LOCUS       NM_014440                890 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interleukin 36 alpha (IL36A), mRNA.
ACCESSION   NM_014440
VERSION     NM_014440.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 890)
  AUTHORS   Ahmad,F., Alam,M.A., Ansari,A.W., Jochebeth,A., Leo,R.,
            Al-Abdulla,M.N., Al-Khawaga,S., AlHammadi,A., Al-Malki,A., Al
            Naama,K., Ahmad,A., Buddenkotte,J. and Steinhoff,M.
  TITLE     Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory
            Skin Diseases
  JOURNAL   J Invest Dermatol 144 (2), 206-224 (2024)
   PUBMED   38189700
  REMARK    GeneRIF: Emerging Role of the IL-36/IL-36R Axis in Multiple
            Inflammatory Skin Diseases.
            Review article
REFERENCE   2  (bases 1 to 890)
  AUTHORS   Zysk,W., Sitko,K., Tukaj,S., Zaryczanska,A. and Trzeciak,M.
  TITLE     Altered Gene Expression of IL-35 and IL-36alpha in the Skin of
            Patients with Atopic Dermatitis
  JOURNAL   Int J Mol Sci 25 (1), 404 (2023)
   PUBMED   38203575
  REMARK    GeneRIF: Altered Gene Expression of IL-35 and IL-36alpha in the
            Skin of Patients with Atopic Dermatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 890)
  AUTHORS   O'Reilly,S.
  TITLE     Interleukin-36alpha is elevated in diffuse systemic sclerosis and
            may potentiate fibrosis
  JOURNAL   Cytokine 156, 155921 (2022)
   PUBMED   35667282
  REMARK    GeneRIF: Interleukin-36alpha is elevated in diffuse systemic
            sclerosis and may potentiate fibrosis.
REFERENCE   4  (bases 1 to 890)
  AUTHORS   Dong,H., Hao,Y., Li,W., Yang,W. and Gao,P.
  TITLE     IL-36 Cytokines: Their Roles in Asthma and Potential as a
            Therapeutic
  JOURNAL   Front Immunol 13, 921275 (2022)
   PUBMED   35903102
  REMARK    GeneRIF: IL-36 Cytokines: Their Roles in Asthma and Potential as a
            Therapeutic.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 890)
  AUTHORS   Huang,S., Feng,T., Wang,J. and Dong,L.
  TITLE     IL-36 is Closely Related to Neutrophilic Inflammation in Chronic
            Obstructive Pulmonary Disease
  JOURNAL   Int J Chron Obstruct Pulmon Dis 17, 1339-1347 (2022)
   PUBMED   35698471
  REMARK    GeneRIF: IL-36 is Closely Related to Neutrophilic Inflammation in
            Chronic Obstructive Pulmonary Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 890)
  AUTHORS   Kumar,S., McDonnell,P.C., Lehr,R., Tierney,L., Tzimas,M.N.,
            Griswold,D.E., Capper,E.A., Tal-Singer,R., Wells,G.I., Doyle,M.L.
            and Young,P.R.
  TITLE     Identification and initial characterization of four novel members
            of the interleukin-1 family
  JOURNAL   J Biol Chem 275 (14), 10308-10314 (2000)
   PUBMED   10744718
REFERENCE   7  (bases 1 to 890)
  AUTHORS   Smith,D.E., Renshaw,B.R., Ketchem,R.R., Kubin,M., Garka,K.E. and
            Sims,J.E.
  TITLE     Four new members expand the interleukin-1 superfamily
  JOURNAL   J Biol Chem 275 (2), 1169-1175 (2000)
   PUBMED   10625660
REFERENCE   8  (bases 1 to 890)
  AUTHORS   Mulero,J.J., Pace,A.M., Nelken,S.T., Loeb,D.B., Correa,T.R.,
            Drmanac,R. and Ford,J.E.
  TITLE     IL1HY1: A novel interleukin-1 receptor antagonist gene
  JOURNAL   Biochem Biophys Res Commun 263 (3), 702-706 (1999)
   PUBMED   10512743
REFERENCE   9  (bases 1 to 890)
  AUTHORS   Nothwang,H.G., Strahm,B., Denich,D., Kubler,M., Schwabe,J.,
            Gingrich,J.C., Jauch,A., Cox,A., Nicklin,M.J., Kurnit,D.M. and
            Hildebrandt,F.
  TITLE     Molecular cloning of the interleukin-1 gene cluster: construction
            of an integrated YAC/PAC contig and a partial transcriptional map
            in the region of chromosome 2q13
  JOURNAL   Genomics 41 (3), 370-378 (1997)
   PUBMED   9169134
REFERENCE   10 (bases 1 to 890)
  AUTHORS   Nicklin,M.J., Weith,A. and Duff,G.W.
  TITLE     A physical map of the region encompassing the human interleukin-1
            alpha, interleukin-1 beta, and interleukin-1 receptor antagonist
            genes
  JOURNAL   Genomics 19 (2), 382-384 (1994)
   PUBMED   8188271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016724.11, AK314149.1 and
            AF201831.1.
            
            On May 17, 2019 this sequence version replaced NM_014440.2.
            
            Summary: The protein encoded by this gene is a cytokine that can
            activate NF-kappa-B and MAPK signaling pathways to generate an
            inflammatory response. The encoded protein functions primarily in
            skin and demonstrates increased expression in psoriasis. In
            addition, decreased expression of this gene has been linked to a
            poor prognosis in both hepatocellular carcinoma and colorectal
            cancer patients. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314149.1, BC107043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259211.7/ ENSP00000259211.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC016724.11        54689-54690
            3-50                AK314149.1         4-51
            51-51               AC016724.11        54739-54739
            52-413              AK314149.1         53-414
            414-890             AF201831.1         1-477
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..890
                     /gene="IL36A"
                     /gene_synonym="FIL1; FIL1(EPSILON); FIL1E; IL-1F6;
                     IL1(EPSILON); IL1F6"
                     /note="interleukin 36 alpha"
                     /db_xref="GeneID:27179"
                     /db_xref="HGNC:HGNC:15562"
                     /db_xref="MIM:605509"
     exon            1..423
                     /gene="IL36A"
                     /gene_synonym="FIL1; FIL1(EPSILON); FIL1E; IL-1F6;
                     IL1(EPSILON); IL1F6"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..890
                     /gene="IL36A"
                     /gene_synonym="FIL1; FIL1(EPSILON); FIL1E; IL-1F6;
                     IL1(EPSILON); IL1F6"
                     /note="interleukin 1 family, member 6 (epsilon);
                     interleukin-1 family member 6; IL-1F6 (FIL-1-epsilon);
                     FIL1 epsilon; IL-1 epsilon; interleukin-1 epsilon"
                     /codon_start=1
                     /product="interleukin-36 alpha"
                     /protein_id="NP_055255.1"
                     /db_xref="CCDS:CCDS42734.1"
                     /db_xref="GeneID:27179"
                     /db_xref="HGNC:HGNC:15562"
                     /db_xref="MIM:605509"
                     /translation="MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTI
                     ALISCRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPV
                     KSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF"
     exon            424..537
                     /gene="IL36A"
                     /gene_synonym="FIL1; FIL1(EPSILON); FIL1E; IL-1F6;
                     IL1(EPSILON); IL1F6"
                     /inference="alignment:Splign:2.1.0"
     exon            538..677
                     /gene="IL36A"
                     /gene_synonym="FIL1; FIL1(EPSILON); FIL1E; IL-1F6;
                     IL1(EPSILON); IL1F6"
                     /inference="alignment:Splign:2.1.0"
     exon            678..890
                     /gene="IL36A"
                     /gene_synonym="FIL1; FIL1(EPSILON); FIL1E; IL-1F6;
                     IL1(EPSILON); IL1F6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaaccca agtgcagtag aagccattgt tcataatggt agggatacag ggtccttcgt
       61 aacagattat cagtgtggcc tatgctggaa agtctggtga cctctgattt tttttgcttc
      121 caggtctttg gccttggcac tctttgtcat attagagttc ctgggtctag gcctgggcag
      181 gattcatagg tgcagctgct tctgctggag gtagactgca tccaacaaag taagggtgct
      241 gggtgagttc tgggagtata gattctgact ggggtcactg ctgggctggc cgccagtctt
      301 tcatctgacc cagggttaaa ctgtggcttg ggactgactc aggtcctctc ttggggtcgg
      361 tctgcacata aaaggactcc tatccttggc agttctgaaa caacaccacc acaatggaaa
      421 aagcattgaa aattgacaca cctcagcagg ggagcattca ggatatcaat catcgggtgt
      481 gggttcttca ggaccagacg ctcatagcag tcccgaggaa ggaccgtatg tctccagtca
      541 ctattgcctt aatctcatgc cgacatgtgg agacccttga gaaagacaga gggaacccca
      601 tctacctggg cctgaatgga ctcaatctct gcctgatgtg tgctaaagtc ggggaccagc
      661 ccacactgca gctgaaggaa aaggatataa tggatttgta caaccaaccc gagcctgtga
      721 agtcctttct cttctaccac agccagagtg gcaggaactc caccttcgag tctgtggctt
      781 tccctggctg gttcatcgct gtcagctctg aaggaggctg tcctctcatc cttacccaag
      841 aactggggaa agccaacact actgactttg ggttaactat gctgttttaa
//
