LOCUS       NM_019618               1211 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens interleukin 36 gamma (IL36G), transcript variant 1,
            mRNA.
ACCESSION   NM_019618
VERSION     NM_019618.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1211)
  AUTHORS   Sato,E., Imayoshi,H., Tsutsui,Y., Shimizu,H. and Imafuku,S.
  TITLE     Mature IL-36gamma Induces Stratum Corneum Exfoliation in
            Generalized Pustular Psoriasis by Suppressing Corneodesmosin
  JOURNAL   J Invest Dermatol 144 (4), 764-773 (2024)
   PUBMED   37827276
  REMARK    GeneRIF: Mature IL-36gamma Induces Stratum Corneum Exfoliation in
            Generalized Pustular Psoriasis by Suppressing Corneodesmosin.
            Erratum:[J Invest Dermatol. 2025 Feb;145(2):456. doi:
            10.1016/j.jid.2024.04.002.. PMID: 39078356]
REFERENCE   2  (bases 1 to 1211)
  AUTHORS   Kischkel,B., Dos Santos,J.C., Lopes-Bezerra,L., Taborda,C.P. and
            Joosten,L.A.B.
  TITLE     Human interleukin-36gamma plays a crucial role in cytokine
            induction during Sporothrix brasiliensis and S. schenckii infection
            in keratinocytes and PBMCs
  JOURNAL   Microb Pathog 188, 106550 (2024)
   PUBMED   38262494
  REMARK    GeneRIF: Human interleukin-36gamma plays a crucial role in cytokine
            induction during Sporothrix brasiliensis and S. schenckii infection
            in keratinocytes and PBMCs.
REFERENCE   3  (bases 1 to 1211)
  AUTHORS   Zhou,Y., Chen,J., Bai,S., Yang,F., Yan,R., Song,Y., Yang,B., Li,C.
            and Wang,J.
  TITLE     Interleukin-36gamma Mediates the In Vitro Activation of CD8+ T
            Cells from Patients Living with Chronic Human Immunodeficiency
            Virus-1 Infection
  JOURNAL   Viral Immunol 37 (1), 24-35 (2024)
   PUBMED   38301135
  REMARK    GeneRIF: Interleukin-36gamma Mediates the In Vitro Activation of
            CD8[+] T Cells from Patients Living with Chronic Human
            Immunodeficiency Virus-1 Infection.
REFERENCE   4  (bases 1 to 1211)
  AUTHORS   Wang,L., Tu,Y., Wu,W., Tu,Y., Yang,Z., Chai,Y., Yang,X. and He,L.
  TITLE     Role of interleukin-36gamma induced by ultraviolet radiation in
            chronic actinic dermatitis
  JOURNAL   Photodermatol Photoimmunol Photomed 39 (6), 598-606 (2023)
   PUBMED   37545106
  REMARK    GeneRIF: Role of interleukin-36gamma induced by ultraviolet
            radiation in chronic actinic dermatitis.
REFERENCE   5  (bases 1 to 1211)
  AUTHORS   Moreira,C.R., de Alcantara,C.C., Flauzino,T., Martin,L.M.M.,
            Lozovoy,M.A.B., Reiche,E.M.V. and Simao,A.N.C.
  TITLE     IL36G genetic variant is independently associated with
            susceptibility, severity and joint involvement in psoriasis
  JOURNAL   Mol Immunol 159, 69-75 (2023)
   PUBMED   37285630
  REMARK    GeneRIF: IL36G genetic variant is independently associated with
            susceptibility, severity and joint involvement in psoriasis.
REFERENCE   6  (bases 1 to 1211)
  AUTHORS   Kumar,S., McDonnell,P.C., Lehr,R., Tierney,L., Tzimas,M.N.,
            Griswold,D.E., Capper,E.A., Tal-Singer,R., Wells,G.I., Doyle,M.L.
            and Young,P.R.
  TITLE     Identification and initial characterization of four novel members
            of the interleukin-1 family
  JOURNAL   J Biol Chem 275 (14), 10308-10314 (2000)
   PUBMED   10744718
REFERENCE   7  (bases 1 to 1211)
  AUTHORS   Smith,D.E., Renshaw,B.R., Ketchem,R.R., Kubin,M., Garka,K.E. and
            Sims,J.E.
  TITLE     Four new members expand the interleukin-1 superfamily
  JOURNAL   J Biol Chem 275 (2), 1169-1175 (2000)
   PUBMED   10625660
REFERENCE   8  (bases 1 to 1211)
  AUTHORS   Mulero,J.J., Pace,A.M., Nelken,S.T., Loeb,D.B., Correa,T.R.,
            Drmanac,R. and Ford,J.E.
  TITLE     IL1HY1: A novel interleukin-1 receptor antagonist gene
  JOURNAL   Biochem Biophys Res Commun 263 (3), 702-706 (1999)
   PUBMED   10512743
REFERENCE   9  (bases 1 to 1211)
  AUTHORS   Nothwang,H.G., Strahm,B., Denich,D., Kubler,M., Schwabe,J.,
            Gingrich,J.C., Jauch,A., Cox,A., Nicklin,M.J., Kurnit,D.M. and
            Hildebrandt,F.
  TITLE     Molecular cloning of the interleukin-1 gene cluster: construction
            of an integrated YAC/PAC contig and a partial transcriptional map
            in the region of chromosome 2q13
  JOURNAL   Genomics 41 (3), 370-378 (1997)
   PUBMED   9169134
REFERENCE   10 (bases 1 to 1211)
  AUTHORS   Nicklin,M.J., Weith,A. and Duff,G.W.
  TITLE     A physical map of the region encompassing the human interleukin-1
            alpha, interleukin-1 beta, and interleukin-1 receptor antagonist
            genes
  JOURNAL   Genomics 19 (2), 382-384 (1994)
   PUBMED   8188271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016724.11 and AF206696.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019618.3.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 cytokine family. The activity of this cytokine is
            mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is
            specifically inhibited by interleukin 1 family, member 5
            (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha
            and interleukin 1, beta (IL1B) are reported to stimulate the
            expression of this cytokine in keratinocytes. The expression of
            this cytokine in keratinocytes can also be induced by a contact
            hypersensitivity reaction or herpes simplex virus infection. This
            gene and eight other interleukin 1 family genes form a cytokine
            gene cluster on chromosome 2. [provided by RefSeq, May 2019].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF206696.1, AF200492.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259205.5/ ENSP00000259205.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC016724.11        27236-27261
            27-1203             AF206696.1         1-1177
            1204-1211           AC016724.11        34881-34888
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..1211
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /note="interleukin 36 gamma"
                     /db_xref="GeneID:56300"
                     /db_xref="HGNC:HGNC:15741"
                     /db_xref="MIM:605542"
     exon            1..73
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /inference="alignment:Splign:2.1.0"
     exon            74..147
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..602
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interleukin-1 homolog 1; interleukin-1 epsilon;
                     interleukin 1-related protein 2; IL-1 related protein 2;
                     interleukin-1 family member 9; IL-1-epsilon"
                     /codon_start=1
                     /product="interleukin-36 gamma isoform 1"
                     /protein_id="NP_062564.1"
                     /db_xref="CCDS:CCDS2108.1"
                     /db_xref="GeneID:56300"
                     /db_xref="HGNC:HGNC:15741"
                     /db_xref="MIM:605542"
                     /translation="MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVA
                     VPRSDSVTPVTVAVITCKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQ
                     KIMDLYGQPEPVKPFLFYRAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYN
                     TAFELNIND"
     exon            148..252
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..392
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..1211
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1184..1189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /note="hexamer: AATAAA"
     polyA_site      1211
                     /gene="IL36G"
                     /gene_synonym="IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9;
                     IL1H1; IL1RP2"
                     /note="major polyA site"
ORIGIN      
        1 atcactgacc ttggaagctg ctggagccac gattcagtcc cctggactgt agataaagac
       61 cctttcttgc caggtgctga gacaaccaca ctatgagagg cactccagga gacgctgatg
      121 gtggaggaag ggccgtctat caatcaatgt gtaaacctat tactgggact attaatgatt
      181 tgaatcagca agtgtggacc cttcagggtc agaaccttgt ggcagttcca cgaagtgaca
      241 gtgtgacccc agtcactgtt gctgttatca catgcaagta tccagaggct cttgagcaag
      301 gcagagggga tcccatttat ttgggaatcc agaatccaga aatgtgtttg tattgtgaga
      361 aggttggaga acagcccaca ttgcagctaa aagagcagaa gatcatggat ctgtatggcc
      421 aacccgagcc cgtgaaaccc ttccttttct accgtgccaa gactggtagg acctccaccc
      481 ttgagtctgt ggccttcccg gactggttca ttgcctcctc caagagagac cagcccatca
      541 ttctgacttc agaacttggg aagtcataca acactgcctt tgaattaaat ataaatgact
      601 gaactcagcc tagaggtggc agcttggtct ttgtcttaaa gtttctggtt cccaatgtgt
      661 tttcgtctac attttcttag tgtcattttc acgctggtgc tgagacaggg gcaaggctgc
      721 tgttatcatc tcattttata atgaagaaga agcaattact tcatagcaac tgaagaacag
      781 gatgtggcct cagaagcagg agagctgggt ggtataaggc tgtcctctca agctggtgct
      841 gtgtaggcca caaggcatct gcatgagtga ctttaagact caaagaccaa acactgagct
      901 ttcttctagg ggtgggtatg aagatgcttc agagctcatg cgcgttaccc acgatggcat
      961 gactagcaca gagctgatct ctgtttctgt tttgctttat tccctcttgg gatgatatca
     1021 tccagtcttt atatgttgcc aatatacctc attgtgtgta atagaacctt cttagcatta
     1081 agaccttgta aacaaaaata attcttgtgt taagttaaat catttttgtc ctaattgtaa
     1141 tgtgtaatct taaagttaaa taaactttgt gtatttatat aataataaag ctaaaactga
     1201 tataaaataa a
//
