456698
  REMARK    GeneRIF: Role of IL3RA in a Family with Lumbar Spinal Stenosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1541)
  AUTHORS   Marques,E.R.M.D.C., Hsieh,R., Lourenco,S.V. and Nico,M.M.S.
  TITLE     Oral lupus erythematosus: Immunohistochemical evaluation of CD1a,
            CD21, CD123, and langerin expression in dendritic cells
  JOURNAL   J Cutan Pathol 51 (5), 368-378 (2024)
   PUBMED   38287771
  REMARK    GeneRIF: Oral lupus erythematosus: Immunohistochemical evaluation
            of CD1a, CD21, CD123, and langerin expression in dendritic cells.
REFERENCE   3  (bases 1 to 1541)
  AUTHORS   Wang,X.Y., Bian,M.R., Lin,G.Q., Yu,L., Zhang,Y.M. and Wu,D.P.
  TITLE     Tandem bispecific CD123/CLL-1 CAR-T cells exhibit specific
            cytolytic effector functions against human acute myeloid leukaemia
  JOURNAL   Eur J Haematol 112 (1), 83-93 (2024)
   PUBMED   37712633
  REMARK    GeneRIF: Tandem bispecific CD123/CLL-1 CAR-T cells exhibit specific
            cytolytic effector functions against human acute myeloid leukaemia.
REFERENCE   4  (bases 1 to 1541)
  AUTHORS   Aisagbonhi,O., Bui,T., Nasamran,C.A., St Louis,H., Pizzo,D.,
            Meads,M., Mulholland,M., Magallanes,C., Lamale-Smith,L.,
            Laurent,L.C., Morey,R., Jacobs,M.B., Fisch,K.M. and Horii,M.
  TITLE     High placental expression of FLT1, LEP, PHYHIP and IL3RA - In
            persons of African ancestry with severe preeclampsia
  JOURNAL   Placenta 144, 13-22 (2023)
   PUBMED   37949031
  REMARK    GeneRIF: High placental expression of FLT1, LEP, PHYHIP and IL3RA -
            In persons of African ancestry with severe preeclampsia.
REFERENCE   5  (bases 1 to 1541)
  AUTHORS   Pelosi,E., Castelli,G. and Testa,U.
  TITLE     CD123 a Therapeutic Target for Acute Myeloid Leukemia and Blastic
            Plasmocytoid Dendritic Neoplasm
  JOURNAL   Int J Mol Sci 24 (3), 2718 (2023)
   PUBMED   36769040
  REMARK    GeneRIF: CD123 a Therapeutic Target for Acute Myeloid Leukemia and
            Blastic Plasmocytoid Dendritic Neoplasm.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1541)
  AUTHORS   Machide,M., Mano,H. and Todokoro,K.
  TITLE     Interleukin 3 and erythropoietin induce association of Vav with Tec
            kinase through Tec homology domain
  JOURNAL   Oncogene 11 (4), 619-625 (1995)
   PUBMED   7651724
REFERENCE   7  (bases 1 to 1541)
  AUTHORS   Yoshimura,A., Ohkubo,T., Kiguchi,T., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Hara,T. and Miyajima,A.
  TITLE     A novel cytokine-inducible gene CIS encodes an SH2-containing
            protein that binds to tyrosine-phosphorylated interleukin 3 and
            erythropoietin receptors
  JOURNAL   EMBO J 14 (12), 2816-2826 (1995)
   PUBMED   7796808
REFERENCE   8  (bases 1 to 1541)
  AUTHORS   Kosugi,H., Nakagawa,Y., Hotta,T., Saito,H., Miyajima,A., Arai,K.
            and Yokota,T.
  TITLE     Structure of the gene encoding the alpha subunit of the human
            interleukin 3 receptor
  JOURNAL   Biochem Biophys Res Commun 208 (1), 360-367 (1995)
   PUBMED   7887951
REFERENCE   9  (bases 1 to 1541)
  AUTHORS   Woodcock,J.M., Zacharakis,B., Plaetinck,G., Bagley,C.J., Qiyu,S.,
            Hercus,T.R., Tavernier,J. and Lopez,A.F.
  TITLE     Three residues in the common beta chain of the human GM-CSF, IL-3
            and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3
            high affinity binding and interact with Glu21 of GM-CSF
  JOURNAL   EMBO J 13 (21), 5176-5185 (1994)
   PUBMED   7957082
REFERENCE   10 (bases 1 to 1541)
  AUTHORS   Kitamura,T., Sato,N., Arai,K. and Miyajima,A.
  TITLE     Expression cloning of the human IL-3 receptor cDNA reveals a shared
            beta subunit for the human IL-3 and GM-CSF receptors
  JOURNAL   Cell 66 (6), 1165-1174 (1991)
   PUBMED   1833064
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035407.1, AK290568.1 and
            AI765858.1.
            
            On May 17, 2019 this sequence version replaced NM_002183.3.
            
            Summary: The protein encoded by this gene is an interleukin 3
            specific subunit of a heterodimeric cytokine receptor. The receptor
            is comprised of a ligand specific alpha subunit and a signal
            transducing beta subunit shared by the receptors for interleukin 3
            (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5
            (IL5). The binding of this protein to IL3 depends on the beta
            subunit. The beta subunit is activated by the ligand binding, and
            is required for the biological activities of IL3. This gene and the
            gene encoding the colony stimulating factor 2 receptor alpha chain
            (CSF2RA) form a cytokine receptor gene cluster in a X-Y
            pseudoautosomal region on chromosomes X or Y. Alternatively spliced
            transcript variants encoding distinct isoforms have been found.
            [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.12228.1,
                                           SRR5189652.32559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331035.10/ ENSP00000327890.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               BC035407.1         170-291
            123-1405            AK290568.1         122-1404
            1406-1537           BC035407.1         1575-1706
            1538-1541           AI765858.1         4-7                 c
FEATURES             Location/Qualifiers
     source          1..1541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..1541
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /note="interleukin 3 receptor subunit alpha"
                     /db_xref="GeneID:3563"
                     /db_xref="HGNC:HGNC:6012"
                     /db_xref="MIM:308385"
                     /db_xref="MIM:430000"
     exon            1..142
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            143..244
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1317
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD123 antigen; IL-3R subunit alpha; IL-3
                     receptor subunit alpha; interleukin 3 receptor, alpha (low
                     affinity)"
                     /codon_start=1
                     /product="interleukin-3 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_002174.1"
                     /db_xref="CCDS:CCDS14113.1"
                     /db_xref="GeneID:3563"
                     /db_xref="HGNC:HGNC:6012"
                     /db_xref="MIM:308385"
                     /db_xref="MIM:430000"
                     /translation="MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLN
                     RNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGK
                     PWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQG
                     TRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCN
                     KTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARE
                     RVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRL
                     FPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT"
     exon            245..363
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            364..478
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            479..611
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            612..796
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            797..912
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            913..939
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1054
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1160
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1242
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1541
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1513..1518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /note="hexamer: GATAAA"
     polyA_site      1541
                     /gene="IL3RA"
                     /gene_synonym="CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RAY;
                     IL3RX; IL3RY"
                     /note="major polyA site"
ORIGIN      
        1 cttcggtttc tcttcgggga aagctgcttt cagcgcacac gggaagatat cagaaacatc
       61 ctaggatcag gacaccccag atcttctcaa ctggaaccac gaaggctgtt tcttccacac
      121 agtactttga tctccattta agcaggcacc tctgtcctgc gttccggagc tgcgttcccg
      181 atggtcctcc tttggctcac gctgctcctg atcgccctgc cctgtctcct gcaaacgaag
      241 gaagatccaa acccaccaat cacgaaccta aggatgaaag caaaggctca gcagttgacc
      301 tgggacctta acagaaatgt gaccgatatc gagtgtgtta aagacgccga ctattctatg
      361 ccggcagtga acaatagcta ttgccagttt ggagcaattt ccttatgtga agtgaccaac
      421 tacaccgtcc gagtggccaa cccaccattc tccacgtgga tcctcttccc tgagaacagt
      481 gggaagcctt gggcaggtgc ggagaatctg acctgctgga ttcatgacgt ggatttcttg
      541 agctgcagct gggcggtagg cccgggggcc cccgcggacg tccagtacga cctgtacttg
      601 aacgttgcca acaggcgtca acagtacgag tgtcttcact acaaaacgga tgctcaggga
      661 acacgtatcg ggtgtcgttt cgatgacatc tctcgactct ccagcggttc tcaaagttcc
      721 cacatcctgg tgcggggcag gagcgcagcc ttcggtatcc cctgcacaga taagtttgtc
      781 gtcttttcac agattgagat attaactcca cccaacatga ctgcaaagtg taataagaca
      841 cattccttta tgcactggaa aatgagaagt catttcaatc gcaaatttcg ctatgagctt
      901 cagatacaaa agagaatgca gcctgtaatc acagaacagg tcagagacag aacctccttc
      961 cagctactca atcctggaac gtacacagta caaataagag cccgggaaag agtgtatgaa
     1021 ttcttgagcg cctggagcac cccccagcgc ttcgagtgcg accaggagga gggcgcaaac
     1081 acacgtgcct ggcggacgtc gctgctgatc gcgctgggga cgctgctggc cctggtctgt
     1141 gtcttcgtga tctgcagaag gtatctggtg atgcagagac tctttccccg catccctcac
     1201 atgaaagacc ccatcggtga cagcttccaa aacgacaagc tggtggtctg ggaggcgggc
     1261 aaagccggcc tggaggagtg tctggtgact gaagtacagg tcgtgcagaa aacttgagac
     1321 tggggttcag ggcttgtggg ggtctgcctc aatctccctg gccgggccag gcgcctgcac
     1381 agactggctg ctggacctgc gcacgcagcc caggaatgga cattcctaac gggtggtggg
     1441 catgggagat gcctgtgtaa tttcgtccga agctgccagg aagaagaaca gaactttgtg
     1501 tgtttatttc atgataaagt gatttttttt tttttaaccc a
//
