LOCUS       NM_014439                864 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens interleukin 37 (IL37), transcript variant 1, mRNA.
ACCESSION   NM_014439 XM_011510963
VERSION     NM_014439.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 864)
  AUTHORS   Lin,C.I., Wang,Y.W., Su,K.Y. and Chuang,Y.H.
  TITLE     Interleukin-37 exacerbates liver inflammation and promotes
            IFN-gamma production in NK cells
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113086 (2024)
   PUBMED   39260304
  REMARK    GeneRIF: Interleukin-37 exacerbates liver inflammation and promotes
            IFN-gamma production in NK cells.
REFERENCE   2  (bases 1 to 864)
  AUTHORS   Cruz-Gregorio,A., Amezcua-Guerra,L.M., Fisher-Bautista,B.,
            Romero-Beltran,A. and Fonseca-Camarillo,G.
  TITLE     The Protective Role of Interleukin-37 in Cardiovascular Diseases
            through Ferroptosis Modulation
  JOURNAL   Int J Mol Sci 25 (18), 9758 (2024)
   PUBMED   39337246
  REMARK    GeneRIF: The Protective Role of Interleukin-37 in Cardiovascular
            Diseases through Ferroptosis Modulation.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 864)
  AUTHORS   Wang,Q., Zhang,G., An,C., Hambly,B.D. and Bao,S.
  TITLE     The role of IL-37 in gastrointestinal diseases
  JOURNAL   Front Immunol 15, 1431495 (2024)
   PUBMED   39206201
  REMARK    GeneRIF: The role of IL-37 in gastrointestinal diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 864)
  AUTHORS   Kim,T.S., Ikeuchi,T., Theofilou,V.I., Williams,D.W.,
            Greenwell-Wild,T., June,A., Adade,E.E., Li,L., Abusleme,L.,
            Dutzan,N., Yuan,Y., Brenchley,L., Bouladoux,N., Sakamachi,Y.,
            Palmer,R.J. Jr., Iglesias-Bartolome,R., Trinchieri,G.,
            Garantziotis,S., Belkaid,Y., Valm,A.M., Diaz,P.I., Holland,S.M. and
            Moutsopoulos,N.M.
  CONSRTM   NIDCD/NIDCR Genomics and Computational Biology Core
  TITLE     Epithelial-derived interleukin-23 promotes oral mucosal
            immunopathology
  JOURNAL   Immunity 57 (4), 859-875 (2024)
   PUBMED   38513665
  REMARK    GeneRIF: Epithelial-derived interleukin-23 promotes oral mucosal
            immunopathology.
REFERENCE   5  (bases 1 to 864)
  AUTHORS   Mei,Y., Zhu,Y., Yong,K.S.M., Hanafi,Z.B., Gong,H., Liu,Y.,
            Teo,H.Y., Hussain,M., Song,Y., Chen,Q. and Liu,H.
  TITLE     IL-37 dampens immunosuppressive functions of MDSCs via metabolic
            reprogramming in the tumor microenvironment
  JOURNAL   Cell Rep 43 (3), 113835 (2024)
   PUBMED   38412100
  REMARK    GeneRIF: IL-37 dampens immunosuppressive functions of MDSCs via
            metabolic reprogramming in the tumor microenvironment.
REFERENCE   6  (bases 1 to 864)
  AUTHORS   Kumar,S., McDonnell,P.C., Lehr,R., Tierney,L., Tzimas,M.N.,
            Griswold,D.E., Capper,E.A., Tal-Singer,R., Wells,G.I., Doyle,M.L.
            and Young,P.R.
  TITLE     Identification and initial characterization of four novel members
            of the interleukin-1 family
  JOURNAL   J Biol Chem 275 (14), 10308-10314 (2000)
   PUBMED   10744718
REFERENCE   7  (bases 1 to 864)
  AUTHORS   Smith,D.E., Renshaw,B.R., Ketchem,R.R., Kubin,M., Garka,K.E. and
            Sims,J.E.
  TITLE     Four new members expand the interleukin-1 superfamily
  JOURNAL   J Biol Chem 275 (2), 1169-1175 (2000)
   PUBMED   10625660
REFERENCE   8  (bases 1 to 864)
  AUTHORS   Mulero,J.J., Pace,A.M., Nelken,S.T., Loeb,D.B., Correa,T.R.,
            Drmanac,R. and Ford,J.E.
  TITLE     IL1HY1: A novel interleukin-1 receptor antagonist gene
  JOURNAL   Biochem Biophys Res Commun 263 (3), 702-706 (1999)
   PUBMED   10512743
REFERENCE   9  (bases 1 to 864)
  AUTHORS   Nothwang,H.G., Strahm,B., Denich,D., Kubler,M., Schwabe,J.,
            Gingrich,J.C., Jauch,A., Cox,A., Nicklin,M.J., Kurnit,D.M. and
            Hildebrandt,F.
  TITLE     Molecular cloning of the interleukin-1 gene cluster: construction
            of an integrated YAC/PAC contig and a partial transcriptional map
            in the region of chromosome 2q13
  JOURNAL   Genomics 41 (3), 370-378 (1997)
   PUBMED   9169134
REFERENCE   10 (bases 1 to 864)
  AUTHORS   Nicklin,M.J., Weith,A. and Duff,G.W.
  TITLE     A physical map of the region encompassing the human interleukin-1
            alpha, interleukin-1 beta, and interleukin-1 receptor antagonist
            genes
  JOURNAL   Genomics 19 (2), 382-384 (1994)
   PUBMED   8188271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079753.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jul 10, 2020 this sequence version replaced
            XM_011510963.3, NM_014439.3.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 cytokine family. This cytokine can bind to, and may
            be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This
            cytokine also binds to interleukin 18 binding protein (IL18BP), an
            inhibitory binding protein of interleukin 18 (IL18), and
            subsequently forms a complex with IL18 receptor beta subunit, and
            through which it inhibits the activity of IL18. This gene along
            with eight other interleukin 1 family genes form a cytokine gene
            cluster on chromosome 2. Five alternatively spliced transcript
            variants encoding distinct isoforms have been reported. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.243447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263326.8/ ENSP00000263326.3
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC079753.7         126575-126658
            85-216              AC079753.7         128373-128504
            217-279             AC079753.7         129202-129264
            280-399             AC079753.7         132539-132658
            400-542             AC079753.7         133045-133187
            543-864             AC079753.7         133971-134292
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..864
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /note="interleukin 37"
                     /db_xref="GeneID:27178"
                     /db_xref="HGNC:HGNC:15563"
                     /db_xref="MIM:605510"
     exon            1..84
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..216
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..791
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interleukin 1, zeta; interleukin-1 homolog 4;
                     interleukin-1 superfamily z; interleukin-1-related
                     protein; IL-1X protein; interleukin 1 family member 7;
                     IL1F7 (canonical product IL-1F7b); IL-1F7b (IL-1H4, IL-1H,
                     IL-1RP1); interleukin-23; FIL1 zeta; IL-1 zeta"
                     /codon_start=1
                     /product="interleukin-37 isoform 1"
                     /protein_id="NP_055254.2"
                     /db_xref="CCDS:CCDS2103.1"
                     /db_xref="GeneID:27178"
                     /db_xref="HGNC:HGNC:15563"
                     /db_xref="MIM:605510"
                     /translation="MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMN
                     FVHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSAS
                     AEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQ
                     VGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
                     "
     exon            217..279
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..399
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..542
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..864
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      837..842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /note="hexamer: TATAAA"
     polyA_site      864
                     /gene="IL37"
                     /gene_synonym="FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H;
                     IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1"
                     /note="major polyA site"
ORIGIN      
        1 aagtaaagga tcctgagaac tgaaggcaaa cagagctcca ggagtccaag acagagccac
       61 agaccacgag gatccctggc ccaggtcttg gacttcattc cattttctgt tgagtaataa
      121 actcaacgtt gaaaatgtcc tttgtggggg agaactcagg agtgaaaatg ggctctgagg
      181 actgggaaaa agatgaaccc cagtgctgct tagaagaccc ggctggaagc cccctggaac
      241 caggcccaag cctccccacc atgaattttg ttcacacaag tccaaaggtg aagaacttaa
      301 acccgaagaa attcagcatt catgaccagg atcacaaagt actggtcctg gactctggga
      361 atctcatagc agttccagat aaaaactaca tacgcccaga gatcttcttt gcattagcct
      421 catccttgag ctcagcctct gcggagaaag gaagtccgat tctcctgggg gtctctaaag
      481 gggagttttg tctctactgt gacaaggata aaggacaaag tcatccatcc cttcagctga
      541 agaaggagaa actgatgaag ctggctgccc aaaaggaatc agcacgccgg cccttcatct
      601 tttatagggc tcaggtgggc tcctggaaca tgctggagtc ggcggctcac cccggatggt
      661 tcatctgcac ctcctgcaat tgtaatgagc ctgttggggt gacagataaa tttgagaaca
      721 ggaaacacat tgaattttca tttcaaccag tttgcaaagc tgaaatgagc cccagtgagg
      781 tcagcgatta ggaaactgcc ccattgaacg ccttcctcgc taatttgaac taattgtata
      841 aaaacaccaa acctgctcac taaa
//
