LOCUS       NM_173178               1052 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interleukin 36 beta (IL36B), transcript variant 2,
            mRNA.
ACCESSION   NM_173178
VERSION     NM_173178.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1052)
  AUTHORS   Ahmad,F., Alam,M.A., Ansari,A.W., Jochebeth,A., Leo,R.,
            Al-Abdulla,M.N., Al-Khawaga,S., AlHammadi,A., Al-Malki,A., Al
            Naama,K., Ahmad,A., Buddenkotte,J. and Steinhoff,M.
  TITLE     Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory
            Skin Diseases
  JOURNAL   J Invest Dermatol 144 (2), 206-224 (2024)
   PUBMED   38189700
  REMARK    GeneRIF: Emerging Role of the IL-36/IL-36R Axis in Multiple
            Inflammatory Skin Diseases.
            Review article
REFERENCE   2  (bases 1 to 1052)
  AUTHORS   Komaki,R., Miyagaki,T., Tanaka,M., Nakajima,K., Okano,T.,
            Takeuchi,S. and Kadono,T.
  TITLE     Increased Interleukin-36beta Expression Promotes Angiogenesis in
            Japanese Atopic Dermatitis
  JOURNAL   Int J Mol Sci 24 (13), 11104 (2023)
   PUBMED   37446281
  REMARK    GeneRIF: Increased Interleukin-36beta Expression Promotes
            Angiogenesis in Japanese Atopic Dermatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1052)
  AUTHORS   Dong,H., Hao,Y., Li,W., Yang,W. and Gao,P.
  TITLE     IL-36 Cytokines: Their Roles in Asthma and Potential as a
            Therapeutic
  JOURNAL   Front Immunol 13, 921275 (2022)
   PUBMED   35903102
  REMARK    GeneRIF: IL-36 Cytokines: Their Roles in Asthma and Potential as a
            Therapeutic.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1052)
  AUTHORS   Huang,S., Feng,T., Wang,J. and Dong,L.
  TITLE     IL-36 is Closely Related to Neutrophilic Inflammation in Chronic
            Obstructive Pulmonary Disease
  JOURNAL   Int J Chron Obstruct Pulmon Dis 17, 1339-1347 (2022)
   PUBMED   35698471
  REMARK    GeneRIF: IL-36 is Closely Related to Neutrophilic Inflammation in
            Chronic Obstructive Pulmonary Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1052)
  AUTHORS   Chen,F., Qu,M., Zhang,F., Tan,Z., Xia,Q., Hambly,B.D., Bao,S. and
            Tao,K.
  TITLE     IL-36 s in the colorectal cancer: is interleukin 36 good or bad for
            the development of colorectal cancer?
  JOURNAL   BMC Cancer 20 (1), 92 (2020)
   PUBMED   32013927
  REMARK    GeneRIF: IL-36 s in the colorectal cancer: is interleukin 36 good
            or bad for the development of colorectal cancer?
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1052)
  AUTHORS   Kumar,S., McDonnell,P.C., Lehr,R., Tierney,L., Tzimas,M.N.,
            Griswold,D.E., Capper,E.A., Tal-Singer,R., Wells,G.I., Doyle,M.L.
            and Young,P.R.
  TITLE     Identification and initial characterization of four novel members
            of the interleukin-1 family
  JOURNAL   J Biol Chem 275 (14), 10308-10314 (2000)
   PUBMED   10744718
REFERENCE   7  (bases 1 to 1052)
  AUTHORS   Smith,D.E., Renshaw,B.R., Ketchem,R.R., Kubin,M., Garka,K.E. and
            Sims,J.E.
  TITLE     Four new members expand the interleukin-1 superfamily
  JOURNAL   J Biol Chem 275 (2), 1169-1175 (2000)
   PUBMED   10625660
REFERENCE   8  (bases 1 to 1052)
  AUTHORS   Mulero,J.J., Pace,A.M., Nelken,S.T., Loeb,D.B., Correa,T.R.,
            Drmanac,R. and Ford,J.E.
  TITLE     IL1HY1: A novel interleukin-1 receptor antagonist gene
  JOURNAL   Biochem Biophys Res Commun 263 (3), 702-706 (1999)
   PUBMED   10512743
REFERENCE   9  (bases 1 to 1052)
  AUTHORS   Nothwang,H.G., Strahm,B., Denich,D., Kubler,M., Schwabe,J.,
            Gingrich,J.C., Jauch,A., Cox,A., Nicklin,M.J., Kurnit,D.M. and
            Hildebrandt,F.
  TITLE     Molecular cloning of the interleukin-1 gene cluster: construction
            of an integrated YAC/PAC contig and a partial transcriptional map
            in the region of chromosome 2q13
  JOURNAL   Genomics 41 (3), 370-378 (1997)
   PUBMED   9169134
REFERENCE   10 (bases 1 to 1052)
  AUTHORS   Nicklin,M.J., Weith,A. and Duff,G.W.
  TITLE     A physical map of the region encompassing the human interleukin-1
            alpha, interleukin-1 beta, and interleukin-1 receptor antagonist
            genes
  JOURNAL   Genomics 19 (2), 382-384 (1994)
   PUBMED   8188271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF201833.1, AC016724.11 and
            CA441070.1.
            
            On May 31, 2019 this sequence version replaced NM_173178.2.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 cytokine family. Protein structure modeling indicated
            that this cytokine may contain a 12-stranded beta-trefoil structure
            that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta).
            This gene and eight other interleukin 1 family genes form a
            cytokine gene cluster on chromosome 2. Two alternatively spliced
            transcript variants encoding distinct isoforms have been reported.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 3' region,
            which includes a part of the coding region and 3' UTR, compared to
            variant 1. The resulting isoform (2) has a distinct and shorter
            C-terminus, as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201833.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2145743 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327407.2/ ENSP00000328420.2
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AF201833.1         3-6
            5-582               AF201833.1         8-585
            583-1042            AC016724.11        76673-77132         c
            1043-1052           CA441070.1         17-26               c
FEATURES             Location/Qualifiers
     source          1..1052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..1052
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /note="interleukin 36 beta"
                     /db_xref="GeneID:27177"
                     /db_xref="HGNC:HGNC:15564"
                     /db_xref="MIM:605508"
     exon            1..51
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /inference="alignment:Splign:2.1.0"
     exon            52..121
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..582
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     interleukin 1 family, member 8 (eta); Interleukin-1
                     Superfamily e; family of interleukin 1-eta; interleukin-1
                     homolog 2; interleukin-1 family member 8; IL-1F8
                     (FIL1-eta); FIL1 eta; IL-1 eta; interleukin-1 eta"
                     /codon_start=1
                     /product="interleukin-36 beta isoform 2"
                     /protein_id="NP_775270.1"
                     /db_xref="CCDS:CCDS2110.1"
                     /db_xref="GeneID:27177"
                     /db_xref="HGNC:HGNC:15564"
                     /db_xref="MIM:605508"
                     /translation="MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLH
                     LIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQK
                     PFLFFHNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE"
     exon            122..229
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /inference="alignment:Splign:2.1.0"
     exon            230..369
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..1052
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      972..977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /note="hexamer: ATTATA"
     polyA_site      991
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
     regulatory      1022..1027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /note="hexamer: ATTAAA"
     polyA_site      1052
                     /gene="IL36B"
                     /gene_synonym="FIL1; FIL1-(ETA); FIL1H; FILI-(ETA);
                     IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2"
                     /note="major polyA site"
ORIGIN      
        1 cacgggttcc tccccactct gtctttctca cctctccttc acttttccta gcctcctcac
       61 caccatctga tctatcttgt tctcttcaca aaaggctctg aagacatcat gaacccacaa
      121 cgggaggcag cacccaaatc ctatgctatt cgtgattctc gacagatggt gtgggtcctg
      181 agtggaaatt ctttaatagc agctcctctt agccgcagca ttaagcctgt cactcttcat
      241 ttaatagcct gtagagacac agaattcagt gacaaggaaa agggtaatat ggtttacctg
      301 ggaatcaagg gaaaagatct ctgtctcttc tgtgcagaaa ttcagggcaa gcctactttg
      361 cagcttaagg aaaaaaatat catggacctg tatgtggaga agaaagcaca gaagcccttt
      421 ctctttttcc acaataaaga aggctccact tctgtctttc agtcagtctc ttaccctggc
      481 tggttcatag ccacctccac cacatcagga cagcccatct ttctcaccaa ggagagaggc
      541 ataactaata acactaactt ctacttagat tctgtggaat aaatccagcc taggctgtgg
      601 gtggctggtt ccaggataga gaatcaagct gtcagagtca tcttaacaga tcattatgcg
      661 actgagttca ctagcagttc agcccatcca tagcttacct cattcttact atccaaaagc
      721 cacctcctcc tccaaacatc catttctgta ccaagaccct cactcgaatg tcactatccc
      781 aagatgaaac ctaaaaatca ctttccattc tttcttgatc ttaccccacc atccactcag
      841 ctgccatgcc cagtttagtc aaccccccaa atgctgcttc atgcaacctt ccattcctat
      901 tccttttgcc aacccatgat gtagagatgt ggattcatga cattttgttc atacaacttc
      961 ttcaataaaa cattataata tgtgccccaa agataaagct gaagaatgag atgaatgtga
     1021 aattaaaggt ttgcatgtct ttctaatcct aa
//
